Polygenic Score (PGS) ID: PGS019928

Predicted Trait
Reported Trait Insomnia
Mapped Trait(s) insomnia (MONDO_0013600)
Additional Trait Information UK Biobank GWAS definition: usual trouble falling asleep at night or waking in the middle of the night; cases answered “Usually,” controls answered “Never/rarely” or “Sometimes.”
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name Insomnia UKB
Development Method
Name PRS-CS
Parameters Posterior SNP effect sizes inferred using PRS-CS; 1000 Genomes European LD reference panel; HapMap target variants lifted to GRCh38; a=1, b=0.5, phi=auto; other parameters default; no clumping or P-value thresholding.
Variants
Original Genome Build GRCh38
Number of Variants 1,069,748
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000836
Citation (link to publication) Wyss AB et al. Sleep (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
453,379 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • East Asian
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007988
 453,379 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038108 PSS013823|
Multi-ancestry (including European)|
16,637 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC) OR: 1.17 [1.111, 1.22] — Incremental variance explained by the PRS for WHIIRS>=10: 0.27 [0.11, 0.48] Age, sex, study center, ancestry principal components; race additionally included in BHS. Incremental variance explained was reported as a percentage and estimated in unrelated HCHS/SOL participants. The score was constructed from UKB GWAS summary statistics using PRS-CS and evaluated across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.69. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 410 cases
  • , 657 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — BHS_b BiCEPS visit.
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 3,837 cases
  • , 8,144 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL Visit 1; survey-weighted analysis.
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 604 cases
  • , 1,465 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA Visit 5.
PSS013823 Modified 3-question WHIIRS score ≥6. —
[
  • 799 cases
  • , 721 controls
]
 — European — ARIC Visit 4 / Sleep Heart Health Study assessment.