Polygenic Score (PGS) ID: PGS005206

Predicted Trait
Reported Trait Bone mineral density
Mapped Trait(s) bone tissue density (OBA_1000110)
Released in PGS Catalog: May 20, 2025
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Score Details

Score Construction
PGS Name BMD_PRS
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 81
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000728
Citation (link to publication) Prijatelj V et al. Bone (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 84.1%
Not Reported: 13.9%
African: 2%
66,945 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Additional Asian Ancestries
  • African
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005348
Europe PMC: 29304378
 56,284 individuals European NR
GWAS Catalog: GCST005348
Europe PMC: 29304378
 1,333 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST005348
Europe PMC: 29304378
 9,328 individuals Not reported NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022584 PSS012023|
Multi-ancestry (including European)|
4,150 individuals
 PGP000728 |
Prijatelj V et al. Bone (2024)
 Reported Trait: BMD levels β: 0.04 (0.003) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012023 — — 3,470 individuals Mean = 9.77 years
Sd = 0.33 years		 European — Generation_R —
PSS012023 — — 266 individuals Mean = 9.77 years
Sd = 0.32 years		 Asian unspecified — Generation_R —
PSS012023 — — 414 individuals Mean = 9.84 years
Sd = 0.39 years		 African unspecified — Generation_R —