PGS Publication: PGP000725

Publication Information (EuropePMC)
Title Polygenic Scores for Adult Testosterone and SHBG Levels Are Associated With Reproductive Hormone Levels in Male Infants.
PubMed ID 38412310(Europe PMC)
doi 10.1210/clinem/dgae104
Publication Date Aug. 1, 2024
Journal J Clin Endocrinol Metab
Author(s) Busch AS, Ljubicic ML, Upners EN, Fischer MB, Odroniec A, Hagen CP, Juul A.
Released in PGS Catalog: May 20, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000323
(snpnet_Testosterone_male-specific)
 PGP000097 |
Flynn E et al. Eur J Hum Genet (2020)
 Serum testosterone levels in males testosterone measurement,
male		 8,235
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000323/ScoringFiles/PGS000323.txt.gz
PGS000694
(snpnet.SHBG)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 SHBG [nmol/L] sex hormone-binding globulin measurement 19,328
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000694/ScoringFiles/PGS000694.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022568 PGS000323
(snpnet_Testosterone_male-specific)
 PSS012020|
European Ancestry|
233 individuals
 PGP000725 |
Busch AS et al. J Clin Endocrinol Metab (2024)
|Ext.		 Reported Trait: Mean total testosterone SDS in infancy β: 5.4 (2.2) — R²: 0.05 — —
PPM022569 PGS000323
(snpnet_Testosterone_male-specific)
 PSS012020|
European Ancestry|
233 individuals
 PGP000725 |
Busch AS et al. J Clin Endocrinol Metab (2024)
|Ext.		 Reported Trait: Mean SHBG SDS in infancy β: 11.7 (2.2) — R²: 0.21 — —
PPM022570 PGS000323
(snpnet_Testosterone_male-specific)
 PSS012020|
European Ancestry|
233 individuals
 PGP000725 |
Busch AS et al. J Clin Endocrinol Metab (2024)
|Ext.		 Reported Trait: Mean LH SDS in infancy β: 5.0 (2.3) — R²: 0.04 — —
PPM022571 PGS000694
(snpnet.SHBG)
 PSS012020|
European Ancestry|
233 individuals
 PGP000725 |
Busch AS et al. J Clin Endocrinol Metab (2024)
|Ext.		 Reported Trait: Mean SHBG SDS in infancy β: 2.4 (0.5) — R²: 0.18 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012020 mean age-specific serum concentrations, i.e., SDS, of reproductive hormone concentrations based on the respective reference curves — 233 individuals,
100.0 % Male samples
 — European — NR —