Trait: nephritis

Trait Information
Identifier MONDO_0001166
Description Inflammation of renal tissue. [NCIT: P378]
Trait category
Other trait
Synonyms 2 synonyms
  • inflammation of kidney
  • kidney inflammation
Child trait(s) IgA glomerulonephritis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "nephritis" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005282
(GRS15_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IgA glomerulonephritis 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005282/ScoringFiles/PGS005282.txt.gz
PGS005283
(GRS21_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IgA glomerulonephritis 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005283/ScoringFiles/PGS005283.txt.gz
PGS005284
(GRS55_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IgA glomerulonephritis 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005284/ScoringFiles/PGS005284.txt.gz
PGS019405
(TPMI_580_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis nephrosis renal sclerosis nephritis 114,961
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019405/ScoringFiles/PGS019405.txt.gz
PGS019406
(TPMI_580_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis nephrosis renal sclerosis nephritis 394,908
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019406/ScoringFiles/PGS019406.txt.gz
PGS019407
(TPMI_580_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis nephrosis renal sclerosis nephritis 41,521
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019407/ScoringFiles/PGS019407.txt.gz
PGS019408
(TPMI_580_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis nephrosis renal sclerosis nephritis 983,816
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019408/ScoringFiles/PGS019408.txt.gz
PGS019409
(TPMI_580_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis nephrosis renal sclerosis nephritis 976,759
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019409/ScoringFiles/PGS019409.txt.gz
PGS019415
(TPMI_580.31_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 222,116
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019415/ScoringFiles/PGS019415.txt.gz
PGS019416
(TPMI_580.31_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 939,830
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019416/ScoringFiles/PGS019416.txt.gz
PGS019417
(TPMI_580.31_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 54,233
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019417/ScoringFiles/PGS019417.txt.gz
PGS019418
(TPMI_580.31_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 983,787
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019418/ScoringFiles/PGS019418.txt.gz
PGS019419
(TPMI_580.31_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 1,071,477
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019419/ScoringFiles/PGS019419.txt.gz
PGS019420
(TPMI_580.31_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy in diseases classified elsewhere Nephropathy,
nephritis		 997,096
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019420/ScoringFiles/PGS019420.txt.gz
PGS019421
(TPMI_580.32_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 217,972
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019421/ScoringFiles/PGS019421.txt.gz
PGS019422
(TPMI_580.32_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 939,872
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019422/ScoringFiles/PGS019422.txt.gz
PGS019423
(TPMI_580.32_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 44,839
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019423/ScoringFiles/PGS019423.txt.gz
PGS019424
(TPMI_580.32_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 983,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019424/ScoringFiles/PGS019424.txt.gz
PGS019425
(TPMI_580.32_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 1,071,476
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019425/ScoringFiles/PGS019425.txt.gz
PGS019426
(TPMI_580.32_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Nephritis and nephropathy with pathological lesion Nephropathy,
nephritis		 966,152
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019426/ScoringFiles/PGS019426.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022989 PGS005282
(GRS15_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.36 [1.3, 1.42] AUROC: 0.59 — — —
PPM022990 PGS005283
(GRS21_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.62 [1.55, 1.69] AUROC: 0.63 — — —
PPM022991 PGS005284
(GRS55_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.62 [1.55, 1.69] AUROC: 0.63 — — —
PPM037587 PGS019405
(TPMI_580_Lassosum2)
 PSS013325|
East Asian Ancestry|
17,796 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis nephrosis renal sclerosis — AUROC: 0.64163 R²: 0.07348 sex, age, array, PCs 1-10 —
PPM037588 PGS019406
(TPMI_580_LDpred2)
 PSS013324|
East Asian Ancestry|
17,796 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis nephrosis renal sclerosis — AUROC: 0.64479 R²: 0.07586 sex, age, array, PCs 1-10 —
PPM037589 PGS019407
(TPMI_580_MegaPRS)
 PSS013326|
East Asian Ancestry|
17,796 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis nephrosis renal sclerosis — AUROC: 0.64159 R²: 0.07297 sex, age, array, PCs 1-10 —
PPM037590 PGS019408
(TPMI_580_PRS-CS)
 PSS013327|
East Asian Ancestry|
17,796 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis nephrosis renal sclerosis — AUROC: 0.64436 R²: 0.07548 sex, age, array, PCs 1-10 —
PPM037591 PGS019409
(TPMI_580_SBayesR)
 PSS013328|
East Asian Ancestry|
17,796 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis nephrosis renal sclerosis — AUROC: 0.64191 R²: 0.07309 sex, age, array, PCs 1-10 —
PPM037597 PGS019415
(TPMI_580.31_Lassosum2)
 PSS013308|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.6585 R²: 0.03931 sex, age, array, PCs 1-10 —
PPM037598 PGS019416
(TPMI_580.31_LDpred2)
 PSS013307|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.66245 R²: 0.04194 sex, age, array, PCs 1-10 —
PPM037599 PGS019417
(TPMI_580.31_MegaPRS)
 PSS013309|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.65425 R²: 0.0357 sex, age, array, PCs 1-10 —
PPM037600 PGS019418
(TPMI_580.31_PRS-CS)
 PSS013310|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.66254 R²: 0.04057 sex, age, array, PCs 1-10 —
PPM037601 PGS019419
(TPMI_580.31_PRSmix+)
 PSS013311|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.69552 R²: 0.05556 sex, age, array, PCs 1-10 —
PPM037602 PGS019420
(TPMI_580.31_SBayesR)
 PSS013312|
East Asian Ancestry|
17,312 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy in diseases classified elsewhere — AUROC: 0.65715 R²: 0.03786 sex, age, array, PCs 1-10 —
PPM037603 PGS019421
(TPMI_580.32_Lassosum2)
 PSS013314|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.63652 R²: 0.03429 sex, age, array, PCs 1-10 —
PPM037604 PGS019422
(TPMI_580.32_LDpred2)
 PSS013313|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.64282 R²: 0.03739 sex, age, array, PCs 1-10 —
PPM037605 PGS019423
(TPMI_580.32_MegaPRS)
 PSS013315|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.63175 R²: 0.03166 sex, age, array, PCs 1-10 —
PPM037606 PGS019424
(TPMI_580.32_PRS-CS)
 PSS013316|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.64305 R²: 0.03686 sex, age, array, PCs 1-10 —
PPM037607 PGS019425
(TPMI_580.32_PRSmix+)
 PSS013317|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.67014 R²: 0.05102 sex, age, array, PCs 1-10 —
PPM037608 PGS019426
(TPMI_580.32_SBayesR)
 PSS013318|
East Asian Ancestry|
17,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Nephritis and nephropathy with pathological lesion — AUROC: 0.63695 R²: 0.03415 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013309 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013310 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013311 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013312 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013313 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013314 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013315 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013316 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013317 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013318 583.7, 583.8, 583.9,N05, N06.0, N06.1, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.6, N07.7, N07.8, N07.9, N14, N15.0, N15.8, N15.9 —
[
  • 797 cases
  • , 16,583 controls
]
,
44.67 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013324 580, 581, 582, 583, 587, V13.03,B52.0, M32.14, M32.15, M35.04, N00, N01, N02.0, N02.1, N02.2, N02.3, N02.4, N02.5, N02.6, N02.7, N02.8, N02.9, N03, N04, N05, N06.0, N06.1, N06.2, N06.3, N06.4, N06.5, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.2, N07.3, N07.4, N07.5, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1, N26.1, N26.9, Z87.441 —
[
  • 1,213 cases
  • , 16,583 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013325 580, 581, 582, 583, 587, V13.03,B52.0, M32.14, M32.15, M35.04, N00, N01, N02.0, N02.1, N02.2, N02.3, N02.4, N02.5, N02.6, N02.7, N02.8, N02.9, N03, N04, N05, N06.0, N06.1, N06.2, N06.3, N06.4, N06.5, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.2, N07.3, N07.4, N07.5, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1, N26.1, N26.9, Z87.441 —
[
  • 1,213 cases
  • , 16,583 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013326 580, 581, 582, 583, 587, V13.03,B52.0, M32.14, M32.15, M35.04, N00, N01, N02.0, N02.1, N02.2, N02.3, N02.4, N02.5, N02.6, N02.7, N02.8, N02.9, N03, N04, N05, N06.0, N06.1, N06.2, N06.3, N06.4, N06.5, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.2, N07.3, N07.4, N07.5, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1, N26.1, N26.9, Z87.441 —
[
  • 1,213 cases
  • , 16,583 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013327 580, 581, 582, 583, 587, V13.03,B52.0, M32.14, M32.15, M35.04, N00, N01, N02.0, N02.1, N02.2, N02.3, N02.4, N02.5, N02.6, N02.7, N02.8, N02.9, N03, N04, N05, N06.0, N06.1, N06.2, N06.3, N06.4, N06.5, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.2, N07.3, N07.4, N07.5, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1, N26.1, N26.9, Z87.441 —
[
  • 1,213 cases
  • , 16,583 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013328 580, 581, 582, 583, 587, V13.03,B52.0, M32.14, M32.15, M35.04, N00, N01, N02.0, N02.1, N02.2, N02.3, N02.4, N02.5, N02.6, N02.7, N02.8, N02.9, N03, N04, N05, N06.0, N06.1, N06.2, N06.3, N06.4, N06.5, N06.6, N06.7, N06.8, N06.9, N07.0, N07.1, N07.2, N07.3, N07.4, N07.5, N07.6, N07.7, N07.8, N07.9, N08, N14, N15.0, N15.8, N15.9, N17.1, N26.1, N26.9, Z87.441 —
[
  • 1,213 cases
  • , 16,583 controls
]
,
44.71 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012087 — —
[
  • 3,365 cases
  • , 8,842 controls
]
 — East Asian
(Chinese)		 — NR PKU-IgAN Cohort
PSS013307 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013308 583.81,M32.14, M32.15, M35.04, N08 —
[
  • 729 cases
  • , 16,583 controls
]
,
44.45 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —