Trait: menstrual disorder

Trait Information
Identifier MONDO_1060204
Description A disorder of the female reproductive system characterized by abnormalities in the menstrual cycle, including disturbances in timing, flow, or associated pain. [PMID: 29489290] [PMID: 32809669]
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019562
(TPMI_626_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders of menstruation and other abnormal bleeding from female genital tract menstrual disorder 704,441
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019562/ScoringFiles/PGS019562.txt.gz
PGS019563
(TPMI_626_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders of menstruation and other abnormal bleeding from female genital tract menstrual disorder 364,062
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019563/ScoringFiles/PGS019563.txt.gz
PGS019564
(TPMI_626_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders of menstruation and other abnormal bleeding from female genital tract menstrual disorder 21,876
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019564/ScoringFiles/PGS019564.txt.gz
PGS019565
(TPMI_626_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders of menstruation and other abnormal bleeding from female genital tract menstrual disorder 983,758
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019565/ScoringFiles/PGS019565.txt.gz
PGS019566
(TPMI_626_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Disorders of menstruation and other abnormal bleeding from female genital tract menstrual disorder 966,753
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019566/ScoringFiles/PGS019566.txt.gz
PGS019567
(TPMI_626.13_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Irregular menstrual cycle menstrual disorder 714,359
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019567/ScoringFiles/PGS019567.txt.gz
PGS019568
(TPMI_626.13_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Irregular menstrual cycle menstrual disorder 323,552
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019568/ScoringFiles/PGS019568.txt.gz
PGS019569
(TPMI_626.13_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Irregular menstrual cycle menstrual disorder 25,323
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019569/ScoringFiles/PGS019569.txt.gz
PGS019570
(TPMI_626.13_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Irregular menstrual cycle menstrual disorder 983,768
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019570/ScoringFiles/PGS019570.txt.gz
PGS019571
(TPMI_626.13_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Irregular menstrual cycle menstrual disorder 991,541
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019571/ScoringFiles/PGS019571.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037744 PGS019562
(TPMI_626_Lassosum2)
 PSS013470|
East Asian Ancestry|
9,073 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Disorders of menstruation and other abnormal bleeding from female genital tract — AUROC: 0.90333 R²: 0.52652 sex, age, array, PCs 1-10 —
PPM037745 PGS019563
(TPMI_626_LDpred2)
 PSS013469|
East Asian Ancestry|
9,073 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Disorders of menstruation and other abnormal bleeding from female genital tract — AUROC: 0.90334 R²: 0.52649 sex, age, array, PCs 1-10 —
PPM037746 PGS019564
(TPMI_626_MegaPRS)
 PSS013471|
East Asian Ancestry|
9,073 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Disorders of menstruation and other abnormal bleeding from female genital tract — AUROC: 0.90332 R²: 0.52642 sex, age, array, PCs 1-10 —
PPM037747 PGS019565
(TPMI_626_PRS-CS)
 PSS013472|
East Asian Ancestry|
9,073 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Disorders of menstruation and other abnormal bleeding from female genital tract — AUROC: 0.90346 R²: 0.52674 sex, age, array, PCs 1-10 —
PPM037748 PGS019566
(TPMI_626_SBayesR)
 PSS013473|
East Asian Ancestry|
9,073 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Disorders of menstruation and other abnormal bleeding from female genital tract — AUROC: 0.90337 R²: 0.52646 sex, age, array, PCs 1-10 —
PPM037749 PGS019567
(TPMI_626.13_Lassosum2)
 PSS013465|
East Asian Ancestry|
8,400 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Irregular menstrual cycle — AUROC: 0.90398 R²: 0.25137 sex, age, array, PCs 1-10 —
PPM037750 PGS019568
(TPMI_626.13_LDpred2)
 PSS013464|
East Asian Ancestry|
8,400 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Irregular menstrual cycle — AUROC: 0.90544 R²: 0.25369 sex, age, array, PCs 1-10 —
PPM037751 PGS019569
(TPMI_626.13_MegaPRS)
 PSS013466|
East Asian Ancestry|
8,400 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Irregular menstrual cycle — AUROC: 0.9054 R²: 0.25285 sex, age, array, PCs 1-10 —
PPM037752 PGS019570
(TPMI_626.13_PRS-CS)
 PSS013467|
East Asian Ancestry|
8,400 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Irregular menstrual cycle — AUROC: 0.90421 R²: 0.25168 sex, age, array, PCs 1-10 —
PPM037753 PGS019571
(TPMI_626.13_SBayesR)
 PSS013468|
East Asian Ancestry|
8,400 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Irregular menstrual cycle — AUROC: 0.90401 R²: 0.25154 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013469 621.4, 625.2, 625.3, 625.4, 626, 628,N85.7, N89.7, N91, N92.0, N92.1, N92.2, N92.3, N92.5, N92.6, N93.8, N93.9, N94.0, N94.3, N94.4, N94.5, N94.6, N97 —
[
  • 921 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013470 621.4, 625.2, 625.3, 625.4, 626, 628,N85.7, N89.7, N91, N92.0, N92.1, N92.2, N92.3, N92.5, N92.6, N93.8, N93.9, N94.0, N94.3, N94.4, N94.5, N94.6, N97 —
[
  • 921 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013471 621.4, 625.2, 625.3, 625.4, 626, 628,N85.7, N89.7, N91, N92.0, N92.1, N92.2, N92.3, N92.5, N92.6, N93.8, N93.9, N94.0, N94.3, N94.4, N94.5, N94.6, N97 —
[
  • 921 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013472 621.4, 625.2, 625.3, 625.4, 626, 628,N85.7, N89.7, N91, N92.0, N92.1, N92.2, N92.3, N92.5, N92.6, N93.8, N93.9, N94.0, N94.3, N94.4, N94.5, N94.6, N97 —
[
  • 921 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013473 621.4, 625.2, 625.3, 625.4, 626, 628,N85.7, N89.7, N91, N92.0, N92.1, N92.2, N92.3, N92.5, N92.6, N93.8, N93.9, N94.0, N94.3, N94.4, N94.5, N94.6, N97 —
[
  • 921 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013464 626.4,N92.6 —
[
  • 248 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013465 626.4,N92.6 —
[
  • 248 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013466 626.4,N92.6 —
[
  • 248 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013467 626.4,N92.6 —
[
  • 248 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013468 626.4,N92.6 —
[
  • 248 cases
  • , 8,152 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —