Trait: neuroticism measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0007660
Description Quantification of some aspect of neuroticism or neurotic behaviour, such as severity or frequency of neurotic behaviour. This is usually assessed via a standardised questionnaire.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001996
(portability-PLR_neuroticism)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Neuroticism score neuroticism measurement 54,715
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001996/ScoringFiles/PGS001996.txt.gz
PGS002213
(portability-ldpred2_neuroticism)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Neuroticism score neuroticism measurement 950,183
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002213/ScoringFiles/PGS002213.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010843 PGS001996
(portability-PLR_neuroticism)
PSS009479|
European Ancestry|
16,206 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1882 [0.1733, 0.203] sex, age, birth date, deprivation index, 16 PCs
PPM010844 PGS001996
(portability-PLR_neuroticism)
PSS009253|
European Ancestry|
2,941 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1696 [0.1341, 0.2046] sex, age, birth date, deprivation index, 16 PCs
PPM010845 PGS001996
(portability-PLR_neuroticism)
PSS008807|
European Ancestry|
5,081 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1732 [0.1464, 0.1998] sex, age, birth date, deprivation index, 16 PCs
PPM010846 PGS001996
(portability-PLR_neuroticism)
PSS008581|
Greater Middle Eastern Ancestry|
632 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1655 [0.0874, 0.2416] sex, age, birth date, deprivation index, 16 PCs
PPM010847 PGS001996
(portability-PLR_neuroticism)
PSS008359|
South Asian Ancestry|
3,839 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1307 [0.0994, 0.1618] sex, age, birth date, deprivation index, 16 PCs
PPM010848 PGS001996
(portability-PLR_neuroticism)
PSS008136|
East Asian Ancestry|
1,138 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1278 [0.0697, 0.185] sex, age, birth date, deprivation index, 16 PCs
PPM010849 PGS001996
(portability-PLR_neuroticism)
PSS007923|
African Ancestry|
1,756 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0778 [0.0308, 0.1243] sex, age, birth date, deprivation index, 16 PCs
PPM010850 PGS001996
(portability-PLR_neuroticism)
PSS009027|
African Ancestry|
2,505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0476 [0.0083, 0.0867] sex, age, birth date, deprivation index, 16 PCs
PPM012551 PGS002213
(portability-ldpred2_neuroticism)
PSS009479|
European Ancestry|
16,206 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.204 [0.1892, 0.2188] sex, age, birth date, deprivation index, 16 PCs
PPM012552 PGS002213
(portability-ldpred2_neuroticism)
PSS009253|
European Ancestry|
2,941 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.184 [0.1487, 0.2188] sex, age, birth date, deprivation index, 16 PCs
PPM012553 PGS002213
(portability-ldpred2_neuroticism)
PSS008807|
European Ancestry|
5,081 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1899 [0.1632, 0.2163] sex, age, birth date, deprivation index, 16 PCs
PPM012554 PGS002213
(portability-ldpred2_neuroticism)
PSS008581|
Greater Middle Eastern Ancestry|
632 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1919 [0.1144, 0.2671] sex, age, birth date, deprivation index, 16 PCs
PPM012555 PGS002213
(portability-ldpred2_neuroticism)
PSS008359|
South Asian Ancestry|
3,839 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1475 [0.1163, 0.1783] sex, age, birth date, deprivation index, 16 PCs
PPM012557 PGS002213
(portability-ldpred2_neuroticism)
PSS007923|
African Ancestry|
1,756 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0769 [0.03, 0.1235] sex, age, birth date, deprivation index, 16 PCs
PPM012558 PGS002213
(portability-ldpred2_neuroticism)
PSS009027|
African Ancestry|
2,505 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.0485 [0.0092, 0.0876] sex, age, birth date, deprivation index, 16 PCs
PPM012556 PGS002213
(portability-ldpred2_neuroticism)
PSS008136|
East Asian Ancestry|
1,138 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Neuroticism score Partial Correlation (partial-r): 0.1161 [0.0578, 0.1735] sex, age, birth date, deprivation index, 16 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009253 2,941 individuals European Poland (NE Europe) UKB
PSS008581 632 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009479 16,206 individuals European UK (+ Ireland) UKB
PSS008807 5,081 individuals European Italy (South Europe) UKB
PSS008359 3,839 individuals South Asian India (South Asia) UKB
PSS008136 1,138 individuals East Asian China (East Asia) UKB
PSS007923 1,756 individuals African American or Afro-Caribbean Carribean UKB
PSS009027 2,505 individuals African unspecified Nigeria (West Africa) UKB