Trait: sebaceous gland disorder

Trait Information
Identifier MONDO_0006607
Description A disease involving the sebaceous gland.
Trait category
Other trait
Synonyms 5 synonyms
  • disease of sebaceous gland
  • disease or disorder of sebaceous gland
  • disorder of sebaceous gland
  • sebaceous gland disease
  • sebaceous gland disease or disorder
Child trait(s) 2 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "sebaceous gland disorder" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000963
(GBE_HC1184)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Follicular cysts of skin and subcutaneous tissue (time-to-event) Follicular Cyst 264
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000963/ScoringFiles/PGS000963.txt.gz
PGS019629
(TPMI_706_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Diseases of sebaceous glands sebaceous gland disorder 732,290
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019629/ScoringFiles/PGS019629.txt.gz
PGS019630
(TPMI_706_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Diseases of sebaceous glands sebaceous gland disorder 338,113
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019630/ScoringFiles/PGS019630.txt.gz
PGS019631
(TPMI_706_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Diseases of sebaceous glands sebaceous gland disorder 464,295
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019631/ScoringFiles/PGS019631.txt.gz
PGS019632
(TPMI_706_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Diseases of sebaceous glands sebaceous gland disorder 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019632/ScoringFiles/PGS019632.txt.gz
PGS019633
(TPMI_706_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Diseases of sebaceous glands sebaceous gland disorder 959,673
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019633/ScoringFiles/PGS019633.txt.gz
PGS019634
(TPMI_706.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 565,294
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019634/ScoringFiles/PGS019634.txt.gz
PGS019635
(TPMI_706.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 273,955
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019635/ScoringFiles/PGS019635.txt.gz
PGS019636
(TPMI_706.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 17,458
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019636/ScoringFiles/PGS019636.txt.gz
PGS019637
(TPMI_706.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 983,822
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019637/ScoringFiles/PGS019637.txt.gz
PGS019638
(TPMI_706.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 961,798
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019638/ScoringFiles/PGS019638.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007639 PGS000963
(GBE_HC1184)
 PSS004168|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE follicular cysts of skin and subcutaneous tissue — AUROC: 0.56399 [0.51489, 0.61308] R²: 0.01027
Incremental AUROC (full-covars): -0.00108
PGS R2 (no covariates): 0.00011
PGS AUROC (no covariates): 0.51899 [0.4747, 0.56328]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007640 PGS000963
(GBE_HC1184)
 PSS004169|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE follicular cysts of skin and subcutaneous tissue — AUROC: 0.64299 [0.54406, 0.74191] R²: 0.02377
Incremental AUROC (full-covars): 0.01591
PGS R2 (no covariates): 0.00898
PGS AUROC (no covariates): 0.60189 [0.51478, 0.689]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007641 PGS000963
(GBE_HC1184)
 PSS004170|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE follicular cysts of skin and subcutaneous tissue — AUROC: 0.61353 [0.59056, 0.63651] R²: 0.02635
Incremental AUROC (full-covars): 0.0691
PGS R2 (no covariates): 0.02281
PGS AUROC (no covariates): 0.59346 [0.56998, 0.61695]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007642 PGS000963
(GBE_HC1184)
 PSS004171|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE follicular cysts of skin and subcutaneous tissue — AUROC: 0.64204 [0.6008, 0.68328] R²: 0.03504
Incremental AUROC (full-covars): 0.04562
PGS R2 (no covariates): 0.02125
PGS AUROC (no covariates): 0.56287 [0.51348, 0.61226]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007643 PGS000963
(GBE_HC1184)
 PSS004172|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE follicular cysts of skin and subcutaneous tissue — AUROC: 0.6146 [0.60131, 0.6279] R²: 0.02902
Incremental AUROC (full-covars): 0.06632
PGS R2 (no covariates): 0.02439
PGS AUROC (no covariates): 0.58761 [0.57398, 0.60124]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM037811 PGS019629
(TPMI_706_Lassosum2)
 PSS013537|
East Asian Ancestry|
19,524 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Diseases of sebaceous glands — AUROC: 0.69368 R²: 0.09446 sex, age, array, PCs 1-10 —
PPM037812 PGS019630
(TPMI_706_LDpred2)
 PSS013536|
East Asian Ancestry|
19,524 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Diseases of sebaceous glands — AUROC: 0.6937 R²: 0.09459 sex, age, array, PCs 1-10 —
PPM037813 PGS019631
(TPMI_706_MegaPRS)
 PSS013538|
East Asian Ancestry|
19,524 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Diseases of sebaceous glands — AUROC: 0.69369 R²: 0.09452 sex, age, array, PCs 1-10 —
PPM037814 PGS019632
(TPMI_706_PRS-CS)
 PSS013539|
East Asian Ancestry|
19,524 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Diseases of sebaceous glands — AUROC: 0.69402 R²: 0.09494 sex, age, array, PCs 1-10 —
PPM037815 PGS019633
(TPMI_706_SBayesR)
 PSS013540|
East Asian Ancestry|
19,524 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Diseases of sebaceous glands — AUROC: 0.6934 R²: 0.09432 sex, age, array, PCs 1-10 —
PPM037816 PGS019634
(TPMI_706.1_Lassosum2)
 PSS013532|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76402 R²: 0.07598 sex, age, array, PCs 1-10 —
PPM037817 PGS019635
(TPMI_706.1_LDpred2)
 PSS013531|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76413 R²: 0.07611 sex, age, array, PCs 1-10 —
PPM037818 PGS019636
(TPMI_706.1_MegaPRS)
 PSS013533|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76454 R²: 0.07604 sex, age, array, PCs 1-10 —
PPM037819 PGS019637
(TPMI_706.1_PRS-CS)
 PSS013534|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76392 R²: 0.07603 sex, age, array, PCs 1-10 —
PPM037820 PGS019638
(TPMI_706.1_SBayesR)
 PSS013535|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.7639 R²: 0.07599 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013533 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013534 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013535 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013536 706,K09.8, L70, L72.0, L72.1, L72.2, L72.3, L72.8, L72.9, L73.0, L85.3 —
[
  • 615 cases
  • , 18,909 controls
]
,
46.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013537 706,K09.8, L70, L72.0, L72.1, L72.2, L72.3, L72.8, L72.9, L73.0, L85.3 —
[
  • 615 cases
  • , 18,909 controls
]
,
46.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013538 706,K09.8, L70, L72.0, L72.1, L72.2, L72.3, L72.8, L72.9, L73.0, L85.3 —
[
  • 615 cases
  • , 18,909 controls
]
,
46.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013539 706,K09.8, L70, L72.0, L72.1, L72.2, L72.3, L72.8, L72.9, L73.0, L85.3 —
[
  • 615 cases
  • , 18,909 controls
]
,
46.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013540 706,K09.8, L70, L72.0, L72.1, L72.2, L72.3, L72.8, L72.9, L73.0, L85.3 —
[
  • 615 cases
  • , 18,909 controls
]
,
46.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS004168 — —
[
  • 141 cases
  • , 6,356 controls
]
 — African unspecified — UKB —
PSS004169 — —
[
  • 29 cases
  • , 1,675 controls
]
 — East Asian — UKB —
PSS004170 — —
[
  • 668 cases
  • , 24,237 controls
]
 — European non-white British ancestry UKB —
PSS004171 — —
[
  • 180 cases
  • , 7,651 controls
]
 — South Asian — UKB —
PSS004172 — —
[
  • 1,995 cases
  • , 65,430 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS013531 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013532 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —