Trait: uric acid measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004761
Description
  • Is a quantification of uric acid, typically in blood. Uric acid is associated with gout, insulin resistance and cardivascular disease.
Trait category
Cardiovascular measurement
Synonyms 2 synonyms
  • uric acid level
  • uric acid levels
Mapped term(s) SNOMEDCT:86228006

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
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South Asian
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000755
(PRS_SUA)
PGP000161 |
Cho SK et al. Sci Rep (2020)
Serum uric acid levels uric acid measurement 14
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000755/ScoringFiles/PGS000755.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001923 PGS000755
(PRS_SUA)
PSS000964|
East Asian Ancestry|
1,167 individuals
PGP000161 |
Cho SK et al. Sci Rep (2020)
Reported Trait: Serum uric acid levels β: 0.237 (0.033) Sex, age, BMI, eGFR, diabetes, hypertension, hyperlipidaemia, systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides Only 11 of the 14 SNPs were utilised within the polygenic score
PPM001924 PGS000755
(PRS_SUA)
PSS000965|
East Asian Ancestry|
2,027 individuals
PGP000161 |
Cho SK et al. Sci Rep (2020)
Reported Trait: Serum uric acid levels β: 0.211 (0.022) Sex, age, BMI, eGFR, diabetes, hypertension, hyperlipidaemia, systolic blood pressure, total cholesterol, HDL cholesterol, triglycerides Only 13 of the 14 SNPs were utilised within the polygenic score

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000964 1,167 individuals,
40.19 % Male samples
Mean = 64.61 years
Sd = 8.26 years
East Asian
(Korean)
KoGES
PSS000965 2,027 individuals,
56.14 % Male samples
Mean = 39.35 years
Sd = 8.87 years
East Asian
(Korean)