Trait: dizziness

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009847
Description A sensation of lightheadedness, unsteadiness, turning, spinning or rocking.
Trait category
Other trait
Synonyms 2 synonyms
  • dizzy
  • lightheadedness

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019101
(TPMI_386.9_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 151,833
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019101/ScoringFiles/PGS019101.txt.gz
PGS019102
(TPMI_386.9_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 364,424
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019102/ScoringFiles/PGS019102.txt.gz
PGS019103
(TPMI_386.9_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 19,338
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019103/ScoringFiles/PGS019103.txt.gz
PGS019104
(TPMI_386.9_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019104/ScoringFiles/PGS019104.txt.gz
PGS019105
(TPMI_386.9_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 931,755
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019105/ScoringFiles/PGS019105.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037283 PGS019101
(TPMI_386.9_Lassosum2)
 PSS013004|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59487 R²: 0.0355 sex, age, array, PCs 1-10 —
PPM037284 PGS019102
(TPMI_386.9_LDpred2)
 PSS013003|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59652 R²: 0.03685 sex, age, array, PCs 1-10 —
PPM037285 PGS019103
(TPMI_386.9_MegaPRS)
 PSS013005|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59305 R²: 0.03412 sex, age, array, PCs 1-10 —
PPM037286 PGS019104
(TPMI_386.9_PRS-CS)
 PSS013006|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59608 R²: 0.0364 sex, age, array, PCs 1-10 —
PPM037287 PGS019105
(TPMI_386.9_SBayesR)
 PSS013007|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.5932 R²: 0.03466 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013003 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013004 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013005 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013006 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013007 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —