PGS Publication: PGP000728

Publication Information (EuropePMC)
Title Bone health index in the assessment of bone health: The Generation R Study.
PubMed ID 38460828(Europe PMC)
doi 10.1016/j.bone.2024.117070
Publication Date March 7, 2024
Journal Bone
Author(s) Prijatelj V, Grgic O, Uitterlinden AG, Wolvius EB, Rivadeneira F, Medina-Gomez C.
Released in PGS Catalog: May 20, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005206
(BMD_PRS)
 PGP000728 |
Prijatelj V et al. Bone (2024)
 Bone mineral density bone tissue density 81
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005206/ScoringFiles/PGS005206.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022584 PGS005206
(BMD_PRS)
 PSS012023|
Multi-ancestry (including European)|
4,150 individuals
 PGP000728 |
Prijatelj V et al. Bone (2024)
 Reported Trait: BMD levels β: 0.04 (0.003) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012023 — — 3,470 individuals Mean = 9.77 years
Sd = 0.33 years		 European — Generation_R —
PSS012023 — — 266 individuals Mean = 9.77 years
Sd = 0.32 years		 Asian unspecified — Generation_R —
PSS012023 — — 414 individuals Mean = 9.84 years
Sd = 0.39 years		 African unspecified — Generation_R —