Trait: monocyte count

Experimental Factor Ontology (EFO) Information
Identifier EFO_0005091
Description
  • quantification of monocytes in the blood
Trait category
Hematological measurement
Mapped term(s) 2 mapped terms
  • NCIt:C64823
  • SNOMEDCT:67776007
Child trait(s) monocyte percentage of leukocytes

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "monocyte count" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000102
(mono)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Monocyte count monocyte count 674
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000102/ScoringFiles/PGS000102.txt.gz
PGS000103
(mono_p)
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Monocyte percentage of white cells monocyte percentage of leukocytes 583
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000103/ScoringFiles/PGS000103.txt.gz
PGS000177
(mono)
PGP000078 |
Vuckovic D et al. Cell (2020)
Monocyte count monocyte count 638
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000177/ScoringFiles/PGS000177.txt.gz
PGS000178
(mono_p)
PGP000078 |
Vuckovic D et al. Cell (2020)
Monocyte percentage of white cells monocyte percentage of leukocytes 549
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000178/ScoringFiles/PGS000178.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000236 PGS000102
(mono)
PSS000167|
European Ancestry|
80,799 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Monocyte count Pearson correlation coefficent (r): 0.4644 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000237 PGS000102
(mono)
PSS000141|
European Ancestry|
39,177 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Monocyte count Pearson correlation coefficent (r): 0.4319 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000238 PGS000103
(mono_p)
PSS000168|
European Ancestry|
80,627 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Monocyte percentage of white cells Pearson correlation coefficent (r): 0.4395 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS)
PPM000239 PGS000103
(mono_p)
PSS000142|
European Ancestry|
39,189 individuals
PGP000051 |
Xu Y et al. bioRxiv (2020)
|Pre
Reported Trait: Monocyte percentage of white cells Pearson correlation coefficent (r): 0.4207 age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment)
PPM000554 PGS000177
(mono)
PSS000290|
European Ancestry|
2,314 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Monocyte count : 0.09474 sex, age, 10 genetic PCs
PPM000533 PGS000177
(mono)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Monocyte count : 0.15859 sex, age, 10 genetic PCs
PPM000534 PGS000178
(mono_p)
PSS000291|
European Ancestry|
39,260 individuals
PGP000078 |
Vuckovic D et al. Cell (2020)
Reported Trait: Monocyte percentage of white cells : 0.14461 sex, age, 10 genetic PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000167 80,799 individuals,
46.0 % Male samples
Mean = 57.23 years
Range = [39.66, 70.7] years
European UKB
PSS000168 80,627 individuals,
46.0 % Male samples
Mean = 57.23 years
Range = [40.19, 71.1] years
European UKB
PSS000290 2,314 individuals European
(French Canadian)
CARTaGENE
PSS000291 39,260 individuals European INTERVAL
PSS000141 39,177 individuals,
50.0 % Male samples
Mean = 43.82 years
Range = [18.0, 76.4] years
European INTERVAL
PSS000142 39,189 individuals,
50.0 % Male samples
Mean = 43.83 years
Range = [18.0, 76.4] years
European INTERVAL