Polygenic Score (PGS) ID: PGS019953

Predicted Trait
Reported Trait Alcohol metabolism
Mapped Trait(s) alcohol drinking (EFO_0004329)
Released in PGS Catalog: Aug. 26, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS10_AD
Development Method
Name Genome wide significant variants
Parameters NR
Variants
Original Genome Build NR
Number of Variants 10
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000841
Citation (link to publication) Park CS et al. Heart Rhythm (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
46,568 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 30482948
[
  • 11,569 cases
  • , 34,999 controls
]
 European 24 cohorts
  • Add Health
  • ,BLTS
  • ,CADD
  • ,CATS
  • ,CEDAR_Penn
  • ,CHDS
  • ,CITA
  • ,COGA
  • ,COGEND
  • ,FSCD
  • ,FinnTwin12
  • ,GEDI
  • ,GESGA
  • ,HBCS
  • ,IASPSAD
  • ,MCTFR
  • ,NAG-Fin
  • ,NESDA
  • ,NIAAA
  • ,OZ-ALC-NAG
  • ,PAGES
  • ,STR
  • ,Spit
  • ,Yale-Penn

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038139 PSS013833|
European Ancestry|
397,164 individuals
 PGP000841 |
Park CS et al. Heart Rhythm (2024)
 Reported Trait: Alcohol consumption HR: 1.01 [0.98, 1.05] — — age, sex, hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, heart failure, valvular heat disease, peripheral artery disease, chronic kidney disease, liver disease, alcohol consumption habit —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013833 — — 397,164 individuals,
45.9 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European
(British)		 — UKB —