| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0009188 |
| Description | Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause. | Trait category |
Hematological measurement
|
| Synonyms |
7 synonyms
|
| Mapped terms |
3 mapped terms
|
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | Ancestry distribution | Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS003503 (cont-decay-erythrocyte_width) |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Red blood cell (erythrocyte) distribution width | Red cell distribution width | 979,739 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003503/ScoringFiles/PGS003503.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM017431 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010864| European Ancestry| 19,389 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.11 | sex, age, deprivation index, PC1-16 | — |
| PPM017515 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010780| European Ancestry| 3,985 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.1 | sex, age, deprivation index, PC1-16 | — |
| PPM017599 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010612| European Ancestry| 6,263 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.09 | sex, age, deprivation index, PC1-16 | — |
| PPM017683 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010528| Greater Middle Eastern Ancestry| 1,114 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.07 | sex, age, deprivation index, PC1-16 | — |
| PPM017851 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010444| South Asian Ancestry| 5,983 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.06 | sex, age, deprivation index, PC1-16 | — |
| PPM017935 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010360| East Asian Ancestry| 1,744 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.06 | sex, age, deprivation index, PC1-16 | — |
| PPM018019 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010276| African Ancestry| 2,315 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.01 | sex, age, deprivation index, PC1-16 | — |
| PPM017767 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010192| European Ancestry| 2,258 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.09 | sex, age, deprivation index, PC1-16 | — |
| PPM018103 | PGS003503 (cont-decay-erythrocyte_width) |
PSS010696| African Ancestry| 3,651 individuals |
PGP000457 | Ding Y et al. bioRxiv (2022) |Pre |
Reported Trait: Red blood cell (erythrocyte) distribution width | — | — | partial-R2: 0.02 | sex, age, deprivation index, PC1-16 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS010528 | — | — | 1,114 individuals, 60.0 % Male samples |
Mean = 52.0 years Sd = 8.0 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
| PSS010276 | — | — | 2,315 individuals, 37.0 % Male samples |
Mean = 52.5 years Sd = 8.1 years |
African American or Afro-Caribbean | Caribbean | UKB | — |
| PSS010696 | — | — | 3,651 individuals, 47.0 % Male samples |
Mean = 51.9 years Sd = 8.1 years |
African unspecified | Nigerian | UKB | — |
| PSS010444 | — | — | 5,983 individuals, 55.0 % Male samples |
Mean = 53.3 years Sd = 8.4 years |
South Asian | Indian | UKB | — |
| PSS010864 | — | — | 19,389 individuals, 46.0 % Male samples |
Mean = 56.9 years Sd = 7.9 years |
European | white British | UKB | — |
| PSS010192 | — | — | 2,258 individuals, 45.0 % Male samples |
Mean = 58.0 years Sd = 7.1 years |
European | Ashkenazi | UKB | — |
| PSS010612 | — | — | 6,263 individuals, 45.0 % Male samples |
Mean = 54.5 years Sd = 8.4 years |
European | Italian | UKB | — |
| PSS010360 | — | — | 1,744 individuals, 33.0 % Male samples |
Mean = 52.5 years Sd = 7.8 years |
East Asian | Chinese | UKB | — |
| PSS010780 | — | — | 3,985 individuals, 38.0 % Male samples |
Mean = 54.3 years Sd = 7.5 years |
European | Polish | UKB | — |