PGS Publication: PGP000841

Publication Information (EuropePMC)
Title Alcohol is neither a risk factor nor a protective factor for sudden cardiac death and/or fatal ventricular arrhythmia: A population-based study with genetic traits and alcohol consumption in the UK Biobank.
PubMed ID 38697272(Europe PMC)
doi 10.1016/j.hrthm.2024.04.097
Publication Date May 1, 2024
Journal Heart Rhythm
Author(s) Park CS, Choi J, Choi J, Lee KY, Ahn HJ, Kwon S, Lee SR, Choi EK, Kwak SH, Oh S.
Released in PGS Catalog: Aug. 26, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019953
(PRS10_AD)
 PGP000841 |
Park CS et al. Heart Rhythm (2024)
 Alcohol metabolism alcohol drinking 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019953/ScoringFiles/PGS019953.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038139 PGS019953
(PRS10_AD)
 PSS013833|
European Ancestry|
397,164 individuals
 PGP000841 |
Park CS et al. Heart Rhythm (2024)
 Reported Trait: Alcohol consumption HR: 1.01 [0.98, 1.05] — — age, sex, hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, heart failure, valvular heat disease, peripheral artery disease, chronic kidney disease, liver disease, alcohol consumption habit —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013833 — — 397,164 individuals,
45.9 % Male samples
 Mean = 56.9 years
Sd = 8.0 years		 European
(British)		 — UKB —