| Experimental Factor Ontology (EFO) Information | |
| Identifier | EFO_0009270 |
| Description | Quantification of the mineral density of the heel bone | Trait category |
Other measurement
|
| Mapped term | PMID:28869591 |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000657 (gSOS) |
PGP000120 | Forgetta V et al. PLoS Med (2020) |
Heel quantitative ultrasound speed of sound (SOS) | heel bone mineral density | 21,716 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz |
| PGS001037 (GBE_INI78) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Heel bone mineral density (BMD) T-score, automated | heel bone mineral density | 14,310 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001037/ScoringFiles/PGS001037.txt.gz |
| PGS001038 (GBE_INI4106) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Left heel bone mineral density (BMD) T-score, automated | heel bone mineral density | 9,275 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001038/ScoringFiles/PGS001038.txt.gz |
| PGS001039 (GBE_INI4125) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Right heel bone mineral density (BMD) T-score, automated | heel bone mineral density | 9,753 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001039/ScoringFiles/PGS001039.txt.gz |
| PGS001402 (GBE_INI3148) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Heel bone mineral density (BMD) | heel bone mineral density | 14,251 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001402/ScoringFiles/PGS001402.txt.gz |
| PGS001403 (GBE_INI4105) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Heel bone mineral density (BMD) (L) | heel bone mineral density | 8,285 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001403/ScoringFiles/PGS001403.txt.gz |
| PGS001404 (GBE_INI4124) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Heel bone mineral density (BMD) (R) | heel bone mineral density | 9,637 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001404/ScoringFiles/PGS001404.txt.gz |
| PGS001529 (GBE_INI3146) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Speed of sound through heel | heel bone mineral density | 13,172 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001529/ScoringFiles/PGS001529.txt.gz |
| PGS001530 (GBE_INI4103) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Speed of sound through heel (L) | heel bone mineral density | 8,419 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001530/ScoringFiles/PGS001530.txt.gz |
| PGS001531 (GBE_INI4122) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Speed of sound through heel (R) | heel bone mineral density | 8,912 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001531/ScoringFiles/PGS001531.txt.gz |
| PGS001955 (portability-PLR_log_heel_BMD) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Heel bone mineral density (BMD) | heel bone mineral density | 73,565 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001955/ScoringFiles/PGS001955.txt.gz |
| PGS001956 (portability-PLR_log_heel_BUA) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Heel Broadband ultrasound attenuation, direct entry | heel bone mineral density | 69,537 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001956/ScoringFiles/PGS001956.txt.gz |
| PGS002173 (portability-ldpred2_log_heel_BMD) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Heel bone mineral density (BMD) | heel bone mineral density | 729,074 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002173/ScoringFiles/PGS002173.txt.gz |
| PGS002174 (portability-ldpred2_log_heel_BUA) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Heel Broadband ultrasound attenuation, direct entry | heel bone mineral density | 732,595 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002174/ScoringFiles/PGS002174.txt.gz |
| PGS002768 (BMD_prscs) |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Osteoporosis | heel bone mineral density, osteoporosis |
1,091,549 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002768/ScoringFiles/PGS002768.txt.gz |
| PGS003535 (cont-decay-log_heel_BMD) |
PGP000457 | Ding Y et al. Nature (2023) |
Heel bone mineral density (BMD) | heel bone mineral density | 979,739 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003535/ScoringFiles/PGS003535.txt.gz |
| PGS004411 (X78.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Heel bone mineral density (BMD) T-score, automated | heel bone mineral density | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004411/ScoringFiles/PGS004411.txt.gz |
| PGS004415 (X3148.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Heel bone mineral density (BMD) | heel bone mineral density | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004415/ScoringFiles/PGS004415.txt.gz |
| PGS004419 (X4105.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Heel bone mineral density (BMD) (left) | heel bone mineral density | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004419/ScoringFiles/PGS004419.txt.gz |
| PGS004420 (X4106.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Heel bone mineral density (BMD) T-score, automated (left) | heel bone mineral density | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004420/ScoringFiles/PGS004420.txt.gz |
| PGS004424 (X4124.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Heel bone mineral density (BMD) (right) | heel bone mineral density | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004424/ScoringFiles/PGS004424.txt.gz |
| PGS004425 (X4125.score) |
PGP000561 | Jung H et al. Commun Biol (2024) |
Heel bone mineral density (BMD) T-score, automated (right) | heel bone mineral density | 1,059,939 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004425/ScoringFiles/PGS004425.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM001343 | PGS000657 (gSOS) |
PSS000586| European Ancestry| 80,027 individuals |
PGP000120 | Forgetta V et al. PLoS Med (2020) |
Reported Trait: Heel bone speed of sound | — | — | R²: 0.2318 [0.2266, 0.2369] | — | — |
| PPM001344 | PGS000657 (gSOS) |
PSS000585| Multi-ancestry (including European)| 21,408 individuals |
PGP000120 | Forgetta V et al. PLoS Med (2020) |
Reported Trait: Screening incorporating a gSOS-based screening step | — | — | Positive Predictive Value (PPV): 0.954 Reduction in individuals requiring Clinical-Risk-Factor FRAX tests (%): 37.0 Percent reduction in individuals requiring BMD FRAX Tests (%): 41.0 |
— | — |
| PPM001862 | PGS000657 (gSOS) |
PSS000950| European Ancestry| 90,172 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | — | AUROC: 0.798 [0.791, 0.805] | Odds ratio (OR, bottom 25% vs. remaining 75%): 1.2 [1.02, 1.41] | Age, sex | — |
| PPM001863 | PGS000657 (gSOS) |
PSS000944| European Ancestry| 8,278 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | — | C-index: 0.623 [0.603, 0.642] | — | Sex | — |
| PPM001864 | PGS000657 (gSOS) |
PSS000943| European Ancestry| 8,278 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | — | C-index: 0.672 [0.65, 0.695] | — | Sex | — |
| PPM001861 | PGS000657 (gSOS) |
PSS000951| European Ancestry| 90,172 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | — | AUROC: 0.734 [0.727, 0.74] | Odds ratio (OR, bottom 25% vs. remaining 75%): 1.68 [1.47, 1.89] | Age, sex | — |
| PPM001867 | PGS000657 (gSOS) |
PSS000942| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.72 [0.66, 0.79] | — | — | Age, sex | — |
| PPM001852 | PGS000657 (gSOS) |
PSS000937| European Ancestry| 80,014 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.69 [0.65, 0.71] | — | — | — | — |
| PPM001853 | PGS000657 (gSOS) |
PSS000937| European Ancestry| 80,014 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.68 [0.64, 0.73] | — | Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] | Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS | — |
| PPM001854 | PGS000657 (gSOS) |
PSS000936| European Ancestry| 80,014 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.67, 0.87] | — | Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] | Basline fracture risk (FRAX), fracture-related drug use | — |
| PPM001855 | PGS000657 (gSOS) |
PSS000936| European Ancestry| 80,014 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.74 [0.64, 0.78] | — | — | — | — |
| PPM001856 | PGS000657 (gSOS) |
PSS000936| European Ancestry| 80,014 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.64, 0.89] | — | — | Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS | — |
| PPM001857 | PGS000657 (gSOS) |
PSS000933| European Ancestry| 12,678 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident major osteoporotic fracture in fracture-related drug users | OR: 0.78 [0.68, 0.88] | — | Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] | Basline fracture risk (FRAX) | — |
| PPM001858 | PGS000657 (gSOS) |
PSS000932| European Ancestry| 12,678 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: incident hip fracture in fracture-related drug users | OR: 0.77 [0.61, 0.98] | — | Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] | Basline fracture risk (FRAX) | — |
| PPM001859 | PGS000657 (gSOS) |
PSS000935| European Ancestry| 67,336 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs | OR: 0.57 [0.54, 0.61] | — | Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] | Basline fracture risk (FRAX) | — |
| PPM001860 | PGS000657 (gSOS) |
PSS000934| European Ancestry| 67,336 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs | OR: 0.36 [0.3, 0.43] | — | Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] | Basline fracture risk (FRAX) | — |
| PPM001865 | PGS000657 (gSOS) |
PSS000948| European Ancestry| 80,014 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.68 [0.65, 0.72] | AUROC: 0.68 [0.673, 0.688] | — | Age, sex | — |
| PPM001868 | PGS000657 (gSOS) |
PSS000942| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.76 [0.69, 0.85] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001869 | PGS000657 (gSOS) |
PSS000940| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.69 [0.61, 0.78] | — | — | Age, sex | — |
| PPM001870 | PGS000657 (gSOS) |
PSS000940| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.72 [0.61, 0.85] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001871 | PGS000657 (gSOS) |
PSS000946| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.74 [0.68, 0.81] | — | — | Age, sex | — |
| PPM001872 | PGS000657 (gSOS) |
PSS000946| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.75 [0.68, 0.83] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001873 | PGS000657 (gSOS) |
PSS000938| East Asian Ancestry| 25,034 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.79 [0.71, 0.88] | — | — | Age, sex | Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel. |
| PPM001874 | PGS000657 (gSOS) |
PSS000938| East Asian Ancestry| 25,034 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.82 [0.74, 0.92] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel. |
| PPM001875 | PGS000657 (gSOS) |
PSS000947| European Ancestry| 80,014 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.73 [0.63, 0.84] | AUROC: 0.739 [0.724, 0.754] | — | Age, sex | — |
| PPM001876 | PGS000657 (gSOS) |
PSS000947| European Ancestry| 80,014 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.75 [0.65, 0.86] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001877 | PGS000657 (gSOS) |
PSS000941| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.73 [0.64, 0.83] | — | — | Age, sex | — |
| PPM001878 | PGS000657 (gSOS) |
PSS000941| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.75 [0.65, 0.87] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001879 | PGS000657 (gSOS) |
PSS000939| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.63, 0.93] | — | — | Age, sex | — |
| PPM001880 | PGS000657 (gSOS) |
PSS000939| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.74 [0.58, 0.95] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001881 | PGS000657 (gSOS) |
PSS000945| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.7, 0.84] | — | — | Age, sex | — |
| PPM001882 | PGS000657 (gSOS) |
PSS000945| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.68, 0.84] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM001883 | PGS000657 (gSOS) |
PSS000949| European Ancestry| 4,717 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.71 [0.59, 0.85] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001884 | PGS000657 (gSOS) |
PSS000942| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.74 [0.67, 0.81] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001885 | PGS000657 (gSOS) |
PSS000940| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.72 [0.63, 0.81] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001886 | PGS000657 (gSOS) |
PSS000946| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.77 [0.7, 0.84] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001887 | PGS000657 (gSOS) |
PSS000941| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.74 [0.65, 0.83] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001888 | PGS000657 (gSOS) |
PSS000939| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.8 [0.67, 0.96] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001889 | PGS000657 (gSOS) |
PSS000945| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.69, 0.84] | — | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001890 | PGS000657 (gSOS) |
PSS000949| European Ancestry| 4,717 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.75 [0.63, 0.9] | — | — | Age, sex, measured femoral neck bone mineral density | — |
| PPM001891 | PGS000657 (gSOS) |
PSS000942| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.82 [0.75, 0.9] | — | — | Age, sex, measured femoral neck bone mineral density | — |
| PPM001892 | PGS000657 (gSOS) |
PSS000940| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.78 [0.68, 0.88] | — | — | Age, sex, measured femoral neck bone mineral density | — |
| PPM001893 | PGS000657 (gSOS) |
PSS000946| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.82 [0.75, 0.9] | — | — | Age, sex, measured femoral neck bone mineral density | — |
| PPM001894 | PGS000657 (gSOS) |
PSS000941| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.85 [0.75, 0.97] | — | — | Age, sex, measured femoral neck bone mineral density | — |
| PPM001895 | PGS000657 (gSOS) |
PSS000945| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.83 [0.76, 0.93] | — | — | Age, sex, measured femoral neck bone mineral density | — |
| PPM001896 | PGS000657 (gSOS) |
PSS000949| European Ancestry| 4,717 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.75 [0.63, 0.89] | — | — | Clinical risk factor-based score including bone mineral density (FRAX-BMD) | — |
| PPM001897 | PGS000657 (gSOS) |
PSS000942| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.78 [0.71, 0.85] | — | — | Clinical risk factor-based score including bone mineral density (FRAX-BMD) | — |
| PPM001898 | PGS000657 (gSOS) |
PSS000940| European Ancestry| 1,880 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.75 [0.66, 0.85] | — | — | Clinical risk factor-based score including bone mineral density (FRAX-BMD) | — |
| PPM001899 | PGS000657 (gSOS) |
PSS000946| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.82 [0.75, 0.89] | — | — | Clinical risk factor-based score including bone mineral density (FRAX-BMD) | — |
| PPM001900 | PGS000657 (gSOS) |
PSS000941| European Ancestry| 4,663 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.76 [0.68, 0.87] | — | — | Clinical risk factor-based score including bone mineral density (FRAX-BMD) | — |
| PPM001901 | PGS000657 (gSOS) |
PSS000945| European Ancestry| 3,615 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | OR: 0.8 [0.73, 0.88] | — | — | Clinical risk factor-based score including bone mineral density (FRAX-BMD) | — |
| PPM001902 | PGS000657 (gSOS) |
PSS000944| European Ancestry| 8,278 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | — | C-index: 0.66 [0.641, 0.679] | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001903 | PGS000657 (gSOS) |
PSS000943| European Ancestry| 8,278 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident hip fracture | — | C-index: 0.682 [0.66, 0.704] | — | Clinical risk factor-based score (FRAX-CRF) | — |
| PPM001851 | PGS000657 (gSOS) |
PSS000937| European Ancestry| 80,014 individuals |
PGP000153 | Manousaki D et al. J Bone Miner Res (2020) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.7 [0.66, 0.75] | — | Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] | Basline fracture risk (FRAX), fracture-related drug use | — |
| PPM001866 | PGS000657 (gSOS) |
PSS000948| European Ancestry| 80,014 individuals |
PGP000154 | Lu T et al. Genome Med (2021) |Ext. |
Reported Trait: Incident major osteoporotic fracture | OR: 0.7 [0.66, 0.75] | — | — | Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis | — |
| PPM007945 | PGS001037 (GBE_INI78) |
PSS007478| European Ancestry| 12,376 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated | — | — | R²: 0.1881 [0.17936, 0.19685] Incremental R2 (full-covars): 0.13506 PGS R2 (no covariates): 0.13678 [0.12885, 0.14471] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007943 | PGS001037 (GBE_INI78) |
PSS007476| African Ancestry| 2,253 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated | — | — | R²: 0.0346 [0.02587, 0.04333] Incremental R2 (full-covars): 0.01755 PGS R2 (no covariates): 0.01827 [0.01182, 0.02472] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007944 | PGS001037 (GBE_INI78) |
PSS007477| East Asian Ancestry| 795 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated | — | — | R²: 0.09833 [0.07154, 0.12513] Incremental R2 (full-covars): 0.06623 PGS R2 (no covariates): 0.06929 [0.04608, 0.09251] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007946 | PGS001037 (GBE_INI78) |
PSS007479| South Asian Ancestry| 2,312 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated | — | — | R²: 0.10193 [0.08923, 0.11462] Incremental R2 (full-covars): 0.06757 PGS R2 (no covariates): 0.07119 [0.06021, 0.08216] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007947 | PGS001037 (GBE_INI78) |
PSS007480| European Ancestry| 38,834 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated | — | — | R²: 0.19661 [0.19123, 0.20198] Incremental R2 (full-covars): 0.1419 PGS R2 (no covariates): 0.14159 [0.13671, 0.14646] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007948 | PGS001038 (GBE_INI4106) |
PSS007296| African Ancestry| 3,560 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) | — | — | R²: 0.02571 [0.01812, 0.03331] Incremental R2 (full-covars): 0.00529 PGS R2 (no covariates): 0.00688 [0.00288, 0.01089] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007949 | PGS001038 (GBE_INI4106) |
PSS007297| East Asian Ancestry| 781 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) | — | — | R²: 0.10298 [0.0757, 0.13026] Incremental R2 (full-covars): 0.08297 PGS R2 (no covariates): 0.082 [0.05709, 0.10691] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007950 | PGS001038 (GBE_INI4106) |
PSS007298| European Ancestry| 10,636 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) | — | — | R²: 0.17491 [0.16634, 0.18348] Incremental R2 (full-covars): 0.11202 PGS R2 (no covariates): 0.11274 [0.10534, 0.12014] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007951 | PGS001038 (GBE_INI4106) |
PSS007299| South Asian Ancestry| 5,043 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) | — | — | R²: 0.08123 [0.06963, 0.09282] Incremental R2 (full-covars): 0.05296 PGS R2 (no covariates): 0.05415 [0.04441, 0.0639] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007952 | PGS001038 (GBE_INI4106) |
PSS007300| European Ancestry| 25,716 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (L) | — | — | R²: 0.17984 [0.17459, 0.18509] Incremental R2 (full-covars): 0.11708 PGS R2 (no covariates): 0.11589 [0.11134, 0.12043] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007953 | PGS001039 (GBE_INI4125) |
PSS007326| African Ancestry| 3,592 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) | — | — | R²: 0.02463 [0.01719, 0.03207] Incremental R2 (full-covars): 0.00616 PGS R2 (no covariates): 0.00698 [0.00294, 0.01101] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007954 | PGS001039 (GBE_INI4125) |
PSS007327| East Asian Ancestry| 782 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) | — | — | R²: 0.09885 [0.072, 0.1257] Incremental R2 (full-covars): 0.07541 PGS R2 (no covariates): 0.07555 [0.05147, 0.09963] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007955 | PGS001039 (GBE_INI4125) |
PSS007328| European Ancestry| 10,633 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) | — | — | R²: 0.1752 [0.16663, 0.18378] Incremental R2 (full-covars): 0.11145 PGS R2 (no covariates): 0.11271 [0.10531, 0.12011] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007956 | PGS001039 (GBE_INI4125) |
PSS007329| South Asian Ancestry| 5,041 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) | — | — | R²: 0.08262 [0.07095, 0.0943] Incremental R2 (full-covars): 0.05817 PGS R2 (no covariates): 0.05815 [0.0481, 0.06821] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007957 | PGS001039 (GBE_INI4125) |
PSS007330| European Ancestry| 25,728 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (R) | — | — | R²: 0.19359 [0.18823, 0.19894] Incremental R2 (full-covars): 0.1242 PGS R2 (no covariates): 0.12266 [0.11802, 0.1273] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007080 | PGS001402 (GBE_INI3148) |
PSS007241| African Ancestry| 2,248 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | R²: 0.03461 [0.02588, 0.04334] Incremental R2 (full-covars): 0.01792 PGS R2 (no covariates): 0.01849 [0.012, 0.02498] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007081 | PGS001402 (GBE_INI3148) |
PSS007242| East Asian Ancestry| 794 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | R²: 0.0956 [0.0691, 0.1221] Incremental R2 (full-covars): 0.06421 PGS R2 (no covariates): 0.06783 [0.04482, 0.09083] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007082 | PGS001402 (GBE_INI3148) |
PSS007243| European Ancestry| 12,374 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | R²: 0.18897 [0.18022, 0.19773] Incremental R2 (full-covars): 0.13548 PGS R2 (no covariates): 0.13714 [0.1292, 0.14508] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007083 | PGS001402 (GBE_INI3148) |
PSS007244| South Asian Ancestry| 2,310 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | R²: 0.10415 [0.09135, 0.11695] Incremental R2 (full-covars): 0.06926 PGS R2 (no covariates): 0.07321 [0.06211, 0.08432] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007084 | PGS001402 (GBE_INI3148) |
PSS007245| European Ancestry| 38,814 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | R²: 0.19926 [0.19386, 0.20465] Incremental R2 (full-covars): 0.14341 PGS R2 (no covariates): 0.14309 [0.1382, 0.14798] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007100 | PGS001403 (GBE_INI4105) |
PSS007291| African Ancestry| 3,558 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (L) | — | — | R²: 0.02599 [0.01836, 0.03363] Incremental R2 (full-covars): 0.00518 PGS R2 (no covariates): 0.00667 [0.00273, 0.01062] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007101 | PGS001403 (GBE_INI4105) |
PSS007292| East Asian Ancestry| 781 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (L) | — | — | R²: 0.10653 [0.07889, 0.13417] Incremental R2 (full-covars): 0.08652 PGS R2 (no covariates): 0.08516 [0.05986, 0.11046] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007102 | PGS001403 (GBE_INI4105) |
PSS007293| European Ancestry| 10,626 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (L) | — | — | R²: 0.17743 [0.16883, 0.18604] Incremental R2 (full-covars): 0.11194 PGS R2 (no covariates): 0.11269 [0.10529, 0.12009] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007103 | PGS001403 (GBE_INI4105) |
PSS007294| South Asian Ancestry| 5,037 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (L) | — | — | R²: 0.08239 [0.07073, 0.09405] Incremental R2 (full-covars): 0.05357 PGS R2 (no covariates): 0.05487 [0.04506, 0.06467] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007104 | PGS001403 (GBE_INI4105) |
PSS007295| European Ancestry| 25,706 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (L) | — | — | R²: 0.18131 [0.17605, 0.18657] Incremental R2 (full-covars): 0.11744 PGS R2 (no covariates): 0.11656 [0.11201, 0.12112] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007110 | PGS001404 (GBE_INI4124) |
PSS007321| African Ancestry| 3,586 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (R) | — | — | R²: 0.02449 [0.01707, 0.03191] Incremental R2 (full-covars): 0.00554 PGS R2 (no covariates): 0.00662 [0.00269, 0.01055] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007111 | PGS001404 (GBE_INI4124) |
PSS007322| East Asian Ancestry| 782 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (R) | — | — | R²: 0.09993 [0.07297, 0.12689] Incremental R2 (full-covars): 0.0765 PGS R2 (no covariates): 0.0766 [0.05238, 0.10082] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007112 | PGS001404 (GBE_INI4124) |
PSS007323| European Ancestry| 10,627 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (R) | — | — | R²: 0.17605 [0.16746, 0.18463] Incremental R2 (full-covars): 0.11134 PGS R2 (no covariates): 0.11225 [0.10487, 0.11964] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007113 | PGS001404 (GBE_INI4124) |
PSS007324| South Asian Ancestry| 5,032 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (R) | — | — | R²: 0.08461 [0.07282, 0.0964] Incremental R2 (full-covars): 0.05881 PGS R2 (no covariates): 0.05872 [0.04862, 0.06882] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007114 | PGS001404 (GBE_INI4124) |
PSS007325| European Ancestry| 25,715 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) (R) | — | — | R²: 0.196 [0.19063, 0.20138] Incremental R2 (full-covars): 0.12507 PGS R2 (no covariates): 0.12352 [0.11887, 0.12817] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007075 | PGS001529 (GBE_INI3146) |
PSS007231| African Ancestry| 1,434 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel | — | — | R²: 0.03275 [0.02202, 0.04347] Incremental R2 (full-covars): 0.0181 PGS R2 (no covariates): 0.01912 [0.01081, 0.02743] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007076 | PGS001529 (GBE_INI3146) |
PSS007232| East Asian Ancestry| 500 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel | — | — | R²: 0.10987 [0.07399, 0.14575] Incremental R2 (full-covars): 0.07069 PGS R2 (no covariates): 0.08324 [0.05108, 0.11541] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007077 | PGS001529 (GBE_INI3146) |
PSS007233| European Ancestry| 7,691 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel | — | — | R²: 0.17225 [0.16143, 0.18307] Incremental R2 (full-covars): 0.13354 PGS R2 (no covariates): 0.13618 [0.12614, 0.14622] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007078 | PGS001529 (GBE_INI3146) |
PSS007234| South Asian Ancestry| 1,449 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel | — | — | R²: 0.11013 [0.09349, 0.12678] Incremental R2 (full-covars): 0.08026 PGS R2 (no covariates): 0.08576 [0.07067, 0.10085] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007079 | PGS001529 (GBE_INI3146) |
PSS007235| European Ancestry| 24,146 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel | — | — | R²: 0.18117 [0.17451, 0.18783] Incremental R2 (full-covars): 0.13986 PGS R2 (no covariates): 0.14001 [0.13386, 0.14616] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007095 | PGS001530 (GBE_INI4103) |
PSS007281| African Ancestry| 3,560 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (L) | — | — | R²: 0.02043 [0.01363, 0.02724] Incremental R2 (full-covars): 0.00372 PGS R2 (no covariates): 0.00552 [0.00193, 0.00911] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007096 | PGS001530 (GBE_INI4103) |
PSS007282| East Asian Ancestry| 781 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (L) | — | — | R²: 0.1024 [0.07518, 0.12962] Incremental R2 (full-covars): 0.0813 PGS R2 (no covariates): 0.08045 [0.05573, 0.10516] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007097 | PGS001530 (GBE_INI4103) |
PSS007283| European Ancestry| 10,636 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (L) | — | — | R²: 0.16053 [0.15218, 0.16889] Incremental R2 (full-covars): 0.10916 PGS R2 (no covariates): 0.11118 [0.10382, 0.11854] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007098 | PGS001530 (GBE_INI4103) |
PSS007284| South Asian Ancestry| 5,043 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (L) | — | — | R²: 0.07631 [0.06501, 0.0876] Incremental R2 (full-covars): 0.05214 PGS R2 (no covariates): 0.05376 [0.04404, 0.06347] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007099 | PGS001530 (GBE_INI4103) |
PSS007285| European Ancestry| 25,716 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (L) | — | — | R²: 0.16377 [0.15866, 0.16887] Incremental R2 (full-covars): 0.11885 PGS R2 (no covariates): 0.118 [0.11343, 0.12257] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007105 | PGS001531 (GBE_INI4122) |
PSS007311| African Ancestry| 3,592 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (R) | — | — | R²: 0.02141 [0.01445, 0.02837] Incremental R2 (full-covars): 0.0063 PGS R2 (no covariates): 0.00698 [0.00295, 0.01101] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007106 | PGS001531 (GBE_INI4122) |
PSS007312| East Asian Ancestry| 782 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (R) | — | — | R²: 0.09852 [0.07171, 0.12534] Incremental R2 (full-covars): 0.07672 PGS R2 (no covariates): 0.07776 [0.05339, 0.10214] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007107 | PGS001531 (GBE_INI4122) |
PSS007313| European Ancestry| 10,633 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (R) | — | — | R²: 0.16134 [0.15298, 0.16971] Incremental R2 (full-covars): 0.10988 PGS R2 (no covariates): 0.11176 [0.10439, 0.11914] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007108 | PGS001531 (GBE_INI4122) |
PSS007314| South Asian Ancestry| 5,041 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (R) | — | — | R²: 0.07785 [0.06646, 0.08924] Incremental R2 (full-covars): 0.05682 PGS R2 (no covariates): 0.05742 [0.04742, 0.06742] |
age, sex, UKB array type, Genotype PCs | — |
| PPM007109 | PGS001531 (GBE_INI4122) |
PSS007315| European Ancestry| 25,728 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Speed of sound through heel (R) | — | — | R²: 0.17507 [0.16986, 0.18028] Incremental R2 (full-covars): 0.12574 PGS R2 (no covariates): 0.12479 [0.12013, 0.12946] |
age, sex, UKB array type, Genotype PCs | — |
| PPM010515 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS009446| European Ancestry| 11,484 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.4537 [0.4391, 0.4682] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010516 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS009220| European Ancestry| 2,146 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.4397 [0.4048, 0.4734] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010519 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS008326| South Asian Ancestry| 1,972 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.3477 [0.3081, 0.3861] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010520 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS008103| East Asian Ancestry| 820 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.3057 [0.2415, 0.3672] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010521 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS007890| African Ancestry| 790 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.1895 [0.1204, 0.2567] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010522 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS008994| African Ancestry| 1,406 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.1746 [0.1231, 0.2252] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010517 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS008774| European Ancestry| 3,461 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.3929 [0.3643, 0.4208] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010518 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS008548| Greater Middle Eastern Ancestry| 506 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.2944 [0.211, 0.3736] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM022387 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of vertebral column without mention of spinal cord injury (Phecode 805) | OR: 1.93 | — | — | — | — |
| PPM022388 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Osteoporosis (Phecode 743.1) | OR: 1.68 | — | — | — | — |
| PPM022389 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Osteoporosis NOS (Phecode 743.11) | OR: 1.68 | — | — | — | — |
| PPM022390 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Osteoporosis (Phecode 743) | OR: 1.61 | — | — | — | — |
| PPM022391 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of upper limb (Phecode 803) | OR: 2.93 | — | — | — | — |
| PPM022392 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of radius and ulna (Phecode 803.2) | OR: 3.64 | — | — | — | — |
| PPM022393 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of lower limb (Phecode 800) | OR: 2.51 | — | — | — | — |
| PPM022394 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of humerus (Phecode 803.1) | OR: 3.54 | — | — | — | — |
| PPM022395 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of ankle and foot (Phecode 801) | OR: 2.78 | — | — | — | — |
| PPM022396 | PGS001955 (portability-PLR_log_heel_BMD) |
PSS011935| East Asian Ancestry| 3,744 individuals |
PGP000710 | Chen JJ et al. Arch Osteoporos (2023) |Ext. |
Reported Trait: Fracture of tibia and fibula (Phecode 800.3) | OR: 4.45 | — | — | — | — |
| PPM010523 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS009447| European Ancestry| 11,485 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.4264 [0.4113, 0.4413] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010524 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS009221| European Ancestry| 2,147 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.4076 [0.3715, 0.4424] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010525 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS008775| European Ancestry| 3,463 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.3665 [0.3372, 0.395] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010526 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS008549| Greater Middle Eastern Ancestry| 505 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.306 [0.223, 0.3845] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010527 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS008327| South Asian Ancestry| 1,968 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.3216 [0.2812, 0.3609] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010528 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS008104| East Asian Ancestry| 819 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.2762 [0.2109, 0.3391] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010529 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS007891| African Ancestry| 795 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.1457 [0.076, 0.2139] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010530 | PGS001956 (portability-PLR_log_heel_BUA) |
PSS008995| African Ancestry| 1,404 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.1465 [0.0946, 0.1977] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012231 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS009446| European Ancestry| 11,484 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.4429 [0.428, 0.4575] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012232 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS009220| European Ancestry| 2,146 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.4242 [0.3886, 0.4584] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012233 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS008774| European Ancestry| 3,461 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.384 [0.3551, 0.4121] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012234 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS008548| Greater Middle Eastern Ancestry| 506 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.3123 [0.2297, 0.3904] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012235 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS008326| South Asian Ancestry| 1,972 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.338 [0.2981, 0.3767] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012236 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS008103| East Asian Ancestry| 820 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.285 [0.22, 0.3474] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012237 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS007890| African Ancestry| 790 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.1699 [0.1005, 0.2377] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012238 | PGS002173 (portability-ldpred2_log_heel_BMD) |
PSS008994| African Ancestry| 1,406 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel bone mineral density (BMD) | — | — | Partial Correlation (partial-r): 0.1647 [0.113, 0.2154] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012240 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS009221| European Ancestry| 2,147 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.3925 [0.3559, 0.4278] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012241 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS008775| European Ancestry| 3,463 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.3599 [0.3305, 0.3887] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012242 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS008549| Greater Middle Eastern Ancestry| 505 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.3282 [0.2463, 0.4054] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012243 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS008327| South Asian Ancestry| 1,968 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.3051 [0.2643, 0.3449] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012244 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS008104| East Asian Ancestry| 819 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.2633 [0.1976, 0.3267] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012245 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS007891| African Ancestry| 795 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.1219 [0.0519, 0.1907] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012246 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS008995| African Ancestry| 1,404 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.1515 [0.0996, 0.2026] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM012239 | PGS002174 (portability-ldpred2_log_heel_BUA) |
PSS009447| European Ancestry| 11,485 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Heel Broadband ultrasound attenuation, direct entry | — | — | Partial Correlation (partial-r): 0.4168 [0.4015, 0.4318] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM014968 | PGS002768 (BMD_prscs) |
PSS009939| European Ancestry| 39,444 individuals |
PGP000364 | Mars N et al. Am J Hum Genet (2022) |
Reported Trait: Osteoporosis | OR: 1.31 [1.25, 1.38] | — | — | age, sex, 10 PCs, technical covariates | — |
| PPM017631 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010647| European Ancestry| 3,384 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.15 | sex, age, deprivation index, PC1-16 | — |
| PPM017799 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010227| European Ancestry| 1,383 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.17 | sex, age, deprivation index, PC1-16 | — |
| PPM017883 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010479| South Asian Ancestry| 1,965 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.11 | sex, age, deprivation index, PC1-16 | — |
| PPM017967 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010395| East Asian Ancestry| 811 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.07 | sex, age, deprivation index, PC1-16 | — |
| PPM018051 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010311| African Ancestry| 786 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.02 | sex, age, deprivation index, PC1-16 | — |
| PPM018135 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010731| African Ancestry| 1,397 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.03 | sex, age, deprivation index, PC1-16 | — |
| PPM017463 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010899| European Ancestry| 11,350 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.2 | sex, age, deprivation index, PC1-16 | — |
| PPM017547 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010815| European Ancestry| 2,145 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.19 | sex, age, deprivation index, PC1-16 | — |
| PPM017715 | PGS003535 (cont-decay-log_heel_BMD) |
PSS010563| Greater Middle Eastern Ancestry| 487 individuals |
PGP000457 | Ding Y et al. Nature (2023) |
Reported Trait: Heel bone mineral density (BMD) | — | — | partial-R2: 0.1 | sex, age, deprivation index, PC1-16 | — |
| PPM020526 | PGS004411 (X78.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated | — | — | PGS R2 (no covariates): 0.30125 | — | — |
| PPM020530 | PGS004415 (X3148.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Heel bone mineral density (BMD) | — | — | PGS R2 (no covariates): 0.30248 | — | — |
| PPM020534 | PGS004419 (X4105.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Heel bone mineral density (BMD) (left) | — | — | PGS R2 (no covariates): 0.2483 | — | — |
| PPM020535 | PGS004420 (X4106.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (left) | — | — | PGS R2 (no covariates): 0.24744 | — | — |
| PPM020539 | PGS004424 (X4124.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Heel bone mineral density (BMD) (right) | — | — | PGS R2 (no covariates): 0.24863 | — | — |
| PPM020540 | PGS004425 (X4125.score) |
PSS011364| European Ancestry| 56,192 individuals |
PGP000561 | Jung H et al. Commun Biol (2024) |
Reported Trait: Heel bone mineral density (BMD) T-score, automated (right) | — | — | PGS R2 (no covariates): 0.24814 | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS007231 | — | — | 1,434 individuals | — | African unspecified | — | UKB | — |
| PSS007232 | — | — | 500 individuals | — | East Asian | — | UKB | — |
| PSS007233 | — | — | 7,691 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007234 | — | — | 1,449 individuals | — | South Asian | — | UKB | — |
| PSS007235 | — | — | 24,146 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS007241 | — | — | 2,248 individuals | — | African unspecified | — | UKB | — |
| PSS007242 | — | — | 794 individuals | — | East Asian | — | UKB | — |
| PSS007243 | — | — | 12,374 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007244 | — | — | 2,310 individuals | — | South Asian | — | UKB | — |
| PSS007245 | — | — | 38,814 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS007281 | — | — | 3,560 individuals | — | African unspecified | — | UKB | — |
| PSS007282 | — | — | 781 individuals | — | East Asian | — | UKB | — |
| PSS007283 | — | — | 10,636 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007284 | — | — | 5,043 individuals | — | South Asian | — | UKB | — |
| PSS007285 | — | — | 25,716 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS007291 | — | — | 3,558 individuals | — | African unspecified | — | UKB | — |
| PSS007292 | — | — | 781 individuals | — | East Asian | — | UKB | — |
| PSS007293 | — | — | 10,626 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007294 | — | — | 5,037 individuals | — | South Asian | — | UKB | — |
| PSS007295 | — | — | 25,706 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS007296 | — | — | 3,560 individuals | — | African unspecified | — | UKB | — |
| PSS007297 | — | — | 781 individuals | — | East Asian | — | UKB | — |
| PSS007298 | — | — | 10,636 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007299 | — | — | 5,043 individuals | — | South Asian | — | UKB | — |
| PSS007300 | — | — | 25,716 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009220 | — | — | 2,146 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS009221 | — | — | 2,147 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS010731 | — | — | 1,397 individuals, 49.0 % Male samples |
Mean = 51.9 years Sd = 8.1 years |
African unspecified | Nigerian | UKB | — |
| PSS007311 | — | — | 3,592 individuals | — | African unspecified | — | UKB | — |
| PSS007312 | — | — | 782 individuals | — | East Asian | — | UKB | — |
| PSS007313 | — | — | 10,633 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007314 | — | — | 5,041 individuals | — | South Asian | — | UKB | — |
| PSS007315 | — | — | 25,728 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS010227 | — | — | 1,383 individuals, 46.0 % Male samples |
Mean = 57.7 years Sd = 7.1 years |
European | Ashkenazi | UKB | — |
| PSS007321 | — | — | 3,586 individuals | — | African unspecified | — | UKB | — |
| PSS007322 | — | — | 782 individuals | — | East Asian | — | UKB | — |
| PSS007323 | — | — | 10,627 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007324 | — | — | 5,032 individuals | — | South Asian | — | UKB | — |
| PSS007325 | — | — | 25,715 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS007326 | — | — | 3,592 individuals | — | African unspecified | — | UKB | — |
| PSS007327 | — | — | 782 individuals | — | East Asian | — | UKB | — |
| PSS007328 | — | — | 10,633 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007329 | — | — | 5,041 individuals | — | South Asian | — | UKB | — |
| PSS007330 | — | — | 25,728 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS008774 | — | — | 3,461 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS008775 | — | — | 3,463 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS011935 | — | — | 3,744 individuals, 24.0 % Male samples |
Mean = 66.7 years | East Asian | — | TPMI | — |
| PSS010815 | — | — | 2,145 individuals, 39.0 % Male samples |
Mean = 54.3 years Sd = 7.2 years |
European | Polish | UKB | — |
| PSS010311 | — | — | 786 individuals, 35.0 % Male samples |
Mean = 52.2 years Sd = 8.1 years |
African American or Afro-Caribbean | Caribbean | UKB | — |
| PSS008326 | — | — | 1,972 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS008327 | — | — | 1,968 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS009939 | — | — | 39,444 individuals | — | European (Finnish) |
— | FinnGen | — |
| PSS010899 | — | — | 11,350 individuals, 46.0 % Male samples |
Mean = 56.9 years Sd = 7.8 years |
European | white British | UKB | — |
| PSS007476 | — | — | 2,253 individuals | — | African unspecified | — | UKB | — |
| PSS007477 | — | — | 795 individuals | — | East Asian | — | UKB | — |
| PSS007478 | — | — | 12,376 individuals | — | European | non-white British ancestry | UKB | — |
| PSS007479 | — | — | 2,312 individuals | — | South Asian | — | UKB | — |
| PSS007480 | — | — | 38,834 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS010395 | — | — | 811 individuals, 35.0 % Male samples |
Mean = 51.9 years Sd = 7.5 years |
East Asian | Chinese | UKB | — |
| PSS007890 | — | — | 790 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS007891 | — | — | 795 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS009446 | — | — | 11,484 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS000585 | — | — | 4,741 individuals, 47.5 % Male samples |
Mean = 55.8 years Sd = 7.6 years |
European | — | UKB | — |
| PSS000585 | — | — | 6,704 individuals, 49.3 % Male samples |
Mean = 62.6 years Sd = 9.9 years |
European, NR | — | CLSA | — |
| PSS000585 | — | — | 3,426 individuals, 0.0 % Male samples |
Mean = 71.5 years Sd = 5.3 years |
European, NR | — | SOF | — |
| PSS000585 | — | — | 4,657 individuals, 100.0 % Male samples |
Mean = 74.0 years Sd = 6.0 years |
European | — | MrOS-USA | — |
| PSS000585 | — | — | 1,880 individuals, 100.0 % Male samples |
Mean = 75.4 years Sd = 3.2 years |
European (Swedish) |
— | MrOS-SWE | — |
| PSS000586 | — | — | 80,027 individuals, 47.5 % Male samples |
Mean = 55.8 years Sd = 7.6 years |
European | — | UKB | — |
| PSS009447 | — | — | 11,485 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS010479 | — | — | 1,965 individuals, 55.0 % Male samples |
Mean = 52.7 years Sd = 8.2 years |
South Asian | Indian | UKB | — |
| PSS011364 | — | — | 56,192 individuals | — | European | — | UKB | — |
| PSS008994 | — | — | 1,406 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008995 | — | — | 1,404 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS000932 | Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 | — | [ ,
40.52 % Male samples |
Mean = 58.6 years Sd = 7.7 years |
European | — | UKB | — |
| PSS000933 | Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 | — | [ ,
40.52 % Male samples |
Mean = 58.6 years Sd = 7.6 years |
European | — | UKB | — |
| PSS000934 | Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322 | — | [ ,
46.27 % Male samples |
Mean = 56.5 years Sd = 8.2 years |
European | — | UKB | — |
| PSS000935 | Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321 | — | [ ,
46.27 % Male samples |
Mean = 56.5 years Sd = 8.1 years |
European | — | UKB | — |
| PSS000936 | Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 | — | [ ,
45.36 % Male samples |
Mean = 56.8 years Sd = 8.1 years |
European | — | UKB | — |
| PSS000937 | Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 | — | [ ,
45.36 % Male samples |
Mean = 56.8 years Sd = 8.0 years |
European | — | UKB | — |
| PSS000938 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. | — | [ ,
42.7 % Male samples |
Mean = 53.7 years Sd = 11.0 years |
East Asian | — | CKB | — |
| PSS000939 | Cases included individuals with a hip fracture that occurred after the baseline visit. | — | [ ,
100.0 % Male samples |
Mean = 75.4 years Sd = 3.2 years |
European | — | MrOS-SWE | — |
| PSS000940 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. | — | [ ,
100.0 % Male samples |
Mean = 75.4 years Sd = 3.2 years |
European | — | MrOS-SWE | — |
| PSS000941 | Cases included individuals with a hip fracture that occurred after the baseline visit. | Mean = 4.5 years | [ ,
100.0 % Male samples |
Mean = 74.0 years Sd = 6.0 years |
European | — | MrOS-USA | — |
| PSS000942 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. | Mean = 4.5 years | [ ,
100.0 % Male samples |
Mean = 74.0 years Sd = 6.0 years |
European | — | MrOS-USA | — |
| PSS000943 | Cases included individuals with a hip fracture that occurred after the baseline visit. | Range = [4.5, 14.5] years | [ ,
56.33 % Male samples |
— | European | — | MrOS-USA, SOF | — |
| PSS000944 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. | Range = [4.5, 14.5] years | [ ,
56.33 % Male samples |
— | European | — | MrOS-USA, SOF | — |
| PSS000945 | Cases included individuals with a hip fracture that occurred after the baseline visit. | Mean = 14.5 years | [ ,
0.0 % Male samples |
Mean = 71.5 years Sd = 5.3 years |
European | — | SOF | — |
| PSS000946 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. | Mean = 14.5 years | [ ,
0.0 % Male samples |
Mean = 71.5 years Sd = 5.3 years |
European | — | SOF | — |
| PSS000947 | Cases included individuals with a hip fracture that occurred after the baseline visit. | — | [ ,
45.36 % Male samples |
Mean = 56.8 years Sd = 8.0 years |
European | — | UKB | — |
| PSS000948 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722. | — | [ ,
45.36 % Male samples |
Mean = 56.8 years Sd = 8.0 years |
European | — | UKB | — |
| PSS000949 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722. | — | [
|
— | European | — | UKB | — |
| PSS000950 | Cases included individuals with a hip fracture that occurred after the baseline visit. | Range = [4.5, 14.5] years | [ ,
31.61 % Male samples |
— | European | — | MrOS-SWE, MrOS-USA, SOF, UKB | — |
| PSS000951 | Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. UKB cohort: Sitespecific major osteoporotic fractures were defined basedon ICD10 codes of primary diagnoses (M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722) and self-reported medical history. | Range = [4.5, 14.5] years | [ ,
31.61 % Male samples |
— | European | — | MrOS-SWE, MrOS-USA, SOF, UKB | — |
| PSS008548 | — | — | 506 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS008549 | — | — | 505 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS010563 | — | — | 487 individuals, 65.0 % Male samples |
Mean = 51.1 years Sd = 7.6 years |
Greater Middle Eastern (Middle Eastern, North African or Persian) | Iranian | UKB | — |
| PSS008103 | — | — | 820 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS008104 | — | — | 819 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS010647 | — | — | 3,384 individuals, 46.0 % Male samples |
Mean = 54.5 years Sd = 8.2 years |
European | Italian | UKB | — |