Trait: neurotic disorder

Trait Information
Identifier MONDO_0005379
Description A form of functional mental illness that manifests in distressed emotional reactions such as anxiety, obsessive thoughts, compulsive behaviors, or irrational fears. [NCIT: C34848]
Trait category
Other trait
Synonyms 12 synonyms
  • Psychoneuroses
  • depressive neurosis
  • disorder, neurotic
  • disorders, neurotic
  • neuroses
  • neurosis
  • neurotic depression
  • neurotic depression reactive type
  • neurotic depressive state
  • neurotic disorder
  • psychoneurosis NOS
  • reactive depression
Child trait(s) post-traumatic stress disorder

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "neurotic disorder" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005393
(PGS_SEXUAL_ASSAULT_PTSD)
 PGP000778 |
Bugiga AVG et al. Braz J Psychiatry (2024)
 Post-traumatic stress disorder post-traumatic stress disorder 53,705
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005393/ScoringFiles/PGS005393.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023435 PGS005393
(PGS_SEXUAL_ASSAULT_PTSD)
 PSS012181|
Hispanic or Latin American Ancestry|
117 individuals
 PGP000778 |
Bugiga AVG et al. Braz J Psychiatry (2024)
 Reported Trait: PTSD diagnosis — — R²: 0.087 PC1-PC10 best p-value threshold of 0.333
PPM023436 PGS005393
(PGS_SEXUAL_ASSAULT_PTSD)
 PSS012181|
Hispanic or Latin American Ancestry|
117 individuals
 PGP000778 |
Bugiga AVG et al. Braz J Psychiatry (2024)
 Reported Trait: PTSD diagnosis OR: 0.035 — — Trauma history, genetic ancestry (10 PCs), age, education, income. best p-value threshold of 0.333

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012181 — —
[
  • 57 cases
  • , 60 controls
]
 — Hispanic or Latin American
(Brazilian)		 — NR —