Trait: depressive symptom measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007006
Description quantification of the existence and severity of depressive symptoms, usually via a questionnaire such as the Center for Epidemiological Studies Depression Scale (CES-D)
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000144
(SelfRepDep)
PGP000068 |
Cai N et al. Nat Genet (2020)
Self-reported depression or depression symptoms depressive symptom measurement,
self-reported trait
21,828
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000144/ScoringFiles/PGS000144.txt.gz
PGS000767
(GRS14)
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Depression unipolar depression,
depressive symptom measurement
14
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000767/ScoringFiles/PGS000767.txt.gz
PGS001898
(portability-PLR_depressed_for_1w)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Ever depressed for a whole week depressive symptom measurement 5,777
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001898/ScoringFiles/PGS001898.txt.gz
PGS001899
(portability-PLR_depression_feelings)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Recent feelings of depression depressive symptom measurement 2,434
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001899/ScoringFiles/PGS001899.txt.gz
PGS002111
(portability-ldpred2_depressed_for_1w)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Ever depressed for a whole week depressive symptom measurement 791,873
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002111/ScoringFiles/PGS002111.txt.gz
PGS002112
(portability-ldpred2_depression_feelings)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Recent feelings of depression depressive symptom measurement 748,601
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002112/ScoringFiles/PGS002112.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000436 PGS000144
(SelfRepDep)
PSS000250|
European Ancestry|
36,709 individuals
PGP000068 |
Cai N et al. Nat Genet (2020)
Reported Trait: Major Depressive Disorder status AUROC: 0.51641 : 0.00117 Cohort
PPM001972 PGS000767
(GRS14)
PSS000984|
Multi-ancestry (including European)|
62 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral Nucleus acumbens stress induced reward prediciton error change : 0.065 PCs(1-2)
PPM001973 PGS000767
(GRS14)
PSS000985|
Multi-ancestry (including European)|
63 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral putamen stress induced reward prediciton error change : 0.074 PCs(1-2)
PPM001974 PGS000767
(GRS14)
PSS000986|
Multi-ancestry (including European)|
73 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral nucleus acumbens volume : 0.064 PCs(1-2)
PPM001975 PGS000767
(GRS14)
PSS000986|
Multi-ancestry (including European)|
73 individuals
PGP000174 |
Guffanti G et al. Transl Psychiatry (2019)
Reported Trait: Bilateral putamen volume : 0.095 PCs(1-2)
PPM010067 PGS001898
(portability-PLR_depressed_for_1w)
PSS009394|
European Ancestry|
6,445 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0769 [0.0526, 0.1012] sex, age, birth date, deprivation index, 16 PCs
PPM010068 PGS001898
(portability-PLR_depressed_for_1w)
PSS009168|
European Ancestry|
1,519 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): -0.0019 [-0.0525, 0.0488] sex, age, birth date, deprivation index, 16 PCs
PPM010069 PGS001898
(portability-PLR_depressed_for_1w)
PSS008722|
European Ancestry|
2,506 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0432 [0.0039, 0.0824] sex, age, birth date, deprivation index, 16 PCs
PPM010070 PGS001898
(portability-PLR_depressed_for_1w)
PSS008496|
Greater Middle Eastern Ancestry|
505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0058 [-0.0833, 0.0947] sex, age, birth date, deprivation index, 16 PCs
PPM010072 PGS001898
(portability-PLR_depressed_for_1w)
PSS008051|
East Asian Ancestry|
751 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): -0.028 [-0.1003, 0.0446] sex, age, birth date, deprivation index, 16 PCs
PPM010073 PGS001898
(portability-PLR_depressed_for_1w)
PSS007838|
African Ancestry|
1,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0344 [-0.0173, 0.086] sex, age, birth date, deprivation index, 16 PCs
PPM010074 PGS001898
(portability-PLR_depressed_for_1w)
PSS008942|
African Ancestry|
2,067 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): -0.031 [-0.0742, 0.0123] sex, age, birth date, deprivation index, 16 PCs
PPM010071 PGS001898
(portability-PLR_depressed_for_1w)
PSS008274|
South Asian Ancestry|
3,525 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.026 [-0.0071, 0.0591] sex, age, birth date, deprivation index, 16 PCs
PPM010075 PGS001899
(portability-PLR_depression_feelings)
PSS009395|
European Ancestry|
6,438 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0302 [0.0058, 0.0546] sex, age, birth date, deprivation index, 16 PCs
PPM010076 PGS001899
(portability-PLR_depression_feelings)
PSS009169|
European Ancestry|
1,240 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): -0.006 [-0.0621, 0.0502] sex, age, birth date, deprivation index, 16 PCs
PPM010077 PGS001899
(portability-PLR_depression_feelings)
PSS008723|
European Ancestry|
2,249 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0308 [-0.0107, 0.0723] sex, age, birth date, deprivation index, 16 PCs
PPM010078 PGS001899
(portability-PLR_depression_feelings)
PSS008497|
Greater Middle Eastern Ancestry|
201 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0872 [-0.0594, 0.2301] sex, age, birth date, deprivation index, 16 PCs
PPM010079 PGS001899
(portability-PLR_depression_feelings)
PSS008275|
South Asian Ancestry|
813 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0462 [-0.0235, 0.1155] sex, age, birth date, deprivation index, 16 PCs
PPM010080 PGS001899
(portability-PLR_depression_feelings)
PSS008052|
East Asian Ancestry|
424 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0145 [-0.0832, 0.1119] sex, age, birth date, deprivation index, 16 PCs
PPM010081 PGS001899
(portability-PLR_depression_feelings)
PSS007839|
African Ancestry|
371 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): -0.0165 [-0.121, 0.0883] sex, age, birth date, deprivation index, 16 PCs
PPM010082 PGS001899
(portability-PLR_depression_feelings)
PSS008943|
African Ancestry|
510 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0197 [-0.069, 0.1081] sex, age, birth date, deprivation index, 16 PCs
PPM011743 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS009394|
European Ancestry|
6,445 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.1053 [0.0811, 0.1295] sex, age, birth date, deprivation index, 16 PCs
PPM011744 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS009168|
European Ancestry|
1,519 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0816 [0.0311, 0.1317] sex, age, birth date, deprivation index, 16 PCs
PPM011745 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS008722|
European Ancestry|
2,506 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0665 [0.0273, 0.1055] sex, age, birth date, deprivation index, 16 PCs
PPM011746 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS008496|
Greater Middle Eastern Ancestry|
505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): -0.0079 [-0.0968, 0.0812] sex, age, birth date, deprivation index, 16 PCs
PPM011747 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS008274|
South Asian Ancestry|
3,525 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0554 [0.0223, 0.0883] sex, age, birth date, deprivation index, 16 PCs
PPM011748 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS008051|
East Asian Ancestry|
751 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): -0.0086 [-0.0811, 0.064] sex, age, birth date, deprivation index, 16 PCs
PPM011749 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS007838|
African Ancestry|
1,457 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): 0.0277 [-0.0241, 0.0793] sex, age, birth date, deprivation index, 16 PCs
PPM011750 PGS002111
(portability-ldpred2_depressed_for_1w)
PSS008942|
African Ancestry|
2,067 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Ever depressed for a whole week Partial Correlation (partial-r): -0.0201 [-0.0633, 0.0233] sex, age, birth date, deprivation index, 16 PCs
PPM011753 PGS002112
(portability-ldpred2_depression_feelings)
PSS008723|
European Ancestry|
2,249 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0477 [0.0062, 0.089] sex, age, birth date, deprivation index, 16 PCs
PPM011751 PGS002112
(portability-ldpred2_depression_feelings)
PSS009395|
European Ancestry|
6,438 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0692 [0.0448, 0.0935] sex, age, birth date, deprivation index, 16 PCs
PPM011752 PGS002112
(portability-ldpred2_depression_feelings)
PSS009169|
European Ancestry|
1,240 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0846 [0.0286, 0.1401] sex, age, birth date, deprivation index, 16 PCs
PPM011754 PGS002112
(portability-ldpred2_depression_feelings)
PSS008497|
Greater Middle Eastern Ancestry|
201 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.1366 [-0.0094, 0.277] sex, age, birth date, deprivation index, 16 PCs
PPM011755 PGS002112
(portability-ldpred2_depression_feelings)
PSS008275|
South Asian Ancestry|
813 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0591 [-0.0105, 0.1282] sex, age, birth date, deprivation index, 16 PCs
PPM011756 PGS002112
(portability-ldpred2_depression_feelings)
PSS008052|
East Asian Ancestry|
424 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): -0.0078 [-0.1053, 0.0898] sex, age, birth date, deprivation index, 16 PCs
PPM011757 PGS002112
(portability-ldpred2_depression_feelings)
PSS007839|
African Ancestry|
371 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): -0.0278 [-0.1321, 0.0771] sex, age, birth date, deprivation index, 16 PCs
PPM011758 PGS002112
(portability-ldpred2_depression_feelings)
PSS008943|
African Ancestry|
510 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Recent feelings of depression Partial Correlation (partial-r): 0.0623 [-0.0264, 0.1501] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009168 1,519 individuals European Poland (NE Europe) UKB
PSS009169 1,240 individuals European Poland (NE Europe) UKB
PSS008274 3,525 individuals South Asian India (South Asia) UKB
PSS008275 813 individuals South Asian India (South Asia) UKB
PSS008942 2,067 individuals African unspecified Nigeria (West Africa) UKB
PSS008943 510 individuals African unspecified Nigeria (West Africa) UKB
PSS008051 751 individuals East Asian China (East Asia) UKB
PSS008052 424 individuals East Asian China (East Asia) UKB
PSS008722 2,506 individuals European Italy (South Europe) UKB
PSS008723 2,249 individuals European Italy (South Europe) UKB
PSS007838 1,457 individuals African American or Afro-Caribbean Carribean UKB
PSS007839 371 individuals African American or Afro-Caribbean Carribean UKB
PSS000984 62 individuals,
0.0 % Male samples
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR NR
PSS000985 63 individuals,
0.0 % Male samples
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR NR
PSS000986 73 individuals,
0.0 % Male samples
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR NR
PSS008496 505 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS008497 201 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009394 6,445 individuals European UK (+ Ireland) UKB
PSS009395 6,438 individuals European UK (+ Ireland) UKB
PSS000250
[
  • 14,696 cases
  • , 22,013 controls
]
European 15 cohorts
  • BOMA
  • ,CoLaus
  • ,Edinburgh
  • ,GenPOD
  • ,GenRED
  • ,MARS
  • ,MPIP
  • ,NESDA
  • ,QIMR
  • ,RADIANT
  • ,RS
  • ,SHIP
  • ,STAR*D
  • ,TwinGene
  • ,i2b2
Part of PGC29 (PMID: 29700475)