Trait: skin neoplasm

Trait Information
Identifier MONDO_0002531
Description A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma. [NCIT: P378]
Trait category
Other trait
Synonyms 18 synonyms
  • neoplasm of skin
  • neoplasm of the skin
  • neoplasm of zone of skin
  • skin
  • skin neoplasm
  • skin neoplasms
  • skin tumor
  • skin tumour
  • tumor of skin
  • tumor of the skin
  • tumor of zone of skin
  • tumour of skin
  • tumour of the skin
  • tumour of zone of skin
  • zone of skin neoplasm
  • zone of skin neoplasm (disease)
  • zone of skin tumor
  • zone of skin tumour
Child trait(s) 9 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "skin neoplasm" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000339
(PRS22_CM)
 PGP000106 |
Law MH et al. Hum Mol Genet (2020)
 Cutaneous melanoma cutaneous melanoma 22
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000339/ScoringFiles/PGS000339.txt.gz
PGS000398
(PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 1,103,220
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000398/ScoringFiles/PGS000398.txt.gz
PGS000399
(PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 6
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000399/ScoringFiles/PGS000399.txt.gz
PGS000400
(PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 95
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000400/ScoringFiles/PGS000400.txt.gz
PGS000401
(PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 1,111,490
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000401/ScoringFiles/PGS000401.txt.gz
PGS000402
(PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 389
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000402/ScoringFiles/PGS000402.txt.gz
PGS000403
(PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 16,316
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000403/ScoringFiles/PGS000403.txt.gz
PGS000404
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 80
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000404/ScoringFiles/PGS000404.txt.gz
PGS000405
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 1,119,238
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000405/ScoringFiles/PGS000405.txt.gz
PGS000406
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 292
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000406/ScoringFiles/PGS000406.txt.gz
PGS000407
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Skin cancer skin carcinoma 3,166
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000407/ScoringFiles/PGS000407.txt.gz
PGS000433
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 108
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000433/ScoringFiles/PGS000433.txt.gz
PGS000434
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 1,111,490
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000434/ScoringFiles/PGS000434.txt.gz
PGS000435
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 446
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000435/ScoringFiles/PGS000435.txt.gz
PGS000436
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 16,626
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000436/ScoringFiles/PGS000436.txt.gz
PGS000437
(PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 63
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000437/ScoringFiles/PGS000437.txt.gz
PGS000438
(PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 1,111,490
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000438/ScoringFiles/PGS000438.txt.gz
PGS000439
(PRSWEB_PHECODE172.2_C44_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 467
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000439/ScoringFiles/PGS000439.txt.gz
PGS000440
(PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 2,111
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000440/ScoringFiles/PGS000440.txt.gz
PGS000441
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 77
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000441/ScoringFiles/PGS000441.txt.gz
PGS000442
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 1,119,238
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000442/ScoringFiles/PGS000442.txt.gz
PGS000443
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 177
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000443/ScoringFiles/PGS000443.txt.gz
PGS000444
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Other non-epithelial skin cancer skin cancer 7,231
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000444/ScoringFiles/PGS000444.txt.gz
PGS000469
(PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Carcinoma in situ of skin skin carcinoma in situ 1,119,238
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000469/ScoringFiles/PGS000469.txt.gz
PGS000470
(PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Carcinoma in situ of skin skin carcinoma in situ 5
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000470/ScoringFiles/PGS000470.txt.gz
PGS000471
(PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Carcinoma in situ of skin skin carcinoma in situ 7
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000471/ScoringFiles/PGS000471.txt.gz
PGS000766
(PRS56_CM)
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Cutaneous melanoma cutaneous melanoma 56
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000766/ScoringFiles/PGS000766.txt.gz
PGS001011
(GBE_HC534)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Viral warts (time-to-event) common wart 5
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001011/ScoringFiles/PGS001011.txt.gz
PGS001040
(GBE_cancer1060)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Non melanoma skin cancer non-melanoma skin carcinoma 1,610
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001040/ScoringFiles/PGS001040.txt.gz
PGS001041
(GBE_cancer1003)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Skin cancer skin carcinoma 1,298
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001041/ScoringFiles/PGS001041.txt.gz
PGS001803
(portability-PLR_172)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Skin cancer skin carcinoma 4,371
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001803/ScoringFiles/PGS001803.txt.gz
PGS001874
(portability-PLR_706.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sebaceous cyst Epidermal Inclusion Cyst 563
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001874/ScoringFiles/PGS001874.txt.gz
PGS002014
(portability-ldpred2_172)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Skin cancer skin carcinoma 534,399
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002014/ScoringFiles/PGS002014.txt.gz
PGS002087
(portability-ldpred2_706.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sebaceous cyst Epidermal Inclusion Cyst 206,669
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002087/ScoringFiles/PGS002087.txt.gz
PGS003382
(best_SKCM)
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Skin cutaneous melanoma cutaneous melanoma 672
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003382/ScoringFiles/PGS003382.txt.gz
PGS003745
(PRS57_SM)
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Skin Melanoma cutaneous melanoma 57
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003745/ScoringFiles/PGS003745.txt.gz
PGS004247
(PRS65_melanoma)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Melanoma cutaneous melanoma 65
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004247/ScoringFiles/PGS004247.txt.gz
PGS004592
(PRS_KC)
 PGP000571 |
Liyanage UE et al. J Eur Acad Dermatol Venereol (2022)
 Keratinocyte cancer keratinocyte carcinoma 78
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004592/ScoringFiles/PGS004592.txt.gz
PGS018440
(TPMI_078_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral warts HPV common wart 85
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018440/ScoringFiles/PGS018440.txt.gz
PGS018441
(TPMI_078_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral warts HPV common wart 939,884
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018441/ScoringFiles/PGS018441.txt.gz
PGS018442
(TPMI_078_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral warts HPV common wart 21,918
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018442/ScoringFiles/PGS018442.txt.gz
PGS018443
(TPMI_078_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral warts HPV common wart 983,817
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018443/ScoringFiles/PGS018443.txt.gz
PGS018444
(TPMI_078_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Viral warts HPV common wart 978,577
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018444/ScoringFiles/PGS018444.txt.gz
PGS018712
(TPMI_246.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroid cyst dermoid cyst 287
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018712/ScoringFiles/PGS018712.txt.gz
PGS018713
(TPMI_246.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroid cyst dermoid cyst 237,092
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018713/ScoringFiles/PGS018713.txt.gz
PGS018714
(TPMI_246.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroid cyst dermoid cyst 552,969
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018714/ScoringFiles/PGS018714.txt.gz
PGS018715
(TPMI_246.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroid cyst dermoid cyst 983,778
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018715/ScoringFiles/PGS018715.txt.gz
PGS018716
(TPMI_246.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Thyroid cyst dermoid cyst 1,016,561
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018716/ScoringFiles/PGS018716.txt.gz
PGS019946
(cm_prs_noannot_sbrc)
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Cutaneous melanoma cutaneous melanoma 7,280,842
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019946/ScoringFiles/PGS019946.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000922 PGS000339
(PRS22_CM)
 PSS000464|
European Ancestry|
1,885 individuals
 PGP000106 |
Law MH et al. Hum Mol Genet (2020)
 Reported Trait: Cutaneous melanoma in multiplex melanoma families — — Difference of PRS (deltaPRS; unaffected melanoma family members vs. unrelated controls): 0.347 (0.104) PCs (1-10) *Sample overlap between the controls used in this analysis and score development
PPM000921 PGS000339
(PRS22_CM)
 PSS000463|
European Ancestry|
3,066 individuals
 PGP000106 |
Law MH et al. Hum Mol Genet (2020)
 Reported Trait: Cutaneous melanoma in multiplex melanoma families — — Difference of PRS (deltaPRS; melanoma family cases vs. unrelated controls): 0.505 (0.036) PCs (1-10) *Sample overlap between the controls used in this analysis and score development
PPM001083 PGS000398
(PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.042 [1.003, 1.082]
β: 0.0407 (0.0195)		 AUROC: 0.51 [0.499, 0.521] Nagelkerke's Pseudo-R²: 0.00028
Brier score: 0.148
Odds Ratio (OR, top 1% vs. Rest): 1.7 [1.22, 2.38]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_20001-1003_PRS-CS_MGI_20200608
PPM001084 PGS000399
(PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.158 [1.116, 1.202]
β: 0.147 (0.0189)		 AUROC: 0.513 [0.503, 0.523] Nagelkerke's Pseudo-R²: 0.00545
Brier score: 0.148
Odds Ratio (OR, top 1% vs. Rest): 1.56 [1.12, 2.16]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_20001-1003_PT_MGI_20200608
PPM001085 PGS000400
(PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.342 [1.291, 1.395]
β: 0.294 (0.0197)		 AUROC: 0.581 [0.57, 0.592] Nagelkerke's Pseudo-R²: 0.0201
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.2 [1.63, 2.98]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_C3-SKIN_P_5e-08_MGI_20200608
PPM001086 PGS000401
(PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.342 [1.291, 1.396]
β: 0.294 (0.0199)		 AUROC: 0.581 [0.57, 0.591] Nagelkerke's Pseudo-R²: 0.0202
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.25 [1.67, 3.03]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_C3-SKIN_PRS-CS_MGI_20200608
PPM001087 PGS000402
(PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.366 [1.314, 1.421]
β: 0.312 (0.0198)		 AUROC: 0.586 [0.576, 0.597] Nagelkerke's Pseudo-R²: 0.0224
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.23 [1.64, 3.03]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_C3-SKIN_PT_MGI_20200608
PPM001088 PGS000403
(PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.359 [1.307, 1.413]
β: 0.307 (0.0199)		 AUROC: 0.584 [0.573, 0.594] Nagelkerke's Pseudo-R²: 0.0219
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 1.65 [1.2, 2.27]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_C3-SKIN_LASSOSUM_MGI_20200608
PPM001089 PGS000404
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.369 [1.317, 1.422]
β: 0.314 (0.0196)		 AUROC: 0.584 [0.574, 0.594] Nagelkerke's Pseudo-R²: 0.0226
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.3 [1.72, 3.09]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_P_5e-08_MGI_20200608
PPM001090 PGS000405
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.338 [1.287, 1.391]
β: 0.291 (0.0199)		 AUROC: 0.58 [0.57, 0.591] Nagelkerke's Pseudo-R²: 0.0192
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.42 [1.81, 3.24]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PRS-CS_MGI_20200608
PPM001091 PGS000406
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.392 [1.339, 1.447]
β: 0.331 (0.0199)		 AUROC: 0.591 [0.581, 0.602] Nagelkerke's Pseudo-R²: 0.0249
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.51 [1.89, 3.34]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_PT_MGI_20200608
PPM001092 PGS000407
(PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608)
 PSS000548|
European Ancestry|
17,607 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Skin cancer OR: 1.38 [1.328, 1.434]
β: 0.322 (0.0197)		 AUROC: 0.586 [0.575, 0.597] Nagelkerke's Pseudo-R²: 0.0245
Brier score: 0.146
Odds Ratio (OR, top 1% vs. Rest): 2.26 [1.69, 3.03]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172_UKBB-SAIGE-HRC-X172_LASSOSUM_MGI_20200608
PPM001118 PGS000433
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.367 [1.31, 1.426]
β: 0.312 (0.0215)		 AUROC: 0.584 [0.572, 0.598] Nagelkerke's Pseudo-R²: 0.0215
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.73 [2.01, 3.72]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C3-OTHER-SKIN_P_5e-08_MGI_20200608
PPM001119 PGS000434
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.361 [1.304, 1.42]
β: 0.308 (0.0217)		 AUROC: 0.586 [0.573, 0.598] Nagelkerke's Pseudo-R²: 0.0208
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 1.99 [1.43, 2.78]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PRS-CS_MGI_20200608
PPM001120 PGS000435
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.357 [1.301, 1.415]
β: 0.305 (0.0215)		 AUROC: 0.584 [0.572, 0.597] Nagelkerke's Pseudo-R²: 0.0201
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.7 [1.99, 3.66]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C3-OTHER-SKIN_PT_MGI_20200608
PPM001121 PGS000436
(PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.361 [1.305, 1.42]
β: 0.308 (0.0216)		 AUROC: 0.584 [0.571, 0.596] Nagelkerke's Pseudo-R²: 0.021
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.22 [1.61, 3.06]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C3-OTHER-SKIN_LASSOSUM_MGI_20200608
PPM001122 PGS000437
(PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.352 [1.296, 1.409]
β: 0.301 (0.0213)		 AUROC: 0.579 [0.566, 0.592] Nagelkerke's Pseudo-R²: 0.0206
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.21 [1.6, 3.06]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C44_P_5e-08_MGI_20200608
PPM001123 PGS000438
(PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.31 [1.256, 1.367]
β: 0.27 (0.0216)		 AUROC: 0.575 [0.562, 0.587] Nagelkerke's Pseudo-R²: 0.0162
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 1.79 [1.28, 2.51]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C44_PRS-CS_MGI_20200608
PPM001124 PGS000439
(PRSWEB_PHECODE172.2_C44_PT_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.348 [1.293, 1.407]
β: 0.299 (0.0216)		 AUROC: 0.583 [0.57, 0.595] Nagelkerke's Pseudo-R²: 0.0197
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.17 [1.57, 3.01]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C44_PT_MGI_20200608
PPM001125 PGS000440
(PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.351 [1.296, 1.409]
β: 0.301 (0.0215)		 AUROC: 0.581 [0.569, 0.592] Nagelkerke's Pseudo-R²: 0.0201
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.55 [1.87, 3.46]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_C44_LASSOSUM_MGI_20200608
PPM001126 PGS000441
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.39 [1.333, 1.449]
β: 0.329 (0.0214)		 AUROC: 0.586 [0.574, 0.599] Nagelkerke's Pseudo-R²: 0.0241
Brier score: 0.136
Odds Ratio (OR, top 1% vs. Rest): 2.65 [1.94, 3.62]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_P_5e-08_MGI_20200608
PPM001127 PGS000442
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.357 [1.301, 1.417]
β: 0.306 (0.0217)		 AUROC: 0.584 [0.572, 0.595] Nagelkerke's Pseudo-R²: 0.0201
Brier score: 0.137
Odds Ratio (OR, top 1% vs. Rest): 2.35 [1.71, 3.22]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PRS-CS_MGI_20200608
PPM001128 PGS000443
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.41 [1.352, 1.471]
β: 0.344 (0.0216)		 AUROC: 0.591 [0.579, 0.603] Nagelkerke's Pseudo-R²: 0.0259
Brier score: 0.136
Odds Ratio (OR, top 1% vs. Rest): 2.89 [2.14, 3.92]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_PT_MGI_20200608
PPM001129 PGS000444
(PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608)
 PSS000546|
European Ancestry|
15,898 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Other non-epithelial cancer of skin OR: 1.399 [1.341, 1.46]
β: 0.336 (0.0216)		 AUROC: 0.59 [0.578, 0.601] Nagelkerke's Pseudo-R²: 0.025
Brier score: 0.136
Odds Ratio (OR, top 1% vs. Rest): 3.5 [2.63, 4.65]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.2_UKBB-SAIGE-HRC-X172.2_LASSOSUM_MGI_20200608
PPM001154 PGS000469
(PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608)
 PSS000547|
European Ancestry|
5,500 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Carcinoma in situ of skin OR: 1.09 [1.001, 1.188]
β: 0.0865 (0.0437)		 AUROC: 0.524 [0.499, 0.549] Nagelkerke's Pseudo-R²: 0.00141
Brier score: 0.0939
Odds Ratio (OR, top 1% vs. Rest): 1.48 [0.703, 3.1]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PRS-CS_MGI_20200608
PPM001155 PGS000470
(PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608)
 PSS000547|
European Ancestry|
5,500 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Carcinoma in situ of skin OR: 1.308 [1.208, 1.417]
β: 0.269 (0.0407)		 AUROC: 0.557 [0.531, 0.582] Nagelkerke's Pseudo-R²: 0.0154
Brier score: 0.093
Odds Ratio (OR, top 1% vs. Rest): 2.45 [1.34, 4.45]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_PT_MGI_20200608
PPM001156 PGS000471
(PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608)
 PSS000547|
European Ancestry|
5,500 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Carcinoma in situ of skin OR: 1.401 [1.297, 1.513]
β: 0.337 (0.0393)		 AUROC: 0.569 [0.541, 0.595] Nagelkerke's Pseudo-R²: 0.0255
Brier score: 0.0923
Odds Ratio (OR, top 1% vs. Rest): 3.77 [2.24, 6.34]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.3_UKBB-SAIGE-HRC-X172.3_LASSOSUM_MGI_20200608
PPM001963 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Incident cutaneous melanoma — — Hazard Ratio (HR, top 20% vs bottom 20%): 2.51 [1.28, 4.92] — Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM001964 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Incident cutaneous melanoma (males) — — Hazard Ratio (HR, top 20% vs bottom 20%): 3.7 [1.37, 9.98] — Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM001965 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Incident cutaneous melanoma (males) — — Hazard Ratio (HR, middle 60% vs bottom 20%): 2.61 [1.03, 6.63] — Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM001966 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Prevalent cutaneous melanoma OR: 1.55 [1.42, 1.69] AUROC: 0.64 [0.62, 0.66] Odds Ratio (OR, top 20% vs bottom 20%): 3.66 [2.69, 5.05] Sex, family history Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM001967 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Prevalent cutaneous melanoma (males) OR: 1.39 [1.23, 1.57] — — Family history Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM001968 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Prevalent cutaneous melanoma (females) OR: 1.72 [1.53, 1.94] — — Family history Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM001962 PGS000766
(PRS56_CM)
 PSS000982|
European Ancestry|
12,712 individuals
 PGP000172 |
Bakshi A et al. J Natl Cancer Inst (2021)
 Reported Trait: Incident cutaneous melanoma HR: 1.46 [1.2, 1.77] C-index: 0.643 [0.584, 0.702] — Sex, melanoma family history, treatment (aspirin/placebo), age at enrolment, PRS*treatment Only 55 of the 56 SNPs within the PGS were utilised. Rs16891982 was not included as the SNP did not pass imputation quality control.
PPM007818 PGS001011
(GBE_HC534)
 PSS004521|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE viral warts — AUROC: 0.62763 [0.56904, 0.68622] R²: 0.01913
Incremental AUROC (full-covars): -0.00455
PGS R2 (no covariates): 0.00116
PGS AUROC (no covariates): 0.48242 [0.41987, 0.54497]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007819 PGS001011
(GBE_HC534)
 PSS004522|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE viral warts — AUROC: 0.65545 [0.57671, 0.73418] R²: 0.03677
Incremental AUROC (full-covars): -0.00026
PGS R2 (no covariates): 1e-05
PGS AUROC (no covariates): 0.50846 [0.40705, 0.60986]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007820 PGS001011
(GBE_HC534)
 PSS004523|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE viral warts — AUROC: 0.56023 [0.54032, 0.58015] R²: 0.0051
Incremental AUROC (full-covars): 0.01103
PGS R2 (no covariates): 0.00154
PGS AUROC (no covariates): 0.53437 [0.51402, 0.55472]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007821 PGS001011
(GBE_HC534)
 PSS004524|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE viral warts — AUROC: 0.5793 [0.54592, 0.61268] R²: 0.01114
Incremental AUROC (full-covars): 0.00245
PGS R2 (no covariates): 0.00048
PGS AUROC (no covariates): 0.51036 [0.47743, 0.54328]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007822 PGS001011
(GBE_HC534)
 PSS004525|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE viral warts — AUROC: 0.56004 [0.54811, 0.57198] R²: 0.00576
Incremental AUROC (full-covars): 0.00636
PGS R2 (no covariates): 0.00167
PGS AUROC (no covariates): 0.53057 [0.51862, 0.54252]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007958 PGS001040
(GBE_cancer1060)
 PSS007651|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Non-melanoma skin cancer — AUROC: 0.80478 [0.72556, 0.884] R²: 0.07029
Incremental AUROC (full-covars): -0.00066
PGS R2 (no covariates): 0.00133
PGS AUROC (no covariates): 0.54127 [0.39017, 0.69237]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007959 PGS001040
(GBE_cancer1060)
 PSS007652|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Non-melanoma skin cancer — AUROC: 0.86455 [0.80574, 0.92335] R²: 0.12918
Incremental AUROC (full-covars): -0.00442
PGS R2 (no covariates): 0.00152
PGS AUROC (no covariates): 0.4523 [0.1694, 0.73519]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007960 PGS001040
(GBE_cancer1060)
 PSS007653|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Non-melanoma skin cancer — AUROC: 0.73342 [0.72065, 0.74619] R²: 0.10751
Incremental AUROC (full-covars): 0.0378
PGS R2 (no covariates): 0.05185
PGS AUROC (no covariates): 0.66327 [0.64889, 0.67765]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007961 PGS001040
(GBE_cancer1060)
 PSS007654|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Non-melanoma skin cancer — AUROC: 0.76366 [0.66832, 0.85901] R²: 0.06447
Incremental AUROC (full-covars): -0.00934
PGS R2 (no covariates): 0.00078
PGS AUROC (no covariates): 0.47181 [0.35611, 0.58752]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007962 PGS001040
(GBE_cancer1060)
 PSS007655|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Non-melanoma skin cancer — AUROC: 0.70656 [0.69863, 0.7145] R²: 0.08615
Incremental AUROC (full-covars): 0.04717
PGS R2 (no covariates): 0.03949
PGS AUROC (no covariates): 0.64209 [0.6334, 0.65078]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM018463 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Ease sunburn β: 0.08836 — R²: 0.01475 — —
PPM018465 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Fitzpatrick scale β: -0.0689 — R²: 0.03786 — —
PPM018459 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Eye colour β: -0.11302 — R²: 0.0106 — —
PPM018460 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Skin colour β: -0.05462 — R²: 0.01757 — —
PPM018461 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Freckles β: 0.09955 — R²: 0.02643 — —
PPM018462 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Ease suntan β: -0.06804 — R²: 0.01892 — —
PPM018464 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Phototype score β: -1.51455 — R²: 0.04441 — —
PPM018466 PGS001040
(GBE_cancer1060)
 PSS010980|
European Ancestry|
4,797 individuals
 PGP000467 |
Farré X et al. Genes (Basel) (2023)
|Ext.		 Reported Trait: Blond hair β: 1.14835 — pseudo R²: 0.01006 — —
PPM007963 PGS001041
(GBE_cancer1003)
 PSS007621|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Skin cancer — AUROC: 0.78777 [0.7126, 0.86293] R²: 0.06151
Incremental AUROC (full-covars): 0.00386
PGS R2 (no covariates): 0.00103
PGS AUROC (no covariates): 0.5229 [0.37426, 0.67153]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007964 PGS001041
(GBE_cancer1003)
 PSS007622|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Skin cancer — AUROC: 0.83061 [0.75233, 0.9089] R²: 0.10839
Incremental AUROC (full-covars): 0.0017
PGS R2 (no covariates): 0.00376
PGS AUROC (no covariates): 0.56985 [0.36492, 0.77477]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007965 PGS001041
(GBE_cancer1003)
 PSS007623|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Skin cancer — AUROC: 0.71667 [0.70431, 0.72902] R²: 0.09613
Incremental AUROC (full-covars): 0.03439
PGS R2 (no covariates): 0.04566
PGS AUROC (no covariates): 0.65086 [0.63722, 0.6645]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007966 PGS001041
(GBE_cancer1003)
 PSS007624|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Skin cancer — AUROC: 0.76232 [0.67332, 0.85131] R²: 0.07091
Incremental AUROC (full-covars): -0.01012
PGS R2 (no covariates): 6e-05
PGS AUROC (no covariates): 0.49291 [0.37897, 0.60686]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007967 PGS001041
(GBE_cancer1003)
 PSS007625|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Skin cancer — AUROC: 0.6935 [0.68584, 0.70116] R²: 0.07834
Incremental AUROC (full-covars): 0.04393
PGS R2 (no covariates): 0.03573
PGS AUROC (no covariates): 0.63289 [0.62459, 0.64118]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM009332 PGS001803
(portability-PLR_172)
 PSS008601|
European Ancestry|
6,656 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0762 [0.0522, 0.1001] sex, age, birth date, deprivation index, 16 PCs —
PPM009333 PGS001803
(portability-PLR_172)
 PSS008379|
Greater Middle Eastern Ancestry|
1,200 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0694 [0.0123, 0.1259] sex, age, birth date, deprivation index, 16 PCs —
PPM009334 PGS001803
(portability-PLR_172)
 PSS008155|
South Asian Ancestry|
6,328 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): -0.0135 [-0.0382, 0.0112] sex, age, birth date, deprivation index, 16 PCs —
PPM009330 PGS001803
(portability-PLR_172)
 PSS009273|
European Ancestry|
19,990 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.1136 [0.0999, 0.1272] sex, age, birth date, deprivation index, 16 PCs —
PPM009331 PGS001803
(portability-PLR_172)
 PSS009047|
European Ancestry|
4,134 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0962 [0.0659, 0.1264] sex, age, birth date, deprivation index, 16 PCs —
PPM009335 PGS001803
(portability-PLR_172)
 PSS007943|
East Asian Ancestry|
1,810 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0054 [-0.041, 0.0517] sex, age, birth date, deprivation index, 16 PCs —
PPM009336 PGS001803
(portability-PLR_172)
 PSS007725|
African Ancestry|
2,483 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): -0.0065 [-0.046, 0.033] sex, age, birth date, deprivation index, 16 PCs —
PPM009337 PGS001803
(portability-PLR_172)
 PSS008827|
African Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0165 [-0.0149, 0.0479] sex, age, birth date, deprivation index, 16 PCs —
PPM009880 PGS001874
(portability-PLR_706.2)
 PSS009351|
European Ancestry|
19,952 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0461 [0.0323, 0.06] sex, age, birth date, deprivation index, 16 PCs —
PPM009881 PGS001874
(portability-PLR_706.2)
 PSS009125|
European Ancestry|
4,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0709 [0.0404, 0.1013] sex, age, birth date, deprivation index, 16 PCs —
PPM009882 PGS001874
(portability-PLR_706.2)
 PSS008679|
European Ancestry|
6,646 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0466 [0.0225, 0.0706] sex, age, birth date, deprivation index, 16 PCs —
PPM009883 PGS001874
(portability-PLR_706.2)
 PSS008453|
Greater Middle Eastern Ancestry|
1,194 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0522 [-0.005, 0.1091] sex, age, birth date, deprivation index, 16 PCs —
PPM009884 PGS001874
(portability-PLR_706.2)
 PSS008233|
South Asian Ancestry|
6,311 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.049 [0.0243, 0.0736] sex, age, birth date, deprivation index, 16 PCs —
PPM009885 PGS001874
(portability-PLR_706.2)
 PSS008013|
East Asian Ancestry|
1,807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0163 [-0.0627, 0.0301] sex, age, birth date, deprivation index, 16 PCs —
PPM009886 PGS001874
(portability-PLR_706.2)
 PSS007798|
African Ancestry|
2,471 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0263 [-0.0659, 0.0133] sex, age, birth date, deprivation index, 16 PCs —
PPM009887 PGS001874
(portability-PLR_706.2)
 PSS008902|
African Ancestry|
3,913 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.01 [-0.0414, 0.0214] sex, age, birth date, deprivation index, 16 PCs —
PPM010986 PGS002014
(portability-ldpred2_172)
 PSS009273|
European Ancestry|
19,990 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.1242 [0.1105, 0.1378] sex, age, birth date, deprivation index, 16 PCs —
PPM010990 PGS002014
(portability-ldpred2_172)
 PSS008155|
South Asian Ancestry|
6,328 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): -0.0147 [-0.0394, 0.01] sex, age, birth date, deprivation index, 16 PCs —
PPM010991 PGS002014
(portability-ldpred2_172)
 PSS007943|
East Asian Ancestry|
1,810 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): -0.0041 [-0.0504, 0.0423] sex, age, birth date, deprivation index, 16 PCs —
PPM010992 PGS002014
(portability-ldpred2_172)
 PSS007725|
African Ancestry|
2,483 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): -0.0062 [-0.0457, 0.0333] sex, age, birth date, deprivation index, 16 PCs —
PPM010993 PGS002014
(portability-ldpred2_172)
 PSS008827|
African Ancestry|
3,924 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0146 [-0.0168, 0.0459] sex, age, birth date, deprivation index, 16 PCs —
PPM010987 PGS002014
(portability-ldpred2_172)
 PSS009047|
European Ancestry|
4,134 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0876 [0.0572, 0.1178] sex, age, birth date, deprivation index, 16 PCs —
PPM010988 PGS002014
(portability-ldpred2_172)
 PSS008601|
European Ancestry|
6,656 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.076 [0.0521, 0.0999] sex, age, birth date, deprivation index, 16 PCs —
PPM010989 PGS002014
(portability-ldpred2_172)
 PSS008379|
Greater Middle Eastern Ancestry|
1,200 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Skin cancer — — Partial Correlation (partial-r): 0.0717 [0.0147, 0.1282] sex, age, birth date, deprivation index, 16 PCs —
PPM011556 PGS002087
(portability-ldpred2_706.2)
 PSS009351|
European Ancestry|
19,952 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0513 [0.0374, 0.0651] sex, age, birth date, deprivation index, 16 PCs —
PPM011557 PGS002087
(portability-ldpred2_706.2)
 PSS009125|
European Ancestry|
4,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0734 [0.0429, 0.1037] sex, age, birth date, deprivation index, 16 PCs —
PPM011558 PGS002087
(portability-ldpred2_706.2)
 PSS008679|
European Ancestry|
6,646 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0454 [0.0214, 0.0694] sex, age, birth date, deprivation index, 16 PCs —
PPM011559 PGS002087
(portability-ldpred2_706.2)
 PSS008453|
Greater Middle Eastern Ancestry|
1,194 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0444 [-0.0128, 0.1014] sex, age, birth date, deprivation index, 16 PCs —
PPM011560 PGS002087
(portability-ldpred2_706.2)
 PSS008233|
South Asian Ancestry|
6,311 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0351 [0.0103, 0.0597] sex, age, birth date, deprivation index, 16 PCs —
PPM011561 PGS002087
(portability-ldpred2_706.2)
 PSS008013|
East Asian Ancestry|
1,807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0299 [-0.0762, 0.0165] sex, age, birth date, deprivation index, 16 PCs —
PPM011562 PGS002087
(portability-ldpred2_706.2)
 PSS007798|
African Ancestry|
2,471 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0274 [-0.067, 0.0122] sex, age, birth date, deprivation index, 16 PCs —
PPM011563 PGS002087
(portability-ldpred2_706.2)
 PSS008902|
African Ancestry|
3,913 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0023 [-0.0291, 0.0338] sex, age, birth date, deprivation index, 16 PCs —
PPM016257 PGS003382
(best_SKCM)
 PSS010085|
European Ancestry|
273,786 individuals
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Reported Trait: skin cutaneous melanoma — AUROC: 0.682 R²: 0.0261 age, sex, top 20 genetic principal components —
PPM018501 PGS003745
(PRS57_SM)
 PSS010995|
European Ancestry|
448 individuals
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Reported Trait: Skin Melanoma OR: 1.49 [1.34, 1.66] — — — —
PPM020312 PGS004247
(PRS65_melanoma)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Melanoma HR: 1.71 [1.55, 1.89] — — first 10 genetic principal components —
PPM020304 PGS004247
(PRS65_melanoma)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Melanoma HR: 1.78 [1.62, 1.96] — — first 10 genetic principal components —
PPM020722 PGS004592
(PRS_KC)
 PSS011383|
European Ancestry|
998 individuals
 PGP000571 |
Liyanage UE et al. J Eur Acad Dermatol Venereol (2022)
 Reported Trait: Keratinocyte cancer OR: 1.51 [1.3, 1.76] AUROC: 0.74 R²: 0.231 Age, sex, self-reported skin tanning ability, clinical grade of neck elastosis, genotyping batch, first 2 PCs —
PPM020723 PGS004592
(PRS_KC)
 PSS011383|
European Ancestry|
998 individuals
 PGP000571 |
Liyanage UE et al. J Eur Acad Dermatol Venereol (2022)
 Reported Trait: Keratinocyte cancer — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 3.45 [2.18, 5.5] Age, sex, self-reported skin tanning ability, clinical grade of neck elastosis, genotyping batch, first 2 PCs —
PPM036622 PGS018440
(TPMI_078_Lassosum2)
 PSS012343|
East Asian Ancestry|
15,250 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral warts HPV — AUROC: 0.68328 R²: 0.05397 sex, age, array, PCs 1-10 —
PPM036623 PGS018441
(TPMI_078_LDpred2)
 PSS012342|
East Asian Ancestry|
15,250 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral warts HPV — AUROC: 0.68573 R²: 0.05489 sex, age, array, PCs 1-10 —
PPM036624 PGS018442
(TPMI_078_MegaPRS)
 PSS012344|
East Asian Ancestry|
15,250 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral warts HPV — AUROC: 0.68774 R²: 0.05587 sex, age, array, PCs 1-10 —
PPM036625 PGS018443
(TPMI_078_PRS-CS)
 PSS012345|
East Asian Ancestry|
15,250 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral warts HPV — AUROC: 0.69124 R²: 0.05719 sex, age, array, PCs 1-10 —
PPM036626 PGS018444
(TPMI_078_SBayesR)
 PSS012346|
East Asian Ancestry|
15,250 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Viral warts HPV — AUROC: 0.68781 R²: 0.05626 sex, age, array, PCs 1-10 —
PPM036894 PGS018712
(TPMI_246.2_Lassosum2)
 PSS012610|
East Asian Ancestry|
17,266 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Thyroid cyst — AUROC: 0.71646 R²: 0.01421 sex, age, array, PCs 1-10 —
PPM036895 PGS018713
(TPMI_246.2_LDpred2)
 PSS012609|
East Asian Ancestry|
17,266 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Thyroid cyst — AUROC: 0.713 R²: 0.01407 sex, age, array, PCs 1-10 —
PPM036896 PGS018714
(TPMI_246.2_MegaPRS)
 PSS012611|
East Asian Ancestry|
17,266 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Thyroid cyst — AUROC: 0.7148 R²: 0.01367 sex, age, array, PCs 1-10 —
PPM036897 PGS018715
(TPMI_246.2_PRS-CS)
 PSS012612|
East Asian Ancestry|
17,266 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Thyroid cyst — AUROC: 0.71979 R²: 0.01449 sex, age, array, PCs 1-10 —
PPM036898 PGS018716
(TPMI_246.2_SBayesR)
 PSS012613|
East Asian Ancestry|
17,266 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Thyroid cyst — AUROC: 0.7132 R²: 0.01354 sex, age, array, PCs 1-10 —
PPM038124 PGS019946
(cm_prs_noannot_sbrc)
 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma — C-index: 0.729 (0.013) — MP16 clinical risk score —
PPM038122 PGS019946
(cm_prs_noannot_sbrc)
 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma OR: 1.685 C-index: 0.643 — — —
PPM038123 PGS019946
(cm_prs_noannot_sbrc)
 PSS013827|
European Ancestry|
16,282 individuals
 PGP000838 |
Wang H et al. Br J Dermatol (2026)
 Reported Trait: Cutaneous melanoma — C-index: 0.67 (0.014) — age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008902 — — 3,913 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007621 — —
[
  • 12 cases
  • , 6,485 controls
]
 — African unspecified — UKB —
PSS007622 — —
[
  • 9 cases
  • , 1,695 controls
]
 — East Asian — UKB —
PSS007623 — —
[
  • 1,649 cases
  • , 23,256 controls
]
 — European non-white British ancestry UKB —
PSS007624 — —
[
  • 20 cases
  • , 7,811 controls
]
 — South Asian — UKB —
PSS007625 — —
[
  • 4,637 cases
  • , 62,788 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS008013 — — 1,807 individuals — East Asian China (East Asia) UKB —
PSS011383 — —
[
  • 432 cases
  • , 566 controls
]
,
44.0 % Male samples
 — European — NSCS —
PSS011328 — — 133,830 individuals,
0.0 % Male samples
 — European
(British)		 — UKB —
PSS011329 — — 115,207 individuals,
100.0 % Male samples
 — European
(British)		 — UKB —
PSS009047 — — 4,134 individuals — European Poland (NE Europe) UKB —
PSS008155 — — 6,328 individuals — South Asian India (South Asia) UKB —
PSS010995 — — 448 individuals Mean = 58.23 years European — TCGA —
PSS000463 Unaffected family members from families with increased melaona risk. Recruited families were ranked as low-, medium- or high-risk using a risk index (T) that factored in the number of confirmed cases of melanoma versus number of unaffected family members, ages and year of birth —
[
  • 1,292 cases
  • , 1,774 controls
]
,
46.28 % Male samples
 — European Australia BATS, QFMP —
PSS000464 Unaffected family members from families with increased melaona risk. Recruited families were ranked as low-, medium- or high-risk using a risk index (T) that factored in the number of confirmed cases of melanoma versus number of unaffected family members, ages and year of birth —
[
  • 111 cases
  • , 1,774 controls
]
,
46.37 % Male samples
 — European Australia BATS, QFMP —
PSS008679 — — 6,646 individuals — European Italy (South Europe) UKB —
PSS007651 — —
[
  • 11 cases
  • , 6,486 controls
]
 — African unspecified — UKB —
PSS007652 — —
[
  • 6 cases
  • , 1,698 controls
]
 — East Asian — UKB —
PSS007653 — —
[
  • 1,442 cases
  • , 23,463 controls
]
 — European non-white British ancestry UKB —
PSS007654 — —
[
  • 18 cases
  • , 7,813 controls
]
 — South Asian — UKB —
PSS007655 — —
[
  • 4,141 cases
  • , 63,284 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS013827 — Median = 10.0 years
[
  • 359 cases
  • , 15,923 controls
]
 — European — QSKIN —
PSS007798 — — 2,471 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008827 — — 3,924 individuals — African unspecified Nigeria (West Africa) UKB —
PSS012342 078.1, 079.4,A63.0, B07, B97.7 —
[
  • 339 cases
  • , 14,911 controls
]
,
45.03 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012343 078.1, 079.4,A63.0, B07, B97.7 —
[
  • 339 cases
  • , 14,911 controls
]
,
45.03 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012344 078.1, 079.4,A63.0, B07, B97.7 —
[
  • 339 cases
  • , 14,911 controls
]
,
45.03 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012345 078.1, 079.4,A63.0, B07, B97.7 —
[
  • 339 cases
  • , 14,911 controls
]
,
45.03 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012346 078.1, 079.4,A63.0, B07, B97.7 —
[
  • 339 cases
  • , 14,911 controls
]
,
45.03 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008453 — — 1,194 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007943 — — 1,810 individuals — East Asian China (East Asia) UKB —
PSS009351 — — 19,952 individuals — European UK (+ Ireland) UKB —
PSS012610 246.2, —
[
  • 186 cases
  • , 17,080 controls
]
,
49.59 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012609 246.2, —
[
  • 186 cases
  • , 17,080 controls
]
,
49.59 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012611 246.2, —
[
  • 186 cases
  • , 17,080 controls
]
,
49.59 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012612 246.2, —
[
  • 186 cases
  • , 17,080 controls
]
,
49.59 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012613 246.2, —
[
  • 186 cases
  • , 17,080 controls
]
,
49.59 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS008601 — — 6,656 individuals — European Italy (South Europe) UKB —
PSS010085 C43 —
[
  • 4,242 cases
  • , 269,544 controls
]
 — European
(British)		 — UKB Controls were samples without any cancer diagnosis or self-reported cancer
PSS000982 Cases were individuals with cutaneous melanoma. Of the 628 cases, 528 were prevalent melanoma, whilst 98 were incident melanoma cases. Endpoints used were primary invasive cutaneous melanoma and metastatic melanoma with unknown primary location occurring during the trial (incident). Metastatic recurrence was excluded. Incident melanomas were confirmed by expert panel using histopathology, imaging of metastasis or other clinical evidence. If a participant had two events during the trial, the time of the first event was used. Prevalent melanomas occurring pre-trial were self-reported by participants but not confirmed by review of medical records and assumed to be invasive. Age at diagnosis for self-reported melanomas was reported as either before or after 50 years. Median = 4.7 years
[
  • 626 cases
  • , 12,086 controls
]
,
45.0 % Male samples
 Mean = 75.0 years
Sd = 4.23 years		 European — ASPREE —
PSS009125 — — 4,124 individuals — European Poland (NE Europe) UKB —
PSS008233 — — 6,311 individuals — South Asian India (South Asia) UKB —
PSS010980 — — 4,797 individuals — European — NR GCAT
PSS007725 — — 2,483 individuals — African American or Afro-Caribbean Carribean UKB —
PSS004521 — —
[
  • 81 cases
  • , 6,416 controls
]
 — African unspecified — UKB —
PSS004522 — —
[
  • 32 cases
  • , 1,672 controls
]
 — East Asian — UKB —
PSS004523 — —
[
  • 781 cases
  • , 24,124 controls
]
 — European non-white British ancestry UKB —
PSS004524 — —
[
  • 307 cases
  • , 7,524 controls
]
 — South Asian — UKB —
PSS004525 — —
[
  • 2,358 cases
  • , 65,067 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS009273 — — 19,990 individuals — European UK (+ Ireland) UKB —
PSS008379 — — 1,200 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS000546 PheCode:172.2; ICD9CM:173.00, 173.01, 173.02, 173.09, 173.10, 173.11, 173.12, 173.19, 173.20, 173.21, 173.22, 173.29, 173.30, 173.31, 173.32, 173.39, 173.40, 173.41, 173.42, 173.49, 173.50, 173.51, 173.52, 173.59, 173.60, 173.61, 173.62, 173.69, 173.70, 173.71, 173.72, 173.79, 173.80, 173.81, 173.82, 173.89, 173.90, 173.91, 173.92, 173.99, 209.31, 209.32, 209.33, 209.34, 209.35, 209.36, V10.83; ICD10CM:C44.0, C44.00, C44.01, C44.02, C44.09, C44.1, C44.10, C44.101, C44.102, C44.109, C44.11, C44.111, C44.112, C44.119, C44.12, C44.121, C44.122, C44.129, C44.19, C44.191, C44.192, C44.199, C44.2, C44.20, C44.201, C44.202, C44.209, C44.21, C44.211, C44.212, C44.219, C44.22, C44.221, C44.222, C44.229, C44.29, C44.291, C44.292, C44.299, C44.30, C44.300, C44.301, C44.309, C44.31, C44.310, C44.311, C44.319, C44.320, C44.321, C44.329, C44.39, C44.390, C44.391, C44.399, C44.4, C44.40, C44.41, C44.42, C44.49, C44.500, C44.501, C44.509, C44.51, C44.510, C44.511, C44.519, C44.52, C44.520, C44.521, C44.529, C44.59, C44.590, C44.591, C44.599, C44.6, C44.60, C44.601, C44.602, C44.609, C44.61, C44.611, C44.612, C44.619, C44.62, C44.621, C44.622, C44.629, C44.69, C44.691, C44.692, C44.699, C44.7, C44.70, C44.701, C44.702, C44.709, C44.71, C44.711, C44.712, C44.719, C44.72, C44.721, C44.722, C44.729, C44.79, C44.791, C44.792, C44.799, C44.8, C44.80, C44.81, C44.82, C44.89, C44.9, C44.90, C44.91, C44.92, C44.99, C4A, C4A.0, C4A.1, C4A.10, C4A.11, C4A.12, C4A.2, C4A.20, C4A.21, C4A.22, C4A.3, C4A.30, C4A.31, C4A.39, C4A.4, C4A.5, C4A.51, C4A.52, C4A.59, C4A.6, C4A.60, C4A.61, C4A.62, C4A.7, C4A.70, C4A.71, C4A.72, C4A.8, C4A.9 —
[
  • 2,954 cases
  • , 12,944 controls
]
 — European — MGI —
PSS000547 PheCode:172.3; ICD9CM:232.0, 232.1, 232.2, 232.3, 232.4, 232.5, 232.6, 232.7, 232.8, 232.9; ICD10CM:D04, D04.0, D04.1, D04.10, D04.11, D04.12, D04.2, D04.20, D04.21, D04.22, D04.3, D04.30, D04.39, D04.4, D04.5, D04.6, D04.60, D04.61, D04.62, D04.7, D04.70, D04.71, D04.72, D04.8, D04.9 —
[
  • 585 cases
  • , 4,915 controls
]
 — European — MGI —
PSS000548 PheCode:172; ICD9CM:172.0, 172.1, 172.2, 172.3, 172.4, 172.5, 172.6, 172.7, 172.8, 172.9, 173.00, 173.01, 173.02, 173.09, 173.10, 173.11, 173.12, 173.19, 173.20, 173.21, 173.22, 173.29, 173.30, 173.31, 173.32, 173.39, 173.40, 173.41, 173.42, 173.49, 173.50, 173.51, 173.52, 173.59, 173.60, 173.61, 173.62, 173.69, 173.70, 173.71, 173.72, 173.79, 173.80, 173.81, 173.82, 173.89, 173.90, 173.91, 173.92, 173.99, 209.31, 209.32, 209.33, 209.34, 209.35, 209.36, 232.0, 232.1, 232.2, 232.3, 232.4, 232.5, 232.6, 232.7, 232.8, 232.9, V10.82, V10.83; ICD10CM:C43, C43.0, C43.1, C43.10, C43.11, C43.12, C43.2, C43.20, C43.21, C43.22, C43.3, C43.30, C43.31, C43.39, C43.4, C43.5, C43.51, C43.52, C43.59, C43.6, C43.60, C43.61, C43.62, C43.7, C43.70, C43.71, C43.72, C43.8, C43.9, C44.0, C44.00, C44.01, C44.02, C44.09, C44.1, C44.10, C44.101, C44.102, C44.109, C44.11, C44.111, C44.112, C44.119, C44.12, C44.121, C44.122, C44.129, C44.19, C44.191, C44.192, C44.199, C44.2, C44.20, C44.201, C44.202, C44.209, C44.21, C44.211, C44.212, C44.219, C44.22, C44.221, C44.222, C44.229, C44.29, C44.291, C44.292, C44.299, C44.30, C44.300, C44.301, C44.309, C44.31, C44.310, C44.311, C44.319, C44.320, C44.321, C44.329, C44.39, C44.390, C44.391, C44.399, C44.4, C44.40, C44.41, C44.42, C44.49, C44.500, C44.501, C44.509, C44.51, C44.510, C44.511, C44.519, C44.52, C44.520, C44.521, C44.529, C44.59, C44.590, C44.591, C44.599, C44.6, C44.60, C44.601, C44.602, C44.609, C44.61, C44.611, C44.612, C44.619, C44.62, C44.621, C44.622, C44.629, C44.69, C44.691, C44.692, C44.699, C44.7, C44.70, C44.701, C44.702, C44.709, C44.71, C44.711, C44.712, C44.719, C44.72, C44.721, C44.722, C44.729, C44.79, C44.791, C44.792, C44.799, C44.8, C44.80, C44.81, C44.82, C44.89, C44.9, C44.90, C44.91, C44.92, C44.99, C4A, C4A.0, C4A.1, C4A.10, C4A.11, C4A.12, C4A.2, C4A.20, C4A.21, C4A.22, C4A.3, C4A.30, C4A.31, C4A.39, C4A.4, C4A.5, C4A.51, C4A.52, C4A.59, C4A.6, C4A.60, C4A.61, C4A.62, C4A.7, C4A.70, C4A.71, C4A.72, C4A.8, C4A.9, D03, D03.0, D03.1, D03.10, D03.11, D03.12, D03.2, D03.20, D03.21, D03.22, D03.3, D03.30, D03.39, D03.4, D03.5, D03.51, D03.52, D03.59, D03.6, D03.60, D03.61, D03.62, D03.7, D03.70, D03.71, D03.72, D03.8, D03.9, D04, D04.0, D04.1, D04.10, D04.11, D04.12, D04.2, D04.20, D04.21, D04.22, D04.3, D04.30, D04.39, D04.4, D04.5, D04.6, D04.60, D04.61, D04.62, D04.7, D04.70, D04.71, D04.72, D04.8, D04.9 —
[
  • 3,557 cases
  • , 14,050 controls
]
 — European — MGI —