Trait: insulin secretion measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008001
Description
  • Measurement of compounds, generally C-peptide or mature insulin, whose levels quantify insulin secretion from the pancreas.
Trait category
Other measurement
Synonyms insulin secretion rate measurement
Mapped term(s) http://orcid.org/0000-0001-9043-693X

Associated Polygenic Score(s)

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Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000871
(IS_14)
PGP000214 |
Aksit MA et al. J Clin Endocrinol Metab (2020)
Insulin secretion insulin secretion measurement 14
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000871/ScoringFiles/PGS000871.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002416 PGS000871
(IS_14)
PSS001092|
Ancestry Not Reported|
5,740 individuals
PGP000214 |
Aksit MA et al. J Clin Endocrinol Metab (2020)
Reported Trait: Cystic-fibrosis related diabetes onset HR: 1.247 PCs(1-4), site of recruitment

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001092 All individuals had cystic fibrosis with either 2 severe CFTR mutations and/or clinically diagnosed exocrine pancreatic insufficiency. Cases are individuals with cystic fibrosis related diabetes (CFRD).Phenotypes were obtained from extracted medical charts and CF Foundation Patient Registry through 2011. CFRD was defined by clinician diagnosis of diabetes plus insulin treatment for at least 1 year. The onset of CFRD was defined as the date at which insulin was started, if it was subsequently continued for at least 1 year. In approximately 50% of the participants, independent laboratory data (such as oral glucose tolerance test or hemoglobin A1c) were able to independently confirm the diagnosis of CFRD. Diabetes data were censored at the last clinic visit or date of solid organ transplant.
[
  • 1,341 cases
  • , 4,399 controls
]
,
47.04 % Male samples
Mean = 20.0 years Not reported CGS, CWRU, FrGMC, JHU, UNC