PGS Publication: PGP000860

Publication Information (EuropePMC)
Title Physical Frailty, Genetic Predisposition, and Incident Heart Failure.
PubMed ID 39101116(Europe PMC)
doi 10.1016/j.jacasi.2024.03.005
Publication Date May 14, 2024
Journal JACC Asia
Author(s) Shi Q, Huang J, Wan J, Zhong Z, Sun Y, Zhou Y, Li J, Tan X, Yu B, Lu Y, Wang N.
Released in PGS Catalog: Oct. 23, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS020002
(PRS12_HF)
 PGP000860 |
Shi Q et al. JACC Asia (2024)
 Heart failure heart failure 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS020002/ScoringFiles/PGS020002.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM038299 PGS020002
(PRS12_HF)
 PSS013907|
European Ancestry|
340,541 individuals
 PGP000860 |
Shi Q et al. JACC Asia (2024)
 Reported Trait: Incident Heart Failure HR: 1.05 [1.03, 1.06] — — age, sex, ethnicity, the Townsend index, lifestyle factors (smoking status, alcohol intake frequency, a healthy diet score), and body mass index, systolic blood pressure, and baseline cancer, diabetes and use of antihypertensive medicine at baseline —
PPM038300 PGS020002
(PRS12_HF)
 PSS013907|
European Ancestry|
340,541 individuals
 PGP000860 |
Shi Q et al. JACC Asia (2024)
 Reported Trait: Incident Heart Failure x frailty interaction — — Hazard ratio (HR, frail and high PRS vs. non-frail and low PRS): 1.72 [1.36, 2.18] demographic variables (including age, sex, and ethnicity), the Townsend Deprivation Index, lifestyle factors (smoking status, alcohol intake frequency, and healthy diet score), body mass index, systolic blood pressure, baseline cancer incidence, diabetes incidence, and use of antihypertensive medicine at baseline —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013907 — — 340,541 individuals,
45.7 % Male samples
 Mean = 55.9 years
Sd = 8.1 years		 European — UKB —