PGS Publication: PGP000557

Publication Information (EuropePMC)
Title Gene-environment interaction in long-term effects of polychlorinated biphenyls exposure on glucose homeostasis and type 2 diabetes: The modifying effects of genetic risk and lifestyle.
PubMed ID 37276697(Europe PMC)
doi 10.1016/j.jhazmat.2023.131757
Publication Date June 1, 2023
Journal J Hazard Mater
Author(s) Tan Q, Yang S, Wang B, Wang M, Yu L, Liang R, Liu W, Song J, Guo Y, Zhou M, Chen W.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004323
(PRS91_T2D)
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Type 2 diabetes type 2 diabetes mellitus 91
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004323/ScoringFiles/PGS004323.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020433 PGS004323
(PRS91_T2D)
 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: Fasting plasma glucose β: 0.292 [0.181, 0.404] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —
PPM020434 PGS004323
(PRS91_T2D)
 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: HOMA-beta β: -0.143 [-0.212, -0.073] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —
PPM020435 PGS004323
(PRS91_T2D)
 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: Impaired fasting glucose β: 1.809 [1.362, 2.402] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —
PPM020436 PGS004323
(PRS91_T2D)
 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: Type 2 diabetes β: 2.263 [1.72, 2.977] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011360 — — 2,676 individuals,
32.47 % Male samples
 Mean = 54.0 years
Sd = 11.8 years		 East Asian
(Chinese)		 — WHZH —