Trait: sex hormone-binding globulin measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004696
Description
  • Is a quantification of sex hormone binding globulin. In men the test is used in when investigating testosterone deficiency. The SHBG glycoprotein binds to circulating estradiol and testosterone, low levels of SHBG may be implicated in breast cancer etiology.
Trait category
Other measurement
Synonyms 2 synonyms
  • SHBG level
  • SHBG levels

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000694
(snpnet.SHBG)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
SHBG [nmol/L] sex hormone-binding globulin measurement 19,328
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000694/ScoringFiles/PGS000694.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001422 PGS000694
(snpnet.SHBG)
PSS000744|
African Ancestry|
5,523 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.22708
Spearman's ρ: 0.235
Age, sex, PCs(1-40)
PPM001457 PGS000694
(snpnet.SHBG)
PSS000745|
East Asian Ancestry|
979 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.31846
Spearman's ρ: 0.311
Age, sex, PCs(1-40)
PPM001492 PGS000694
(snpnet.SHBG)
PSS000746|
European Ancestry|
21,313 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.35511
Spearman's ρ: 0.384
Age, sex, PCs(1-40)
PPM001527 PGS000694
(snpnet.SHBG)
PSS000747|
South Asian Ancestry|
6,638 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.28079
Spearman's ρ: 0.326
Age, sex, PCs(1-40)
PPM001562 PGS000694
(snpnet.SHBG)
PSS000748|
European Ancestry|
57,677 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] : 0.34576
Spearman's ρ: 0.414
Age, sex, PCs(1-40)
PPM001571 PGS000694
(snpnet.SHBG)
PSS000830|
European Ancestry|
2,129 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: SHBG [nmol/L] Spearman's ρ: 0.19 Age, sex

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000744 5,523 individuals African unspecified UKB
PSS000745 979 individuals East Asian UKB
PSS000746 21,313 individuals European Non-British White UKB
PSS000747 6,638 individuals South Asian UKB
PSS000748 57,677 individuals European
(British)
UKB
PSS000830 2,129 individuals European Participants self-identifying as white MESA