Polygenic Score (PGS) ID: PGS005251

Predicted Trait
Reported Trait INFLA-Score
Mapped Trait(s)
Additional Trait Information The INFLA-Score is a composite measure of low-grade systemic inflammation based on circulating levels of biomarkers of inflammation including C-Reactive Protein, white blood cell (WBC) count, platelet count, and neutrophil-lymphocyte ratio
Released in PGS Catalog: Feb. 26, 2026
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name iPRS
Development Method
Name PRSice-2
Parameters p = 5e-8, clump-kb = 250kb, clump-p = 1.0, clump-r2 = 0.1
Variants
Original Genome Build hg19
Number of Variants 1,113
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000744
Citation (link to publication) Olowofela AS et al. JCO Precis Oncol (2025)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
633,698 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 33462484
 372,999 individuals,
46.0 % Male samples
 European UKB
Europe PMC: 33462484
 260,699 individuals,
46.0 % Male samples
 European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022732 PSS012063|
European Ancestry|
55,845 individuals
 PGP000744 |
Olowofela AS et al. JCO Precis Oncol (2025)
 Reported Trait: INFLA-Score β: 0.4274 [0.4072, 0.4472] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012063 The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. — 55,845 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European Caucasian Ancestry as determined by the UK Biobank UKB —