Trait: neuroticism measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007660
Description Quantification of some aspect of neuroticism or neurotic behaviour, such as severity or frequency of neurotic behaviour. This is usually assessed via a standardised questionnaire.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001996
(portability-PLR_neuroticism)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Neuroticism score neuroticism measurement 54,715
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001996/ScoringFiles/PGS001996.txt.gz
PGS002213
(portability-ldpred2_neuroticism)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Neuroticism score neuroticism measurement 950,183
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002213/ScoringFiles/PGS002213.txt.gz
PGS002342
(mental_NEUROTICISM.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002342/ScoringFiles/PGS002342.txt.gz
PGS002414
(mental_NEUROTICISM.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 3,578
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002414/ScoringFiles/PGS002414.txt.gz
PGS002463
(mental_NEUROTICISM.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 16,660
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002463/ScoringFiles/PGS002463.txt.gz
PGS002512
(mental_NEUROTICISM.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 103,865
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002512/ScoringFiles/PGS002512.txt.gz
PGS002561
(mental_NEUROTICISM.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 469
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002561/ScoringFiles/PGS002561.txt.gz
PGS002610
(mental_NEUROTICISM.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 196
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002610/ScoringFiles/PGS002610.txt.gz
PGS002659
(mental_NEUROTICISM.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 546,323
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002659/ScoringFiles/PGS002659.txt.gz
PGS002708
(mental_NEUROTICISM.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Neuroticism neuroticism measurement 989,963
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002708/ScoringFiles/PGS002708.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010843 PGS001996
(portability-PLR_neuroticism)
PSS009479|
European Ancestry|
16,206 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1882 [0.1733, 0.203] sex, age, birth date, deprivation index, 16 PCs
PPM010844 PGS001996
(portability-PLR_neuroticism)
PSS009253|
European Ancestry|
2,941 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1696 [0.1341, 0.2046] sex, age, birth date, deprivation index, 16 PCs
PPM010845 PGS001996
(portability-PLR_neuroticism)
PSS008807|
European Ancestry|
5,081 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1732 [0.1464, 0.1998] sex, age, birth date, deprivation index, 16 PCs
PPM010846 PGS001996
(portability-PLR_neuroticism)
PSS008581|
Greater Middle Eastern Ancestry|
632 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1655 [0.0874, 0.2416] sex, age, birth date, deprivation index, 16 PCs
PPM010847 PGS001996
(portability-PLR_neuroticism)
PSS008359|
South Asian Ancestry|
3,839 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1307 [0.0994, 0.1618] sex, age, birth date, deprivation index, 16 PCs
PPM010848 PGS001996
(portability-PLR_neuroticism)
PSS008136|
East Asian Ancestry|
1,138 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1278 [0.0697, 0.185] sex, age, birth date, deprivation index, 16 PCs
PPM010849 PGS001996
(portability-PLR_neuroticism)
PSS007923|
African Ancestry|
1,756 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0778 [0.0308, 0.1243] sex, age, birth date, deprivation index, 16 PCs
PPM010850 PGS001996
(portability-PLR_neuroticism)
PSS009027|
African Ancestry|
2,505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0476 [0.0083, 0.0867] sex, age, birth date, deprivation index, 16 PCs
PPM012551 PGS002213
(portability-ldpred2_neuroticism)
PSS009479|
European Ancestry|
16,206 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.204 [0.1892, 0.2188] sex, age, birth date, deprivation index, 16 PCs
PPM012552 PGS002213
(portability-ldpred2_neuroticism)
PSS009253|
European Ancestry|
2,941 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.184 [0.1487, 0.2188] sex, age, birth date, deprivation index, 16 PCs
PPM012553 PGS002213
(portability-ldpred2_neuroticism)
PSS008807|
European Ancestry|
5,081 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1899 [0.1632, 0.2163] sex, age, birth date, deprivation index, 16 PCs
PPM012554 PGS002213
(portability-ldpred2_neuroticism)
PSS008581|
Greater Middle Eastern Ancestry|
632 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1919 [0.1144, 0.2671] sex, age, birth date, deprivation index, 16 PCs
PPM012555 PGS002213
(portability-ldpred2_neuroticism)
PSS008359|
South Asian Ancestry|
3,839 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1475 [0.1163, 0.1783] sex, age, birth date, deprivation index, 16 PCs
PPM012557 PGS002213
(portability-ldpred2_neuroticism)
PSS007923|
African Ancestry|
1,756 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0769 [0.03, 0.1235] sex, age, birth date, deprivation index, 16 PCs
PPM012558 PGS002213
(portability-ldpred2_neuroticism)
PSS009027|
African Ancestry|
2,505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0485 [0.0092, 0.0876] sex, age, birth date, deprivation index, 16 PCs
PPM012556 PGS002213
(portability-ldpred2_neuroticism)
PSS008136|
East Asian Ancestry|
1,138 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1161 [0.0578, 0.1735] sex, age, birth date, deprivation index, 16 PCs
PPM013107 PGS002342
(mental_NEUROTICISM.BOLT-LMM)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0025 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013156 PGS002342
(mental_NEUROTICISM.BOLT-LMM)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0099 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013205 PGS002342
(mental_NEUROTICISM.BOLT-LMM)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0309 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013254 PGS002342
(mental_NEUROTICISM.BOLT-LMM)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0238 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013395 PGS002414
(mental_NEUROTICISM.P+T.0.0001)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013444 PGS002414
(mental_NEUROTICISM.P+T.0.0001)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0037 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013493 PGS002414
(mental_NEUROTICISM.P+T.0.0001)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0064 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013542 PGS002414
(mental_NEUROTICISM.P+T.0.0001)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0028 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013591 PGS002463
(mental_NEUROTICISM.P+T.0.001)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013689 PGS002463
(mental_NEUROTICISM.P+T.0.001)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0077 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013738 PGS002463
(mental_NEUROTICISM.P+T.0.001)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0021 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013640 PGS002463
(mental_NEUROTICISM.P+T.0.001)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013934 PGS002512
(mental_NEUROTICISM.P+T.0.01)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013787 PGS002512
(mental_NEUROTICISM.P+T.0.01)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013836 PGS002512
(mental_NEUROTICISM.P+T.0.01)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013885 PGS002512
(mental_NEUROTICISM.P+T.0.01)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0043 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013983 PGS002561
(mental_NEUROTICISM.P+T.1e-06)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0005 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014032 PGS002561
(mental_NEUROTICISM.P+T.1e-06)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0079 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014081 PGS002561
(mental_NEUROTICISM.P+T.1e-06)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0029 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014130 PGS002561
(mental_NEUROTICISM.P+T.1e-06)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0029 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014179 PGS002610
(mental_NEUROTICISM.P+T.5e-08)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0012 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014228 PGS002610
(mental_NEUROTICISM.P+T.5e-08)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0079 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014326 PGS002610
(mental_NEUROTICISM.P+T.5e-08)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0018 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014277 PGS002610
(mental_NEUROTICISM.P+T.5e-08)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0017 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014375 PGS002659
(mental_NEUROTICISM.PolyFun-pred)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0024 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014424 PGS002659
(mental_NEUROTICISM.PolyFun-pred)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0099 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014473 PGS002659
(mental_NEUROTICISM.PolyFun-pred)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0296 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014522 PGS002659
(mental_NEUROTICISM.PolyFun-pred)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0145 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See mental_NEUROTICISM.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014669 PGS002708
(mental_NEUROTICISM.SBayesR)
PSS009813|
European Ancestry|
34,276 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0284 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014571 PGS002708
(mental_NEUROTICISM.SBayesR)
PSS009811|
African Ancestry|
4,454 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0039 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014620 PGS002708
(mental_NEUROTICISM.SBayesR)
PSS009812|
East Asian Ancestry|
603 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0089 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014718 PGS002708
(mental_NEUROTICISM.SBayesR)
PSS009814|
South Asian Ancestry|
4,984 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Neuroticism Incremental R2 (full model vs. covariates alone): 0.0227 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009253 2,941 individuals European Poland (NE Europe) UKB
PSS008581 632 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009479 16,206 individuals European UK (+ Ireland) UKB
PSS008807 5,081 individuals European Italy (South Europe) UKB
PSS008359 3,839 individuals South Asian India (South Asia) UKB
PSS008136 1,138 individuals East Asian China (East Asia) UKB
PSS009811 4,454 individuals African unspecified UKB
PSS009812 603 individuals East Asian UKB
PSS009813 34,276 individuals European Non-British European UKB
PSS009814 4,984 individuals South Asian UKB
PSS007923 1,756 individuals African American or Afro-Caribbean Carribean UKB
PSS009027 2,505 individuals African unspecified Nigeria (West Africa) UKB