Polygenic Score (PGS) ID: PGS004323

Predicted Trait
Reported Trait Type 2 diabetes
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name PRS91_T2D
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 91
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000557
Citation (link to publication) Tan Q et al. J Hazard Mater (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
210,865 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90013693
Europe PMC: 32514122
 210,865 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020433 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: Fasting plasma glucose β: 0.292 [0.181, 0.404] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —
PPM020434 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: HOMA-beta β: -0.143 [-0.212, -0.073] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —
PPM020435 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: Impaired fasting glucose β: 1.809 [1.362, 2.402] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —
PPM020436 PSS011360|
East Asian Ancestry|
2,676 individuals
 PGP000557 |
Tan Q et al. J Hazard Mater (2023)
 Reported Trait: Type 2 diabetes β: 2.263 [1.72, 2.977] — — Age, gender, BMI, community, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011360 — — 2,676 individuals,
32.47 % Male samples
 Mean = 54.0 years
Sd = 11.8 years		 East Asian
(Chinese)		 — WHZH —