Trait: FEV/FEC ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004713
Trait category
Other measurement
Synonyms 2 synonyms
  • FEV/FVC
  • FEV1/FVC

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000210
(LF279)
PGP000086 |
Shrine N et al. Nat Genet (2019)
Lung function (FEV1/FVC) FEV/FEC ratio 279
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000210/ScoringFiles/PGS000210.txt.gz
PGS001180
(GBE_INI1003063)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Lung function (FEV1/FVC) FEV/FEC ratio 15,141
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001180/ScoringFiles/PGS001180.txt.gz
PGS001801
(PRS_Ratio)
PGP000264 |
Moll M et al. Lancet Respir Med (2020)
FEV1/FVC ratio FEV/FEC ratio 1,232,916
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001801/ScoringFiles/PGS001801.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000638 PGS000210
(LF279)
PSS000345|
East Asian Ancestry|
75,580 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.219 [1.182, 1.256] age, age^2, sex, height, smoking Models were stratified by geographical region and meta-analyzed. 12 Proxy SNPs were used
PPM000636 PGS000210
(LF279)
PSS000348|
European Ancestry|
303,570 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.436 [1.411, 1.461] age, age^2, sex, height, smoking, 10 genetic PCs *Potential inflation (some weights are derived in a UKB GWAS)
PPM000645 PGS000210
(LF279)
PSS000351|
East Asian Ancestry|
72,796 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.078 [-0.085, -0.071] age, age^2, sex, height, smoking Models were stratified by geographical region and meta-analyzed. 12 Proxy SNPs were used
PPM000647 PGS000210
(LF279)
PSS000346|
European Ancestry|
10,894 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.546 [1.476, 1.62] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000642 PGS000210
(LF279)
PSS000355|
European Ancestry|
303,570 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.224 [-0.227, -0.221] age, age^2, sex, height, smoking, 10 genetic PCs *Potential inflation (some weights are derived in a UKB GWAS)
PPM000643 PGS000210
(LF279)
PSS000353|
Additional Diverse Ancestries|
1,208 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.176 [-0.231, -0.12] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000641 PGS000210
(LF279)
PSS000354|
East Asian Ancestry|
1,607 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.142 [-0.191, -0.093] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000640 PGS000210
(LF279)
PSS000357|
South Asian Ancestry|
6,358 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.181 [-0.205, -0.156] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000639 PGS000210
(LF279)
PSS000352|
African Ancestry|
4,225 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.086 [-0.116, -0.056] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000644 PGS000210
(LF279)
PSS000356|
Additional Diverse Ancestries|
6,033 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.186 [-0.211, -0.162] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000637 PGS000210
(LF279)
PSS000349|
Additional Diverse Ancestries|
6,033 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.506 [1.325, 1.712] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000635 PGS000210
(LF279)
PSS000350|
South Asian Ancestry|
6,358 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.414 [1.254, 1.594] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000634 PGS000210
(LF279)
PSS000347|
African Ancestry|
4,225 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.348 [1.152, 1.577] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000646 PGS000210
(LF279)
PSS000344|
African Ancestry|
2,466 individuals
PGP000086 |
Shrine N et al. Nat Genet (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.255 [1.147, 1.374] age, age^2, sex, height, smoking, 10 genetic PCs
PPM008589 PGS001180
(GBE_INI1003063)
PSS004771|
African Ancestry|
5,852 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FEV FVC ratio : 0.01124 [0.00614, 0.01633]
Incremental R2 (full-covars): -0.00411
PGS R2 (no covariates): 0.00217 [-0.00009, 0.00443]
age, sex, UKB array type, Genotype PCs
PPM008590 PGS001180
(GBE_INI1003063)
PSS004772|
East Asian Ancestry|
1,587 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FEV FVC ratio : 0.04374 [0.02479, 0.06269]
Incremental R2 (full-covars): 0.02108
PGS R2 (no covariates): 0.02152 [0.00792, 0.03513]
age, sex, UKB array type, Genotype PCs
PPM008591 PGS001180
(GBE_INI1003063)
PSS004773|
European Ancestry|
22,763 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FEV FVC ratio : 0.09646 [0.08949, 0.10343]
Incremental R2 (full-covars): 0.04766
PGS R2 (no covariates): 0.05063 [0.04532, 0.05593]
age, sex, UKB array type, Genotype PCs
PPM008592 PGS001180
(GBE_INI1003063)
PSS004774|
South Asian Ancestry|
7,136 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FEV FVC ratio : 0.04322 [0.03442, 0.05203]
Incremental R2 (full-covars): 0.01609
PGS R2 (no covariates): 0.01838 [0.01249, 0.02427]
age, sex, UKB array type, Genotype PCs
PPM008593 PGS001180
(GBE_INI1003063)
PSS004775|
European Ancestry|
61,887 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: FEV FVC ratio : 0.11465 [0.11013, 0.11918]
Incremental R2 (full-covars): 0.05769
PGS R2 (no covariates): 0.06034 [0.05685, 0.06382]
age, sex, UKB array type, Genotype PCs
PPM009320 PGS001801
(PRS_Ratio)
PSS007722|
European Ancestry|
19,229 individuals
PGP000264 |
Moll M et al. Lancet Respir Med (2020)
Reported Trait: Chronic obstructive pulmonary disease (moderate-to-severe) Odds Ratio of Combined PRS (OR): 1.81 [1.74, 1.88) Age, sex, height, smoking pack-years, PCs of genetic ancestry, study clinic, PRS_FEV1 NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-score
PPM009321 PGS001801
(PRS_Ratio)
PSS007723|
Multi-ancestry (excluding European)|
7,122 individuals
PGP000264 |
Moll M et al. Lancet Respir Med (2020)
Reported Trait: Chronic obstructive pulmonary disease (moderate-to-severe) Odds Ratio of Combined PRS (OR): 1.42 [1.34, 1.51) Age, sex, height, smoking pack-years, PCs of genetic ancestry, study clinic, PRS_FEV1 NOTE: A combined PRS is used to account for both PRS. The combined score can be derived using code from: http://www.copdconsortium.org/polygenic-risk-score
PPM009317 PGS001801
(PRS_Ratio)
PSS007721|
European Ancestry|
5,175 individuals
PGP000264 |
Moll M et al. Lancet Respir Med (2020)
Reported Trait: GOLD spirometry grades Association (p-value): 2.02e-69

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000352 4,225 individuals African unspecified UKB
PSS000353 1,208 individuals Other admixed ancestry
(Admixed African (unspecified) and European)
UKB
PSS000354 1,607 individuals East Asian UKB
PSS000355 303,570 individuals European UKB
PSS000356 6,033 individuals Other admixed ancestry UKB
PSS000357 6,358 individuals South Asian UKB
PSS007721 5,175 individuals,
52.27 % Male samples
European COPDGene
PSS007722
[
  • 3,065 cases
  • , 2,110 controls
]
,
52.27 % Male samples
European COPDGene Fixed-effects meta-analysis
PSS007722
[
  • 609 cases
  • , 1,480 controls
]
,
36.19 % Male samples
European CHS Fixed-effects meta-analysis
PSS007722
[
  • 1,713 cases
  • , 147 controls
]
,
66.34 % Male samples
European ECLIPSE Fixed-effects meta-analysis
PSS007722
[
  • 1,809 cases
  • , 946 controls
]
,
63.74 % Male samples
European LHS Fixed-effects meta-analysis
PSS007722
[
  • 208 cases
  • , 948 controls
]
,
47.66 % Male samples
European MESA Fixed-effects meta-analysis
PSS007722
[
  • 371 cases
  • , 429 controls
]
,
83.12 % Male samples
European NAS, NETT Fixed-effects meta-analysis
PSS007722
[
  • 127 cases
  • , 911 controls
]
,
42.87 % Male samples
European RS Fixed-effects meta-analysis
PSS007722
[
  • 96 cases
  • , 867 controls
]
,
46.73 % Male samples
European RS Fixed-effects meta-analysis
PSS007722
[
  • 131 cases
  • , 1,737 controls
]
,
43.36 % Male samples
European RS Fixed-effects meta-analysis
PSS007722
[
  • 988 cases
  • , 537 controls
]
,
52.85 % Male samples
European SPIROMICS Fixed-effects meta-analysis
PSS007723
[
  • 910 cases
  • , 1,556 controls
]
,
57.62 % Male samples
African American or Afro-Caribbean COPDGene Fixed-effects meta-analysis
PSS007723
[
  • 116 cases
  • , 258 controls
]
,
34.49 % Male samples
African American or Afro-Caribbean CHS Fixed-effects meta-analysis
PSS007723
[
  • 794 cases
  • , 1,600 controls
]
,
74.56 % Male samples
Not reported NR Fixed-effects meta-analysis
PSS007723
[
  • 115 cases
  • , 645 controls
]
,
46.58 % Male samples
African American or Afro-Caribbean MESA Fixed-effects meta-analysis
PSS007723
[
  • 31 cases
  • , 422 controls
]
,
49.89 % Male samples
East Asian MESA Fixed-effects meta-analysis
PSS007723
[
  • 62 cases
  • , 613 controls
]
,
47.26 % Male samples
Hispanic or Latin American MESA Fixed-effects meta-analysis
PSS004771 5,852 individuals African unspecified UKB
PSS004772 1,587 individuals East Asian UKB
PSS004773 22,763 individuals European non-white British ancestry UKB
PSS004774 7,136 individuals South Asian UKB
PSS004775 61,887 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS000344
[
  • 910 cases
  • , 1,556 controls
]
African American or Afro-Caribbean COPDGene
PSS000345 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 69,567 cases
  • , 6,013 controls
]
East Asian
(Chinese)
CKB
PSS000346
[
  • 6,979 cases
  • , 3,915 controls
]
European 6 cohorts
  • COPDGene
  • ,ECLIPSE
  • ,GenKOLS
  • ,NAS
  • ,NETT
  • ,SPIROMICS
PSS000347 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 172 cases
  • , 4,053 controls
]
African unspecified UKB
PSS000348 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 288,467 cases
  • , 15,103 controls
]
European UKB
PSS000349 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 5,752 cases
  • , 281 controls
]
Other admixed ancestry UKB
PSS000350 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 6,046 cases
  • , 312 controls
]
South Asian UKB
PSS000351 72,796 individuals East Asian
(Chinese)
CKB