Trait: hemorrhagic stroke

Trait Information
Identifier MONDO_1060199
Description A stroke disorder caused by bleeding into the brain parenchyma or surrounding spaces. Hemorrhagic stroke includes intracerebral hemorrhage (bleeding within the brain tissue) and subarachnoid hemorrhage (bleeding in the space between the brain and the surrounding membrane). [PMID: 29763173]
Trait category
Other trait
Synonym haemorrhagic stroke
Child trait(s) intracerebral hemorrhage

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "hemorrhagic stroke" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003457
(GRS_ICH)
 PGP000450 |
Mayerhofer E et al. Stroke (2023)
 Intracerebral hemorrhage intracerebral hemorrhage 682,890
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003457/ScoringFiles/PGS003457.txt.gz
PGS004943
(ICH_MetaPRS)
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Intracerebral hemorrhage intracerebral hemorrhage 2,124,631
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004943/ScoringFiles/PGS004943.txt.gz
PGS019220
(TPMI_430.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracerebral hemorrhage intracerebral hemorrhage 239,850
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019220/ScoringFiles/PGS019220.txt.gz
PGS019221
(TPMI_430.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracerebral hemorrhage intracerebral hemorrhage 939,827
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019221/ScoringFiles/PGS019221.txt.gz
PGS019222
(TPMI_430.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracerebral hemorrhage intracerebral hemorrhage 26,024
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019222/ScoringFiles/PGS019222.txt.gz
PGS019223
(TPMI_430.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracerebral hemorrhage intracerebral hemorrhage 983,782
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019223/ScoringFiles/PGS019223.txt.gz
PGS019224
(TPMI_430.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Intracerebral hemorrhage intracerebral hemorrhage 1,012,521
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019224/ScoringFiles/PGS019224.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017258 PGS003457
(GRS_ICH)
 PSS010179|
Multi-ancestry (including European)|
5,530 individuals
 PGP000450 |
Mayerhofer E et al. Stroke (2023)
 Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapy HR: 1.24 [1.01, 1.53] — R²: 0.02 age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array —
PPM017259 PGS003457
(GRS_ICH)
 PSS010179|
Multi-ancestry (including European)|
5,530 individuals
 PGP000450 |
Mayerhofer E et al. Stroke (2023)
 Reported Trait: Incident intracerebral hemorrhage in anticoagulation therapy HR: 1.33 [1.11, 1.59] C-index: 0.57 [0.5, 0.64] — age at baseline (controls) or ICH event (cases), sex, PC1 to 10, and genotyping array, clinical risk score —
PPM021741 PGS004943
(ICH_MetaPRS)
 PSS011773|
East Asian Ancestry|
72,149 individuals
 PGP000668 |
China Kadoorie Biobank Collaborative Group. et al. Nat Hum Behav (2024)
 Reported Trait: Incident intracerebral hemorrhage HR: 1.31 [1.24, 1.39] C-index: 0.748 [0.734, 0.761] — age, sex —
PPM037402 PGS019220
(TPMI_430.2_Lassosum2)
 PSS013118|
East Asian Ancestry|
17,486 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracerebral hemorrhage — AUROC: 0.66204 R²: 0.00902 sex, age, array, PCs 1-10 —
PPM037403 PGS019221
(TPMI_430.2_LDpred2)
 PSS013117|
East Asian Ancestry|
17,486 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracerebral hemorrhage — AUROC: 0.66451 R²: 0.00928 sex, age, array, PCs 1-10 —
PPM037404 PGS019222
(TPMI_430.2_MegaPRS)
 PSS013119|
East Asian Ancestry|
17,486 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracerebral hemorrhage — AUROC: 0.66942 R²: 0.01012 sex, age, array, PCs 1-10 —
PPM037405 PGS019223
(TPMI_430.2_PRS-CS)
 PSS013120|
East Asian Ancestry|
17,486 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracerebral hemorrhage — AUROC: 0.66267 R²: 0.00903 sex, age, array, PCs 1-10 —
PPM037406 PGS019224
(TPMI_430.2_SBayesR)
 PSS013121|
East Asian Ancestry|
17,486 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Intracerebral hemorrhage — AUROC: 0.66098 R²: 0.00882 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013117 431,I61 —
[
  • 170 cases
  • , 17,316 controls
]
,
44.64 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013118 431,I61 —
[
  • 170 cases
  • , 17,316 controls
]
,
44.64 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013119 431,I61 —
[
  • 170 cases
  • , 17,316 controls
]
,
44.64 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013120 431,I61 —
[
  • 170 cases
  • , 17,316 controls
]
,
44.64 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013121 431,I61 —
[
  • 170 cases
  • , 17,316 controls
]
,
44.64 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS011773 ICD10: I61 Median = 12.2 years 72,149 individuals,
40.2 % Male samples
 Mean = 51.7 years
Sd = 10.5 years		 East Asian
(Chinese)		 — CKB —
PSS010179 The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care data Mean = 11.9 years
[
  • 86 cases
  • , 4,972 controls
]
,
69.0 % Male samples
 Mean = 62.0 years European — UKB —
PSS010179 The test cohort consisted of individuals without a history of ICH at baseline and anticoagulant use defined by self-report in the verbal interview at inclusion. Furthermore, individuals were included if they had a diagnosis of the International Classification of Diseases, Tenth Revision code Z92.1 (personal history of long-term (current) use of anticoagulants) or D68.3 (hemorrhagic disorder due to circulating anticoagulants) at baseline or a prescription of an anticoagulant medication between baseline and 6 months thereafter in the primary care data Mean = 11.9 years
[
  • 8 cases
  • , 464 controls
]
,
69.0 % Male samples
 Mean = 62.0 years Not reported — UKB —