Polygenic Score (PGS) ID: PGS019935

Predicted Trait
Reported Trait Excessive Daytime Sleepiness
Mapped Trait(s) excessive daytime sleepiness measurement (EFO_0007875)
Additional Trait Information Million Veteran Program phenotype: yes/no response to feeling excessively sleepy during the day, excluding regular naps; European ancestry-specific score.
Released in PGS Catalog: July 29, 2026
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Score Details

Score Construction
PGS Name Excessive Daytime Sleepiness MVP EUR
Development Method
Name PRS-CSx
Parameters Ancestry-specific posterior SNP effect sizes inferred using PRS-CSx; 1000 Genomes European LD reference panel for the EUR component; HapMap target variants on GRCh38; a=1, b=0.5, phi=auto; other parameters default; no clumping or P-value thresholding.
Variants
Original Genome Build GRCh38
Number of Variants 1,089,038
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000836
Citation (link to publication) Wyss AB et al. Sleep (2026)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
246,850 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
  • Hispanic or Latin American
  • East Asian
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90479440
 246,850 individuals European MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038112 PSS013822|
Multi-ancestry (including European)|
16,767 individuals
 PGP000836 |
Wyss AB et al. Sleep (2026)
 Reported Trait: Excessive daytime sleepiness (Epworth Sleepiness Scale >=11) OR: 1.15 [1.07, 1.24] — — Age, sex, study center, ancestry principal components; race additionally included in BHS. European-ancestry score constructed from MVP GWAS summary statistics using PRS-CSx and evaluated as a stand-alone score across ARIC, HCHS/SOL, MESA and BHS. Fixed-effect meta-analysis p for heterogeneity = 0.29. HCHS/SOL analyses incorporated sampling weights.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 1,905 cases
  • , 10,220 controls
]
 — Hispanic or Latin American
(Central American, Cuban, Dominican, Mexican, Puerto Rican, and South America)		 — HCHS/SOL —
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 287 cases
  • , 1,786 controls
]
 — European, African American or Afro-Caribbean, Hispanic or Latin American, East Asian
(European, Black, Hispanic/Latino, and Chinese American)		 — MESA —
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 431 cases
  • , 1,066 controls
]
 — European — ARIC —
PSS013822 Excessive daytime sleepiness defined as Epworth Sleepiness Scale score ≥11. —
[
  • 169 cases
  • , 903 controls
]
 — European, African American or Afro-Caribbean
(European and Black/African American)		 — BHS_b —