Trait: triglyceride measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004530
Description
  • A triglyceride measurement is a quantification of triglycerides in some body fluid, used as a biomarker for cardiovascular disease.
Trait category
Lipid or lipoprotein measurement
Synonyms triglyceride levels
Mapped term(s) NCIt:C64812

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000063
(GRS_TG)
PGP000045 |
Johnson L et al. PLoS One (2015)
triglycerides triglyceride measurement 32
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000063/ScoringFiles/PGS000063.txt.gz
PGS000066
(GLGC2017_TG)
PGP000046 |
Kuchenbaecker K et al. Nat Commun (2019)
Triglycerides (TG) triglyceride measurement 101
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000066/ScoringFiles/PGS000066.txt.gz
PGS000312
(GRS190_TG)
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Triglycerides triglyceride measurement 190
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000312/ScoringFiles/PGS000312.txt.gz
PGS000659
(PRS-TG)
PGP000121 |
Tam CHT et al. Genome Med (2021)
Triglycerides triglyceride measurement 142
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000659/ScoringFiles/PGS000659.txt.gz
PGS000699
(snpnet.Triglycerides)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Triglycerides [mmol/L] triglyceride measurement 16,003
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000699/ScoringFiles/PGS000699.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000163 PGS000063
(GRS_TG)
PSS000098|
European Ancestry|
2,063 individuals
PGP000045 |
Johnson L et al. PLoS One (2015)
Reported Trait: Serum triglyceride (TG) levels β: 0.464 Beta (p-value): 1.71e-11 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC Association (p-value; unadjusted for covariates) < 0.001
PPM000164 PGS000063
(GRS_TG)
PSS000097|
East Asian Ancestry|
666 individuals
PGP000045 |
Johnson L et al. PLoS One (2015)
Reported Trait: Serum triglyceride (TG) levels β: 0.337 Beta (p-value): 0.0107 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC Association (p-value; unadjusted for covariates) < 0.001
PPM000166 PGS000063
(GRS_TG)
PSS000099|
Hispanic or Latin American Ancestry|
1,256 individuals
PGP000045 |
Johnson L et al. PLoS One (2015)
Reported Trait: Serum triglyceride (TG) levels β: 0.5 Beta (p-value): 1.09e-10 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC Association (p-value; unadjusted for covariates) < 0.001
PPM000169 PGS000066
(GLGC2017_TG)
PSS000104|
European Ancestry|
9,962 individuals
PGP000046 |
Kuchenbaecker K et al. Nat Commun (2019)
Reported Trait: Serum triglyceride (TG) levels correlation (r): 0.204 [0.183, 0.223] age, sex Relatedness and population structure were accounted for using a linear mixed model with random polygenic effect implemented in GEMMA
PPM000172 PGS000066
(GLGC2017_TG)
PSS000102|
European Ancestry|
1,641 individuals
PGP000046 |
Kuchenbaecker K et al. Nat Commun (2019)
Reported Trait: Serum triglyceride (TG) levels correlation (r): 0.235 [0.176, 0.294] age, sex Relatedness and population structure were accounted for using a linear mixed model with random polygenic effect implemented in GEMMA
PPM000175 PGS000066
(GLGC2017_TG)
PSS000103|
European Ancestry|
1,945 individuals
PGP000046 |
Kuchenbaecker K et al. Nat Commun (2019)
Reported Trait: Serum triglyceride (TG) levels correlation (r): 0.234 [0.175, 0.293] age, sex Relatedness and population structure were accounted for using a linear mixed model with random polygenic effect implemented in GEMMA
PPM000178 PGS000066
(GLGC2017_TG)
PSS000100|
African Ancestry|
6,407 individuals
PGP000046 |
Kuchenbaecker K et al. Nat Commun (2019)
Reported Trait: Serum triglyceride (TG) levels correlation (r): 0.063 [0.038, 0.089] age, sex Relatedness and population structure were accounted for using a linear mixed model with random polygenic effect implemented in GEMMA
PPM000181 PGS000066
(GLGC2017_TG)
PSS000101|
East Asian Ancestry|
21,295 individuals
PGP000046 |
Kuchenbaecker K et al. Nat Commun (2019)
Reported Trait: Serum triglyceride (TG) levels correlation (r): 0.139 [0.1, 0.178] age, sex, region, 20 PCs of genetic ancestry Relatedness and population structure were accounted for using a linear mixed model with random polygenic effect implemented in GEMMA
PPM000165 PGS000063
(GRS_TG)
PSS000096|
African Ancestry|
1,355 individuals
PGP000045 |
Johnson L et al. PLoS One (2015)
Reported Trait: Serum triglyceride (TG) levels β: 0.047 Beta (p-value): 0.526 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC
PPM000782 PGS000312
(GRS190_TG)
PSS000376|
European Ancestry|
1,354 individuals
PGP000092 |
Xie T et al. Circ Genom Precis Med (2020)
Reported Trait: Triglycerides (mmol/l) : 0.0656 Sex, age, age^2
PPM001356 PGS000659
(PRS-TG)
PSS000591|
East Asian Ancestry|
865 individuals
PGP000121 |
Tam CHT et al. Genome Med (2021)
Reported Trait: Triglycerides at baseline (log transformed) β: 0.14 (0.019) Pearson Correlation Coefficient (r): 0.231
Incremental R² (PRS and covariates vs. covariates-alone): 0.0558
age, sex, BMI, PCs
PPM001353 PGS000659
(PRS-TG)
PSS000587|
East Asian Ancestry|
426 individuals
PGP000121 |
Tam CHT et al. Genome Med (2021)
Reported Trait: Triglycerides at baseline (log transformed) β: 0.133 (0.023) Pearson Correlation Coefficient (r): 0.251
Incremental R² (PRS and covariates vs. covariates-alone): 0.0514
age, sex, BMI, PCs
PPM001354 PGS000659
(PRS-TG)
PSS000593|
East Asian Ancestry|
4,917 individuals
PGP000121 |
Tam CHT et al. Genome Med (2021)
Reported Trait: Triglycerides at baseline (log transformed) β: 0.165 (0.008) Pearson Correlation Coefficient (r): 0.2
Incremental R² (PRS and covariates vs. covariates-alone): 0.0731
age, sex, BMI, PCs
PPM001355 PGS000659
(PRS-TG)
PSS000589|
East Asian Ancestry|
1,941 individuals
PGP000121 |
Tam CHT et al. Genome Med (2021)
Reported Trait: Triglycerides at baseline (log transformed) β: 0.133 (0.013) Pearson Correlation Coefficient (r): 0.209
Incremental R² (PRS and covariates vs. covariates-alone): 0.05
age, sex, BMI, PCs
PPM001427 PGS000699
(snpnet.Triglycerides)
PSS000772|
African Ancestry|
6,014 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] : 0.10632
Spearman's ρ: 0.169
Age, sex, PCs(1-40)
PPM001462 PGS000699
(snpnet.Triglycerides)
PSS000773|
East Asian Ancestry|
1,081 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] : 0.1757
Spearman's ρ: 0.256
Age, sex, PCs(1-40)
PPM001497 PGS000699
(snpnet.Triglycerides)
PSS000774|
European Ancestry|
23,559 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] : 0.23168
Spearman's ρ: 0.339
Age, sex, PCs(1-40)
PPM001532 PGS000699
(snpnet.Triglycerides)
PSS000775|
South Asian Ancestry|
7,330 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] : 0.16187
Spearman's ρ: 0.317
Age, sex, PCs(1-40)
PPM001567 PGS000699
(snpnet.Triglycerides)
PSS000776|
European Ancestry|
63,731 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] : 0.22344
Spearman's ρ: 0.352
Age, sex, PCs(1-40)
PPM001582 PGS000699
(snpnet.Triglycerides)
PSS000833|
European Ancestry|
2,004 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] Spearman's ρ: 0.29 Age, sex
PPM001581 PGS000699
(snpnet.Triglycerides)
PSS000832|
European Ancestry|
2,129 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Triglycerides [mmol/L] Spearman's ρ: 0.258 Age, sex

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000832 2,129 individuals European Participants self-identifying as white MESA
PSS000833 2,004 individuals European Participants self-identifying as white MESA
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years
European TRAILS
PSS000587 Measured using fasting blood samples 426 individuals,
46.0 % Male samples
Mean = 43.3 years
Sd = 11.4 years
East Asian
(Chinese)
Adults
PSS000589 Measured using fasting blood samples 1,941 individuals,
57.7 % Male samples
Mean = 58.2 years
Sd = 12.34 years
East Asian
(Chinese)
HKDB
PSS000591 Measured using fasting blood samples 865 individuals,
57.6 % Male samples
Mean = 57.0 years
Sd = 12.08 years
East Asian
(Chinese)
HKDB
PSS000593 Measured using fasting blood samples 4,917 individuals,
44.9 % Male samples
Mean = 56.3 years
Sd = 13.5 years
East Asian
(Chinese)
HKDR
PSS000096 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 1,355 individuals,
46.2 % Male samples
Mean = 61.68 years African American or Afro-Caribbean MESA MESA Classic Cohort
PSS000097 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 666 individuals,
50.15 % Male samples
Mean = 61.5 years East Asian MESA MESA Classic Cohort
PSS000098 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 2,063 individuals,
46.78 % Male samples
Mean = 62.09 years European MESA MESA Classic Cohort
PSS000099 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 1,256 individuals,
48.89 % Male samples
Mean = 60.65 years Hispanic or Latin American MESA MESA Classic Cohort
PSS000772 6,014 individuals African unspecified UKB
PSS000773 1,081 individuals East Asian UKB
PSS000774 23,559 individuals European Non-British White UKB
PSS000775 7,330 individuals South Asian UKB
PSS000776 63,731 individuals European
(British)
UKB
PSS000100 Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triglycerides (TG) 6,407 individuals,
44.0 % Male samples
Mean = 34.0 years Sub-Saharan African APCDR APCDR-Uganda study
PSS000101 Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triglycerides (TG) 21,295 individuals,
38.0 % Male samples
Mean = 60.0 years East Asian
(Chinese)
CKB - 20810 samples had HDL measurements - 17662 samples had LDL measurements - 20222 samples had triglyceride measurements
PSS000102 Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triglycerides (TG) 1,641 individuals,
58.0 % Male samples
Mean = 62.0 years European
(Greek)
Population isolate from the Pomak villages in the North of Greece HELIC - 1186 samples had HDL measurements - 1186 samples had LDL measurements - 1176 samples had triglyceride measurements
PSS000103 Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triglycerides (TG) 1,945 individuals,
66.0 % Male samples
Mean = 45.0 years European
(Greek)
Population isolate from the Mylopotamos villages in Crete HELIC - 1078 samples had HDL measurements - 1075 samples had LDL measurements - 1066 samples had triglyceride measurements
PSS000104 Serum levels of high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triglycerides (TG) 9,962 individuals,
56.0 % Male samples
Mean = 52.0 years European UKHLS - 9706 samples had HDL measurements - 9767 samples had LDL measurements - 9635 samples had triglyceride measurements