Polygenic Score (PGS) ID: PGS020002

Predicted Trait
Reported Trait Heart failure
Mapped Trait(s) heart failure (MONDO_0005252)
Released in PGS Catalog: Oct. 23, 2026
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS12_HF
Development Method
Name Genome-wide sigificant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 12
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000860
Citation (link to publication) Shi Q et al. JACC Asia (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
977,323 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009541
Europe PMC: 31919418
 977,323 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038299 PSS013907|
European Ancestry|
340,541 individuals
 PGP000860 |
Shi Q et al. JACC Asia (2024)
 Reported Trait: Incident Heart Failure HR: 1.05 [1.03, 1.06] — — age, sex, ethnicity, the Townsend index, lifestyle factors (smoking status, alcohol intake frequency, a healthy diet score), and body mass index, systolic blood pressure, and baseline cancer, diabetes and use of antihypertensive medicine at baseline —
PPM038300 PSS013907|
European Ancestry|
340,541 individuals
 PGP000860 |
Shi Q et al. JACC Asia (2024)
 Reported Trait: Incident Heart Failure x frailty interaction — — Hazard ratio (HR, frail and high PRS vs. non-frail and low PRS): 1.72 [1.36, 2.18] demographic variables (including age, sex, and ethnicity), the Townsend Deprivation Index, lifestyle factors (smoking status, alcohol intake frequency, and healthy diet score), body mass index, systolic blood pressure, baseline cancer incidence, diabetes incidence, and use of antihypertensive medicine at baseline —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013907 — — 340,541 individuals,
45.7 % Male samples
 Mean = 55.9 years
Sd = 8.1 years		 European — UKB —