Trait: short sleep

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004807
Description Is a quantification of sleep time in humans where average sleep time was less than five hours.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019924
(Short Sleep UKB)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Short Sleep short sleep 1,116,211
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019924/ScoringFiles/PGS019924.txt.gz
PGS019925
(Short Sleep MVP EUR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Short Sleep short sleep 761,060
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019925/ScoringFiles/PGS019925.txt.gz
PGS019926
(Short Sleep MVP AFR)
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Short Sleep short sleep 790,064
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019926/ScoringFiles/PGS019926.txt.gz
PGS019927
(Short Sleep UKB+MVP EUR (meta-analyzed))
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Short Sleep short sleep 1,116,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019927/ScoringFiles/PGS019927.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038102 PGS019924
(Short Sleep UKB)
 PSS013825|
Multi-ancestry (including European)|
16,265 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Short sleep (<=6 hours) OR: 1.23 [1.14, 1.33] — Incremental variance explained by the PRS: 0.16 [0.04, 0.33] Age, sex, study center, ancestry principal components; race additionally included in BHS. Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.97. HCHS/SOL analyses incorporated sampling weights.
PPM038103 PGS019925
(Short Sleep MVP EUR)
 PSS013825|
Multi-ancestry (including European)|
16,265 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Short sleep (<=6 hours) OR: 1.23 [1.13, 1.34] — — Age, sex, study center, ancestry principal components; race additionally included in BHS. European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.04. HCHS/SOL analyses incorporated sampling weights.
PPM038104 PGS019927
(Short Sleep UKB+MVP EUR (meta-analyzed))
 PSS013825|
Multi-ancestry (including European)|
16,265 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Short sleep (<=6 hours) OR: 1.14 — — Age, sex, study center, ancestry principal components; race additionally included in BHS. The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.47. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 269 cases
  • , 722 controls
]
 — African American or Afro-Caribbean, European — BHS_b —
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 1,156 cases
  • , 10,565 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL Visit 1; survey-weighted analysis.
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 178 cases
  • , 1,884 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA Visit 5.
PSS013825 Short sleep defined as ≤6 hours. —
[
  • 117 cases
  • , 1,374 controls
]
 — European — ARIC Visit 4 / Sleep Heart Health Study assessment.