Polygenic Scores (PGS)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003443
(PRScsx_T2D_LAT_EURweights)
 PGP000445 |
Huerta-Chagoya A et al. Diabetologia (2023)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,092,496
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003443/ScoringFiles/PGS003443.txt.gz
PGS000882
(25OHD_SBayesR_PGS)
 PGP000228 |
Revez JA et al. Nat Commun (2020)
 25-hydroxyvitamin D vitamin D amount 1,094,650
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000882/ScoringFiles/PGS000882.txt.gz
PGS000201
(PROB_ALC_COGA)
 PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
 Problematic alcohol use alcohol dependence measurement 1,094,954
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000201/ScoringFiles/PGS000201.txt.gz
PGS000607
(PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 1,095,241
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000607/ScoringFiles/PGS000607.txt.gz
PGS004845
(tg_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Triglycerides triglyceride measurement 1,095,976
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004845/ScoringFiles/PGS004845.txt.gz
PGS003018
(ExPRSweb_Hypertension_I10_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Hypertension hypertension 1,096,197
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003018/ScoringFiles/PGS003018.txt.gz
PGS000608
(PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 1,097,063
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000608/ScoringFiles/PGS000608.txt.gz
PGS004594
(ukb.sbp.female)
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Systolic blood pressure systolic blood pressure 1,097,355
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004594/ScoringFiles/PGS004594.txt.gz
PGS002271
(PRS_MVP)
 PGP000301 |
Roselli C et al. Eur Heart J (2022)
 Mitral valve prolapse Mitral valve prolapse 1,097,364
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002271/ScoringFiles/PGS002271.txt.gz
PGS000900
(PRS_SBP_f)
 PGP000233 |
Kauko A et al. Hypertension (2021)
 Systolic blood pressure (female) systolic blood pressure,
female		 1,098,015
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000900/ScoringFiles/PGS000900.txt.gz
PGS000901
(PRS_SBP_m)
 PGP000233 |
Kauko A et al. Hypertension (2021)
 Systolic blood pressure (male) systolic blood pressure,
male		 1,098,015
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000901/ScoringFiles/PGS000901.txt.gz
PGS000912
(ukb_dbp_prs)
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Diastolic blood pressure diastolic blood pressure 1,098,015
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000912/ScoringFiles/PGS000912.txt.gz
PGS000913
(ukb_sbp_prs)
 PGP000240 |
Vaura F et al. Hypertension (2021)
 Systolic blood pressure systolic blood pressure 1,098,015
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000913/ScoringFiles/PGS000913.txt.gz
PGS000558
(PRSWEB_PHECODE184.11_Phelan-OCCC_LASSOSUM_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Malignant neoplasm of ovary ovarian neoplasm 1,098,236
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000558/ScoringFiles/PGS000558.txt.gz
PGS004946
(DCM_GWAS_exclMGBB)
 PGP000672 |
Jurgens SJ et al. Nat Genet (2024)
 Dilated cardiomyopathy dilated cardiomyopathy 1,098,677
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004946/ScoringFiles/PGS004946.txt.gz
PGS004950
(DCM_GWAS_exclAUMC)
 PGP000672 |
Jurgens SJ et al. Nat Genet (2024)
 Dilated cardiomyopathy dilated cardiomyopathy 1,098,677
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004950/ScoringFiles/PGS004950.txt.gz
PGS000206
(RISK_PC_FT12)
 PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
 Risk-taking tendency (4-domain principal component model) risk-taking behaviour 1,098,765
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000206/ScoringFiles/PGS000206.txt.gz
PGS004791
(ldl_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,098,797
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004791/ScoringFiles/PGS004791.txt.gz
PGS002804
(GIANT_HEIGHT_YENGO_2022_PGS_WEIGHTS_EUR)
 PGP000382 |
Yengo L et al. Nature (2022)
 Height body height 1,099,005
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002804/ScoringFiles/PGS002804.txt.gz
PGS004801
(Monocytes_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Monocyte count monocyte count 1,099,478
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004801/ScoringFiles/PGS004801.txt.gz
PGS000204
(GSCAN_DPW_FT12)
 PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
 Alcohol consumption (drinks per week) alcohol consumption quality 1,099,480
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000204/ScoringFiles/PGS000204.txt.gz
PGS000761
(LDpred2_hypoT_PRS)
 PGP000164 |
Khan Z et al. Nat Commun (2021)
 Hypothyroidism hypothyroidism 1,099,649
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000761/ScoringFiles/PGS000761.txt.gz
PGS004580
(CRC_PRSCS)
 PGP000562 |
Youssef O et al. Lab Invest (2024)
 Colorectal cancer colorectal carcinoma 1,099,906
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004580/ScoringFiles/PGS004580.txt.gz
PGS000896
(GLGC_2021_SAS_LDL_PRS_weights_PRS-CS)
 PGP000230 |
Graham SE et al. Nature (2021)
 LDL cholesterol low density lipoprotein cholesterol measurement 1,100,062
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000896/ScoringFiles/PGS000896.txt.gz
PGS003168
(ExPRSweb_VitB12_Wood-et-al-2013-1000G_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Vitamin B12 vitamin B12 measurement 1,100,788
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003168/ScoringFiles/PGS003168.txt.gz
PGS003173
(ExPRSweb_VitB12_Wood-et-al-2013-1000G_PRSCS_UKB_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Vitamin B12 vitamin B12 measurement 1,101,425
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003173/ScoringFiles/PGS003173.txt.gz
PGS004593
(pe)
 PGP000574 |
Nurkkala J et al. J Hypertens (2022)
 Preeclampsia preeclampsia 1,102,059
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004593/ScoringFiles/PGS004593.txt.gz
PGS004151
(UKBB_EnsPGS.GCST004131.IBD)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Inflammatory bowel disease (IBD) inflammatory bowel disease 1,102,205
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004151/ScoringFiles/PGS004151.txt.gz
PGS004581
(PRCA_PRSCS)
 PGP000562 |
Youssef O et al. Lab Invest (2024)
 Prostate cancer prostate carcinoma 1,102,292
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004581/ScoringFiles/PGS004581.txt.gz
PGS003773
(HDL_AFR_CTSLEB)
 PGP000489 |
Zhang H et al. Nat Genet (2023)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,102,319
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003773/ScoringFiles/PGS003773.txt.gz
PGS002802
(GIANT_HEIGHT_YENGO_2022_PGS_WEIGHTS_ALL)
 PGP000382 |
Yengo L et al. Nature (2022)
 Height body height 1,103,042
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002802/ScoringFiles/PGS002802.txt.gz
PGS000398
(PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 1,103,220
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000398/ScoringFiles/PGS000398.txt.gz
PGS003981
(dbslmm.auto.GCST004131.IBD)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Inflammatory bowel disease (IBD) inflammatory bowel disease 1,103,311
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003981/ScoringFiles/PGS003981.txt.gz
PGS004086
(prscs.auto.GCST007140.HDL)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,103,534
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004086/ScoringFiles/PGS004086.txt.gz
PGS004100
(prscs.CV.GCST007140.HDL)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 HDL cholesterol high density lipoprotein cholesterol measurement 1,103,534
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004100/ScoringFiles/PGS004100.txt.gz
PGS004083
(prscs.auto.GCST004988.Breast_cancer)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Breast cancer breast carcinoma 1,103,877
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004083/ScoringFiles/PGS004083.txt.gz
PGS000384
(PRSWEB_PHECODE153.3_C3-RECTUM_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Malignant neoplasm of rectum, rectosigmoid junction, and anus rectum cancer,
rectosigmoid junction neoplasm		 1,104,018
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000384/ScoringFiles/PGS000384.txt.gz
PGS003431
(LDPred2-inf)
 PGP000438 |
Briggs SEW et al. BMJ (2022)
 Colorectal cancer colorectal cancer 1,104,409
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003431/ScoringFiles/PGS003431.txt.gz
PGS003432
(LDPred2-grid)
 PGP000438 |
Briggs SEW et al. BMJ (2022)
 Colorectal cancer colorectal cancer 1,104,409
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003432/ScoringFiles/PGS003432.txt.gz
PGS004085
(prscs.auto.GCST006085.Prostate_cancer)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Prostate cancer prostate carcinoma 1,105,199
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004085/ScoringFiles/PGS004085.txt.gz
PGS004099
(prscs.CV.GCST006085.Prostate_cancer)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Prostate cancer prostate carcinoma 1,105,199
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004099/ScoringFiles/PGS004099.txt.gz
PGS003807
(logTG_AFR_CTSLEB)
 PGP000489 |
Zhang H et al. Nat Genet (2023)
 Log triglycerides triglyceride measurement 1,106,476
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003807/ScoringFiles/PGS003807.txt.gz
PGS005112
(PGS_CAD)
 PGP000701 |
Loesch DP et al. Nat Commun (2025)
 Coronary artery disease coronary artery disease 1,106,628
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005112/ScoringFiles/PGS005112.txt.gz
PGS004701
(a1c_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 HbA1c HbA1c measurement 1,107,927
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004701/ScoringFiles/PGS004701.txt.gz
PGS004859
(T2D_PRS_CS)
 PGP000605 |
Deutsch AJ et al. Diabetes Care (2023)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,108,235
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004859/ScoringFiles/PGS004859.txt.gz
PGS003967
(SBP_EUR)
 PGP000510 |
Kurniansyah N et al. Nat Commun (2023)
 Systolic blood pressure systolic blood pressure 1,108,368
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003967/ScoringFiles/PGS003967.txt.gz
PGS003003
(ExPRSweb_Hypertension_20002-1072_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Hypertension hypertension 1,109,030
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003003/ScoringFiles/PGS003003.txt.gz
PGS000388
(PRSWEB_PHECODE165.1_C3-BRONCHUS-LUNG_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Lung and bronchus cancer tracheal cancer,
bronchus cancer,
lung cancer		 1,109,069
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000388/ScoringFiles/PGS000388.txt.gz
PGS003253
(ExPRSweb_Creatine_CKDGen-1000Genomes-DiscoveryMeta-eGFRcrea_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estimated glomerular filtration rate (Creatine) glomerular filtration rate,
creatine amount		 1,109,085
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003253/ScoringFiles/PGS003253.txt.gz
PGS004088
(prscs.auto.GCST008059.CKD)
 PGP000517 |
Monti R et al. Am J Hum Genet (2024)
 Chronic kidney disease (CKD) chronic kidney disease 1,109,217
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004088/ScoringFiles/PGS004088.txt.gz
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