Trait: neutrophil-to-lymphocyte ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008447
Description The ratio of neutrophil count to lymphocyte count, quantified in a blood sample. Both neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio have been proposed as biomarkers for the diagnosis or prognostic prediction of disease.
Trait category
Hematological measurement
Synonym neutrophil:lymphocyte ratio

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005251
(iPRS)
 PGP000744 |
Olowofela AS et al. JCO Precis Oncol (2025)
 INFLA-Score platelet count,
C-reactive protein measurement,
neutrophil-to-lymphocyte ratio,
leukocyte quantity		 1,113
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005251/ScoringFiles/PGS005251.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022732 PGS005251
(iPRS)
 PSS012063|
European Ancestry|
55,845 individuals
 PGP000744 |
Olowofela AS et al. JCO Precis Oncol (2025)
 Reported Trait: INFLA-Score β: 0.4274 [0.4072, 0.4472] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012063 The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. — 55,845 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European Caucasian Ancestry as determined by the UK Biobank UKB —