Trait: Nephropathy

Trait Information
Identifier HP_0000112
Description A nonspecific term referring to disease or damage of the kidneys.
Trait category
Other trait
Synonyms 2 synonyms
  • Kidney damage
  • Kidney disease

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019410
(TPMI_580.3_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy without mention of glomerulonephritis Nephropathy 238,700
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019410/ScoringFiles/PGS019410.txt.gz
PGS019411
(TPMI_580.3_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy without mention of glomerulonephritis Nephropathy 939,838
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019411/ScoringFiles/PGS019411.txt.gz
PGS019412
(TPMI_580.3_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy without mention of glomerulonephritis Nephropathy 55,104
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019412/ScoringFiles/PGS019412.txt.gz
PGS019413
(TPMI_580.3_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy without mention of glomerulonephritis Nephropathy 983,793
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019413/ScoringFiles/PGS019413.txt.gz
PGS019414
(TPMI_580.3_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy without mention of glomerulonephritis Nephropathy 998,548
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019414/ScoringFiles/PGS019414.txt.gz
PGS019415
(TPMI_580.31_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 222,116
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019415/ScoringFiles/PGS019415.txt.gz
PGS019416
(TPMI_580.31_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 939,830
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019416/ScoringFiles/PGS019416.txt.gz
PGS019417
(TPMI_580.31_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 54,233
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019417/ScoringFiles/PGS019417.txt.gz
PGS019418
(TPMI_580.31_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 983,787
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019418/ScoringFiles/PGS019418.txt.gz
PGS019419
(TPMI_580.31_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 1,071,477
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019419/ScoringFiles/PGS019419.txt.gz
PGS019420
(TPMI_580.31_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 997,096
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019420/ScoringFiles/PGS019420.txt.gz
PGS019421
(TPMI_580.32_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 217,972
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019421/ScoringFiles/PGS019421.txt.gz
PGS019422
(TPMI_580.32_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 939,872
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019422/ScoringFiles/PGS019422.txt.gz
PGS019423
(TPMI_580.32_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 44,839
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019423/ScoringFiles/PGS019423.txt.gz
PGS019424
(TPMI_580.32_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 983,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019424/ScoringFiles/PGS019424.txt.gz
PGS019425
(TPMI_580.32_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 1,071,476
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019425/ScoringFiles/PGS019425.txt.gz
PGS019426
(TPMI_580.32_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 966,152
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019426/ScoringFiles/PGS019426.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037592 PGS019410
(TPMI_580.3_Lassosum2)
 PSS013320|
East Asian Ancestry|
17,456 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy without mention of glomerulonephritis — AUROC: 0.64589 R²: 0.04626 sex, age, array, PCs 1-10 —
PPM037593 PGS019411
(TPMI_580.3_LDpred2)
 PSS013319|
East Asian Ancestry|
17,456 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy without mention of glomerulonephritis — AUROC: 0.65111 R²: 0.04906 sex, age, array, PCs 1-10 —
PPM037594 PGS019412
(TPMI_580.3_MegaPRS)
 PSS013321|
East Asian Ancestry|
17,456 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy without mention of glomerulonephritis — AUROC: 0.643 R²: 0.04408 sex, age, array, PCs 1-10 —
PPM037595 PGS019413
(TPMI_580.3_PRS-CS)
 PSS013322|
East Asian Ancestry|
17,456 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy without mention of glomerulonephritis — AUROC: 0.65017 R²: 0.0485 sex, age, array, PCs 1-10 —
PPM037596 PGS019414
(TPMI_580.3_SBayesR)
 PSS013323|
East Asian Ancestry|
17,456 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy without mention of glomerulonephritis — AUROC: 0.64737 R²: 0.04608 sex, age, array, PCs 1-10 —
PPM037597 PGS019415
(TPMI_580.31_Lassosum2)
 PSS013308|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.6585 R²: 0.03931 sex, age, array, PCs 1-10 —
PPM037598 PGS019416
(TPMI_580.31_LDpred2)
 PSS013307|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.66245 R²: 0.04194 sex, age, array, PCs 1-10 —
PPM037599 PGS019417
(TPMI_580.31_MegaPRS)
 PSS013309|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.65425 R²: 0.0357 sex, age, array, PCs 1-10 —
PPM037600 PGS019418
(TPMI_580.31_PRS-CS)
 PSS013310|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.66254 R²: 0.04057 sex, age, array, PCs 1-10 —
PPM037601 PGS019419
(TPMI_580.31_PRSmix+)
 PSS013311|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.69552 R²: 0.05556 sex, age, array, PCs 1-10 —
PPM037602 PGS019420
(TPMI_580.31_SBayesR)
 PSS013312|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.65715 R²: 0.03786 sex, age, array, PCs 1-10 —
PPM037603 PGS019421
(TPMI_580.32_Lassosum2)
 PSS013314|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.63652 R²: 0.03429 sex, age, array, PCs 1-10 —
PPM037604 PGS019422
(TPMI_580.32_LDpred2)
 PSS013313|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.64282 R²: 0.03739 sex, age, array, PCs 1-10 —
PPM037605 PGS019423
(TPMI_580.32_MegaPRS)
 PSS013315|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.63175 R²: 0.03166 sex, age, array, PCs 1-10 —
PPM037606 PGS019424
(TPMI_580.32_PRS-CS)
 PSS013316|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.64305 R²: 0.03686 sex, age, array, PCs 1-10 —
PPM037607 PGS019425
(TPMI_580.32_PRSmix+)
 PSS013317|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.67014 R²: 0.05102 sex, age, array, PCs 1-10 —
PPM037608 PGS019426
(TPMI_580.32_SBayesR)
 PSS013318|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.63695 R²: 0.03415 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013309 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013310 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013311 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013312 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013313 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013314 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013315 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013316 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013317 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013318 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013319 583.6, 583.7, 583.8, 583.9,M32.14, M32.15, M35.04, N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1 —
[
  • 873 cases
  • , 16,583 controls
]
,
44.52 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013320 583.6, 583.7, 583.8, 583.9,M32.14, M32.15, M35.04, N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1 —
[
  • 873 cases
  • , 16,583 controls
]
,
44.52 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013321 583.6, 583.7, 583.8, 583.9,M32.14, M32.15, M35.04, N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1 —
[
  • 873 cases
  • , 16,583 controls
]
,
44.52 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013322 583.6, 583.7, 583.8, 583.9,M32.14, M32.15, M35.04, N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1 —
[
  • 873 cases
  • , 16,583 controls
]
,
44.52 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013323 583.6, 583.7, 583.8, 583.9,M32.14, M32.15, M35.04, N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1 —
[
  • 873 cases
  • , 16,583 controls
]
,
44.52 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013307 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013308 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —