Polygenic Score (PGS) ID: PGS019927

Predicted Trait
Reported Trait Short Sleep
Mapped Trait(s) short sleep (EFO_0004807)
Additional Trait Information Short-sleep GWAS summary statistics from UK Biobank and MVP European-ancestry participants were meta-analyzed before score construction. UKB defined short sleep as <7 hours; MVP defined it as ≤5 hours.
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name Short Sleep UKB+MVP EUR (meta-analyzed)
Development Method
Name PRS-CS
Parameters UKB and MVP EUR GWAS summary statistics were meta-analyzed using GWAMA v2.2.2 with default settings. Posterior SNP effect sizes were then inferred using PRS-CS with the 1000 Genomes European LD reference panel, HapMap target variants on GRCh38, a=1, b=0.5, phi=auto, and other parameters default; no clumping or P-value thresholding.
Variants
Original Genome Build GRCh38
Number of Variants 1,116,612
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000836
Citation (link to publication) Wyss AB et al. Sleep (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
833,845 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • East Asian
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007559
 339,926 individuals European UKB
GWAS Catalog: GCST90428611
 493,919 individuals European MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038104 PSS013825|
Multi-ancestry (including European)|
16,265 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Short sleep (<=6 hours) OR: 1.14 — — Age, sex, study center, ancestry principal components; race additionally included in BHS. The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.47. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 269 cases
  • , 722 controls
]
 — African American or Afro-Caribbean, European — BHS_b —
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 1,156 cases
  • , 10,565 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL Visit 1; survey-weighted analysis.
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 178 cases
  • , 1,884 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA Visit 5.
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 117 cases
  • , 1,374 controls
]
 — European — ARIC Visit 4 / Sleep Heart Health Study assessment.