PGS Catalog - Wyss AB, Sleep (2026) (Publication)

PGS Publication: PGP000836

Publication Information (EuropePMC)
Title	Using Polygenic Risk Scores to Evaluate Definitions of Self-Reported Sleep Phenotypes Across Cohorts.
PubMed ID	42479672(Europe PMC)
doi	10.1093/sleep/zsag200
Publication Date	July 21, 2026
Journal	*Sleep*
Author(s)	Wyss AB, Brown M, Li X, Spitzer BW, Huang Z, Wang H, Saxena R, Gallo L, Qi Q, Tarraf W, Kaplan R, Lamar M, González HM, DeCarli C, Fornage M, Rotter JI, Rich SS, Taylor KD, Guo X, Wood AC, Liu PY, Heckbert SR, Sarnowski C, Bressler J, Morrison AC, Yu B, Lutsey PL, Isasi CR, Redline S, Sofer T.

Released in PGS Catalog: July 29, 2026

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS019930 (Insomnia MVP AFR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Insomnia	insomnia	1,211,512	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019930/ScoringFiles/PGS019930.txt.gz
PGS019924 (Short Sleep UKB)	PGP000836 \| Wyss AB et al. Sleep (2026)	Short Sleep	short sleep	1,116,211	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019924/ScoringFiles/PGS019924.txt.gz
PGS019937 (Excessive Daytime Sleepiness MVP AMR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Excessive Daytime Sleepiness	excessive daytime sleepiness measurement	1,170,607	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019937/ScoringFiles/PGS019937.txt.gz
PGS019939 (Excessive Daytime Sleepiness UKB+MVP EUR (meta-analyzed))	PGP000836 \| Wyss AB et al. Sleep (2026)	Excessive Daytime Sleepiness	excessive daytime sleepiness measurement	1,116,797	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019939/ScoringFiles/PGS019939.txt.gz
PGS019934 (Excessive Daytime Sleepiness UKB)	PGP000836 \| Wyss AB et al. Sleep (2026)	Excessive Daytime Sleepiness	excessive daytime sleepiness measurement	1,116,191	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019934/ScoringFiles/PGS019934.txt.gz
PGS019938 (Excessive Daytime Sleepiness MVP EAS)	PGP000836 \| Wyss AB et al. Sleep (2026)	Excessive Daytime Sleepiness	excessive daytime sleepiness measurement	1,022,672	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019938/ScoringFiles/PGS019938.txt.gz
PGS019921 (Long Sleep MVP EUR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Long Sleep	sleep duration trait	769,142	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019921/ScoringFiles/PGS019921.txt.gz
PGS019927 (Short Sleep UKB+MVP EUR (meta-analyzed))	PGP000836 \| Wyss AB et al. Sleep (2026)	Short Sleep	short sleep	1,116,612	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019927/ScoringFiles/PGS019927.txt.gz
PGS019929 (Insomnia MVP EUR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Insomnia	insomnia	1,085,967	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019929/ScoringFiles/PGS019929.txt.gz
PGS019936 (Excessive Daytime Sleepiness MVP AFR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Excessive Daytime Sleepiness	excessive daytime sleepiness measurement	1,218,411	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019936/ScoringFiles/PGS019936.txt.gz
PGS019922 (Long Sleep MVP AFR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Long Sleep	sleep duration trait	831,373	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019922/ScoringFiles/PGS019922.txt.gz
PGS019923 (Long Sleep UKB+MVP EUR (meta-analyzed))	PGP000836 \| Wyss AB et al. Sleep (2026)	Long Sleep	sleep duration trait	1,116,622	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019923/ScoringFiles/PGS019923.txt.gz
PGS019925 (Short Sleep MVP EUR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Short Sleep	short sleep	761,060	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019925/ScoringFiles/PGS019925.txt.gz
PGS019926 (Short Sleep MVP AFR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Short Sleep	short sleep	790,064	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019926/ScoringFiles/PGS019926.txt.gz
PGS019928 (Insomnia UKB)	PGP000836 \| Wyss AB et al. Sleep (2026)	Insomnia	insomnia	1,069,748	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019928/ScoringFiles/PGS019928.txt.gz
PGS019931 (Insomnia MVP AMR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Insomnia	insomnia	1,166,626	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019931/ScoringFiles/PGS019931.txt.gz
PGS019932 (Insomnia MVP EAS)	PGP000836 \| Wyss AB et al. Sleep (2026)	Insomnia	insomnia	1,021,391	- -	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019932/ScoringFiles/PGS019932.txt.gz
PGS019933 (Insomnia UKB+MVP EUR (meta-analyzed))	PGP000836 \| Wyss AB et al. Sleep (2026)	Insomnia	insomnia	1,116,570	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019933/ScoringFiles/PGS019933.txt.gz
PGS019935 (Excessive Daytime Sleepiness MVP EUR)	PGP000836 \| Wyss AB et al. Sleep (2026)	Excessive Daytime Sleepiness	excessive daytime sleepiness measurement	1,089,038	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019935/ScoringFiles/PGS019935.txt.gz
PGS019920 (Long Sleep UKB)	PGP000836 \| Wyss AB et al. Sleep (2026)	Long Sleep	sleep duration trait	1,116,211	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019920/ScoringFiles/PGS019920.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	Evaluated Score	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM038103	PGS019925 (Short Sleep MVP EUR)	PSS013825\| Multi-ancestry (including European)\| 16,265 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Short sleep (<=6 hours)	OR: 1.23 [1.13, 1.34]	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.04. HCHS/SOL analyses incorporated sampling weights.
PPM038102	PGS019924 (Short Sleep UKB)	PSS013825\| Multi-ancestry (including European)\| 16,265 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Short sleep (<=6 hours)	OR: 1.23 [1.14, 1.33]	—	Incremental variance explained by the PRS: 0.16 [0.04, 0.33]	Age, sex, study center, ancestry principal components; race additionally included in BHS.	Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.97. HCHS/SOL analyses incorporated sampling weights.
PPM038104	PGS019927 (Short Sleep UKB+MVP EUR (meta-analyzed))	PSS013825\| Multi-ancestry (including European)\| 16,265 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Short sleep (<=6 hours)	OR: 1.14	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.47. HCHS/SOL analyses incorporated sampling weights.
PPM038105	PGS019920 (Long Sleep UKB)	PSS013824\| Multi-ancestry (including European)\| 16,265 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Long sleep (>=9 hours)	OR: 1.09 [1.04, 1.16]	—	Incremental variance explained by the PRS: 0.21 [0.07, 0.39]	Age, sex, study center, ancestry principal components; race additionally included in BHS.	Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.77. HCHS/SOL analyses incorporated sampling weights.
PPM038106	PGS019921 (Long Sleep MVP EUR)	PSS013824\| Multi-ancestry (including European)\| 16,265 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Long sleep (>=9 hours)	OR: 1.08 [1.03, 1.14]	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.52. HCHS/SOL analyses incorporated sampling weights.
PPM038107	PGS019923 (Long Sleep UKB+MVP EUR (meta-analyzed))	PSS013824\| Multi-ancestry (including European)\| 16,265 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Long sleep (>=9 hours)	OR: 1.09	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.94. HCHS/SOL analyses incorporated sampling weights.
PPM038108	PGS019928 (Insomnia UKB)	PSS013823\| Multi-ancestry (including European)\| 16,637 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC)	OR: 1.17 [1.111, 1.22]	—	Incremental variance explained by the PRS for WHIIRS>=10: 0.27 [0.11, 0.48]	Age, sex, study center, ancestry principal components; race additionally included in BHS.	Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.69. HCHS/SOL analyses incorporated sampling weights.
PPM038109	PGS019929 (Insomnia MVP EUR)	PSS013823\| Multi-ancestry (including European)\| 16,637 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC)	OR: 1.19	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.49. HCHS/SOL analyses incorporated sampling weights.
PPM038110	PGS019933 (Insomnia UKB+MVP EUR (meta-analyzed))	PSS013823\| Multi-ancestry (including European)\| 16,637 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC)	OR: 1.27	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Significant between-study heterogeneity was observed (p for heterogeneity = 0.006); the manuscript also reports random-effects results. HCHS/SOL analyses incorporated sampling weights.
PPM038111	PGS019934 (Excessive Daytime Sleepiness UKB)	PSS013822\| Multi-ancestry (including European)\| 16,767 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11)	OR: 1.23 [1.16, 1.3]	—	Incremental variance explained by the PRS: 0.47 [0.25, 0.73]	Age, sex, study center, ancestry principal components; race additionally included in BHS	Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.83. HCHS/SOL analyses incorporated sampling weights.
PPM038112	PGS019935 (Excessive Daytime Sleepiness MVP EUR)	PSS013822\| Multi-ancestry (including European)\| 16,767 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11)	OR: 1.15 [1.07, 1.24]	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.29. HCHS/SOL analyses incorporated sampling weights.
PPM038113	PGS019939 (Excessive Daytime Sleepiness UKB+MVP EUR (meta-analyzed))	PSS013822\| Multi-ancestry (including European)\| 16,767 individuals	PGP000836 \| Wyss AB et al. Sleep (2026)	Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11)	OR: 1.12	—	—	Age, sex, study center, ancestry principal components; race additionally included in BHS.	The score was constructed from meta-analysed UKB and MVP European-ancestry GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.11. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS013825	Short sleep defined as ≤6 hours.	—	991 individuals [ 269 cases , 722 controls ]	—	African American or Afro-Caribbean, European	—	BHS_b	—
PSS013822	Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11.	—	12,125 individuals [ 1,905 cases , 10,220 controls ]	—	Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)	—	HCHS/SOL	—
PSS013822	Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11.	—	2,073 individuals [ 287 cases , 1,786 controls ]	—	European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian (European, Black, Hispanic/Latino, and Chinese American)	—	MESA	—
PSS013822	Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11.	—	1,497 individuals [ 431 cases , 1,066 controls ]	—	European	—	ARIC	—
PSS013822	Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11.	—	1,072 individuals [ 169 cases , 903 controls ]	—	European, African American or Afro-Caribbean (European and Black/African American)	—	BHS_b	—
PSS013823	WHIIRS 5-question score ≥10.	—	11,981 individuals [ 3,837 cases , 8,144 controls ]	—	Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)	—	HCHS/SOL	Visit 1; survey-weighted analysis.
PSS013823	WHIIRS 5-question score ≥10.	—	2,069 individuals [ 604 cases , 1,465 controls ]	—	European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian (European, Black, Hispanic/Latino, and Chinese American)	—	MESA	Visit 5.
PSS013823	Modified 3-question WHIIRS score ≥6.	—	1,520 individuals [ 799 cases , 721 controls ]	—	European	—	ARIC	Visit 4 / Sleep Heart Health Study assessment.
PSS013823	WHIIRS 5-question score ≥10.	—	1,067 individuals [ 410 cases , 657 controls ]	—	European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian (European, Black, Hispanic/Latino, and Chinese American)	—	BHS_b	BiCEPS visit.
PSS013824	Long sleep defined as ≥9 hours.	—	11,721 individuals [ 2,740 cases , 8,981 controls ]	—	Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)	—	HCHS/SOL	Visit 1; survey-weighted analysis.
PSS013824	Long sleep defined as ≥9 hours.	—	2,062 individuals [ 503 cases , 1,559 controls ]	—	European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian (European, Black, Hispanic/Latino, and Chinese American)	—	MESA	Visit 5.
PSS013824	Long sleep defined as ≥9 hours.	—	1,491 individuals [ 94 cases , 1,397 controls ]	—	European	—	ARIC	Visit 4 / Sleep Heart Health Study assessment.
PSS013824	Long sleep defined as ≥9 hours.	—	991 individuals [ 67 cases , 924 controls ]	—	African American or Afro-Caribbean, European	—	BHS_b	—
PSS013825	Short sleep defined as ≤6 hours.	—	11,721 individuals [ 1,156 cases , 10,565 controls ]	—	Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)	—	HCHS/SOL	Visit 1; survey-weighted analysis.
PSS013825	Short sleep defined as ≤6 hours.	—	2,062 individuals [ 178 cases , 1,884 controls ]	—	European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian (European, Black, Hispanic/Latino, and Chinese American)	—	MESA	Visit 5.
PSS013825	Short sleep defined as ≤6 hours.	—	1,491 individuals [ 117 cases , 1,374 controls ]	—	European	—	ARIC	Visit 4 / Sleep Heart Health Study assessment.