Polygenic Score (PGS) ID: PGS019929

Predicted Trait
Reported Trait Insomnia
Mapped Trait(s) insomnia (MONDO_0013600)
Additional Trait Information Million Veteran Program electronic-health-record phenotype: at least one qualifying ICD-9 or ICD-10 insomnia diagnosis code; European ancestry-specific score.
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name Insomnia MVP EUR
Development Method
Name PRS-CSx
Parameters Ancestry-specific posterior SNP effect sizes inferred using PRS-CSx; 1000 Genomes European LD reference panel for the EUR component; HapMap target variants on GRCh38; a=1, b=0.5, phi=auto; other parameters default; no clumping or P-value thresholding.
Variants
Original Genome Build GRCh38
Number of Variants 1,085,967
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000836
Citation (link to publication) Wyss AB et al. Sleep (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
414,517 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • East Asian
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90475826
 414,517 individuals European MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038109 PSS013823|
Multi-ancestry (including European)|
16,637 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Insomnia (WHIIRS >=10, or modified 3-question WHIIRS >=6 in ARIC) OR: 1.19 — — Age, sex, study center, ancestry principal components; race additionally included in BHS. European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.49. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 410 cases
  • , 657 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — BHS_b BiCEPS visit.
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 3,837 cases
  • , 8,144 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL Visit 1; survey-weighted analysis.
PSS013823 WHIIRS 5-question score ≥10. —
[
  • 604 cases
  • , 1,465 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA Visit 5.
PSS013823 Modified 3-question WHIIRS score ≥6. —
[
  • 799 cases
  • , 721 controls
]
 — European — ARIC Visit 4 / Sleep Heart Health Study assessment.