Trait: Red cell distribution width

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009188
Description Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause.
Trait category
Hematological measurement
Synonyms 7 synonyms
  • Erythrocyte Distribution Width Measurement
  • RCDW
  • RDW
  • RDW-CV
  • RDW-SD
  • Red blood cell erythrocyte distribution width
  • Red cell distribution width (RDW) blood test
Mapped terms 3 mapped terms
  • MedDRA:10051168
  • NCIt:C64800
  • Wikipedia:Red_blood_cell_distribution_width

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS003503
(cont-decay-erythrocyte_width)
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Red blood cell (erythrocyte) distribution width Red cell distribution width 979,739
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003503/ScoringFiles/PGS003503.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017431 PGS003503
(cont-decay-erythrocyte_width)
PSS010864|
European Ancestry|
19,389 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.11 sex, age, deprivation index, PC1-16
PPM017515 PGS003503
(cont-decay-erythrocyte_width)
PSS010780|
European Ancestry|
3,985 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.1 sex, age, deprivation index, PC1-16
PPM017599 PGS003503
(cont-decay-erythrocyte_width)
PSS010612|
European Ancestry|
6,263 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.09 sex, age, deprivation index, PC1-16
PPM017683 PGS003503
(cont-decay-erythrocyte_width)
PSS010528|
Greater Middle Eastern Ancestry|
1,114 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.07 sex, age, deprivation index, PC1-16
PPM017851 PGS003503
(cont-decay-erythrocyte_width)
PSS010444|
South Asian Ancestry|
5,983 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.06 sex, age, deprivation index, PC1-16
PPM017935 PGS003503
(cont-decay-erythrocyte_width)
PSS010360|
East Asian Ancestry|
1,744 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.06 sex, age, deprivation index, PC1-16
PPM018019 PGS003503
(cont-decay-erythrocyte_width)
PSS010276|
African Ancestry|
2,315 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.01 sex, age, deprivation index, PC1-16
PPM017767 PGS003503
(cont-decay-erythrocyte_width)
PSS010192|
European Ancestry|
2,258 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.09 sex, age, deprivation index, PC1-16
PPM018103 PGS003503
(cont-decay-erythrocyte_width)
PSS010696|
African Ancestry|
3,651 individuals
PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre
Reported Trait: Red blood cell (erythrocyte) distribution width partial-R2: 0.02 sex, age, deprivation index, PC1-16

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010528 1,114 individuals,
60.0 % Male samples
Mean = 52.0 years
Sd = 8.0 years
Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB
PSS010276 2,315 individuals,
37.0 % Male samples
Mean = 52.5 years
Sd = 8.1 years
African American or Afro-Caribbean Caribbean UKB
PSS010696 3,651 individuals,
47.0 % Male samples
Mean = 51.9 years
Sd = 8.1 years
African unspecified Nigerian UKB
PSS010444 5,983 individuals,
55.0 % Male samples
Mean = 53.3 years
Sd = 8.4 years
South Asian Indian UKB
PSS010864 19,389 individuals,
46.0 % Male samples
Mean = 56.9 years
Sd = 7.9 years
European white British UKB
PSS010192 2,258 individuals,
45.0 % Male samples
Mean = 58.0 years
Sd = 7.1 years
European Ashkenazi UKB
PSS010612 6,263 individuals,
45.0 % Male samples
Mean = 54.5 years
Sd = 8.4 years
European Italian UKB
PSS010360 1,744 individuals,
33.0 % Male samples
Mean = 52.5 years
Sd = 7.8 years
East Asian Chinese UKB
PSS010780 3,985 individuals,
38.0 % Male samples
Mean = 54.3 years
Sd = 7.5 years
European Polish UKB