Trait: coronary heart disease

Information

Experimental Factor Ontology ID: EFO_0001645

EFO Trait Description:

  • An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
  • Narrowing of the coronary arteries due to fatty deposits inside the arterial walls.
  • Coronary heart disease is a cardiovascular disease in which there is a failure of coronary circulation to supply adequate circulation to cardiac muscle and surrounding tissue.

Associated PGS

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000014 PGS000010 (GRS27) PSS000008 Mega JL et al. (2015) Reported Trait: Coronary heart disease HR: 1.21 [1.17 - 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PGS000010 (GRS27) PSS000009 Mega JL et al. (2015) Reported Trait: Coronary heart disease HR: 1.14 [1.02 - 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000017 PGS000010 (GRS27) PSS000010 Tada H et al. (2015) Ext. Reported Trait: Incident coronary heart disease HR: 1.2 [1.15 - 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000019 PGS000010 (GRS27) PSS000012 Abraham G et al. (2016) Ext. Reported Trait: Incident coronary artery disease HR: 1.21 [1.12 - 1.3]
PPM000021 PGS000010 (GRS27) PSS000011 Abraham G et al. (2016) Ext. Reported Trait: Incident coronary artery disease HR: 1.2 [1.07 - 1.26]
PPM000144 PGS000057 (CHD57) PSS000091 Natarajan P et al. (2017) Reported Trait: Coronary heart disease (incident) HR (highest vs. lowest quintile of PGS): 1.66 [1.21 - 2.29] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000145 PGS000057 (CHD57) PSS000090 Natarajan P et al. (2017) Reported Trait: Coronary artery calcification OR: 1.32 [1.04 - 1.68] OR (highest vs. lowest quintile of PGS): 2.51 [1.08 - 5.85] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000146 PGS000057 (CHD57) PSS000089 Natarajan P et al. (2017) Reported Trait: Carotid artery plaque burden β: 1.097 [1.022 - 1.178] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000149 PGS000059 (CHD46) PSS000095 Hajek C et al. (2018) Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 1.92 [1.19 - 3.11]
p-value (association between risk and incidence): 0.029
NR
PPM000150 PGS000059 (CHD46) PSS000094 Hajek C et al. (2018) Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 0.76 [0.41 - 1.39]
p-value (association between risk and incidence): 0.31
NR

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals
38.70 %% Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 8,749 individuals
[ 108 cases, 8,641 controls]
67.80 %% Male samples
European JUPITER Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 6,978 individuals
[ 149 cases, 6,829 controls]
79.70 %% Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 2,878 individuals
[ 320 cases, 2,558 controls]
86.10 %% Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 1,999 individuals
[ 229 cases, 1,770 controls]
77.50 %% Male samples
European PROVEIT Secondary prevention cohorts
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease. 23,595 individuals
[ 2,213 cases, 21,382 controls]
38.03 %% Male samples
European
(Swedish)
MDC Prospective study
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24) 3,406 individuals
[ 587 cases, 2,819 controls]
45.00 %% Male samples
European FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures. 12,676 individuals
[ 757 cases, 11,919 controls]
46.00 %% Male samples
European
(Finnish)
FINRISK FR92, FR97, FR02
PSS000089 Total carotid plaque burden (mm2) 4,392 individuals BioImage
PSS000090 Total coronary arterial clacification (CAC) was coded as a a dichotomous outcome variable (CAC>0 versus CAC=0), and quantified by the Agatston method 1,154 individuals CARDIA
PSS000091 Nonfatal myocardial infarction or death from CHD 2,440 individuals
100.00 %% Male samples
Participants were all men hypercholesterolemia but without a history of myocardial infarction, allocated to the placebo group
PSS000094 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death 1,320 individuals
[ 86 cases, 1,234 controls]
European Analysis restricted to "White participants" MESA
PSS000095 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death 1,206 individuals
[ 144 cases, 1,062 controls]
European Analysis restricted to "White participants" MESA