| Publication Information (EuropePMC) | |
| Title | Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study. |
| PubMed ID | 32376654(Europe PMC) |
| doi | 10.1136/bmj.m1203 |
| Publication Date | May 6, 2020 |
| Journal | BMJ |
| Author(s) | Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey Smith G. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000716 (PGS295_elbs) |
PGP000132 | Richardson TG et al. BMJ (2020) |
Early life body size | body mass index, comparative body size at age 10, self-reported |
295 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000716/ScoringFiles/PGS000716.txt.gz |
| PGS000717 (PGS557_albs) |
PGP000132 | Richardson TG et al. BMJ (2020) |
Adult life body size | body mass index | 557 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000717/ScoringFiles/PGS000717.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001633 | PGS000716 (PGS295_elbs) |
PSS000849| European Ancestry| 5,898 individuals |
PGP000132 | Richardson TG et al. BMJ (2020) |
Reported Trait: Childhood body mass index | — | AUROC: 0.64 | — | — | — |
| PPM001634 | PGS000717 (PGS557_albs) |
PSS000849| European Ancestry| 5,898 individuals |
PGP000132 | Richardson TG et al. BMJ (2020) |
Reported Trait: Childhood body mass index | — | AUROC: 0.61 | — | — | — |
| PPM001635 | PGS000716 (PGS295_elbs) |
PSS000847| European Ancestry| 3,997 individuals |
PGP000132 | Richardson TG et al. BMJ (2020) |
Reported Trait: Adolescent body mass index | — | AUROC: 0.63 | — | — | — |
| PPM001636 | PGS000717 (PGS557_albs) |
PSS000847| European Ancestry| 3,997 individuals |
PGP000132 | Richardson TG et al. BMJ (2020) |
Reported Trait: Adolescent body mass index | — | AUROC: 0.63 | — | — | — |
| PPM001637 | PGS000716 (PGS295_elbs) |
PSS000848| European Ancestry| 2,199 individuals |
PGP000132 | Richardson TG et al. BMJ (2020) |
Reported Trait: Adult body mass index | — | AUROC: 0.57 | — | — | — |
| PPM001638 | PGS000717 (PGS557_albs) |
PSS000848| European Ancestry| 2,199 individuals |
PGP000132 | Richardson TG et al. BMJ (2020) |
Reported Trait: Adult body mass index | — | AUROC: 0.6 | — | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000847 | Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. | — | 3,997 individuals | Mean = 17.8 years | European | — | ALSPAC | ALSPAC offspring |
| PSS000848 | Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. | — | 2,199 individuals, 0.0 % Male samples |
Mean = 50.8 years | European | — | ALSPAC | ALSPAC mothers |
| PSS000849 | Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. | — | 5,898 individuals | Mean = 9.9 years | European | — | ALSPAC | ALSPAC offspring |