Trait: bowel opening frequency

Trait Information
Identifier OBA_2045221
Description The frequency of a defecation rhythm. [AUTO: patterns/patterns/entity_attribute]
Trait category
Other measurement
Synonym frequency of defecation rhythm

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001376
(GBE_INI21044)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Average number of times bowels opened per day bowel opening frequency 845
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001376/ScoringFiles/PGS001376.txt.gz
PGS002232
(STLFRQPGS)
 PGP000265 |
Bonfiglio F et al. Cell Genom (2021)
 Stool Frequency bowel opening frequency 263,279
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002232/ScoringFiles/PGS002232.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005265 PGS001376
(GBE_INI21044)
 PSS004926|
African Ancestry|
994 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ave. # of times bowels opened per day — — R²: 0.0174 [0.0111, 0.0237]
Incremental R2 (full-covars): -0.00408
PGS R2 (no covariates): 0.00131 [-0.00045, 0.00307]		 age, sex, UKB array type, Genotype PCs —
PPM005266 PGS001376
(GBE_INI21044)
 PSS004927|
East Asian Ancestry|
390 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ave. # of times bowels opened per day — — R²: 0.03393 [0.01707, 0.05079]
Incremental R2 (full-covars): -0.00945
PGS R2 (no covariates): 0.0038 [-0.00202, 0.00961]		 age, sex, UKB array type, Genotype PCs —
PPM005267 PGS001376
(GBE_INI21044)
 PSS004928|
European Ancestry|
9,083 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ave. # of times bowels opened per day — — R²: 0.01143 [0.0088, 0.01405]
Incremental R2 (full-covars): 0.00179
PGS R2 (no covariates): 0.00187 [0.0008, 0.00294]		 age, sex, UKB array type, Genotype PCs —
PPM005268 PGS001376
(GBE_INI21044)
 PSS004929|
South Asian Ancestry|
1,179 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ave. # of times bowels opened per day — — R²: 0.02854 [0.02128, 0.03581]
Incremental R2 (full-covars): 0.00207
PGS R2 (no covariates): 0.00214 [0.0001, 0.00419]		 age, sex, UKB array type, Genotype PCs —
PPM005269 PGS001376
(GBE_INI21044)
 PSS004930|
European Ancestry|
24,268 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Ave. # of times bowels opened per day — — R²: 0.00354 [0.00264, 0.00443]
Incremental R2 (full-covars): 0.00201
PGS R2 (no covariates): 0.00204 [0.00136, 0.00273]		 age, sex, UKB array type, Genotype PCs —
PPM012702 PGS002232
(STLFRQPGS)
 PSS009498|
European Ancestry|
291,496 individuals
 PGP000265 |
Bonfiglio F et al. Cell Genom (2021)
 Reported Trait: Irritable bowel syndrome — — p-value (PGS difference between cases and controls): 1.90e-08
Odds Ratio (OR, top 1%): 1.3 [1.1, 1.5]		 sex, age, the first 10 PCs and genotyping array —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004926 — — 994 individuals — African unspecified — UKB —
PSS004927 — — 390 individuals — East Asian — UKB —
PSS004928 — — 9,083 individuals — European non-white British ancestry UKB —
PSS004929 — — 1,179 individuals — South Asian — UKB —
PSS004930 — — 24,268 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009498 IBS based on health records (self-reported and ICD10 diagnoses) and data from the remainder of UKBB (DHQ-) — 291,496 individuals,
47.1 % Male samples
 Mean = 57.2 years
Sd = 8.2 years		 European — UKB Non-overlaping Validation cohort (DHQ-)