PGS Publication: PGP000693

Publication Information (EuropePMC)
Title Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.
PubMed ID 41844147(Europe PMC)
doi 10.1016/j.cmet.2026.02.009
Publication Date March 16, 2026
Journal Cell Metab
Author(s) Kim MS, Chen Q, Sui Y, Yang X, Wang S, Weng LC, Cho SMJ, Koyama S, Zhu X, Yu K, Chen X, Zhang R, Yin W, Liao S, Liu Z, Alkuraya FS, Natarajan P, Ellinor PT, Fahed AC, Wang M.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005344
(D_MetPRS_noUKB_SAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005344/ScoringFiles/PGS005344.txt.gz
PGS005332
(O_MetPRS_SAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005332/ScoringFiles/PGS005332.txt.gz
PGS005339
(O_MetPRS_noUKB_EUR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005339/ScoringFiles/PGS005339.txt.gz
PGS005102
(O_MetPRS_AFR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005102/ScoringFiles/PGS005102.txt.gz
PGS005103
(O_MetPRS_EAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005103/ScoringFiles/PGS005103.txt.gz
PGS005331
(O_MetPRS_EUR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005331/ScoringFiles/PGS005331.txt.gz
PGS005334
(D_MetPRS_EAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005334/ScoringFiles/PGS005334.txt.gz
PGS005335
(D_MetPRS_EUR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005335/ScoringFiles/PGS005335.txt.gz
PGS005336
(D_MetPRS_SAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005336/ScoringFiles/PGS005336.txt.gz
PGS005337
(O_MetPRS_noUKB_AFR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005337/ScoringFiles/PGS005337.txt.gz
PGS005340
(O_MetPRS_noUKB_SAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005340/ScoringFiles/PGS005340.txt.gz
PGS005333
(D_MetPRS_AFR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005333/ScoringFiles/PGS005333.txt.gz
PGS005343
(D_MetPRS_noUKB_EUR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005343/ScoringFiles/PGS005343.txt.gz
PGS005338
(O_MetPRS_noUKB_EAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Body mass index (BMI) body mass index 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005338/ScoringFiles/PGS005338.txt.gz
PGS005341
(D_MetPRS_noUKB_AFR)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005341/ScoringFiles/PGS005341.txt.gz
PGS005342
(D_MetPRS_noUKB_EAS)
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,297,046
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005342/ScoringFiles/PGS005342.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023078 PGS005103
(O_MetPRS_EAS)
 PSS012129|
East Asian Ancestry|
1,304 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥25) OR: 2.07 [1.8, 2.39]
β: 0.72988		 AUROC: 0.72902 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023079 PGS005331
(O_MetPRS_EUR)
 PSS012132|
European Ancestry|
34,623 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.47 [2.4, 2.54]
β: 0.90366		 AUROC: 0.72773 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023080 PGS005332
(O_MetPRS_SAS)
 PSS012135|
South Asian Ancestry|
6,605 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.37 [2.22, 2.54]
β: 0.86446		 AUROC: 0.72675 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023082 PGS005103
(O_MetPRS_EAS)
 PSS012128|
East Asian Ancestry|
1,304 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.05151 — delta R2: 0.13505 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023083 PGS005331
(O_MetPRS_EUR)
 PSS012131|
European Ancestry|
34,623 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.07149 — delta R2: 0.18178 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023084 PGS005332
(O_MetPRS_SAS)
 PSS012134|
South Asian Ancestry|
6,605 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.06361 — delta R2: 0.16575 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023085 PGS005337
(O_MetPRS_noUKB_AFR)
 PSS012126|
African Ancestry|
6,842 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.65 [1.56, 1.74]
β: 0.49867		 AUROC: 0.67611 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023086 PGS005338
(O_MetPRS_noUKB_EAS)
 PSS012129|
East Asian Ancestry|
1,304 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥25) OR: 2.08 [1.81, 2.4]
β: 0.73463		 AUROC: 0.73074 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023087 PGS005339
(O_MetPRS_noUKB_EUR)
 PSS012132|
European Ancestry|
34,623 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.43 [2.36, 2.5]
β: 0.88718		 AUROC: 0.7249 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023088 PGS005340
(O_MetPRS_noUKB_SAS)
 PSS012135|
South Asian Ancestry|
6,605 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.37 [2.21, 2.54]
β: 0.86176		 AUROC: 0.72633 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023089 PGS005337
(O_MetPRS_noUKB_AFR)
 PSS012125|
African Ancestry|
6,842 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.046 — delta R2: 0.06996 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023093 PGS005102
(O_MetPRS_AFR)
 PSS012113|
African Ancestry|
56,913 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.55 [1.52, 1.58]
β: 0.439		 AUROC: 0.693 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023094 PGS005331
(O_MetPRS_EUR)
 PSS012114|
Hispanic or Latin American Ancestry|
45,035 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.92 [1.88, 1.97]
β: 0.654		 AUROC: 0.678 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023095 PGS005103
(O_MetPRS_EAS)
 PSS012115|
East Asian Ancestry|
5,706 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥25) OR: 2.16 [2.02, 2.3]
β: 0.768		 AUROC: 0.75 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023096 PGS005331
(O_MetPRS_EUR)
 PSS012116|
European Ancestry|
133,581 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.22 [2.19, 2.26]
β: 0.8		 AUROC: 0.706 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023097 PGS005331
(O_MetPRS_EUR)
 PSS012117|
Greater Middle Eastern Ancestry|
942 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.1 [1.78, 2.48]
β: 0.741		 AUROC: 0.721 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023098 PGS005332
(O_MetPRS_SAS)
 PSS012118|
South Asian Ancestry|
3,217 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.24 [2.02, 2.48]
β: 0.805		 AUROC: 0.726 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023099 PGS005102
(O_MetPRS_AFR)
 PSS012120|
African Ancestry|
2,892 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.79 [1.63, 1.95]
β: 0.58		 AUROC: 0.684 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023100 PGS005331
(O_MetPRS_EUR)
 PSS012121|
Hispanic or Latin American Ancestry|
3,851 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.43 [2.22, 2.65]
β: 0.886		 AUROC: 0.746 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023101 PGS005103
(O_MetPRS_EAS)
 PSS012122|
East Asian Ancestry|
1,064 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥25) OR: 2.01 [1.7, 2.38]
β: 0.698		 AUROC: 0.729 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023102 PGS005331
(O_MetPRS_EUR)
 PSS012123|
European Ancestry|
44,892 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 2.3 [2.24, 2.36]
β: 0.831		 AUROC: 0.72 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023104 PGS005331
(O_MetPRS_EUR)
 PSS012119|
Greater Middle Eastern Ancestry|
6,416 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.5 [1.41, 1.6]
β: 0.405		 AUROC: 0.674 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023105 PGS005102
(O_MetPRS_AFR)
 PSS012113|
African Ancestry|
56,913 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.062 — R²: 0.1393
delta R2: 0.05607		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023106 PGS005331
(O_MetPRS_EUR)
 PSS012114|
Hispanic or Latin American Ancestry|
45,035 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.078 — R²: 0.1348
delta R2: 0.12245		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023107 PGS005103
(O_MetPRS_EAS)
 PSS012115|
East Asian Ancestry|
5,706 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.075 — R²: 0.2447
delta R2: 0.14805		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023108 PGS005331
(O_MetPRS_EUR)
 PSS012116|
European Ancestry|
133,581 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.093 — R²: 0.1712
delta R2: 0.16456		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023109 PGS005331
(O_MetPRS_EUR)
 PSS012117|
Greater Middle Eastern Ancestry|
942 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.071 — R²: 0.1789
delta R2: 0.124		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023110 PGS005332
(O_MetPRS_SAS)
 PSS012118|
South Asian Ancestry|
3,217 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.073 — R²: 0.1815
delta R2: 0.13795		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023111 PGS005102
(O_MetPRS_AFR)
 PSS012120|
African Ancestry|
2,892 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.068 — R²: 0.1342
delta R2: 0.08936		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023112 PGS005331
(O_MetPRS_EUR)
 PSS012121|
Hispanic or Latin American Ancestry|
3,851 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.089 — R²: 0.2379
delta R2: 0.17917		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023113 PGS005103
(O_MetPRS_EAS)
 PSS012122|
East Asian Ancestry|
1,064 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.059 — R²: 0.2087
delta R2: 0.11685		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023114 PGS005331
(O_MetPRS_EUR)
 PSS012123|
European Ancestry|
44,892 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.083 — R²: 0.2007
delta R2: 0.16702		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023115 PGS005332
(O_MetPRS_SAS)
 PSS012124|
South Asian Ancestry|
607 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.082 — R²: 0.2307
delta R2: 0.19405		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023116 PGS005331
(O_MetPRS_EUR)
 PSS012119|
Greater Middle Eastern Ancestry|
6,416 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.045 — R²: 0.1255
delta R2: 0.0479		 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023117 PGS005333
(D_MetPRS_AFR)
 PSS012127|
African Ancestry|
6,842 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.42 [1.33, 1.51]
β: 0.34765		 AUROC: 0.70608 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023118 PGS005334
(D_MetPRS_EAS)
 PSS012130|
East Asian Ancestry|
1,304 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.97 [1.58, 2.45]
β: 0.67712		 AUROC: 0.77222 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023119 PGS005335
(D_MetPRS_EUR)
 PSS012133|
European Ancestry|
34,623 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 2.1 [2.02, 2.2]
β: 0.74395		 AUROC: 0.74549 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023120 PGS005336
(D_MetPRS_SAS)
 PSS012136|
South Asian Ancestry|
6,605 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.78 [1.68, 1.9]
β: 0.57931		 AUROC: 0.72007 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023121 PGS005341
(D_MetPRS_noUKB_AFR)
 PSS012127|
African Ancestry|
6,842 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.4 [1.31, 1.49]
β: 0.3351		 AUROC: 0.70443 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023122 PGS005342
(D_MetPRS_noUKB_EAS)
 PSS012130|
East Asian Ancestry|
1,304 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 2.0 [1.61, 2.49]
β: 0.69355		 AUROC: 0.778 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023123 PGS005343
(D_MetPRS_noUKB_EUR)
 PSS012133|
European Ancestry|
34,623 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.97 [1.89, 2.05]
β: 0.67792		 AUROC: 0.73454 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023124 PGS005344
(D_MetPRS_noUKB_SAS)
 PSS012136|
South Asian Ancestry|
6,605 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.73 [1.63, 1.84]
β: 0.54766		 AUROC: 0.71595 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023125 PGS005333
(D_MetPRS_AFR)
 PSS012113|
African Ancestry|
56,913 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.34 [1.31, 1.37]
β: 0.289		 AUROC: 0.705 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023127 PGS005334
(D_MetPRS_EAS)
 PSS012115|
East Asian Ancestry|
5,706 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.83 [1.65, 2.03]
β: 0.603		 AUROC: 0.807 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023128 PGS005335
(D_MetPRS_EUR)
 PSS012116|
European Ancestry|
133,581 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.87 [1.84, 1.9]
β: 0.626		 AUROC: 0.727 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023134 PGS005335
(D_MetPRS_EUR)
 PSS012123|
European Ancestry|
44,892 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.8 [1.73, 1.86]
β: 0.585		 AUROC: 0.744 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023135 PGS005336
(D_MetPRS_SAS)
 PSS012124|
South Asian Ancestry|
607 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.68 [1.15, 2.46]
β: 0.518		 AUROC: 0.834 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023136 PGS005335
(D_MetPRS_EUR)
 PSS012119|
Greater Middle Eastern Ancestry|
6,416 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.77 [1.66, 1.89]
β: 0.571		 AUROC: 0.74 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023129 PGS005335
(D_MetPRS_EUR)
 PSS012117|
Greater Middle Eastern Ancestry|
942 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.49 [1.21, 1.84]
β: 0.398		 AUROC: 0.778 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023130 PGS005336
(D_MetPRS_SAS)
 PSS012118|
South Asian Ancestry|
3,217 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 2.05 [1.79, 2.34]
β: 0.717		 AUROC: 0.839 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023131 PGS005333
(D_MetPRS_AFR)
 PSS012120|
African Ancestry|
2,892 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.42 [1.28, 1.57]
β: 0.353		 AUROC: 0.723 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023090 PGS005338
(O_MetPRS_noUKB_EAS)
 PSS012128|
East Asian Ancestry|
1,304 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.05169 — delta R2: 0.13605 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023091 PGS005339
(O_MetPRS_noUKB_EUR)
 PSS012131|
European Ancestry|
34,623 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.07036 — delta R2: 0.17608 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023077 PGS005102
(O_MetPRS_AFR)
 PSS012126|
African Ancestry|
6,842 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.66 [1.57, 1.75]
β: 0.50712		 AUROC: 0.67734 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023081 PGS005102
(O_MetPRS_AFR)
 PSS012125|
African Ancestry|
6,842 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.04685 — delta R2: 0.07256 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023092 PGS005340
(O_MetPRS_noUKB_SAS)
 PSS012134|
South Asian Ancestry|
6,605 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Log transform of body mass index [log(BMI)] β: 0.06339 — delta R2: 0.16465 Age, sex, genotying array and the first ten principal components of genetic ancestry delta R2 is the proportion of the variance explained by PRS alone
PPM023103 PGS005332
(O_MetPRS_SAS)
 PSS012124|
South Asian Ancestry|
607 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Obesity (BMI≥30) OR: 1.79 [1.63, 1.95]
β: 1.099		 AUROC: 0.785 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023126 PGS005335
(D_MetPRS_EUR)
 PSS012114|
Hispanic or Latin American Ancestry|
45,035 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.73 [1.68, 1.78]
β: 0.546		 AUROC: 0.767 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023132 PGS005335
(D_MetPRS_EUR)
 PSS012121|
Hispanic or Latin American Ancestry|
3,851 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.76 [1.57, 1.98]
β: 0.566		 AUROC: 0.807 — Age, sex, genotying array and the first ten principal components of genetic ancestry —
PPM023133 PGS005334
(D_MetPRS_EAS)
 PSS012122|
East Asian Ancestry|
1,064 individuals
 PGP000693 |
Kim MS et al. Cell Metab (2026)
 Reported Trait: Type 2 diabetes (T2D) OR: 1.65 [1.23, 2.21]
β: 0.502		 AUROC: 0.836 — Age, sex, genotying array and the first ten principal components of genetic ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012113 — — 56,913 individuals — African unspecified — AllofUs —
PSS012114 — — 45,035 individuals — Hispanic or Latin American — AllofUs —
PSS012115 — — 5,706 individuals — East Asian — AllofUs —
PSS012116 — — 133,581 individuals — European — AllofUs —
PSS012117 — — 942 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) — AllofUs —
PSS012118 — — 3,217 individuals — South Asian — AllofUs —
PSS012119 — — 6,416 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) — KFSH&RC —
PSS012120 — — 2,892 individuals — African unspecified — MGBB —
PSS012121 — — 3,851 individuals — Hispanic or Latin American — MGBB —
PSS012122 — — 1,064 individuals — East Asian — MGBB —
PSS012123 — — 44,892 individuals — European — MGBB —
PSS012124 — — 607 individuals — South Asian — MGBB —
PSS012125 — — 6,842 individuals,
43.4 % Male samples
 Mean = 52.0 years African unspecified — UKB —
PSS012126 — —
[
  • 2,731 cases
  • , 4,111 controls
]
,
43.4 % Male samples
 Mean = 52.0 years African unspecified — UKB —
PSS012127 Type 2 diabetes (T2D); ICD 10: E11.0,E11.1,E11.2,E11.3,E11.4,E11.5,E11.6,E11.7,E11.8,E11.9 —
[
  • 1,222 cases
  • , 5,620 controls
]
,
43.4 % Male samples
 Mean = 52.0 years African unspecified — UKB —
PSS012128 — — 1,304 individuals,
37.3 % Male samples
 Mean = 53.0 years East Asian — UKB —
PSS012129 — —
[
  • 404 cases
  • , 900 controls
]
,
37.3 % Male samples
 Mean = 53.0 years East Asian — UKB —
PSS012130 Type 2 diabetes (T2D); ICD 10: E11.0,E11.1,E11.2,E11.3,E11.4,E11.5,E11.6,E11.7,E11.8,E11.9 —
[
  • 109 cases
  • , 1,195 controls
]
,
37.3 % Male samples
 Mean = 53.0 years East Asian — UKB —
PSS012131 — — 34,623 individuals,
45.8 % Male samples
 Mean = 57.0 years European — UKB —
PSS012132 — —
[
  • 8,689 cases
  • , 25,934 controls
]
,
45.8 % Male samples
 Mean = 57.0 years European — UKB —
PSS012133 Type 2 diabetes (T2D); ICD 10: E11.0,E11.1,E11.2,E11.3,E11.4,E11.5,E11.6,E11.7,E11.8,E11.9 —
[
  • 2,724 cases
  • , 31,899 controls
]
,
45.8 % Male samples
 Mean = 57.0 years European — UKB —
PSS012134 — — 6,605 individuals,
52.7 % Male samples
 Mean = 53.0 years South Asian — UKB —
PSS012135 — —
[
  • 1,517 cases
  • , 5,088 controls
]
,
52.7 % Male samples
 Mean = 53.0 years South Asian — UKB —
PSS012136 Type 2 diabetes (T2D); ICD 10: E11.0,E11.1,E11.2,E11.3,E11.4,E11.5,E11.6,E11.7,E11.8,E11.9 —
[
  • 1,722 cases
  • , 4,883 controls
]
,
52.7 % Male samples
 Mean = 53.0 years South Asian — UKB —