Trait: peripheral nervous system disorder

Trait Information
Identifier MONDO_0003620
Description A disease involving the peripheral nervous system.
Trait category
Other trait
Synonyms 18 synonyms
  • PNS (peripheral nervous system) diseases
  • PNS disease
  • PNS diseases
  • disease of peripheral nervous system
  • disease or disorder of peripheral nervous system
  • disorder of peripheral nervous system
  • disorder of the peripheral nervous system
  • nerve disease, peripheral
  • nerve diseases, peripheral
  • neuropathy, peripheral
  • peripheral Neuropathies
  • peripheral nerve disease
  • peripheral nerve diseases
  • peripheral nervous system disease
  • peripheral nervous system disease or disorder
  • peripheral nervous system disorder
  • peripheral nervous system disorders
  • peripheral neuropathy
Child trait(s) 4 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "peripheral nervous system disorder" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS001832
(portability-PLR_351)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Other peripheral nerve disorders peripheral nervous system disorder 8,393
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001832/ScoringFiles/PGS001832.txt.gz
PGS002039
(portability-ldpred2_351)
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Other peripheral nerve disorders peripheral nervous system disorder 799,326
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002039/ScoringFiles/PGS002039.txt.gz
PGS004453
(disease.G56.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
G56 (Mononeuropathies of upper limb) mononeuropathy 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004453/ScoringFiles/PGS004453.txt.gz
PGS004523
(meta.G56.score)
PGP000561 |
Jung H et al. Commun Biol (2024)
G56 (Mononeuropathies of upper limb) mononeuropathy 1,059,939
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004523/ScoringFiles/PGS004523.txt.gz
PGS018630
(TPMI_225_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 105,501
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018630/ScoringFiles/PGS018630.txt.gz
PGS018631
(TPMI_225_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 939,890
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018631/ScoringFiles/PGS018631.txt.gz
PGS018632
(TPMI_225_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 18,584
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018632/ScoringFiles/PGS018632.txt.gz
PGS018633
(TPMI_225_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018633/ScoringFiles/PGS018633.txt.gz
PGS018634
(TPMI_225_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 994,892
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018634/ScoringFiles/PGS018634.txt.gz
PGS018734
(TPMI_250.6_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Polyneuropathy in diabetes diabetic neuropathy 669
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018734/ScoringFiles/PGS018734.txt.gz
PGS018735
(TPMI_250.6_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Polyneuropathy in diabetes diabetic neuropathy 939,815
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018735/ScoringFiles/PGS018735.txt.gz
PGS018736
(TPMI_250.6_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Polyneuropathy in diabetes diabetic neuropathy 54,980
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018736/ScoringFiles/PGS018736.txt.gz
PGS018737
(TPMI_250.6_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Polyneuropathy in diabetes diabetic neuropathy 983,767
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018737/ScoringFiles/PGS018737.txt.gz
PGS018738
(TPMI_250.6_PRSmix+)
PGP000835 |
Chen HH et al. Nature (2025)
Polyneuropathy in diabetes diabetic neuropathy 1,071,477
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018738/ScoringFiles/PGS018738.txt.gz
PGS018739
(TPMI_250.6_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Polyneuropathy in diabetes diabetic neuropathy 996,392
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018739/ScoringFiles/PGS018739.txt.gz
PGS018996
(TPMI_352.2_Lassosum2)
PGP000835 |
Chen HH et al. Nature (2025)
Facial nerve disorders CN7 facial nerve disorder 241,782
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018996/ScoringFiles/PGS018996.txt.gz
PGS018997
(TPMI_352.2_LDpred2)
PGP000835 |
Chen HH et al. Nature (2025)
Facial nerve disorders CN7 facial nerve disorder 939,882
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018997/ScoringFiles/PGS018997.txt.gz
PGS018998
(TPMI_352.2_MegaPRS)
PGP000835 |
Chen HH et al. Nature (2025)
Facial nerve disorders CN7 facial nerve disorder 18,580
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018998/ScoringFiles/PGS018998.txt.gz
PGS018999
(TPMI_352.2_PRS-CS)
PGP000835 |
Chen HH et al. Nature (2025)
Facial nerve disorders CN7 facial nerve disorder 983,821
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018999/ScoringFiles/PGS018999.txt.gz
PGS019000
(TPMI_352.2_SBayesR)
PGP000835 |
Chen HH et al. Nature (2025)
Facial nerve disorders CN7 facial nerve disorder 1,002,253
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019000/ScoringFiles/PGS019000.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009548 PGS001832
(portability-PLR_351)
PSS009302|
European Ancestry|
19,840 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0393 [0.0253, 0.0531] sex, age, birth date, deprivation index, 16 PCs
PPM009549 PGS001832
(portability-PLR_351)
PSS009076|
European Ancestry|
4,112 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0324 [0.0018, 0.063] sex, age, birth date, deprivation index, 16 PCs
PPM009550 PGS001832
(portability-PLR_351)
PSS008630|
European Ancestry|
6,611 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0341 [0.0099, 0.0582] sex, age, birth date, deprivation index, 16 PCs
PPM009552 PGS001832
(portability-PLR_351)
PSS008184|
South Asian Ancestry|
6,277 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0367 [0.0119, 0.0614] sex, age, birth date, deprivation index, 16 PCs
PPM009553 PGS001832
(portability-PLR_351)
PSS007968|
East Asian Ancestry|
1,801 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0055 [-0.041, 0.0519] sex, age, birth date, deprivation index, 16 PCs
PPM009554 PGS001832
(portability-PLR_351)
PSS007750|
African Ancestry|
2,471 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): -0.0227 [-0.0623, 0.0169] sex, age, birth date, deprivation index, 16 PCs
PPM009555 PGS001832
(portability-PLR_351)
PSS008854|
African Ancestry|
3,898 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): -0.0063 [-0.0378, 0.0252] sex, age, birth date, deprivation index, 16 PCs
PPM009551 PGS001832
(portability-PLR_351)
PSS008404|
Greater Middle Eastern Ancestry|
1,191 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): -0.039 [-0.0961, 0.0183] sex, age, birth date, deprivation index, 16 PCs
PPM011178 PGS002039
(portability-ldpred2_351)
PSS009302|
European Ancestry|
19,840 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0728 [0.059, 0.0867] sex, age, birth date, deprivation index, 16 PCs
PPM011179 PGS002039
(portability-ldpred2_351)
PSS009076|
European Ancestry|
4,112 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0556 [0.025, 0.0861] sex, age, birth date, deprivation index, 16 PCs
PPM011180 PGS002039
(portability-ldpred2_351)
PSS008630|
European Ancestry|
6,611 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0652 [0.0412, 0.0892] sex, age, birth date, deprivation index, 16 PCs
PPM011182 PGS002039
(portability-ldpred2_351)
PSS008184|
South Asian Ancestry|
6,277 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0433 [0.0186, 0.068] sex, age, birth date, deprivation index, 16 PCs
PPM011183 PGS002039
(portability-ldpred2_351)
PSS007968|
East Asian Ancestry|
1,801 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0229 [-0.0235, 0.0693] sex, age, birth date, deprivation index, 16 PCs
PPM011184 PGS002039
(portability-ldpred2_351)
PSS007750|
African Ancestry|
2,471 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0037 [-0.0359, 0.0432] sex, age, birth date, deprivation index, 16 PCs
PPM011185 PGS002039
(portability-ldpred2_351)
PSS008854|
African Ancestry|
3,898 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.005 [-0.0265, 0.0365] sex, age, birth date, deprivation index, 16 PCs
PPM011181 PGS002039
(portability-ldpred2_351)
PSS008404|
Greater Middle Eastern Ancestry|
1,191 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Other peripheral nerve disorders Partial Correlation (partial-r): 0.0081 [-0.0492, 0.0654] sex, age, birth date, deprivation index, 16 PCs
PPM020568 PGS004453
(disease.G56.score)
PSS011364|
European Ancestry|
56,192 individuals
PGP000561 |
Jung H et al. Commun Biol (2024)
Reported Trait: G56 (Mononeuropathies of upper limb) OR: 1.2757
PPM020638 PGS004523
(meta.G56.score)
PSS011364|
European Ancestry|
56,192 individuals
PGP000561 |
Jung H et al. Commun Biol (2024)
Reported Trait: G56 (Mononeuropathies of upper limb) OR: 1.41928
PPM036812 PGS018630
(TPMI_225_Lassosum2)
PSS012533|
East Asian Ancestry|
19,663 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Benign neoplasm of brain and other parts of nervous system AUROC: 0.66017 : 0.00803 sex, age, array, PCs 1-10
PPM036813 PGS018631
(TPMI_225_LDpred2)
PSS012532|
East Asian Ancestry|
19,663 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Benign neoplasm of brain and other parts of nervous system AUROC: 0.66156 : 0.00841 sex, age, array, PCs 1-10
PPM036814 PGS018632
(TPMI_225_MegaPRS)
PSS012534|
East Asian Ancestry|
19,663 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Benign neoplasm of brain and other parts of nervous system AUROC: 0.66091 : 0.00806 sex, age, array, PCs 1-10
PPM036815 PGS018633
(TPMI_225_PRS-CS)
PSS012535|
East Asian Ancestry|
19,663 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Benign neoplasm of brain and other parts of nervous system AUROC: 0.65907 : 0.00795 sex, age, array, PCs 1-10
PPM036816 PGS018634
(TPMI_225_SBayesR)
PSS012536|
East Asian Ancestry|
19,663 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Benign neoplasm of brain and other parts of nervous system AUROC: 0.65916 : 0.00802 sex, age, array, PCs 1-10
PPM036916 PGS018734
(TPMI_250.6_Lassosum2)
PSS012666|
East Asian Ancestry|
14,427 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Polyneuropathy in diabetes AUROC: 0.64672 : 0.02095 sex, age, array, PCs 1-10
PPM036917 PGS018735
(TPMI_250.6_LDpred2)
PSS012665|
East Asian Ancestry|
14,427 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Polyneuropathy in diabetes AUROC: 0.66143 : 0.02491 sex, age, array, PCs 1-10
PPM036918 PGS018736
(TPMI_250.6_MegaPRS)
PSS012667|
East Asian Ancestry|
14,427 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Polyneuropathy in diabetes AUROC: 0.63648 : 0.017 sex, age, array, PCs 1-10
PPM036919 PGS018737
(TPMI_250.6_PRS-CS)
PSS012668|
East Asian Ancestry|
14,427 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Polyneuropathy in diabetes AUROC: 0.6604 : 0.02481 sex, age, array, PCs 1-10
PPM036920 PGS018738
(TPMI_250.6_PRSmix+)
PSS012669|
East Asian Ancestry|
14,427 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Polyneuropathy in diabetes AUROC: 0.72686 : 0.05052 sex, age, array, PCs 1-10
PPM036921 PGS018739
(TPMI_250.6_SBayesR)
PSS012670|
East Asian Ancestry|
14,427 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Polyneuropathy in diabetes AUROC: 0.65242 : 0.02202 sex, age, array, PCs 1-10
PPM037178 PGS018996
(TPMI_352.2_Lassosum2)
PSS012899|
East Asian Ancestry|
18,297 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Facial nerve disorders CN7 AUROC: 0.67307 : 0.01135 sex, age, array, PCs 1-10
PPM037179 PGS018997
(TPMI_352.2_LDpred2)
PSS012898|
East Asian Ancestry|
18,297 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Facial nerve disorders CN7 AUROC: 0.67176 : 0.01121 sex, age, array, PCs 1-10
PPM037180 PGS018998
(TPMI_352.2_MegaPRS)
PSS012900|
East Asian Ancestry|
18,297 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Facial nerve disorders CN7 AUROC: 0.67501 : 0.01142 sex, age, array, PCs 1-10
PPM037181 PGS018999
(TPMI_352.2_PRS-CS)
PSS012901|
East Asian Ancestry|
18,297 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Facial nerve disorders CN7 AUROC: 0.67303 : 0.01128 sex, age, array, PCs 1-10
PPM037182 PGS019000
(TPMI_352.2_SBayesR)
PSS012902|
East Asian Ancestry|
18,297 individuals
PGP000835 |
Chen HH et al. Nature (2025)
Reported Trait: Facial nerve disorders CN7 AUROC: 0.67171 : 0.0112 sex, age, array, PCs 1-10

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012669 357.2,E08.42, E09.42, E10.42
[
  • 421 cases
  • , 14,006 controls
]
,
42.51 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012670 357.2,E08.42, E09.42, E10.42
[
  • 421 cases
  • , 14,006 controls
]
,
42.51 % Male samples
East Asian
(Han Chinese)
TPMI
PSS007750 2,471 individuals African American or Afro-Caribbean Carribean UKB
PSS008404 1,191 individuals Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB
PSS009302 19,840 individuals European UK (+ Ireland) UKB
PSS009076 4,112 individuals European Poland (NE Europe) UKB
PSS008184 6,277 individuals South Asian India (South Asia) UKB
PSS008854 3,898 individuals African unspecified Nigeria (West Africa) UKB
PSS011364 56,192 individuals European UKB
PSS007968 1,801 individuals East Asian China (East Asia) UKB
PSS012898 351,G51
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012899 351,G51
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012900 351,G51
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012901 351,G51
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012902 351,G51
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
East Asian
(Han Chinese)
TPMI
PSS008630 6,611 individuals European Italy (South Europe) UKB
PSS012532 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012533 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012534 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012535 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012536 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012665 357.2,E08.42, E09.42, E10.42
[
  • 421 cases
  • , 14,006 controls
]
,
42.51 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012666 357.2,E08.42, E09.42, E10.42
[
  • 421 cases
  • , 14,006 controls
]
,
42.51 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012667 357.2,E08.42, E09.42, E10.42
[
  • 421 cases
  • , 14,006 controls
]
,
42.51 % Male samples
East Asian
(Han Chinese)
TPMI
PSS012668 357.2,E08.42, E09.42, E10.42
[
  • 421 cases
  • , 14,006 controls
]
,
42.51 % Male samples
East Asian
(Han Chinese)
TPMI