Trait: attention deficit hyperactivity disorder

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003888
Description A mental disorder characterized by inattention, easy distraction, careless mistakes and avoidance of tasks that require sustained mental focus. These behaviors can lead to maladaptive consequences in the affected individual's life. [NCIT: C35092]
Trait category
Neurological disorder
Synonyms 25 synonyms
  • ADD
  • ADDH
  • ADHD
  • ATTENTION DEFICIT DIS
  • ATTENTION DEFICIT DIS WITH HYPERACTIVITY
  • ATTENTION DEFICIT HYPERACTIVITY DIS
  • Attention Deficit Disorder
  • Attention Deficit Disorder with Hyperactivity
  • Attention Deficit Disorders
  • Attention Deficit Disorders with Hyperactivity
  • Attention Deficit Hyperactivity Disorders
  • Brain Dysfunction, Minimal
  • Deficit Disorder, Attention
  • Deficit Disorders, Attention
  • Disorder, Attention Deficit
  • Disorders, Attention Deficit
  • Dysfunction, Minimal Brain
  • Hyperkinetic Syndrome
  • Minimal Brain Dysfunction
  • Syndromes, Hyperkinetic
  • attention deficit disorder
  • attention deficit hyperactivity disorder, inattentive type
  • attention deficit hyperactivity disorder, inattentive/distractible type
  • attention deficit hyperactivity disorder, predominantly inattentive type
  • hyperkinetic disorder
Mapped terms 16 mapped terms
  • DOID:1094
  • ICD9:314.01
  • ICD9:314.8
  • ICD9:314.9
  • MESH:D001289
  • MONDO:0005302
  • MeSH:D001289
  • MedDRA:10003735
  • MedDRA:10003736
  • MedDRA:10083622
  • NCIT:C35092
  • NCIt:C97160
  • OMIM:143465
  • OMIM:613003
  • SCTID:406506008
  • SNOMEDCT:406506008

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002746
(PRS_ADHD)
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Attention-deficit hyperactivity disorder attention deficit hyperactivity disorder 513,659
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002746/ScoringFiles/PGS002746.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014920 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Specific internalizing (at baseline) β: -0.06 (0.02)
PPM014921 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Specific conduct problem (1-year follow-up) β: 0.09 (0.02)
PPM014922 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Specific ADHD (1-year follow-up) β: 0.11 (0.03)
PPM014924 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: UPPS Impulsive Behavior Scale (Positive urgency) β: 0.046 (0.016) Age, sex, and the first 10 principal components of population structure
PPM014925 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: Latent executive functioning β: -0.042 Age, sex, and the first 10 principal components of population structure
PPM014919 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: General factor of psychological problems (1-year follow-up) β: 0.07 (0.02)
PPM014923 PGS002746
(PRS_ADHD)
PSS009931|
European Ancestry|
4,483 individuals
PGP000358 |
Lahey BB et al. J Psychiatr Res (2022)
Reported Trait: UPPS Impulsive Behavior Scale (Low perseverance) β: 0.043 (0.017) Age, sex, and the first 10 principal components of population structure

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009931 4,483 individuals,
53.2 % Male samples
Mean = 118.94 months
Sd = 7.48 months
European NR ABCD