Trait: chronic hepatitis

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008496
Description
  • Acute cases of hepatitis are seen to be resolved well within a six-month period. When hepatitis is continued for more than six months it is termed chronic hepatitis.
  • An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders.
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018430
(TPMI_070.4_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 305
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018430/ScoringFiles/PGS018430.txt.gz
PGS018431
(TPMI_070.4_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 939,883
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018431/ScoringFiles/PGS018431.txt.gz
PGS018432
(TPMI_070.4_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 35,057
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018432/ScoringFiles/PGS018432.txt.gz
PGS018433
(TPMI_070.4_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 983,814
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018433/ScoringFiles/PGS018433.txt.gz
PGS018434
(TPMI_070.4_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic hepatitis chronic hepatitis 947,767
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018434/ScoringFiles/PGS018434.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036612 PGS018430
(TPMI_070.4_Lassosum2)
 PSS012328|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.65199 R²: 0.07014 sex, age, array, PCs 1-10 —
PPM036613 PGS018431
(TPMI_070.4_LDpred2)
 PSS012327|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.65308 R²: 0.07119 sex, age, array, PCs 1-10 —
PPM036614 PGS018432
(TPMI_070.4_MegaPRS)
 PSS012329|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.64771 R²: 0.06696 sex, age, array, PCs 1-10 —
PPM036615 PGS018433
(TPMI_070.4_PRS-CS)
 PSS012330|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.65273 R²: 0.07088 sex, age, array, PCs 1-10 —
PPM036616 PGS018434
(TPMI_070.4_SBayesR)
 PSS012331|
East Asian Ancestry|
16,631 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic hepatitis — AUROC: 0.64746 R²: 0.06666 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012327 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012328 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012329 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012330 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012331 571.4,K71.5, K73, K75.4 —
[
  • 1,720 cases
  • , 14,911 controls
]
,
45.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —