Trait: heart failure

Trait Information
Identifier MONDO_0005252
Description Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. [EFO: 0003144]
Trait categories
Cardiovascular disease
Other disease
Synonyms 5 synonyms
  • cardiac failure
  • cardiac insufficiency
  • failure, heart
  • heart failure
  • insufficiency, Cardiac
Child trait(s) 3 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "heart failure" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000709
(HC299)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Heart failure heart failure 183,287
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000709/ScoringFiles/PGS000709.txt.gz - Check Terms/Licenses
PGS001790
(1kgeur_gbmi_leaveUKBBout_HF_pst_eff_a1_b0.5_phiauto)
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Heart failure heart failure 910,146
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001790/ScoringFiles/PGS001790.txt.gz
PGS001840
(portability-PLR_415)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Pulmonary heart disease cor pulmonale 330
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001840/ScoringFiles/PGS001840.txt.gz
PGS001842
(portability-PLR_428)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Congestive heart failure; nonhypertensive congestive heart failure 2,759
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001842/ScoringFiles/PGS001842.txt.gz
PGS002049
(portability-ldpred2_415)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Pulmonary heart disease cor pulmonale 222,371
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002049/ScoringFiles/PGS002049.txt.gz
PGS002051
(portability-ldpred2_428)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Congestive heart failure; nonhypertensive congestive heart failure 642,241
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002051/ScoringFiles/PGS002051.txt.gz
PGS003969
(PRS39_HF)
 PGP000511 |
Rasooly D et al. Nat Commun (2023)
 Heart failure heart failure 39
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003969/ScoringFiles/PGS003969.txt.gz
PGS004462
(disease.I50.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 I50 (Heart failure) heart failure 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004462/ScoringFiles/PGS004462.txt.gz
PGS004532
(meta.I50.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 I50 (Heart failure) heart failure 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004532/ScoringFiles/PGS004532.txt.gz
PGS004598
(PRS12_HF)
 PGP000576 |
Peng H et al. Nutrients (2023)
 Heart failure heart failure 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004598/ScoringFiles/PGS004598.txt.gz
PGS005073
(Phe_428_1_ldpred_AFRss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005073/ScoringFiles/PGS005073.txt.gz
PGS005074
(Phe_428_1_ldpred_EURss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005074/ScoringFiles/PGS005074.txt.gz
PGS005075
(Phe_428_1_ldpred_HISss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005075/ScoringFiles/PGS005075.txt.gz
PGS005076
(Phe_428_1_ldpred_METAss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005076/ScoringFiles/PGS005076.txt.gz
PGS005077
(Phe_428_1_ldpred_METAss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005077/ScoringFiles/PGS005077.txt.gz
PGS005078
(Phe_428_1_ldpred_METAss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,286,612
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005078/ScoringFiles/PGS005078.txt.gz
PGS005079
(Phe_428_1_prscs_AFRss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005079/ScoringFiles/PGS005079.txt.gz
PGS005080
(Phe_428_1_prscs_EURss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005080/ScoringFiles/PGS005080.txt.gz
PGS005081
(Phe_428_1_prscs_HISss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005081/ScoringFiles/PGS005081.txt.gz
PGS005082
(Phe_428_1_prscs_METAss_afrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005082/ScoringFiles/PGS005082.txt.gz
PGS005083
(Phe_428_1_prscs_METAss_amrld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005083/ScoringFiles/PGS005083.txt.gz
PGS005084
(Phe_428_1_prscs_METAss_eurld)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,273,897
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005084/ScoringFiles/PGS005084.txt.gz
PGS005085
(Phe_428_1_prscsx_METAweight)
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Congestive heart failure (CHF), NOS (PheCode 428.1) congestive heart failure 1,256,161
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005085/ScoringFiles/PGS005085.txt.gz
PGS005097
(prscsx_meta_HF)
 PGP000691 |
Lee DSM et al. Nat Genet (2025)
 Heart failure heart failure 1,274,692
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005097/ScoringFiles/PGS005097.txt.gz
PGS005285
(BBJ_HF_PRS_HG19)
 PGP000757 |
Enzan N et al. Nat Commun (2025)
 Heart failure heart failure 993,899
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005285/ScoringFiles/PGS005285.txt.gz
PGS005299
(Jorda_HF_MTAG-PGS-inf_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 923,722
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005299/ScoringFiles/PGS005299.txt.gz
PGS005300
(Jorda_HF_MTAG-PGS_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 923,722
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005300/ScoringFiles/PGS005300.txt.gz
PGS005301
(Jorda_HF_MTAG-PGS_females_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 923,722
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005301/ScoringFiles/PGS005301.txt.gz
PGS005302
(Jorda_HF_MTAG-PGS_males_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 923,722
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005302/ScoringFiles/PGS005302.txt.gz
PGS005303
(Jorda_HF_SingleTrait-PGS-inf_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 1,042,531
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005303/ScoringFiles/PGS005303.txt.gz
PGS005304
(Jorda_HF_SingleTrait-PGS_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 1,042,531
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005304/ScoringFiles/PGS005304.txt.gz
PGS005305
(Jorda_HF_SingleTrait-PGS_females_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 1,042,531
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005305/ScoringFiles/PGS005305.txt.gz
PGS005306
(Jorda_HF_SingleTrait-PGS_males_2024)
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Heart failure heart failure 1,042,531
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005306/ScoringFiles/PGS005306.txt.gz
PGS005319
(HF_PRS)
 PGP000766 |
Türkmen D et al. Pharmacogenomics J (2024)
 Heart failure heart failure 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005319/ScoringFiles/PGS005319.txt.gz
PGS012544
(EN_model_HF)
 PGP000790 |
Hu J et al. Genet Med (2026)
 Heart failure heart failure 969,507
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012544/ScoringFiles/PGS012544.txt.gz
PGS012552
(PRS_HF)
 PGP000794 |
Ye Y et al. Front Bioinform (2024)
 Heart failure heart failure 1,935,626
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012552/ScoringFiles/PGS012552.txt.gz
PGS018409
(MultiPRS_heart-failure)
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Heart failure heart failure 1,105,535
-
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018409/ScoringFiles/PGS018409.txt.gz
PGS019170
(TPMI_411.8_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other chronic ischemic heart disease unspecified chronic pulmonary heart disease 36,363
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019170/ScoringFiles/PGS019170.txt.gz
PGS019171
(TPMI_411.8_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other chronic ischemic heart disease unspecified chronic pulmonary heart disease 939,887
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019171/ScoringFiles/PGS019171.txt.gz
PGS019172
(TPMI_411.8_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other chronic ischemic heart disease unspecified chronic pulmonary heart disease 36,574
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019172/ScoringFiles/PGS019172.txt.gz
PGS019173
(TPMI_411.8_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other chronic ischemic heart disease unspecified chronic pulmonary heart disease 983,825
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019173/ScoringFiles/PGS019173.txt.gz
PGS019174
(TPMI_411.8_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other chronic ischemic heart disease unspecified chronic pulmonary heart disease 935,962
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019174/ScoringFiles/PGS019174.txt.gz
PGS019175
(TPMI_414_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other forms of chronic heart disease chronic pulmonary heart disease 583,608
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019175/ScoringFiles/PGS019175.txt.gz
PGS019176
(TPMI_414_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other forms of chronic heart disease chronic pulmonary heart disease 939,813
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019176/ScoringFiles/PGS019176.txt.gz
PGS019177
(TPMI_414_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other forms of chronic heart disease chronic pulmonary heart disease 189,507
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019177/ScoringFiles/PGS019177.txt.gz
PGS019178
(TPMI_414_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other forms of chronic heart disease chronic pulmonary heart disease 983,765
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019178/ScoringFiles/PGS019178.txt.gz
PGS019179
(TPMI_414_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other forms of chronic heart disease chronic pulmonary heart disease 1,024,278
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019179/ScoringFiles/PGS019179.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001601 PGS000709
(HC299)
 PSS000820|
European Ancestry|
87,413 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Heart failure — AUROC: 0.53217 — Age, sex, PCs(1-10) —
PPM001614 PGS000709
(HC299)
 PSS000821|
European Ancestry|
135,300 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Heart failure HR: 1.08 [1.06, 1.1] C-index: 0.635 — Age as time scale, sex, batch, PCs(1-10) —
PPM009294 PGS001790
(1kgeur_gbmi_leaveUKBBout_HF_pst_eff_a1_b0.5_phiauto)
 PSS007713|
European Ancestry|
358,905 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Heart Failure — AUROC: 0.75 Nagelkerke's R2 (covariates regressed out): 0.00698 sex,age,age2,age*sex,age^2*sex, 20PCs —
PPM009610 PGS001840
(portability-PLR_415)
 PSS009312|
European Ancestry|
19,808 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0355 [0.0216, 0.0494] sex, age, birth date, deprivation index, 16 PCs —
PPM009611 PGS001840
(portability-PLR_415)
 PSS009086|
European Ancestry|
4,113 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0647 [0.0341, 0.0952] sex, age, birth date, deprivation index, 16 PCs —
PPM009612 PGS001840
(portability-PLR_415)
 PSS008640|
European Ancestry|
6,617 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.038 [0.0139, 0.0621] sex, age, birth date, deprivation index, 16 PCs —
PPM009613 PGS001840
(portability-PLR_415)
 PSS008414|
Greater Middle Eastern Ancestry|
1,190 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): -0.0071 [-0.0643, 0.0503] sex, age, birth date, deprivation index, 16 PCs —
PPM009614 PGS001840
(portability-PLR_415)
 PSS008194|
South Asian Ancestry|
6,283 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.03 [0.0052, 0.0547] sex, age, birth date, deprivation index, 16 PCs —
PPM009615 PGS001840
(portability-PLR_415)
 PSS007976|
East Asian Ancestry|
1,805 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0109 [-0.0355, 0.0572] sex, age, birth date, deprivation index, 16 PCs —
PPM009616 PGS001840
(portability-PLR_415)
 PSS007759|
African Ancestry|
2,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0171 [-0.0226, 0.0568] sex, age, birth date, deprivation index, 16 PCs —
PPM009617 PGS001840
(portability-PLR_415)
 PSS008863|
African Ancestry|
3,858 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0366 [0.005, 0.0682] sex, age, birth date, deprivation index, 16 PCs —
PPM009626 PGS001842
(portability-PLR_428)
 PSS009314|
European Ancestry|
19,961 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0293 [0.0154, 0.0432] sex, age, birth date, deprivation index, 16 PCs —
PPM009627 PGS001842
(portability-PLR_428)
 PSS009088|
European Ancestry|
4,128 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0213 [-0.0093, 0.0519] sex, age, birth date, deprivation index, 16 PCs —
PPM009628 PGS001842
(portability-PLR_428)
 PSS008642|
European Ancestry|
6,648 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0227 [-0.0014, 0.0467] sex, age, birth date, deprivation index, 16 PCs —
PPM009629 PGS001842
(portability-PLR_428)
 PSS008416|
Greater Middle Eastern Ancestry|
1,197 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0369 [-0.0203, 0.0938] sex, age, birth date, deprivation index, 16 PCs —
PPM009631 PGS001842
(portability-PLR_428)
 PSS007978|
East Asian Ancestry|
1,808 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0692 [0.023, 0.1152] sex, age, birth date, deprivation index, 16 PCs —
PPM009632 PGS001842
(portability-PLR_428)
 PSS007761|
African Ancestry|
2,472 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0218 [-0.0178, 0.0613] sex, age, birth date, deprivation index, 16 PCs —
PPM009633 PGS001842
(portability-PLR_428)
 PSS008865|
African Ancestry|
3,905 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): -0.0133 [-0.0447, 0.0182] sex, age, birth date, deprivation index, 16 PCs —
PPM009630 PGS001842
(portability-PLR_428)
 PSS008196|
South Asian Ancestry|
6,294 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0004 [-0.0244, 0.0251] sex, age, birth date, deprivation index, 16 PCs —
PPM011254 PGS002049
(portability-ldpred2_415)
 PSS009312|
European Ancestry|
19,808 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0397 [0.0258, 0.0536] sex, age, birth date, deprivation index, 16 PCs —
PPM011255 PGS002049
(portability-ldpred2_415)
 PSS009086|
European Ancestry|
4,113 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0663 [0.0357, 0.0967] sex, age, birth date, deprivation index, 16 PCs —
PPM011256 PGS002049
(portability-ldpred2_415)
 PSS008640|
European Ancestry|
6,617 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0336 [0.0095, 0.0577] sex, age, birth date, deprivation index, 16 PCs —
PPM011257 PGS002049
(portability-ldpred2_415)
 PSS008414|
Greater Middle Eastern Ancestry|
1,190 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): -0.0019 [-0.0592, 0.0554] sex, age, birth date, deprivation index, 16 PCs —
PPM011258 PGS002049
(portability-ldpred2_415)
 PSS008194|
South Asian Ancestry|
6,283 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0331 [0.0083, 0.0578] sex, age, birth date, deprivation index, 16 PCs —
PPM011259 PGS002049
(portability-ldpred2_415)
 PSS007976|
East Asian Ancestry|
1,805 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0075 [-0.0389, 0.0539] sex, age, birth date, deprivation index, 16 PCs —
PPM011260 PGS002049
(portability-ldpred2_415)
 PSS007759|
African Ancestry|
2,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.014 [-0.0257, 0.0537] sex, age, birth date, deprivation index, 16 PCs —
PPM011261 PGS002049
(portability-ldpred2_415)
 PSS008863|
African Ancestry|
3,858 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Pulmonary heart disease — — Partial Correlation (partial-r): 0.0322 sex, age, birth date, deprivation index, 16 PCs —
PPM011270 PGS002051
(portability-ldpred2_428)
 PSS009314|
European Ancestry|
19,961 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0235 [0.0097, 0.0374] sex, age, birth date, deprivation index, 16 PCs —
PPM011271 PGS002051
(portability-ldpred2_428)
 PSS009088|
European Ancestry|
4,128 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0368 [0.0062, 0.0673] sex, age, birth date, deprivation index, 16 PCs —
PPM011272 PGS002051
(portability-ldpred2_428)
 PSS008642|
European Ancestry|
6,648 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0327 [0.0086, 0.0567] sex, age, birth date, deprivation index, 16 PCs —
PPM011274 PGS002051
(portability-ldpred2_428)
 PSS008196|
South Asian Ancestry|
6,294 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0021 [-0.0226, 0.0269] sex, age, birth date, deprivation index, 16 PCs —
PPM011275 PGS002051
(portability-ldpred2_428)
 PSS007978|
East Asian Ancestry|
1,808 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0376 [-0.0087, 0.0838] sex, age, birth date, deprivation index, 16 PCs —
PPM011276 PGS002051
(portability-ldpred2_428)
 PSS007761|
African Ancestry|
2,472 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.025 [-0.0146, 0.0645] sex, age, birth date, deprivation index, 16 PCs —
PPM011277 PGS002051
(portability-ldpred2_428)
 PSS008865|
African Ancestry|
3,905 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): 0.0121 [-0.0193, 0.0436] sex, age, birth date, deprivation index, 16 PCs —
PPM011273 PGS002051
(portability-ldpred2_428)
 PSS008416|
Greater Middle Eastern Ancestry|
1,197 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Congestive heart failure; nonhypertensive — — Partial Correlation (partial-r): -0.0001 [-0.0572, 0.0571] sex, age, birth date, deprivation index, 16 PCs —
PPM019123 PGS003969
(PRS39_HF)
 PSS011190|
European Ancestry|
75,119 individuals
 PGP000511 |
Rasooly D et al. Nat Commun (2023)
 Reported Trait: Heart failure OR: 1.28 [1.24, 1.31] — — — —
PPM020577 PGS004462
(disease.I50.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: I50 (Heart failure) OR: 1.15815 — — — —
PPM020647 PGS004532
(meta.I50.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: I50 (Heart failure) OR: 1.26713 — — — —
PPM020747 PGS004598
(PRS12_HF)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident heart failure in breast cancer survivors — — Hazard ratio (HR, top 50% vs bottom 50% of PRS): 1.4 [1.06, 1.84] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM020750 PGS004598
(PRS12_HF)
 PSS011390|
Multi-ancestry (including European)|
13,348 individuals
 PGP000576 |
Peng H et al. Nutrients (2023)
 Reported Trait: Incident heart failure in breast cancer survivors with lifestyle — — Hazard ratio (HR, unhealthy lifestyle and PRS in top 50% vs healthy lifestyle and PRS in bottom 50%): 0.39 [0.21, 0.73] Age at diagnosis of breast cancer, race, Townsend Deprivation Index, diabetes, hypertension, antihypertensive medications, insulin treatment, lipid treatments, hormone replacement therapy, menopause, surgical treatment of breast cancer, genetic testing batches, 10 PCs —
PPM021956 PGS005073
(Phe_428_1_ldpred_AFRss_afrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.139 [1.01, 1.29] C-index: 0.79007 — age, sex, 20 PCs —
PPM021962 PGS005073
(Phe_428_1_ldpred_AFRss_afrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.128 [1.07, 1.19] C-index: 0.74096 — age, sex, 20 PCs —
PPM021968 PGS005073
(Phe_428_1_ldpred_AFRss_afrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.22 [1.12, 1.33] C-index: 0.71526 — age, sex, 20 PCs —
PPM021958 PGS005074
(Phe_428_1_ldpred_EURss_eurld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.386 [1.14, 1.68] C-index: 0.79052 — age, sex, 20 PCs —
PPM021964 PGS005074
(Phe_428_1_ldpred_EURss_eurld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.427 [1.35, 1.51] C-index: 0.75177 — age, sex, 20 PCs —
PPM021970 PGS005074
(Phe_428_1_ldpred_EURss_eurld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.291 [1.11, 1.5] C-index: 0.71208 — age, sex, 20 PCs —
PPM021957 PGS005075
(Phe_428_1_ldpred_HISss_amrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.052 [0.92, 1.2] C-index: 0.78786 — age, sex, 20 PCs —
PPM021963 PGS005075
(Phe_428_1_ldpred_HISss_amrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.095 [1.04, 1.15] C-index: 0.73981 — age, sex, 20 PCs —
PPM021969 PGS005075
(Phe_428_1_ldpred_HISss_amrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.089 [1.0, 1.19] C-index: 0.70971 — age, sex, 20 PCs —
PPM021953 PGS005076
(Phe_428_1_ldpred_METAss_afrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.354 [1.17, 1.57] C-index: 0.79231 — age, sex, 20 PCs —
PPM021965 PGS005076
(Phe_428_1_ldpred_METAss_afrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.369 [1.23, 1.52] C-index: 0.71935 — age, sex, 20 PCs —
PPM021959 PGS005076
(Phe_428_1_ldpred_METAss_afrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.443 [1.37, 1.52] C-index: 0.75325 — age, sex, 20 PCs —
PPM021954 PGS005077
(Phe_428_1_ldpred_METAss_amrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.315 [1.14, 1.52] C-index: 0.7917 — age, sex, 20 PCs —
PPM021960 PGS005077
(Phe_428_1_ldpred_METAss_amrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.452 [1.38, 1.53] C-index: 0.75358 — age, sex, 20 PCs —
PPM021966 PGS005077
(Phe_428_1_ldpred_METAss_amrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.37 [1.24, 1.52] C-index: 0.7197 — age, sex, 20 PCs —
PPM021955 PGS005078
(Phe_428_1_ldpred_METAss_eurld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.371 [1.18, 1.59] C-index: 0.79286 — age, sex, 20 PCs —
PPM021961 PGS005078
(Phe_428_1_ldpred_METAss_eurld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.442 [1.37, 1.52] C-index: 0.75253 — age, sex, 20 PCs —
PPM021967 PGS005078
(Phe_428_1_ldpred_METAss_eurld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.38 [1.24, 1.54] C-index: 0.71824 — age, sex, 20 PCs —
PPM021863 PGS005079
(Phe_428_1_prscs_AFRss_afrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.098 [0.97, 1.24] C-index: 0.78907 — age, sex, 20 PCs —
PPM021870 PGS005079
(Phe_428_1_prscs_AFRss_afrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.127 [1.07, 1.19] C-index: 0.7408 — age, sex, 20 PCs —
PPM021877 PGS005079
(Phe_428_1_prscs_AFRss_afrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.24 [1.13, 1.36] C-index: 0.71475 — age, sex, 20 PCs —
PPM021865 PGS005080
(Phe_428_1_prscs_EURss_eurld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.364 [1.15, 1.62] C-index: 0.79082 — age, sex, 20 PCs —
PPM021872 PGS005080
(Phe_428_1_prscs_EURss_eurld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.44 [1.37, 1.52] C-index: 0.75317 — age, sex, 20 PCs —
PPM021879 PGS005080
(Phe_428_1_prscs_EURss_eurld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.287 [1.13, 1.47] C-index: 0.71297 — age, sex, 20 PCs —
PPM021864 PGS005081
(Phe_428_1_prscs_HISss_amrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.033 [0.91, 1.18] C-index: 0.78774 — age, sex, 20 PCs —
PPM021871 PGS005081
(Phe_428_1_prscs_HISss_amrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.09 [1.04, 1.15] C-index: 0.73963 — age, sex, 20 PCs —
PPM021878 PGS005081
(Phe_428_1_prscs_HISss_amrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.07 [0.98, 1.17] C-index: 0.70939 — age, sex, 20 PCs —
PPM021867 PGS005082
(Phe_428_1_prscs_METAss_afrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.39 [1.32, 1.47] C-index: 0.75065 — age, sex, 20 PCs —
PPM021874 PGS005082
(Phe_428_1_prscs_METAss_afrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.317 [1.19, 1.46] C-index: 0.7165 — age, sex, 20 PCs —
PPM021860 PGS005082
(Phe_428_1_prscs_METAss_afrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.31 [1.14, 1.5] C-index: 0.79176 — age, sex, 20 PCs —
PPM021861 PGS005083
(Phe_428_1_prscs_METAss_amrld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.319 [1.14, 1.53] C-index: 0.79127 — age, sex, 20 PCs —
PPM021868 PGS005083
(Phe_428_1_prscs_METAss_amrld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.455 [1.38, 1.54] C-index: 0.75368 — age, sex, 20 PCs —
PPM021875 PGS005083
(Phe_428_1_prscs_METAss_amrld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.314 [1.18, 1.46] C-index: 0.71674 — age, sex, 20 PCs —
PPM021862 PGS005084
(Phe_428_1_prscs_METAss_eurld)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.396 [1.2, 1.62] C-index: 0.79297 — age, sex, 20 PCs —
PPM021876 PGS005084
(Phe_428_1_prscs_METAss_eurld)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.385 [1.24, 1.54] C-index: 0.71868 — age, sex, 20 PCs —
PPM021869 PGS005084
(Phe_428_1_prscs_METAss_eurld)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.45 [1.37, 1.53] C-index: 0.75272 — age, sex, 20 PCs —
PPM021866 PGS005085
(Phe_428_1_prscsx_METAweight)
 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.303 [1.14, 1.49] C-index: 0.79251 — age, sex, 20 PCs —
PPM021873 PGS005085
(Phe_428_1_prscsx_METAweight)
 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.437 [1.36, 1.51] C-index: 0.7528 — age, sex, 20 PCs —
PPM021880 PGS005085
(Phe_428_1_prscsx_METAweight)
 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.333 [1.21, 1.47] C-index: 0.71878 — age, sex, 20 PCs —
PPM022207 PGS005097
(prscsx_meta_HF)
 PSS011843|
Multi-ancestry (including European)|
40,989 individuals
 PGP000691 |
Lee DSM et al. Nat Genet (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.72 [0.72, 0.73] Brier skill score: 0.065 [0.063, 0.068] Age, sex, 5 genetic principal components —
PPM022992 PGS005285
(BBJ_HF_PRS_HG19)
 PSS012088|
East Asian Ancestry|
13,157 individuals
 PGP000757 |
Enzan N et al. Nat Commun (2025)
 Reported Trait: incident all-cause heart failure cases — — R²: 0.0737 — —
PPM023007 PGS005299
(Jorda_HF_MTAG-PGS-inf_2024)
 PSS012090|
European Ancestry|
12,677 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.616 R²: 0.03455 age, sex, four first principal components of genetic ancestry —
PPM023008 PGS005300
(Jorda_HF_MTAG-PGS_2024)
 PSS012090|
European Ancestry|
12,677 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.612 R²: 0.03182 age, sex, four first principal components of genetic ancestry —
PPM023009 PGS005301
(Jorda_HF_MTAG-PGS_females_2024)
 PSS012091|
European Ancestry|
5,152 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.62709 R²: 0.03046 age, sex, four first principal components of genetic ancestry —
PPM023010 PGS005302
(Jorda_HF_MTAG-PGS_males_2024)
 PSS012092|
European Ancestry|
7,525 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.57482 R²: 0.01618 age, sex, four first principal components of genetic ancestry —
PPM023011 PGS005303
(Jorda_HF_SingleTrait-PGS-inf_2024)
 PSS012090|
European Ancestry|
12,677 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.613 R²: 0.03272 age, sex, four first principal components of genetic ancestry —
PPM023012 PGS005304
(Jorda_HF_SingleTrait-PGS_2024)
 PSS012090|
European Ancestry|
12,677 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.611 R²: 0.03107 age, sex, four first principal components of genetic ancestry —
PPM023013 PGS005305
(Jorda_HF_SingleTrait-PGS_females_2024)
 PSS012091|
European Ancestry|
5,152 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.628 R²: 0.03192 age, sex, four first principal components of genetic ancestry —
PPM023014 PGS005306
(Jorda_HF_SingleTrait-PGS_males_2024)
 PSS012092|
European Ancestry|
7,525 individuals
 PGP000759 |
Jordà P et al. NPJ Genom Med (2025)
 Reported Trait: Prevalent heart failure — AUROC: 0.57178 R²: 0.01529 age, sex, four first principal components of genetic ancestry —
PPM023066 PGS005319
(HF_PRS)
 PSS012106|
European Ancestry|
32,360 individuals
 PGP000766 |
Türkmen D et al. Pharmacogenomics J (2024)
 Reported Trait: Incident heart failure HR: 1.14 [1.09, 1.19] — — sex, age at first prescription and genetic principal components 1 to 10 —
PPM030650 PGS012544
(EN_model_HF)
 PSS012218|
European Ancestry|
122,892 individuals
 PGP000790 |
Hu J et al. Genet Med (2026)
 Reported Trait: Heart failure OR: 1.55 [1.49, 1.62] AUROC: 0.62 [0.61, 0.63] — — —
PPM030661 PGS012552
(PRS_HF)
 PSS012228|
European Ancestry|
21,092 individuals
 PGP000794 |
Ye Y et al. Front Bioinform (2024)
 Reported Trait: HF — AUROC: 0.524 [0.495, 0.554] AUROC of meta-PRS (PRS_CAD + PRS_IS + PRS_HF) for HF: 0.558 [0.528, 0.588] PRS_CAD (PGS Catalog ID: PGS005236) + PRS_IS (this paper) + PRS_HF (this paper) combined to derive meta-PRS The meta-PRS was constructed by combining PRS_CAD, PRS_IS, and PRS_HF at the PRS level using weights described in the study. Implementation details are available at: https://github.com/JqiHu/meta-PRS-CVD
PPM036539 PGS018409
(MultiPRS_heart-failure)
 PSS012295|
European Ancestry|
2,553 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Prevalent Heart failure OR: 3.1 AUROC: 0.6913 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (diagnostic). OR per 1 SD of PRS (logOR=1.1328); DeLong p=0.183869673873534. Sex='Both' (male/female strata also in Suppl. Data 27).
PPM036540 PGS018409
(MultiPRS_heart-failure)
 PSS012296|
European Ancestry|
8,142 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Incident Heart failure (1-10 yr) HR: 0.96 [0.94, 0.97]
OR: 3.16		 AUROC: 0.6932 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (prognostic, 1-10 yr). OR per 1 SD (logOR=1.1508); HR per SD of PRS from Cox model (col D); DeLong p=0.6353568793886567. Sex='Both'.
PPM036541 PGS018409
(MultiPRS_heart-failure)
 PSS012297|
European Ancestry|
14,172 individuals
 PGP000826 |
Ometto S et al. Nat Commun (2026)
 Reported Trait: Heart failure OR: 3.01 AUROC: 0.6836 — age, sex, body surface area, PC1-PC20 Multi-PRS + baseline (whole cohort). OR per 1 SD (logOR=1.102); DeLong p=0.7920128596259659. Sex='Both'.
PPM037352 PGS019170
(TPMI_411.8_Lassosum2)
 PSS013068|
East Asian Ancestry|
18,717 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other chronic ischemic heart disease unspecified — AUROC: 0.64399 R²: 0.05893 sex, age, array, PCs 1-10 —
PPM037353 PGS019171
(TPMI_411.8_LDpred2)
 PSS013067|
East Asian Ancestry|
18,717 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other chronic ischemic heart disease unspecified — AUROC: 0.6462 R²: 0.06032 sex, age, array, PCs 1-10 —
PPM037354 PGS019172
(TPMI_411.8_MegaPRS)
 PSS013069|
East Asian Ancestry|
18,717 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other chronic ischemic heart disease unspecified — AUROC: 0.64462 R²: 0.05974 sex, age, array, PCs 1-10 —
PPM037355 PGS019173
(TPMI_411.8_PRS-CS)
 PSS013070|
East Asian Ancestry|
18,717 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other chronic ischemic heart disease unspecified — AUROC: 0.64634 R²: 0.06059 sex, age, array, PCs 1-10 —
PPM037356 PGS019174
(TPMI_411.8_SBayesR)
 PSS013071|
East Asian Ancestry|
18,717 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other chronic ischemic heart disease unspecified — AUROC: 0.64553 R²: 0.05976 sex, age, array, PCs 1-10 —
PPM037357 PGS019175
(TPMI_414_Lassosum2)
 PSS013083|
East Asian Ancestry|
17,594 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other forms of chronic heart disease — AUROC: 0.66792 R²: 0.06004 sex, age, array, PCs 1-10 —
PPM037358 PGS019176
(TPMI_414_LDpred2)
 PSS013082|
East Asian Ancestry|
17,594 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other forms of chronic heart disease — AUROC: 0.66784 R²: 0.05974 sex, age, array, PCs 1-10 —
PPM037359 PGS019177
(TPMI_414_MegaPRS)
 PSS013084|
East Asian Ancestry|
17,594 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other forms of chronic heart disease — AUROC: 0.66895 R²: 0.06063 sex, age, array, PCs 1-10 —
PPM037360 PGS019178
(TPMI_414_PRS-CS)
 PSS013085|
East Asian Ancestry|
17,594 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other forms of chronic heart disease — AUROC: 0.66862 R²: 0.06079 sex, age, array, PCs 1-10 —
PPM037361 PGS019179
(TPMI_414_SBayesR)
 PSS013086|
East Asian Ancestry|
17,594 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other forms of chronic heart disease — AUROC: 0.66786 R²: 0.05991 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007759 — — 2,457 individuals — African American or Afro-Caribbean Carribean UKB —
PSS012228 — —
[
  • 1,989 cases
  • , 19,103 controls
]
 — European
(British)		 — UKB —
PSS000820 — — 87,413 individuals — European — UKB —
PSS000821 ICD-10 I50, I11.0, I13.0 —
[
  • 13,965 cases
  • , 121,335 controls
]
 — European
(Finnish)		 — FinnGen —
PSS007761 — — 2,472 individuals — African American or Afro-Caribbean Carribean UKB —
PSS013068 414,I25 —
[
  • 2,087 cases
  • , 16,630 controls
]
,
45.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013067 414,I25 —
[
  • 2,087 cases
  • , 16,630 controls
]
,
45.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013069 414,I25 —
[
  • 2,087 cases
  • , 16,630 controls
]
,
45.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013070 414,I25 —
[
  • 2,087 cases
  • , 16,630 controls
]
,
45.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013071 414,I25 —
[
  • 2,087 cases
  • , 16,630 controls
]
,
45.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008414 — — 1,190 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008416 — — 1,197 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009312 — — 19,808 individuals — European UK (+ Ireland) UKB —
PSS009314 — — 19,961 individuals — European UK (+ Ireland) UKB —
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 12,780 individuals,
0.0 % Male samples
 — European — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS011390 CVD ICD-10: I20-I25, I60-I64, G45 — 568 individuals,
0.0 % Male samples
 — Not reported — UKB Mean age of full combined ancestry cohort = 58.8 years (sd = 7.1)
PSS013083 429,B33.2, I23.4, I23.5, I51.1, I51.2, I51.5, I51.8, I51.9, I52 —
[
  • 964 cases
  • , 16,630 controls
]
,
44.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013082 429,B33.2, I23.4, I23.5, I51.1, I51.2, I51.5, I51.8, I51.9, I52 —
[
  • 964 cases
  • , 16,630 controls
]
,
44.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013084 429,B33.2, I23.4, I23.5, I51.1, I51.2, I51.5, I51.8, I51.9, I52 —
[
  • 964 cases
  • , 16,630 controls
]
,
44.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012088 — —
[
  • 1,837 cases
  • , 11,320 controls
]
,
63.8 % Male samples
 Mean = 66.4 years East Asian
(Japanese)		 — BBJ —
PSS013085 429,B33.2, I23.4, I23.5, I51.1, I51.2, I51.5, I51.8, I51.9, I52 —
[
  • 964 cases
  • , 16,630 controls
]
,
44.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013086 429,B33.2, I23.4, I23.5, I51.1, I51.2, I51.5, I51.8, I51.9, I52 —
[
  • 964 cases
  • , 16,630 controls
]
,
44.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012090 Atrial fibrillation or flutter — 12,677 individuals — European — MHI —
PSS012091 Atrial fibrillation or flutter — 5,152 individuals,
0.0 % Male samples
 — European — MHI —
PSS012092 Atrial fibrillation or flutter — 7,525 individuals — European — MHI —
PSS009086 — — 4,113 individuals — European Poland (NE Europe) UKB —
PSS009088 — — 4,128 individuals — European Poland (NE Europe) UKB —
PSS008194 — — 6,283 individuals — South Asian India (South Asia) UKB —
PSS008196 — — 6,294 individuals — South Asian India (South Asia) UKB —
PSS011843 HF defined as 2 instances of phecode 428 — 29,888 individuals — European — PMB —
PSS011843 HF defined as 2 instances of phecode 428 — 11,101 individuals — African unspecified — PMB —
PSS012295 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 2,553 individuals — European — UKB —
PSS012296 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 8,142 individuals — European — UKB —
PSS012297 Balanced case/control cohort: cases from UK Biobank hospital/EHR & self-report; equal number of super-controls (no cardiac/metabolic disease) matched on age and sex. — 14,172 individuals — European — UKB —
PSS011821 — —
[
  • 1,687 cases
  • , 30,117 controls
]
 — European — AllofUs —
PSS007713 — —
[
  • 6,285 cases
  • , 352,619 controls
]
 — European — UKB —
PSS012106 — — 32,360 individuals,
54.4 % Male samples
 — European — UKB —
PSS008863 — — 3,858 individuals — African unspecified Nigeria (West Africa) UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS008865 — — 3,905 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007976 — — 1,805 individuals — East Asian China (East Asia) UKB —
PSS011190 — —
[
  • 5,845 cases
  • , 69,274 controls
]
,
43.9 % Male samples
 — European — BioVU —
PSS007978 — — 1,808 individuals — East Asian China (East Asia) UKB —
PSS011801 — —
[
  • 741 cases
  • , 9,941 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS011811 — —
[
  • 315 cases
  • , 7,804 controls
]
 — Hispanic or Latin American — AllofUs —
PSS012218 — —
[
  • 2,162 cases
  • , 120,730 controls
]
 — European — UKB —
PSS008640 — — 6,617 individuals — European Italy (South Europe) UKB —
PSS008642 — — 6,648 individuals — European Italy (South Europe) UKB —