Trait: nervous system neoplasm

Trait Information
Identifier MONDO_0021248
Description A neoplasm (disease) that involves the nervous system. [MONDO: patterns/location]
Trait categories
Neurological disorder
Other disease
Synonyms 10 synonyms
  • neoplasm of nervous system
  • neoplasm of the nervous system
  • nervous system neoplasm (disease)
  • nervous system neoplasms
  • nervous system tumor
  • nervous system tumour
  • tumor of nervous system
  • tumor of the nervous system
  • tumour of nervous system
  • tumour of the nervous system
Child trait(s) 9 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "nervous system neoplasm" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000155
(cGRS_Glioma)
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Glioma glioma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000155/ScoringFiles/PGS000155.txt.gz
PGS000617
(PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Ocular cancer ocular cancer 834,009
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000617/ScoringFiles/PGS000617.txt.gz
PGS000618
(PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain and nervous system cancer central nervous system cancer 23
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000618/ScoringFiles/PGS000618.txt.gz
PGS000619
(PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain and nervous system cancer central nervous system cancer 19
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000619/ScoringFiles/PGS000619.txt.gz
PGS000620
(PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain cancer brain cancer 522
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000620/ScoringFiles/PGS000620.txt.gz
PGS000621
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain cancer brain cancer 12
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000621/ScoringFiles/PGS000621.txt.gz
PGS000622
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain cancer brain cancer 12
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000622/ScoringFiles/PGS000622.txt.gz
PGS000623
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain cancer brain cancer 11
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000623/ScoringFiles/PGS000623.txt.gz
PGS000624
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain cancer brain cancer 5
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000624/ScoringFiles/PGS000624.txt.gz
PGS000625
(PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Brain cancer brain cancer 11
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000625/ScoringFiles/PGS000625.txt.gz
PGS000781
(GRS7_Glio)
 PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
 Glioma glioma,
brain neoplasm		 5
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000781/ScoringFiles/PGS000781.txt.gz
PGS001808
(portability-PLR_191.11)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Brain cancer brain cancer 117
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001808/ScoringFiles/PGS001808.txt.gz
PGS002261
(PRS22_NB)
 PGP000287 |
Testori A et al. Cancer Epidemiol Biomarkers Prev (2022)
 Neuroblastoma neuroblastoma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002261/ScoringFiles/PGS002261.txt.gz
PGS002302
(PRS28_glioma)
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Glioma glioma 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002302/ScoringFiles/PGS002302.txt.gz
PGS003384
(best_GBM)
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Glioblastoma glioblastoma 910
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003384/ScoringFiles/PGS003384.txt.gz
PGS003737
(PRS26_BrC)
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Brain cancer brain neoplasm 26
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003737/ScoringFiles/PGS003737.txt.gz
PGS018460
(TPMI_145.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 11
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018460/ScoringFiles/PGS018460.txt.gz
PGS018461
(TPMI_145.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 34,059
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018461/ScoringFiles/PGS018461.txt.gz
PGS018462
(TPMI_145.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 570,182
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018462/ScoringFiles/PGS018462.txt.gz
PGS018463
(TPMI_145.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 983,776
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018463/ScoringFiles/PGS018463.txt.gz
PGS018464
(TPMI_145.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 1,003,968
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018464/ScoringFiles/PGS018464.txt.gz
PGS018575
(TPMI_191_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Manlignant and unknown neoplasms of brain and nervous system central nervous system cancer 43
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018575/ScoringFiles/PGS018575.txt.gz
PGS018576
(TPMI_191_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Manlignant and unknown neoplasms of brain and nervous system central nervous system cancer 90,905
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018576/ScoringFiles/PGS018576.txt.gz
PGS018577
(TPMI_191_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Manlignant and unknown neoplasms of brain and nervous system central nervous system cancer 487,886
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018577/ScoringFiles/PGS018577.txt.gz
PGS018578
(TPMI_191_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Manlignant and unknown neoplasms of brain and nervous system central nervous system cancer 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018578/ScoringFiles/PGS018578.txt.gz
PGS018579
(TPMI_191_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Manlignant and unknown neoplasms of brain and nervous system central nervous system cancer 996,644
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018579/ScoringFiles/PGS018579.txt.gz
PGS018630
(TPMI_225_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 105,501
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018630/ScoringFiles/PGS018630.txt.gz
PGS018631
(TPMI_225_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 939,890
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018631/ScoringFiles/PGS018631.txt.gz
PGS018632
(TPMI_225_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 18,584
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018632/ScoringFiles/PGS018632.txt.gz
PGS018633
(TPMI_225_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018633/ScoringFiles/PGS018633.txt.gz
PGS018634
(TPMI_225_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Benign neoplasm of brain and other parts of nervous system benign neoplasm of peripheral nervous system 994,892
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018634/ScoringFiles/PGS018634.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000475 PGS000155
(cGRS_Glioma)
 PSS000275|
European Ancestry|
14,419 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Glioma — — Mean realative risk: 1.22 [1.18, 1.26]
Wilcoxon test (case vs. control) p-value: 1.39e-37		 — —
PPM000486 PGS000155
(cGRS_Glioma)
 PSS000275|
European Ancestry|
14,419 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Glioma — — Odds Ratio (OR; high vs. average risk groups): 1.8 [1.55, 2.1] — —
PPM001302 PGS000617
(PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608)
 PSS000556|
European Ancestry|
672 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of eye OR: 1.339 [1.033, 1.736]
β: 0.292 (0.132)		 AUROC: 0.586 [0.508, 0.658] Nagelkerke's Pseudo-R²: 0.0152
Brier score: 0.0831
Odds Ratio (OR, top 1% vs. Rest): 4.74 [1.2, 18.7]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE190_20001-1030_PRS-CS_MGI_20200608
PPM001303 PGS000618
(PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608)
 PSS000578|
European Ancestry|
3,110 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain and nervous system OR: 1.569 [1.399, 1.759]
β: 0.45 (0.0585)		 AUROC: 0.623 [0.592, 0.656] Nagelkerke's Pseudo-R²: 0.0401
Brier score: 0.0812
Odds Ratio (OR, top 1% vs. Rest): 3.64 [1.76, 7.53]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_P_5e-08_UKB_20200608
PPM001304 PGS000619
(PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608)
 PSS000578|
European Ancestry|
3,110 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain and nervous system OR: 1.564 [1.396, 1.753]
β: 0.448 (0.0581)		 AUROC: 0.622 [0.59, 0.653] Nagelkerke's Pseudo-R²: 0.0401
Brier score: 0.0812
Odds Ratio (OR, top 1% vs. Rest): 2.93 [1.34, 6.41]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.1_GWAS-Catalog-r2019-05-03-X191.1_PT_UKB_20200608
PPM001305 PGS000620
(PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608)
 PSS000557|
European Ancestry|
2,563 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain OR: 1.195 [1.045, 1.367]
β: 0.179 (0.0686)		 AUROC: 0.546 [0.504, 0.587] Nagelkerke's Pseudo-R²: 0.00561
Brier score: 0.0824
Odds Ratio (OR, top 1% vs. Rest): 1.42 [0.453, 4.47]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.11_C71_LASSOSUM_MGI_20200608
PPM001306 PGS000621
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608)
 PSS000557|
European Ancestry|
2,563 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain OR: 1.159 [1.015, 1.324]
β: 0.148 (0.068)		 AUROC: 0.54 [0.503, 0.579] Nagelkerke's Pseudo-R²: 0.00394
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 1.02 [0.271, 3.86]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_MGI_20200608
PPM001307 PGS000622
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608)
 PSS000577|
European Ancestry|
3,020 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain OR: 1.486 [1.315, 1.679]
β: 0.396 (0.0624)		 AUROC: 0.605 [0.569, 0.639] Nagelkerke's Pseudo-R²: 0.0289
Brier score: 0.0815
Odds Ratio (OR, top 1% vs. Rest): 3.38 [1.59, 7.2]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_P_5e-08_UKB_20200608
PPM001308 PGS000623
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608)
 PSS000557|
European Ancestry|
2,563 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain OR: 1.153 [1.01, 1.316]
β: 0.142 (0.0676)		 AUROC: 0.538 [0.501, 0.577] Nagelkerke's Pseudo-R²: 0.00369
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 0.602 [0.113, 3.22]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_MGI_20200608
PPM001309 PGS000624
(PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608)
 PSS000577|
European Ancestry|
3,020 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain OR: 1.515 [1.344, 1.708]
β: 0.415 (0.0611)		 AUROC: 0.606 [0.568, 0.642] Nagelkerke's Pseudo-R²: 0.0326
Brier score: 0.0813
Odds Ratio (OR, top 1% vs. Rest): 4.15 [2.04, 8.41]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.11_GWAS-Catalog-r2019-05-03-X191.11_PT_UKB_20200608
PPM001310 PGS000625
(PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608)
 PSS000557|
European Ancestry|
2,563 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of brain OR: 1.142 [1.004, 1.299]
β: 0.133 (0.0657)		 AUROC: 0.53 [0.492, 0.57] Nagelkerke's Pseudo-R²: 0.00328
Brier score: 0.0825
Odds Ratio (OR, top 1% vs. Rest): 2.28 [0.88, 5.88]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE191.11_UKBB-SAIGE-HRC-X191.11_PT_MGI_20200608
PPM002036 PGS000781
(GRS7_Glio)
 PSS001009|
Multi-ancestry (including European)|
734 individuals
 PGP000185 |
Adel Fahmideh M et al. Sci Rep (2019)
 Reported Trait: Pediatric brain tumors OR: 1.25 [1.06, 1.49] — R²: 0.012 Age, sex, country —
PPM009371 PGS001808
(portability-PLR_191.11)
 PSS007947|
East Asian Ancestry|
1,801 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0004 [-0.0461, 0.0468] sex, age, birth date, deprivation index, 16 PCs —
PPM009367 PGS001808
(portability-PLR_191.11)
 PSS009278|
European Ancestry|
19,895 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0144 sex, age, birth date, deprivation index, 16 PCs —
PPM009368 PGS001808
(portability-PLR_191.11)
 PSS009052|
European Ancestry|
4,114 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0179 [-0.0128, 0.0485] sex, age, birth date, deprivation index, 16 PCs —
PPM009369 PGS001808
(portability-PLR_191.11)
 PSS008606|
European Ancestry|
6,626 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0237 sex, age, birth date, deprivation index, 16 PCs —
PPM009370 PGS001808
(portability-PLR_191.11)
 PSS008160|
South Asian Ancestry|
6,310 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0098 [-0.0149, 0.0345] sex, age, birth date, deprivation index, 16 PCs —
PPM009372 PGS001808
(portability-PLR_191.11)
 PSS007729|
African Ancestry|
2,477 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0217 [-0.0179, 0.0612] sex, age, birth date, deprivation index, 16 PCs —
PPM009373 PGS001808
(portability-PLR_191.11)
 PSS008832|
African Ancestry|
3,913 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of brain — — Partial Correlation (partial-r): 0.0343 [0.0029, 0.0657] sex, age, birth date, deprivation index, 16 PCs —
PPM012873 PGS002261
(PRS22_NB)
 PSS009587|
African Ancestry|
3,619 individuals
 PGP000287 |
Testori A et al. Cancer Epidemiol Biomarkers Prev (2022)
 Reported Trait: Neuroblastoma risk — — R²: 0.0203 — —
PPM013031 PGS002302
(PRS28_glioma)
 PSS009663|
European Ancestry|
312 individuals
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Reported Trait: Glioma — AUROC: 0.61 [0.57, 0.64] — — —
PPM013039 PGS002302
(PRS28_glioma)
 PSS009663|
European Ancestry|
312 individuals
 PGP000328 |
Choi J et al. Int J Cancer (2020)
 Reported Trait: Glioma — — Hazard ratio (HR top 5% vs average): 2.55 [1.72, 3.77] Age, birth cohort, genotyping array, top 10 PCs for ancestry and sex (for nonsex specific cancer only) —
PPM016259 PGS003384
(best_GBM)
 PSS010078|
European Ancestry|
269,806 individuals
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Reported Trait: glioblastoma — AUROC: 0.758 R²: 0.0216 age, sex, top 20 genetic principal components —
PPM018493 PGS003737
(PRS26_BrC)
 PSS010987|
European Ancestry|
890 individuals
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Reported Trait: Brain cancer OR: 1.5 [1.38, 1.63] — — — —
PPM036642 PGS018460
(TPMI_145.2_Lassosum2)
 PSS012358|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68616 R²: 0.01171 sex, age, array, PCs 1-10 —
PPM036643 PGS018461
(TPMI_145.2_LDpred2)
 PSS012357|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68599 R²: 0.01168 sex, age, array, PCs 1-10 —
PPM036644 PGS018462
(TPMI_145.2_MegaPRS)
 PSS012359|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68604 R²: 0.0117 sex, age, array, PCs 1-10 —
PPM036645 PGS018463
(TPMI_145.2_PRS-CS)
 PSS012360|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68622 R²: 0.0117 sex, age, array, PCs 1-10 —
PPM036646 PGS018464
(TPMI_145.2_SBayesR)
 PSS012361|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68563 R²: 0.01173 sex, age, array, PCs 1-10 —
PPM036757 PGS018575
(TPMI_191_Lassosum2)
 PSS012478|
East Asian Ancestry|
19,669 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Manlignant and unknown neoplasms of brain and nervous system — AUROC: 0.69472 R²: 0.01255 sex, age, array, PCs 1-10 —
PPM036758 PGS018576
(TPMI_191_LDpred2)
 PSS012477|
East Asian Ancestry|
19,669 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Manlignant and unknown neoplasms of brain and nervous system — AUROC: 0.69446 R²: 0.01254 sex, age, array, PCs 1-10 —
PPM036759 PGS018577
(TPMI_191_MegaPRS)
 PSS012479|
East Asian Ancestry|
19,669 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Manlignant and unknown neoplasms of brain and nervous system — AUROC: 0.69455 R²: 0.0126 sex, age, array, PCs 1-10 —
PPM036760 PGS018578
(TPMI_191_PRS-CS)
 PSS012480|
East Asian Ancestry|
19,669 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Manlignant and unknown neoplasms of brain and nervous system — AUROC: 0.69562 R²: 0.01269 sex, age, array, PCs 1-10 —
PPM036761 PGS018579
(TPMI_191_SBayesR)
 PSS012481|
East Asian Ancestry|
19,669 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Manlignant and unknown neoplasms of brain and nervous system — AUROC: 0.69618 R²: 0.01269 sex, age, array, PCs 1-10 —
PPM036812 PGS018630
(TPMI_225_Lassosum2)
 PSS012533|
East Asian Ancestry|
19,663 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Benign neoplasm of brain and other parts of nervous system — AUROC: 0.66017 R²: 0.00803 sex, age, array, PCs 1-10 —
PPM036813 PGS018631
(TPMI_225_LDpred2)
 PSS012532|
East Asian Ancestry|
19,663 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Benign neoplasm of brain and other parts of nervous system — AUROC: 0.66156 R²: 0.00841 sex, age, array, PCs 1-10 —
PPM036814 PGS018632
(TPMI_225_MegaPRS)
 PSS012534|
East Asian Ancestry|
19,663 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Benign neoplasm of brain and other parts of nervous system — AUROC: 0.66091 R²: 0.00806 sex, age, array, PCs 1-10 —
PPM036815 PGS018633
(TPMI_225_PRS-CS)
 PSS012535|
East Asian Ancestry|
19,663 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Benign neoplasm of brain and other parts of nervous system — AUROC: 0.65907 R²: 0.00795 sex, age, array, PCs 1-10 —
PPM036816 PGS018634
(TPMI_225_SBayesR)
 PSS012536|
East Asian Ancestry|
19,663 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Benign neoplasm of brain and other parts of nervous system — AUROC: 0.65916 R²: 0.00802 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000556 PheCode:190; ICD9CM:190.0, 190.1, 190.2, 190.3, 190.4, 190.5, 190.6, 190.7, 190.8, 190.9, 234.0, V10.84; ICD10CM:C69, C69.0, C69.00, C69.01, C69.02, C69.1, C69.10, C69.11, C69.12, C69.2, C69.20, C69.21, C69.22, C69.3, C69.30, C69.31, C69.32, C69.4, C69.40, C69.41, C69.42, C69.5, C69.50, C69.51, C69.52, C69.6, C69.60, C69.61, C69.62, C69.8, C69.80, C69.81, C69.82, C69.9, C69.90, C69.91, C69.92, D09.2, D09.20, D09.21, D09.22 —
[
  • 62 cases
  • , 610 controls
]
 — European — MGI —
PSS000557 PheCode:191.11; ICD9CM:191.0, 191.1, 191.2, 191.3, 191.4, 191.5, 191.6, 191.7, 191.8, 191.9, V10.85; ICD10CM:C71, C71.0, C71.1, C71.2, C71.3, C71.4, C71.5, C71.6, C71.7, C71.8, C71.9 —
[
  • 233 cases
  • , 2,330 controls
]
 — European — MGI —
PSS010987 — — 890 individuals Mean = 50.88 years European — TCGA —
PSS000577 PheCode:191.11; ICD9:191, 191.0, 191.1, 191.2, 191.3, 191.4, 191.5, 191.6, 191.7, 191.8, 191.9; ICD10:C71.0, C71.1, C71.2, C71.3, C71.4, C71.5, C71.6, C71.7, C71.8, C71.9 —
[
  • 275 cases
  • , 2,745 controls
]
 — European — UKB —
PSS000578 PheCode:191.1; ICD9:192, 192.0, 192.1, 192.2, 192.3, 192.8, 192.9; ICD10:C70.0, C70.1, C70.9, C71.0, C71.1, C71.2, C71.3, C71.4, C71.5, C71.6, C71.7, C71.8, C71.9, C72.0, C72.1, C72.2, C72.3, C72.4, C72.5, C72.8, C72.9 —
[
  • 283 cases
  • , 2,827 controls
]
 — European — UKB —
PSS009052 — — 4,114 individuals — European Poland (NE Europe) UKB —
PSS008160 — — 6,310 individuals — South Asian India (South Asia) UKB —
PSS009587 — —
[
  • 629 cases
  • , 2,990 controls
]
 — African American or Afro-Caribbean
(African American)		 — COG —
PSS008832 — — 3,913 individuals — African unspecified Nigeria (West Africa) UKB —
PSS012477 191, 192, 237.5, 237.6, 239.6, V10.85, V10.86,C70, C71, C72, D42, D43.0, D43.1, D43.2, D43.4, D49.6, Z85.841, Z85.848 —
[
  • 197 cases
  • , 19,472 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012478 191, 192, 237.5, 237.6, 239.6, V10.85, V10.86,C70, C71, C72, D42, D43.0, D43.1, D43.2, D43.4, D49.6, Z85.841, Z85.848 —
[
  • 197 cases
  • , 19,472 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012479 191, 192, 237.5, 237.6, 239.6, V10.85, V10.86,C70, C71, C72, D42, D43.0, D43.1, D43.2, D43.4, D49.6, Z85.841, Z85.848 —
[
  • 197 cases
  • , 19,472 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012480 191, 192, 237.5, 237.6, 239.6, V10.85, V10.86,C70, C71, C72, D42, D43.0, D43.1, D43.2, D43.4, D49.6, Z85.841, Z85.848 —
[
  • 197 cases
  • , 19,472 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012481 191, 192, 237.5, 237.6, 239.6, V10.85, V10.86,C70, C71, C72, D42, D43.0, D43.1, D43.2, D43.4, D49.6, Z85.841, Z85.848 —
[
  • 197 cases
  • , 19,472 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007947 — — 1,801 individuals — East Asian China (East Asia) UKB —
PSS012357 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012358 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012359 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012360 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012361 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS010078 C71, histology was either Giant cell glioblastoma or Glioblastoma (NOS) —
[
  • 262 cases
  • , 269,544 controls
]
 — European
(British)		 — UKB Controls were samples without any cancer diagnosis or self-reported cancer
PSS000275 Primary tumor samples from TCGA —
[
  • 992 cases
  • , 0 controls
]
 Mean = 52.0 years
Sd = 16.0 years		 European — TCGA —
PSS000275 — —
[
  • 0 cases
  • , 13,427 controls
]
 — European — eMERGE —
PSS008606 — — 6,626 individuals — European Italy (South Europe) UKB —
PSS009663 glioma (ICD-9 = 191 or ICD-10 = C71; ICD-O: 9380-9480) — 312 individuals — European — UKB —
PSS012533 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011 —
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007729 — — 2,477 individuals — African American or Afro-Caribbean Carribean UKB —
PSS012535 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011 —
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012532 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011 —
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS001009 Cases include participants with the following tumors: Astrocytomas (ICCC-3 group IIIb), Other gliomas (ICCC-3 group IIId), Ependymomas (ICCC-3 group IIIa), Intracranial embryonal tumors (ICCC-3 group IIIc), other specified intracranial neoplasms (ICCC-3 group IIIe), unspecified intracranial neoplasms (ICCC-3 group IIIf) —
[
  • 245 cases
  • , 489 controls
]
,
54.09 % Male samples
 — European, NR European = 454, NR =280 CEFALO —
PSS012534 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011 —
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS009278 — — 19,895 individuals — European UK (+ Ireland) UKB —
PSS012536 225, V12.41,D32.0, D32.1, D32.9, D33.0, D33.1, D33.2, D33.3, D33.4, D33.7, D33.9, Z86.011 —
[
  • 191 cases
  • , 19,472 controls
]
,
46.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —