Trait: bone tissue density

Trait Information
Identifier OBA_1000110
Description The mass density of a bone tissue. [AUTO: patterns/patterns/entity_attribute]
Trait category
Other measurement
Synonyms 2 synonyms
  • bone tissue mass density trait
  • mass density of bone tissue

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000121
(2018_BMD62_GRS.FN)
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Bone mineral density (BMD) bone tissue density 62
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000121/ScoringFiles/PGS000121.txt.gz
PGS000122
(2018_BMD33_GRS.FN)
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Bone mineral density (BMD) bone tissue density 33
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000122/ScoringFiles/PGS000122.txt.gz
PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 1,109,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002315/ScoringFiles/PGS002315.txt.gz
PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 25,831
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002387/ScoringFiles/PGS002387.txt.gz
PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 53,472
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002436/ScoringFiles/PGS002436.txt.gz
PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 171,392
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002485/ScoringFiles/PGS002485.txt.gz
PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 11,440
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002534/ScoringFiles/PGS002534.txt.gz
PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 7,908
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002583/ScoringFiles/PGS002583.txt.gz
PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 432,286
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002632/ScoringFiles/PGS002632.txt.gz
PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Bone mineral density (BMD) bone tissue density 984,276
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002681/ScoringFiles/PGS002681.txt.gz
PGS005206
(BMD_PRS)
 PGP000728 |
Prijatelj V et al. Bone (2024)
 Bone mineral density bone tissue density 81
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005206/ScoringFiles/PGS005206.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000368 PGS000121
(2018_BMD62_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.25 [1.02, 1.56] — — Age —
PPM000376 PGS000121
(2018_BMD62_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.48 [1.07, 2.06] — — Age —
PPM000377 PGS000121
(2018_BMD62_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.5 [1.08, 2.09] — — Age, sex, prior fracture or fall —
PPM000378 PGS000121
(2018_BMD62_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.41 [1.01, 1.96] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000360 PGS000121
(2018_BMD62_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.21 [0.91, 1.59] — — Age —
PPM000352 PGS000121
(2018_BMD62_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.19 [1.03, 1.37] — — Age —
PPM000362 PGS000121
(2018_BMD62_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.03 [0.77, 1.36] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000354 PGS000121
(2018_BMD62_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.13 [0.98, 1.29] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000367 PGS000121
(2018_BMD62_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.28 [1.02, 1.59] — — — —
PPM000359 PGS000121
(2018_BMD62_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.23 [0.92, 1.63] — — — —
PPM000351 PGS000121
(2018_BMD62_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.2 [1.04, 1.38] — — — —
PPM000350 PGS000121
(2018_BMD62_GRS.FN)
 PSS000212|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Lumbar spine BMD β: -0.037 (0.007) — — — —
PPM000349 PGS000121
(2018_BMD62_GRS.FN)
 PSS000212|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Femoral neck BMD β: -0.019 (0.004) — — — —
PPM000375 PGS000121
(2018_BMD62_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.51 [1.08, 2.1] — — — —
PPM000369 PGS000121
(2018_BMD62_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.24 [1.0, 1.54] — — Age, sex, prior fracture or fall —
PPM000361 PGS000121
(2018_BMD62_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.19 [0.91, 1.57] — — Age, sex, prior fracture or fall —
PPM000353 PGS000121
(2018_BMD62_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.18 [1.03, 1.36] — — Age, sex, prior fracture or fall —
PPM000370 PGS000121
(2018_BMD62_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.14 [0.92, 1.42] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000372 PGS000122
(2018_BMD33_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.36 [1.04, 1.78] — — Age —
PPM000380 PGS000122
(2018_BMD33_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.62 [1.08, 2.43] — — Age —
PPM000374 PGS000122
(2018_BMD33_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.28 [0.97, 1.68] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000364 PGS000122
(2018_BMD33_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.11 [0.78, 1.57] — — Age —
PPM000356 PGS000122
(2018_BMD33_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.26 [1.06, 1.5] — — Age —
PPM000366 PGS000122
(2018_BMD33_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.01 [0.65, 1.35] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000358 PGS000122
(2018_BMD33_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.23 [1.02, 1.46] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM000371 PGS000122
(2018_BMD33_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.39 [1.06, 1.82] — — — —
PPM000363 PGS000122
(2018_BMD33_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.09 [0.77, 1.54] — — — —
PPM000355 PGS000122
(2018_BMD33_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.26 [1.06, 1.5] — — — —
PPM000379 PGS000122
(2018_BMD33_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.65 [1.09, 2.48] — — — —
PPM000381 PGS000122
(2018_BMD33_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.6 [1.06, 2.4] — — Age, sex, prior fracture or fall —
PPM000373 PGS000122
(2018_BMD33_GRS.FN)
 PSS000215|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Vertebral fracture HR: 1.35 [1.03, 1.78] — — Age, sex, prior fracture or fall —
PPM000365 PGS000122
(2018_BMD33_GRS.FN)
 PSS000213|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Hip fracture HR: 1.06 [0.74, 1.51] — — Age, sex, prior fracture or fall —
PPM000357 PGS000122
(2018_BMD33_GRS.FN)
 PSS000214|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Total fracture HR: 1.24 [1.04, 1.47] — — Age, sex, prior fracture or fall —
PPM000382 PGS000122
(2018_BMD33_GRS.FN)
 PSS000216|
European Ancestry|
1,459 individuals
 PGP000056 |
Ho-Le TP et al. J Bone Miner Res (2016)
 Reported Trait: Wrist fracture HR: 1.53 [1.01, 2.31] — — Age, sex, prior fracture or fall, femoral neck bone mineral density —
PPM013129 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.087 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013080 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0299 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013178 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.2324 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013227 PGS002315
(bmd_HEEL_TSCOREz.BOLT-LMM)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1529 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013368 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013417 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0509 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013515 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0961 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013466 PGS002387
(bmd_HEEL_TSCOREz.P+T.0.0001)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1523 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013564 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013613 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0318 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013662 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1546 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013711 PGS002436
(bmd_HEEL_TSCOREz.P+T.0.001)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0589 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013760 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013809 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.01 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013858 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1186 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013907 PGS002485
(bmd_HEEL_TSCOREz.P+T.0.01)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0253 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013956 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0195 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014005 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.046 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014054 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1395 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014103 PGS002534
(bmd_HEEL_TSCOREz.P+T.1e-06)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0891 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014152 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0203 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014201 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0426 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014250 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1328 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014299 PGS002583
(bmd_HEEL_TSCOREz.P+T.5e-08)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0836 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014348 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0416 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014397 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0991 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014446 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.2504 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014495 PGS002632
(bmd_HEEL_TSCOREz.PolyFun-pred)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1707 age, sex, age*sex, assessment center, genotyping array, 10 PCs See bmd_HEEL_TSCOREz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014544 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
 PSS009703|
African Ancestry|
5,639 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0298 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014593 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
 PSS009704|
East Asian Ancestry|
889 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.0805 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014642 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
 PSS009705|
European Ancestry|
42,030 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.228 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014691 PGS002681
(bmd_HEEL_TSCOREz.SBayesR)
 PSS009706|
South Asian Ancestry|
7,588 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Bone Mineral Density — — Incremental R2 (full model vs. covariates alone): 0.1583 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM022584 PGS005206
(BMD_PRS)
 PSS012023|
Multi-ancestry (including European)|
4,150 individuals
 PGP000728 |
Prijatelj V et al. Bone (2024)
 Reported Trait: BMD levels β: 0.04 (0.003) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012023 — — 3,470 individuals Mean = 9.77 years
Sd = 0.33 years		 European — Generation_R —
PSS012023 — — 266 individuals Mean = 9.77 years
Sd = 0.32 years		 Asian unspecified — Generation_R —
PSS012023 — — 414 individuals Mean = 9.84 years
Sd = 0.39 years		 African unspecified — Generation_R —
PSS000212 — — 902 individuals,
0.0 % Male samples
 Mean = 70.1 years
Sd = 7.0 years		 European — DOES —
PSS000212 — — 557 individuals,
100.0 % Male samples
 Mean = 69.5 years
Sd = 5.9 years		 European — DOES —
PSS000213 — —
[
  • 95 cases
  • , 807 controls
]
,
0.0 % Male samples
 Mean = 70.1 years
Sd = 7.0 years		 European — DOES —
PSS000213 — —
[
  • 135 cases
  • , 422 controls
]
,
100.0 % Male samples
 Mean = 69.5 years
Sd = 5.9 years		 European — DOES —
PSS000214 — —
[
  • 395 cases
  • , 507 controls
]
,
0.0 % Male samples
 Mean = 70.1 years
Sd = 7.0 years		 European — DOES —
PSS000214 — —
[
  • 135 cases
  • , 422 controls
]
,
100.0 % Male samples
 Mean = 69.5 years
Sd = 5.9 years		 European — DOES —
PSS000215 — —
[
  • 166 cases
  • , 736 controls
]
,
0.0 % Male samples
 Mean = 70.1 years
Sd = 7.0 years		 European — DOES —
PSS000215 — —
[
  • 53 cases
  • , 504 controls
]
,
100.0 % Male samples
 Mean = 69.5 years
Sd = 5.9 years		 European — DOES —
PSS000216 — —
[
  • 103 cases
  • , 799 controls
]
,
0.0 % Male samples
 Mean = 70.1 years
Sd = 7.0 years		 European — DOES —
PSS000216 — —
[
  • 9 cases
  • , 548 controls
]
,
100.0 % Male samples
 Mean = 69.5 years
Sd = 5.9 years		 European — DOES —
PSS009703 — — 5,639 individuals — African unspecified — UKB —
PSS009704 — — 889 individuals — East Asian — UKB —
PSS009705 — — 42,030 individuals — European Non-British European UKB —
PSS009706 — — 7,588 individuals — South Asian — UKB —