PGS Publication: PGP000744

Publication Information (EuropePMC)
Title Association of Genetic Predisposition to Inflammation With Cancer-Related Cognitive Impairment and Fatigue in Women Who Received Chemotherapy for Nonmetastatic Breast Cancer.
PubMed ID 40956996(Europe PMC)
doi 10.1200/po-25-00303
Publication Date Sept. 16, 2025
Journal JCO Precis Oncol
Author(s) Olowofela AS, Auer PL, Janelsins M, Mustian K, Conlin A, Onitilo AA, Melnik M, Li CS, Gada U, Sun H, Kerns SL.
Released in PGS Catalog: Feb. 26, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005251
(iPRS)
 PGP000744 |
Olowofela AS et al. JCO Precis Oncol (2025)
 INFLA-Score platelet count,
C-reactive protein measurement,
neutrophil-to-lymphocyte ratio,
leukocyte quantity		 1,113
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005251/ScoringFiles/PGS005251.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022732 PGS005251
(iPRS)
 PSS012063|
European Ancestry|
55,845 individuals
 PGP000744 |
Olowofela AS et al. JCO Precis Oncol (2025)
 Reported Trait: INFLA-Score β: 0.4274 [0.4072, 0.4472] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012063 The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. — 55,845 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European Caucasian Ancestry as determined by the UK Biobank UKB —