Trait: frailty measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009885
Description Quantification of some aspect of frailty. Frailty is usually described as clinical state of heightened vulnerability to poor resolution of homeostasis after a stressor event, which thereby increases the risk of adverse outcomes, including falls, delirium, disability and mortality.
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005221
(General_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 General factor of frailty frailty measurement 943,126
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005221/ScoringFiles/PGS005221.txt.gz
PGS005222
(F1_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Factor 1 (social isolation) of frailty frailty measurement 1,727,299
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005222/ScoringFiles/PGS005222.txt.gz
PGS005223
(F2_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Factor 2 (unhealthy lifestyle) of frailty frailty measurement 1,719,220
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005223/ScoringFiles/PGS005223.txt.gz
PGS005224
(F3_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Factor 3 (multimorbidity) of frailty frailty measurement 1,588,232
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005224/ScoringFiles/PGS005224.txt.gz
PGS005225
(F4_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Factor 4 (metabolic/respiratory problems) of frailty frailty measurement 710,413
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005225/ScoringFiles/PGS005225.txt.gz
PGS005226
(F5_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Factor 5 (poorer cognition) of frailty frailty measurement 1,715,891
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005226/ScoringFiles/PGS005226.txt.gz
PGS005227
(F6_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Factor 6 (disability) of frailty frailty measurement 1,726,064
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005227/ScoringFiles/PGS005227.txt.gz
PGS005228
(FI_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Frailty Index frailty measurement 2,379,429
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005228/ScoringFiles/PGS005228.txt.gz
PGS005229
(FFS_Frailty)
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Fried Frailty Score frailty measurement 2,761,868
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005229/ScoringFiles/PGS005229.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022627 PGS005221
(General_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.09
β: 0.09		 — R²: 0.009
FDR corrected P-value: 3.29e-08		 age, sex, PC1-PC10 —
PPM022636 PGS005221
(General_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.11
β: 0.1		 — R²: 0.006
FDR corrected P-value: 2.00e-16		 age, sex, PC1-PC10 —
PPM022645 PGS005221
(General_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.08
β: 0.08		 — R²: 0.0002
FDR corrected P-value: 0.00846		 age, sex, PC1-PC4 —
PPM022621 PGS005222
(F1_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.0
β: 0.0021		 — R²: 0.0
FDR corrected P-value: 0.84		 age, sex, PC1-PC10 —
PPM022630 PGS005222
(F1_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 0.99
β: -0.008		 — R²: 0.0058
FDR corrected P-value: 0.48		 age, sex, PC1-PC10 —
PPM022639 PGS005222
(F1_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 0.96
β: -0.037		 — R²: 0.007
FDR corrected P-value: 0.24		 age, sex, PC1-PC4 —
PPM022622 PGS005223
(F2_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.05
β: 0.053		 — R²: 0.0
FDR corrected P-value: 7.50e-07		 age, sex, PC1-PC10 —
PPM022631 PGS005223
(F2_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.03
β: 0.029		 — R²: 0.00015
FDR corrected P-value: 0.02		 age, sex, PC1-PC10 —
PPM022640 PGS005223
(F2_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.06
β: 0.06		 — R²: 0.0
FDR corrected P-value: 0.0502		 age, sex, PC1-PC4 —
PPM022623 PGS005224
(F3_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.06
β: 0.056		 — R²: 0.0034
FDR corrected P-value: 1.35e-07		 age, sex, PC1-PC10 —
PPM022632 PGS005224
(F3_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.03
β: 0.03		 — R²: 0.00155
FDR corrected P-value: 0.007		 age, sex, PC1-PC10 —
PPM022641 PGS005224
(F3_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.13
β: 0.12		 — R²: 0.001
FDR corrected P-value: 0.00021		 age, sex, PC1-PC4 —
PPM022624 PGS005225
(F4_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.04
β: 0.037		 — R²: 0.0015
FDR corrected P-value: 0.00043		 age, sex, PC1-PC10 —
PPM022633 PGS005225
(F4_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.04
β: 0.042		 — R²: 0.0021
FDR corrected P-value: 0.001		 age, sex, PC1-PC10 —
PPM022642 PGS005225
(F4_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.03
β: 0.03		 — R²: 0.011
FDR corrected P-value: 0.331		 age, sex, PC1-PC4 —
PPM022625 PGS005226
(F5_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.06
β: 0.06		 — R²: 0.004
FDR corrected P-value: 1.22e-08		 age, sex, PC1-PC10 —
PPM022634 PGS005226
(F5_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.01
β: 0.006		 — R²: 0.003
FDR corrected P-value: 0.62		 age, sex, PC1-PC10 —
PPM022643 PGS005226
(F5_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.09
β: 0.082		 — R²: 0.0
FDR corrected P-value: 0.082		 age, sex, PC1-PC4 —
PPM022626 PGS005227
(F6_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.05
β: 0.046		 — R²: 0.0022
FDR corrected P-value: 2e-05		 age, sex, PC1-PC10 —
PPM022635 PGS005227
(F6_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.05
β: 0.05		 — R²: 7e-05
FDR corrected P-value: 3.91e-06		 age, sex, PC1-PC10 —
PPM022644 PGS005227
(F6_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.05
β: 0.048		 — R²: 0.005
FDR corrected P-value: 0.129		 age, sex, PC1-PC4 —
PPM022628 PGS005228
(FI_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.12
β: 0.11		 — R²: 0.02
FDR corrected P-value: 2.00e-16		 age, sex, PC1-PC10 —
PPM022637 PGS005228
(FI_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.11
β: 0.1		 — R²: 0.021
FDR corrected P-value: 9.79e-07		 age, sex, PC1-PC10 —
PPM022646 PGS005228
(FI_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.15
β: 0.14		 — R²: 0.005
FDR corrected P-value: 3.93e-06		 age, sex, PC1-PC4 —
PPM022629 PGS005229
(FFS_Frailty)
 PSS012044|
European Ancestry|
7,181 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.08
β: 0.076		 — R²: 0.0138
FDR corrected P-value: 2.48e-06		 age, sex, PC1-PC10 —
PPM022638 PGS005229
(FFS_Frailty)
 PSS012046|
European Ancestry|
3,265 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.08
β: 0.073		 — R²: 0.03
FDR corrected P-value: 2e-05		 age, sex, PC1-PC10 —
PPM022647 PGS005229
(FFS_Frailty)
 PSS012045|
European Ancestry|
1,005 individuals
 PGP000735 |
Foote IF et al. Nat Genet (2024)
 Reported Trait: Frailty Index OR: 1.16
β: 0.15		 — R²: 0.019
FDR corrected P-value: 2.48e-06		 age, sex, PC1-PC4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012046 — — 3,265 individuals,
32.0 % Male samples
 Mean = 60.34 years
Sd = 6.98 years		 European — PISA —
PSS012044 — — 7,181 individuals,
46.0 % Male samples
 Mean = 68.45 years European — ELSA —
PSS012045 — — 1,005 individuals,
51.0 % Male samples
 Mean = 69.6 years
Sd = 6.98 years		 European — LBC —