Trait: Vertigo

Trait Information
Identifier HP_0002321
Description An abnormal sensation of spinning while the body is actually stationary.
Trait category
Other trait
Synonyms 2 synonyms
  • Dizziness
  • Dizzy spell

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019091
(TPMI_386.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Peripheral or central vertigo Vertigo 230,260
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019091/ScoringFiles/PGS019091.txt.gz
PGS019092
(TPMI_386.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Peripheral or central vertigo Vertigo 939,888
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019092/ScoringFiles/PGS019092.txt.gz
PGS019093
(TPMI_386.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Peripheral or central vertigo Vertigo 508,434
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019093/ScoringFiles/PGS019093.txt.gz
PGS019094
(TPMI_386.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Peripheral or central vertigo Vertigo 983,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019094/ScoringFiles/PGS019094.txt.gz
PGS019095
(TPMI_386.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Peripheral or central vertigo Vertigo 968,450
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019095/ScoringFiles/PGS019095.txt.gz
PGS019101
(TPMI_386.9_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 151,833
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019101/ScoringFiles/PGS019101.txt.gz
PGS019102
(TPMI_386.9_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 364,424
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019102/ScoringFiles/PGS019102.txt.gz
PGS019103
(TPMI_386.9_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 19,338
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019103/ScoringFiles/PGS019103.txt.gz
PGS019104
(TPMI_386.9_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019104/ScoringFiles/PGS019104.txt.gz
PGS019105
(TPMI_386.9_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dizziness and giddiness Light headedness and vertigo dizziness,
Vertigo		 931,755
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019105/ScoringFiles/PGS019105.txt.gz
PGS019106
(TPMI_386.21_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Central origin vertigo Vertigo 408
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019106/ScoringFiles/PGS019106.txt.gz
PGS019107
(TPMI_386.21_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Central origin vertigo Vertigo 939,886
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019107/ScoringFiles/PGS019107.txt.gz
PGS019108
(TPMI_386.21_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Central origin vertigo Vertigo 17,870
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019108/ScoringFiles/PGS019108.txt.gz
PGS019109
(TPMI_386.21_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Central origin vertigo Vertigo 983,824
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019109/ScoringFiles/PGS019109.txt.gz
PGS019110
(TPMI_386.21_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Central origin vertigo Vertigo 968,081
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019110/ScoringFiles/PGS019110.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037273 PGS019091
(TPMI_386.2_Lassosum2)
 PSS012994|
East Asian Ancestry|
18,043 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Peripheral or central vertigo — AUROC: 0.59398 R²: 0.02847 sex, age, array, PCs 1-10 —
PPM037274 PGS019092
(TPMI_386.2_LDpred2)
 PSS012993|
East Asian Ancestry|
18,043 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Peripheral or central vertigo — AUROC: 0.59663 R²: 0.03001 sex, age, array, PCs 1-10 —
PPM037275 PGS019093
(TPMI_386.2_MegaPRS)
 PSS012995|
East Asian Ancestry|
18,043 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Peripheral or central vertigo — AUROC: 0.59699 R²: 0.03001 sex, age, array, PCs 1-10 —
PPM037276 PGS019094
(TPMI_386.2_PRS-CS)
 PSS012996|
East Asian Ancestry|
18,043 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Peripheral or central vertigo — AUROC: 0.59548 R²: 0.02932 sex, age, array, PCs 1-10 —
PPM037277 PGS019095
(TPMI_386.2_SBayesR)
 PSS012997|
East Asian Ancestry|
18,043 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Peripheral or central vertigo — AUROC: 0.59357 R²: 0.0281 sex, age, array, PCs 1-10 —
PPM037283 PGS019101
(TPMI_386.9_Lassosum2)
 PSS013004|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59487 R²: 0.0355 sex, age, array, PCs 1-10 —
PPM037284 PGS019102
(TPMI_386.9_LDpred2)
 PSS013003|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59652 R²: 0.03685 sex, age, array, PCs 1-10 —
PPM037285 PGS019103
(TPMI_386.9_MegaPRS)
 PSS013005|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59305 R²: 0.03412 sex, age, array, PCs 1-10 —
PPM037286 PGS019104
(TPMI_386.9_PRS-CS)
 PSS013006|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.59608 R²: 0.0364 sex, age, array, PCs 1-10 —
PPM037287 PGS019105
(TPMI_386.9_SBayesR)
 PSS013007|
East Asian Ancestry|
18,550 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dizziness and giddiness Light headedness and vertigo — AUROC: 0.5932 R²: 0.03466 sex, age, array, PCs 1-10 —
PPM037288 PGS019106
(TPMI_386.21_Lassosum2)
 PSS012989|
East Asian Ancestry|
17,964 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Central origin vertigo — AUROC: 0.58104 R²: 0.0104 sex, age, array, PCs 1-10 —
PPM037289 PGS019107
(TPMI_386.21_LDpred2)
 PSS012988|
East Asian Ancestry|
17,964 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Central origin vertigo — AUROC: 0.5823 R²: 0.0109 sex, age, array, PCs 1-10 —
PPM037290 PGS019108
(TPMI_386.21_MegaPRS)
 PSS012990|
East Asian Ancestry|
17,964 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Central origin vertigo — AUROC: 0.58279 R²: 0.0107 sex, age, array, PCs 1-10 —
PPM037291 PGS019109
(TPMI_386.21_PRS-CS)
 PSS012991|
East Asian Ancestry|
17,964 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Central origin vertigo — AUROC: 0.5819 R²: 0.0107 sex, age, array, PCs 1-10 —
PPM037292 PGS019110
(TPMI_386.21_SBayesR)
 PSS012992|
East Asian Ancestry|
17,964 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Central origin vertigo — AUROC: 0.58029 R²: 0.01028 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012989 386.2,H81 —
[
  • 783 cases
  • , 17,181 controls
]
,
46.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012990 386.2,H81 —
[
  • 783 cases
  • , 17,181 controls
]
,
46.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012991 386.2,H81 —
[
  • 783 cases
  • , 17,181 controls
]
,
46.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012992 386.2,H81 —
[
  • 783 cases
  • , 17,181 controls
]
,
46.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012993 386.1, 386.2,H81 —
[
  • 862 cases
  • , 17,181 controls
]
,
46.8 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012994 386.1, 386.2,H81 —
[
  • 862 cases
  • , 17,181 controls
]
,
46.8 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012995 386.1, 386.2,H81 —
[
  • 862 cases
  • , 17,181 controls
]
,
46.8 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012996 386.1, 386.2,H81 —
[
  • 862 cases
  • , 17,181 controls
]
,
46.8 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012997 386.1, 386.2,H81 —
[
  • 862 cases
  • , 17,181 controls
]
,
46.8 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013003 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013004 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013005 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013006 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013007 780.4,R42 —
[
  • 1,369 cases
  • , 17,181 controls
]
,
46.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012988 386.2,H81 —
[
  • 783 cases
  • , 17,181 controls
]
,
46.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —