Trait: coronary artery disease

Experimental Factor Ontology (EFO) Information
Identifier EFO_0001645
Description Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC) [NCIT: C26732]
Trait category
Cardiovascular disease
Synonyms 37 synonyms
  • coronary artery disease
  • Artery Disease, Coronary
  • Coronary Heart Diseases
  • Diseases, Coronary Heart
  • Coronary Arteriosclerosis
  • Arteriosclerosis, Coronary
  • Diseases, Coronary
  • Coronary Atheroscleroses
  • disorder of coronary artery
  • CORONARY HEART DIS
  • Atheroscleroses, Coronary
  • Atherosclerosis, Coronary
  • Arterioscleroses, Coronary
  • coronary disease
  • Coronary Diseases
  • Coronary Atherosclerosis
  • Coronary Artery Diseases
  • Coronary Disease
  • coronary artery disease or disorder
  • CORONARY DIS
  • Artery Diseases, Coronary
  • Disease, Coronary Artery
  • Diseases, Coronary Artery
  • CHD (coronary heart disease)
  • Heart Diseases, Coronary
  • CAD
  • Disease, Coronary
  • Coronary Artery Disease
  • Disease, Coronary Heart
  • Coronary Arterioscleroses
  • disease or disorder of coronary artery
  • coronary heart disease
  • disease of coronary artery
  • CORONARY ARTERY DIS
  • CHD - Coronary heart disease
  • CHD
  • Heart Disease, Coronary
Mapped term(s) 29 mapped terms
  • GARD:0011944
  • OMIM:608901
  • SNOMEDCT:53741008
  • UMLS:C1956346
  • OMIM:617347
  • ICD10:I25.9
  • SNOMEDCT:414545008
  • ICD9:410-414.99
  • SNOMEDCT:443502000
  • OMIM:608320
  • ICD10:I20-I25
  • OMIM:610938
  • NCIt:C26732
  • NCIt:C50625
  • MSH:D003324
  • ICD10:I25.1
  • ICD10:K76.1
  • DOID:3393
  • MESH:D003324
  • ICD10:I25
  • NCIT:C26732
  • ICD9:414.9
  • OMIM:614466
  • ICD9:414.0
  • MSH:D003327
  • MONDO:0005010
  • ICD10:I25.10
  • COHD:317576
  • SCTID:414024009

Associated Polygenic Score(s)

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000010 GRS27 PGP000003 Mega JL et al. Lancet (2015) Coronary heart disease coronary artery disease 27 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000010/ScoringFiles/PGS000010.txt.gz
PGS000011 GRS50 PGP000004 Tada H et al. Eur Heart J (2015) Coronary artery disease coronary artery disease 50 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz
PGS000012 GRS49K PGP000005 Abraham G et al. Eur Heart J (2016) Coronary artery disease coronary artery disease 49,310 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000012/ScoringFiles/PGS000012.txt.gz
PGS000013 GPS_CAD PGP000006 Khera AV et al. Nat Genet (2018) Coronary artery disease coronary artery disease 6,630,150 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses
PGS000018 metaGRS_CAD PGP000007 Inouye M et al. J Am Coll Cardiol (2018) Coronary artery disease coronary artery disease 1,745,179 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000019 GRS_CAD PGP000009 Paquette M et al. J Clin Lipidol (2017) Coronary artery disease coronary artery disease 192 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000019/ScoringFiles/PGS000019.txt.gz
PGS000057 CHD57 PGP000042 Natarajan P et al. Circulation (2017) Coronary heart disease coronary artery disease 57 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000057/ScoringFiles/PGS000057.txt.gz
PGS000058 CAD_GRS_204 PGP000043 Morieri ML et al. Diabetes Care (2018) Coronary artery disease coronary artery disease 204 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000058/ScoringFiles/PGS000058.txt.gz
PGS000059 CHD46 PGP000044 Hajek C et al. Circ Genom Precis Med (2018) Coronary heart disease coronary artery disease 46 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000059/ScoringFiles/PGS000059.txt.gz
PGS000116 CAD_EJ2020 PGP000054 Elliott J et al. JAMA (2020) Coronary Artery Disease coronary artery disease 40,079 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000116/ScoringFiles/PGS000116.txt.gz
PGS000200 GRS28 PGP000082 Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013) Coronary heart disease coronary artery disease 28 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz
PGS000296 GPS_CAD_SA PGP000090 Wang M et al. J Am Coll Cardiol (2020) Coronary artery disease coronary artery disease 6,630,150 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000296/ScoringFiles/PGS000296.txt.gz - Check Terms/Licenses
PGS000329 PRS_CHD PGP000100 Mars N et al. Nat Med (2020) Coronary heart disease coronary artery disease 6,423,165 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000329/ScoringFiles/PGS000329.txt.gz
PGS000337 MetaPRS_CAD PGP000104 Koyama S et al. Nat Genet (2020) Coronary artery disease coronary artery disease 75,028 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000337/ScoringFiles/PGS000337.txt.gz - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000014 PGS000010 (GRS27) PSS000008 PGP000003
Mega JL et al. (2015)
Reported Trait: Coronary heart disease HR: 1.21[1.17, 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PGS000010 (GRS27) PSS000009 PGP000003
Mega JL et al. (2015)
Reported Trait: Coronary heart disease HR: 1.14[1.02, 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000018 PGS000012 (GRS49K) PSS000012 PGP000005
Abraham G et al. (2016)
Reported Trait: Incident coronary artery disease HR: 1.74[1.61, 1.86]
OR: 1.74[1.61, 1.89]
sex, sub-cohort, location (east/west), 5 genetic PCs Used only the 42,364 SNPs that were available in FINRISK
PPM000020 PGS000012 (GRS49K) PSS000011 PGP000005
Abraham G et al. (2016)
Reported Trait: Incident coronary artery disease HR: 1.28[1.18, 1.38]
OR: 1.28[1.17, 1.41]
sex, sub-cohort, 5 genetic PCs Used only the 46,773 SNPs that were available in FHS
PPM000027 PGS000018 (metaGRS_CAD) PSS000018 PGP000007
Inouye M et al. (2018)
Reported Trait: Incident coronary artery disease HR: 1.706[1.682, 1.73] AUROC: 0.79
C-index: 0.623[0.615, 0.631]
AUPRC: 0.161 sex, genetic PCs (1-10), genotyping array age-as-time-scale Cox regression
PPM000028 PGS000012 (GRS49K) PSS000018 PGP000007
Inouye M et al. (2018)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.524[1.498, 1.551] sex, genetic PCs (1-10), genotyping array Used GRS46K (excludes A/T and C/G SNPs, with performance similar to GRS49K)
PPM000038 PGS000019 (GRS_CAD) PSS000023 PGP000009
Paquette M et al. (2017)
Reported Trait: Coronary artery disease in familial hypercholesterolemia patients OR: 1.66[1.06, 2.62] age, gender, prior statin use, smoking, diabetes, hypertension, BMI, LDL-C, HDL-C, TGs, Lp(a), and type of LDLR mutation Performance metrics are from Model 2 (adjusted for cardiovascular risk factors)
PPM000039 PGS000019 (GRS_CAD) PSS000024 PGP000009
Paquette M et al. (2017)
Reported Trait: Coronary artery disease in familial hypercholesterolemia patients OR: 1.8[1.14, 2.85] age, gender, prior statin use, smoking, diabetes, hypertension, BMI, LDL-C, HDL-C, TGs, Lp(a), and type of LDLR mutation Performance metrics are from Model 2 (adjusted for cardiovascular risk factors)
PPM000016 PGS000011 (GRS50) PSS000010 PGP000004
Tada H et al. (2015)
Reported Trait: Incident coronary heart disease HR: 1.23[1.18, 1.28] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000583 PGS000200 (GRS28) PSS000330 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident cardiovascular disease HR: 1.18[1.12, 1.24] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000150 PGS000059 (CHD46) PSS000094 PGP000044
Hajek C et al. (2018)
Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 0.76[0.41, 1.39]
p-value (association between risk and incidence): 0.31
NR
PPM000589 PGS000011 (GRS50) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.2[1.15, 1.25] C-index: 0.698 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000588 PGS000200 (GRS28) PSS000328 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident acute coronary syndrome C-index: 0.859 ΔC-index (over covariate only model): 0.004[0.003, 0.005] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000587 PGS000200 (GRS28) PSS000329 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident coronary heart disease C-index: 0.856 ΔC-index (over covariate only model): 0.005[0.004, 0.006] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000586 PGS000200 (GRS28) PSS000330 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident cardiovascular disease C-index: 0.84 ΔC-index (over covariate only model): 0.003[0.002, 0.004] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000585 PGS000200 (GRS28) PSS000328 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident acute coronary syndrome HR: 1.27[1.18, 1.37] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000605 PGS000013 (GPS_CAD) PSS000335 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.42[1.25, 1.61] AUROC: 0.776 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000604 PGS000011 (GRS50) PSS000335 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.2[1.06, 1.35] AUROC: 0.769 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000603 PGS000018 (metaGRS_CAD) PSS000331 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.4[1.3, 1.52] AUROC: 0.775 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000602 PGS000013 (GPS_CAD) PSS000331 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.3[1.21, 1.41] AUROC: 0.771 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000601 PGS000011 (GRS50) PSS000331 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.05[0.98, 1.14] AUROC: 0.763 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000600 PGS000018 (metaGRS_CAD) PSS000333 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.73[1.68, 1.78] AUROC: 0.772 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000599 PGS000013 (GPS_CAD) PSS000333 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.66[1.62, 1.71] AUROC: 0.77 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000598 PGS000011 (GRS50) PSS000333 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.28[1.25, 1.32] AUROC: 0.75 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000597 PGS000018 (metaGRS_CAD) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.53[1.23, 1.9] C-index: 0.683 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000596 PGS000013 (GPS_CAD) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.16[0.96, 1.41] C-index: 0.659 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000595 PGS000011 (GRS50) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.13[0.93, 1.36] C-index: 0.654 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000594 PGS000018 (metaGRS_CAD) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.27[1.13, 1.43] C-index: 0.663 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000593 PGS000013 (GPS_CAD) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.19[1.07, 1.33] C-index: 0.656 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000592 PGS000011 (GRS50) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.05[0.94, 1.17] C-index: 0.649 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000591 PGS000018 (metaGRS_CAD) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.53[1.46, 1.6] C-index: 0.719 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000619 PGS000013 (GPS_CAD) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.17[1.04, 1.31] C-index: 0.712 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000618 PGS000011 (GRS50) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.05[0.94, 1.18] C-index: 0.704 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000617 PGS000200 (GRS28) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.11[0.99, 1.25] C-index: 0.706 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000616 PGS000018 (metaGRS_CAD) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.49[1.43, 1.56] C-index: 0.75 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000615 PGS000013 (GPS_CAD) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.47[1.41, 1.54] C-index: 0.75 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000614 PGS000011 (GRS50) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.2[1.15, 1.25] C-index: 0.736 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000613 PGS000200 (GRS28) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.17[1.12, 1.22] C-index: 0.735 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000612 PGS000200 (GRS28) PSS000335 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.27[1.12, 1.42] AUROC: 0.771 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000611 PGS000200 (GRS28) PSS000331 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.07[0.99, 1.16] AUROC: 0.763 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000610 PGS000200 (GRS28) PSS000333 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.24[1.21, 1.28] AUROC: 0.748 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000609 PGS000200 (GRS28) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.14[0.94, 1.37] C-index: 0.655 sex, eMERGE site, first five ancestry-specific principal components
PPM000608 PGS000200 (GRS28) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.11[0.99, 1.24] C-index: 0.652 sex, eMERGE site, first five ancestry-specific principal components
PPM000607 PGS000200 (GRS28) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.18[1.13, 1.23] C-index: 0.697 sex, eMERGE site, first five ancestry-specific principal components
PPM000620 PGS000018 (metaGRS_CAD) PSS000332 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.25[1.12, 1.41] C-index: 0.723 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000624 PGS000018 (metaGRS_CAD) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.5[1.21, 1.87] C-index: 0.725 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000623 PGS000013 (GPS_CAD) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.14[0.94, 1.39] C-index: 0.708 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000622 PGS000011 (GRS50) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.12[0.93, 1.36] C-index: 0.708 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000621 PGS000200 (GRS28) PSS000336 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.13[0.93, 1.37] C-index: 0.709 sex, eMERGE site, diabetes, hypertension, hyperlipidemia, statin use, first 5 ancestry-specific principal components Age-as-time-scale Cox regression
PPM000606 PGS000018 (metaGRS_CAD) PSS000335 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Coronary heart disease (incident and prevalent) OR: 1.93[1.67, 2.22] AUROC: 0.794 age at first EHR record, duration of EHR, sex, eMERGE site, first five ancestry-specific principal components
PPM000590 PGS000013 (GPS_CAD) PSS000334 PGP000083
Dikilitas O et al. (2020)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.5[1.43, 1.56] C-index: 0.719 sex, eMERGE site, first five ancestry-specific principal components Age-as-time-scale Cox regression
PPM000584 PGS000200 (GRS28) PSS000329 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident coronary heart disease HR: 1.27[1.2, 1.35] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000496 PGS000011 (GRS50) PSS000285 PGP000076
Khera AV et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.98[1.76, 2.23] age, sex, self reported education level
PPM000495 PGS000011 (GRS50) PSS000286 PGP000076
Khera AV et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.94[1.58, 2.39] age, self reported education level, treatment (vitamin E vs aspirin), 5 genetic principal components
PPM000494 PGS000011 (GRS50) PSS000283 PGP000076
Khera AV et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.75[1.46, 2.1] age, sex, self reported education level, 5 genetic principal components
PPM000836 PGS000116 (CAD_EJ2020) PSS000401 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease C-index: 0.74[0.73, 0.75] QRISK3
PPM000837 PGS000116 (CAD_EJ2020) PSS000389 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.75[0.74, 0.76] QRISK3
PPM000838 PGS000116 (CAD_EJ2020) PSS000385 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.83[0.81, 0.84] QRISK3
PPM000839 PGS000116 (CAD_EJ2020) PSS000393 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.73[0.72, 0.74] QRISK3
PPM000840 PGS000116 (CAD_EJ2020) PSS000397 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.78[0.76, 0.79] QRISK3
PPM000743 PGS000296 (GPS_CAD_SA) PSS000365 PGP000090
Wang M et al. (2020)
Reported Trait: Myocardial infarction (first-ever) OR: 1.6[1.32, 1.94] AUROC: 0.6632 age, sex, top 5 genetic PCs
PPM000745 PGS000296 (GPS_CAD_SA) PSS000366 PGP000090
Wang M et al. (2020)
Reported Trait: Coronary artery disease OR: 1.66[1.53, 1.81] AUROC: 0.712 age, sex, top 5 genetic PCs
PPM000746 PGS000296 (GPS_CAD_SA) PSS000366 PGP000090
Wang M et al. (2020)
Reported Trait: Coronary artery disease OR: 1.58[1.42, 1.75] age, sex, top 5 genetic PCs, diabetes, hypertension, hypercholesterolemia, smoking, body mass index
PPM000747 PGS000013 (GPS_CAD) PSS000367 PGP000090
Wang M et al. (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.5302 AUROC: 0.8021 age, sex, top 5 genetic PCs
PPM000017 PGS000010 (GRS27) PSS000010 PGP000004
Tada H et al. (2015)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.2[1.15, 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000022 PGS000013 (GPS_CAD) PSS000015 PGP000006
Khera AV et al. (2018)
Reported Trait: Coronary artery disease AUROC: 0.81[0.81, 0.81] Nagelkerke’s R2 (estimate of variance explained by the PGS after covariate adjustment): 0.04 age; sex; Ancestry PC 1-4; genotyping chip
PPM000029 PGS000011 (GRS50) PSS000018 PGP000007
Inouye M et al. (2018)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.263[1.247, 1.28] sex, genetic PCs (1-10), genotyping array
PPM000030 PGS000013 (GPS_CAD) PSS000021 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.64[1.48, 1.81] AUROC: 0.72[0.7, 0.74] age, sex, first four genetic PCs
PPM000031 PGS000013 (GPS_CAD) PSS000022 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.55[1.38, 1.73] AUROC: 0.89[0.88, 0.91] age, sex, first four genetic PCs
PPM000032 PGS000013 (GPS_CAD) PSS000019 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.69[1.44, 1.99] AUROC: 0.84[0.81, 0.87] age, sex, first four genetic PCs, cohort recruitment centre
PPM000033 PGS000013 (GPS_CAD) PSS000020 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Reccurent coronary artery disease events OR: 1.13[1.06, 1.22] age, sex, first four genetic PCs
PPM000034 PGS000018 (metaGRS_CAD) PSS000021 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.74[1.57, 1.93] AUROC: 0.72[0.7, 0.75] age, sex, first four genetic PCs
PPM000035 PGS000018 (metaGRS_CAD) PSS000022 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.6[1.43, 1.8] AUROC: 0.89[0.88, 0.91] age, sex, first four genetic PCs
PPM000036 PGS000018 (metaGRS_CAD) PSS000019 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Coronary artery disease (prevalent) OR: 1.75[1.49, 2.05] AUROC: 0.84[0.81, 0.87] age, sex, first four genetic PCs, cohort recruitment centre
PPM000037 PGS000018 (metaGRS_CAD) PSS000020 PGP000008
Wünnemann F et al. (2019)
Ext.
Reported Trait: Reccurent coronary artery disease events OR: 1.17[1.08, 1.26] age, sex, first four genetic PCs
PPM000748 PGS000013 (GPS_CAD) PSS000365 PGP000090
Wang M et al. (2020)
Ext.
Reported Trait: Myocardial infarction (first-ever) OR: 1.4605 AUROC: 0.6482 age, sex, top 5 genetic PCs
PPM000749 PGS000013 (GPS_CAD) PSS000366 PGP000090
Wang M et al. (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.5793 AUROC: 0.7066 age, sex, top 5 genetic PCs
PPM000144 PGS000057 (CHD57) PSS000091 PGP000042
Natarajan P et al. (2017)
Reported Trait: Coronary heart disease (incident) HR (highest vs. lowest quintile of PGS): 1.66[1.21, 2.29] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000145 PGS000057 (CHD57) PSS000090 PGP000042
Natarajan P et al. (2017)
Reported Trait: Coronary artery calcification OR: 1.32[1.04, 1.68] OR (highest vs. lowest quintile of PGS): 2.51[1.08, 5.85] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000146 PGS000057 (CHD57) PSS000089 PGP000042
Natarajan P et al. (2017)
Reported Trait: Carotid artery plaque burden β: 1.097[1.022, 1.178] age, sex, diabetes meliitus status, smoking status, LDL cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication status, family history of CHD
PPM000147 PGS000058 (CAD_GRS_204) PSS000092 PGP000043
Morieri ML et al. (2018)
Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.27[1.18, 1.37] age, sex, ACCORD study covariates (randomized treament assignement, clinical network, genotyping platform, PCs of genetic ancestry)
PPM000148 PGS000058 (CAD_GRS_204) PSS000093 PGP000043
Morieri ML et al. (2018)
Reported Trait: Major coronary events (MCE) events among Type 2 Diabetes patients HR: 1.35[1.16, 1.58] age, sex, ORIGIN study covariates (randomized treament assignement, PCs of genetic ancestry)
PPM000149 PGS000059 (CHD46) PSS000095 PGP000044
Hajek C et al. (2018)
Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 1.92[1.19, 3.11]
p-value (association between risk and incidence): 0.029
NR
PPM000896 PGS000329 (PRS_CHD) PSS000440 PGP000100
Mars N et al. (2020)
Reported Trait: Incident coronary heart disease C-index: 0.82 ASCVD risk calculator(age, sex, total cholesterol, HDL, SBP, blood-pressure-lowering medication, diabetes and smoking status), FINRISK cohort, genotyping array/batch, 10 ancestry PCs 10-year risk
PPM000891 PGS000329 (PRS_CHD) PSS000440 PGP000100
Mars N et al. (2020)
Reported Trait: Incident coronary heart disease HR: 1.25[1.18, 1.32] C-index: 0.832 age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs 10-year risk
PPM000886 PGS000329 (PRS_CHD) PSS000445 PGP000100
Mars N et al. (2020)
Reported Trait: Coronary heart disease (incident and prevalent cases) HR: 1.31[1.29, 1.33] genotyping array/batch, 10 ancestry PCs, stratified by sex
PPM000909 PGS000337 (MetaPRS_CAD) PSS000456 PGP000104
Koyama S et al. (2020)
Reported Trait: Mortality (diseases of the circulatory system) HR: 1.10351[1.057, 1.152] Sex, age, age^2, PCs (1-10), disease status
PPM000908 PGS000337 (MetaPRS_CAD) PSS000454 PGP000104
Koyama S et al. (2020)
Reported Trait: All-cause Mortality HR: 1.03159[1.011, 1.052] Sex, age, age^2, PCs (1-10), disease status
PPM000383 PGS000013 (GPS_CAD) PSS000219 PGP000057
Homburger JR et al. (2019)
Ext.
Reported Trait: Coronary artery disease (personal history) OR: 1.589[1.32, 1.92] AUROC: 0.86 age, sex
PPM000402 PGS000013 (GPS_CAD) PSS000227 PGP000060
Khera AV et al. (2019)
Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.16[1.35, 1.59] Odds Ratio (OR; top 5% vs. rest): 3.33[0.82, 13.51] 4 genetic PCs
PPM000401 PGS000013 (GPS_CAD) PSS000229 PGP000060
Khera AV et al. (2019)
Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.56[1.29, 1.88] Odds Ratio (OR; top 5% vs. rest): 3.38[2.03, 5.64] 4 genetic PCs
PPM000400 PGS000013 (GPS_CAD) PSS000228 PGP000060
Khera AV et al. (2019)
Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 1.46[1.28, 1.66] Odds Ratio (OR; top 5% vs. rest): 2.02[1.29, 3.16] 4 genetic PCs
PPM000399 PGS000013 (GPS_CAD) PSS000230 PGP000060
Khera AV et al. (2019)
Ext.
Reported Trait: Early-onset mycardial infarction (age ≤55 years) OR: 2.06[1.89, 2.25] Odds Ratio (OR; top 5% vs. rest): 5.09[3.82, 6.78] 4 genetic PCs
PPM000518 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Plaque vulnerability score β: 0.07[0.003, 0.137] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000517 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Microvessels β: 0.037[-0.006, 0.08] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000516 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of smoooth muscle cells β: -0.004[-0.038, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000515 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of macrophages β: 0.01[-0.015, 0.036] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000514 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy macrophages OR: 1.103[0.983, 1.237] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000513 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy smooth muscle cells OR: 1.004[0.88, 1.145] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000512 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of IPH OR: 1.126[0.999, 1.27] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000511 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of lipid core >10% OR: 1.171[1.026, 1.337] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000510 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy collagen OR: 1.064[0.919, 1.231] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000509 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy calficiations OR: 0.94[0.826, 1.07] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000508 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Plaque vulnerability score OR: 0.198[0.003, 0.364] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000507 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Microvessels Beta (top 20% vs. rest): 0.072[-0.037, 0.182] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000506 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of smoooth muscle cells Beta (top 20% vs. rest): -0.056[-0.143, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000505 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of macrophages Beta (top 20% vs. rest): 0.55[-0.012, 0.121] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000504 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy macrophages Odds Ratio (OR; top 20% vs. rest): 1.49[1.118, 1.986] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000503 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy smooth muscle cells Odds Ratio (OR; top 20% vs. rest): 0.908[0.652, 1.265] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000502 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of IPH Odds Ratio (OR; top 20% vs. rest): 1.112[0.821, 1.506] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000501 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of lipid core >10% Odds Ratio (OR; top 20% vs. rest): 1.591[1.105, 2.291] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000500 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy collagen Odds Ratio (OR; top 20% vs. rest): 1.091[0.755, 1.577] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000499 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy calficiations Odds Ratio (OR; top 20% vs. rest): 1.001[0.754, 1.33] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000498 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Secondary cardiovascular events HR: 1.15[1.02, 1.29] Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs
PPM000019 PGS000010 (GRS27) PSS000012 PGP000005
Abraham G et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.21[1.12, 1.3]
PPM000021 PGS000010 (GRS27) PSS000011 PGP000005
Abraham G et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.2[1.07, 1.26]
PPM000387 PGS000013 (GPS_CAD) PSS000219 PGP000057
Homburger JR et al. (2019)
Ext.
Reported Trait: Coronary artery disease (personal history) AUROC: 0.6
PPM000497 PGS000011 (GRS50) PSS000284 PGP000076
Khera AV et al. (2016)
Ext.
Reported Trait: Coronary artery calcification Agatston score (mean, top 20% of GRS): 46.0[9.0, 54.0]
Agatston score (mean, btttom 25% of GRS): 21.0[18.0, 25.0]
PPM000806 PGS000116 (CAD_EJ2020) PSS000399 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease HR: 1.32[1.3, 1.34] C-index: 0.61[0.6, 0.62]
PPM000807 PGS000116 (CAD_EJ2020) PSS000399 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease C-index: 0.76[0.75, 0.76] age,sex
PPM000808 PGS000116 (CAD_EJ2020) PSS000399 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease C-index: 0.78[0.77, 0.79] pooled cohort equations
PPM000809 PGS000116 (CAD_EJ2020) PSS000387 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.6[0.59, 0.61]
PPM000810 PGS000116 (CAD_EJ2020) PSS000387 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.71[0.7, 0.72] age,sex
PPM000811 PGS000116 (CAD_EJ2020) PSS000387 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (over age 55) C-index: 0.74[0.73, 0.74] pooled cohort equations
PPM000812 PGS000116 (CAD_EJ2020) PSS000383 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.64[0.63, 0.66]
PPM000813 PGS000116 (CAD_EJ2020) PSS000383 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.76[0.75, 0.78] age,sex
PPM000814 PGS000116 (CAD_EJ2020) PSS000383 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (under age 55) C-index: 0.8[0.79, 0.82] pooled cohort equations
PPM000815 PGS000116 (CAD_EJ2020) PSS000391 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.61[0.6, 0.62]
PPM000816 PGS000116 (CAD_EJ2020) PSS000391 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.68[0.67, 0.69] age,sex
PPM000817 PGS000116 (CAD_EJ2020) PSS000391 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in males) C-index: 0.71[0.7, 0.72] pooled cohort equations
PPM000818 PGS000116 (CAD_EJ2020) PSS000395 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.61[0.6, 0.63]
PPM000819 PGS000116 (CAD_EJ2020) PSS000395 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.71[0.7, 0.73] age,sex
PPM000820 PGS000116 (CAD_EJ2020) PSS000395 PGP000054
Elliott J et al. (2020)
Reported Trait: Incident coronary artery disease (in females) C-index: 0.76[0.74, 0.77] pooled cohort equations
PPM000744 PGS000296 (GPS_CAD_SA) PSS000365 PGP000090
Wang M et al. (2020)
Reported Trait: Myocardial infarction (first-ever) OR: 1.51[1.22, 1.88] age, sex, top 5 genetic PCs, diabetes, hypertension, hypercholesterolemia, family history of heart disease, current smoking, family history of myocardial infarction
PPM000911 PGS000337 (MetaPRS_CAD) PSS000457 PGP000104
Koyama S et al. (2020)
Reported Trait: Mortality (ischemic heart disease) HR: 1.2158[1.109, 1.333] Sex, age, age^2, PCs (1-10), disease status
PPM000912 PGS000337 (MetaPRS_CAD) PSS000455 PGP000104
Koyama S et al. (2020)
Reported Trait: Mortality (congestive heart failure) HR: 1.15604[1.042, 1.2283] Sex, age, age^2, PCs (1-10), disease status
PPM000910 PGS000337 (MetaPRS_CAD) PSS000458 PGP000104
Koyama S et al. (2020)
Reported Trait: Mortality (diseases of the respiratory system) HR: 1.07133[1.012, 1.134] Sex, age, age^2, PCs (1-10), disease status
PPM000907 PGS000337 (MetaPRS_CAD) PSS000459 PGP000104
Koyama S et al. (2020)
Reported Trait: Coronary artery disease OR: 1.84[1.744, 1.943] AUROC: 0.674[0.661, 0.687] : 0.087[0.074, 0.101]
PPM000933 PGS000013 (GPS_CAD) PSS000469 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease C-index: 0.768[0.76, 0.776] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000932 PGS000013 (GPS_CAD) PSS000469 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease C-index: 0.756[0.75, 0.762] age, sex, PCs (1-10)
PPM000930 PGS000013 (GPS_CAD) PSS000469 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.53[1.49, 1.56] age, sex
PPM000929 PGS000013 (GPS_CAD) PSS000468 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease C-index: 0.802[0.763, 0.8841] age, sex, PCs (1-10), Pooled Cohort Equations risk estimator
PPM000928 PGS000013 (GPS_CAD) PSS000468 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease C-index: 0.759[0.724, 0.794] age, sex, PCs (1-10)
PPM000927 PGS000013 (GPS_CAD) PSS000468 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.45[1.34, 1.56] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD
PPM000926 PGS000013 (GPS_CAD) PSS000467 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.45[1.4, 1.49] age, sex
PPM000931 PGS000013 (GPS_CAD) PSS000469 PGP000108
Hindy G et al. (2020)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.46[1.42, 1.49] age, sex, clinical risk factors (systolic blood pressure, diastolic blood pressure, apolipoprotein B, apolipoprotein A1, total cholesterol, LDL cholesterol, HDL cholesterol, body mass index, current smoker, diabetes), family history of CAD

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals,
38.7 % Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 108 cases
  • , 8,641 controls
]
,
67.8 % Male samples
European JUPITER Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 149 cases
  • , 6,829 controls
]
,
79.7 % Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 320 cases
  • , 2,558 controls
]
,
86.1 % Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 229 cases
  • , 1,770 controls
]
,
77.5 % Male samples
European PROVEIT Secondary prevention cohorts
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease.
[
  • 2,213 cases
  • , 21,382 controls
]
,
38.03 % Male samples
European
(Swedish)
MDC Prospective study
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24)
[
  • 587 cases
  • , 2,819 controls
]
,
45.0 % Male samples
European FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures.
[
  • 757 cases
  • , 11,919 controls
]
,
46.0 % Male samples
European
(Finnish)
FINRISK FR92, FR97, FR02
PSS000015 CAD ascertainment was based on a composite of myocardial infarction or coronary revascularization. Myocardial infarction was based on self-report or hospital admission diagnosis, as performed centrally. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 8,676 cases
  • , 280,302 controls
]
European UKB UKB Phase 2
PSS000018 CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75.
[
  • 22,242 cases
  • , 460,387 controls
]
,
45.6 % Male samples
Other ~95% European ancestry samples, <5% non-European ancestry UKB
PSS000019 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 173 cases
  • , 5,589 controls
]
,
41.29 % Male samples
European
(French Canadian)
CARTaGENE
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 446 cases
  • , 416 controls
]
European
(French Canadian)
MHI Phase 1
PSS000020 Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 937 cases
  • , 1,396 controls
]
European
(French Canadian)
MHI Phase 2
PSS000021 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 974 cases
  • , 976 controls
]
,
72.7 % Male samples
European
(French Canadian)
MHI Phase 1
PSS000022 Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting).
[
  • 2,492 cases
  • , 817 controls
]
,
72.38 % Male samples
European
(French Canadian)
MHI Phase 2
PSS000023 CAD case endpoints were defined as: angina, myocardial infarction, coronary angioplasty, and coronary bypass surgery. Participants are described as Caucasian with diagnosed Familial hypercholesterolemia(FH; Dutch Lipid Criteria score >= 3 [possible, probable, or definite FH]) and carriers of classical French Canadian mutations in the LDLR gene including del .15 kb of the promoter and exon 1, del .5 kb of exons 2 and 3, W66G (exon 3), E207K (exon 4), Y468X (exon 10), and C646Y (exon 14).
[
  • 206 cases
  • , 519 controls
]
,
42.8 % Male samples
European CNMA Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) of Institut de recherches cliniques de Montréal
PSS000024 Cerebrovascular disease (CVD) case endpoints were defined as: transient ischemic attack, stroke, and carotid endarterectomy. Participants are described as Caucasian with diagnosed Familial hypercholesterolemia(FH; Dutch Lipid Criteria score >= 3 [possible, probable, or definite FH]) and carriers of classical French Canadian mutations in the LDLR gene including del .15 kb of the promoter and exon 1, del .5 kb of exons 2 and 3, W66G (exon 3), E207K (exon 4), Y468X (exon 10), and C646Y (exon 14).
[
  • 231 cases
  • , 494 controls
]
,
42.8 % Male samples
European CNMA Nutrition, Metabolism and Atherosclerosis Clinic (CNMA) of Institut de recherches cliniques de Montréal
PSS000440 Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complications following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first.
[
  • 1,209 cases
  • , 18,956 controls
]
,
47.3 % Male samples
Mean (Age At Baseline) = 48.0 years European
(Finnish)
FINRISK FINRISK surveys from 1992, 1997, 2002 and 2007
PSS000445 Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complications following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first.
[
  • 20,179 cases
  • , 115,121 controls
]
,
43.7 % Male samples
Mean (Age At Baseline) = 59.2 years
Sd = 16.6 years
European
(Finnish)
FinnGen
PSS000454 Cause of death under ICD-10 code Median = 7.7 years
[
  • 9,816 cases
  • , 39,414 controls
]
East Asian
(Japanese)
BBJ
PSS000455 Cause of death under ICD-10.CHF code Median = 7.7 years
[
  • 362 cases
  • , 48,868 controls
]
East Asian
(Japanese)
BBJ
PSS000456 Cause of death under ICD-10.I codes Median = 7.7 years
[
  • 2,122 cases
  • , 47,108 controls
]
East Asian
(Japanese)
BBJ
PSS000457 Cause of death under ICD-10.IHD code Median = 7.7 years
[
  • 464 cases
  • , 48,766 controls
]
East Asian
(Japanese)
BBJ
PSS000458 Cause of death under ICD-10.J codes Median = 7.7 years
[
  • 1,193 cases
  • , 48,037 controls
]
East Asian
(Japanese)
BBJ
PSS000459 CAD was defined as a composite of stable angina, unstable angina and myocardial infarction. The disease definitions are dependent on the physician's diagnosis based on general medical practices following relevant guidelines and according to the clinical symptoms and diagnotic tests.
[
  • 1,827 cases
  • , 9,172 controls
]
,
84.0 % Male samples
East Asian
(Japanese)
BBJ
PSS000467 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. Median = 21.3 years
Iqr = [16.1, 23.1] years
[
  • 4,122 cases
  • , 24,434 controls
]
,
38.7 % Male samples
Mean = 57.9 years European, NR European=28286, NR=270 MDC
PSS000468 Individuals were free of CAD at time of enrollment. CAD was defined as (1)fatal or nonfatal myocardial infarction: defined based on either International Classification of Diseases, Ninth Revision (ICD-9) code 410 or Tenth Revision (ICD-10) code I21, (2)coronary artery bypass graft surgery: defined as procedure codes 3065, 3066, 3068, 3080, 3092, 3105, 3127 or 3158 (the Op6 system) or procedure code FN (the KKA97 system), (3)percutaneous coronary intervention, (4)death due to CAD: defined as ICD-9 codes 412 and 414 or ICD-10 codes I22, I23 and I25. All individuals included had measured cholesterol concentrations. Median = 23.2 years
Iqr = [17.6, 24.2] years
[
  • 815 cases
  • , 4,870 controls
]
,
41.16 % Male samples
European, NR European=5640, NR=45 MDC-CC Cardiovascular Cohort
PSS000469 Individuals were free of CAD at time of enrollment. CAD was defined based on hospitalisation with or death due to ICD-10 codes for acute or subsequent myocaridal infarction (I21, I22, I23, I24.1, and I25.2); or hospitalisation with ICD-9 codes for myocaridal. infarction (410, 411, and 412); or hospitalisation with OPCS-4 (Office of Population Censuses and Surveys) codes. for coronary artery bypass grafting (K40, K41, and K45) or coronary angioplasty with or without stenting (K49, K50.2, and K75). Median = 8.1 years
Iqr = [7.4, 8.8] years
[
  • 7,708 cases
  • , 317,295 controls
]
,
44.2 % Male samples
Mean = 56.8 years European, African unspecified, South Asian, East Asian, NR European=304270, African unspecified=5760, South Asian=6832, East Asian (Chinese)=1117, NR=7024 UKB
PSS000219 Phenotypic information was self-reported by the individual through an online, interactive health history tool
[
  • 126 cases
  • , 10,884 controls
]
,
17.1 % Male samples
European CG Samples are individuals whose healthcare provider had ordered a Color Genomics multi-gene panel test
PSS000227
[
  • 40 cases
  • , 504 controls
]
Asian unspecified MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000228
[
  • 336 cases
  • , 962 controls
]
African American or Afro-Caribbean MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000229
[
  • 168 cases
  • , 751 controls
]
Hispanic or Latin American MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000230
[
  • 1,537 cases
  • , 1,544 controls
]
European MESA, VIRGO Cases are from VIRGO, controls are from MESA
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 19.0 years
[
  • 235 cases
  • , 4,869 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 14.0 years
[
  • 229 cases
  • , 6,338 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 9.0 years
[
  • 148 cases
  • , 7,182 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 8.0 years
[
  • 119 cases
  • , 5,004 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 19.0 years
[
  • 343 cases
  • , 4,761 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 14.0 years
[
  • 344 cases
  • , 6,223 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 9.0 years
[
  • 209 cases
  • , 7,121 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 8.0 years
[
  • 197 cases
  • , 4,926 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 19.0 years
[
  • 501 cases
  • , 4,603 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 14.0 years
[
  • 499 cases
  • , 6,068 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 9.0 years
[
  • 291 cases
  • , 7,039 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 8.0 years
[
  • 261 cases
  • , 4,862 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000331 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 838 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioVU
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,Partners
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000332 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 9.2 years
Iqr = [5.5, 13.0] years
[
  • 311 cases
  • , 6,759 controls
]
,
31.0 % Male samples
Mean = 43.6 years
Sd = 12.5 years
African American or Afro-Caribbean 7 cohorts
  • BioVU
  • ,Columbia
  • ,KP
  • ,Mount Sinai
  • ,Nugene
  • ,Partners
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000333 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 8,108 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,Marshfield
  • ,Mayo
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,Partners
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000334 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 11.7 years
Iqr = [6.0, 18.5] years
[
  • 2,221 cases
  • , 37,537 controls
]
,
44.6 % Male samples
Mean = 49.0 years
Sd = 14.1 years
European 11 cohorts
  • BioVU
  • ,CCHMC
  • ,Columbia
  • ,KP
  • ,Marshfield
  • ,Mayo
  • ,Mount Sinai
  • ,MyCode
  • ,Nugene
  • ,Partners
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000335 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 419 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioVU
  • ,Columbia
  • ,KP
  • ,Mayo
  • ,Mount Sinai
  • ,Nugene
  • ,Partners
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000336 CHD was defined as occurrence of either myocardial infarction (MI) or coronary revascularization events (such as percutaneous coronary intervention or coronary artery bypass grafting) using ICD codes. Individuals with MI were defined as those whose EHR included at least two related diagnostic codes on separate occasions within a 5-day window, and individuals with coronary revascularization were defined as those who had at least one relevant procedural code in the EHR. We identified the first CHD event and classified it as ‘‘incident’’ if the event occurred at least 6 months after the participant’s first record in the EHR and if there were no previous ICD-9-CM or ICD-10-CM codes associated with CHD. ICD codelists and phenotyping algorithm in PMID:27678441 and PMID:25717410 Median = 10.4 years
Iqr = [5.7, 14.7] years
[
  • 120 cases
  • , 2,074 controls
]
,
36.2 % Male samples
Mean = 41.1 years
Sd = 13.2 years
Hispanic or Latin American 8 cohorts
  • BioVU
  • ,Columbia
  • ,KP
  • ,Mayo
  • ,Mount Sinai
  • ,Nugene
  • ,Partners
  • ,eMERGE
right censored at age 75 years or at the age of last observation (whichever was first)
PSS000089 Total carotid plaque burden (mm2) 4,392 individuals Range = [55.0, 80.0] years BioImage
PSS000090 Total coronary arterial clacification (CAC) was coded as a a dichotomous outcome variable (CAC>0 versus CAC=0), and quantified by the Agatston method Mean = 15.0 years 1,154 individuals Range = [32.0, 47.0] years CARDIA
PSS000091 Nonfatal myocardial infarction or death from CHD Mean = 13.5 years
Sd = 2.8 years
2,440 individuals,
100.0 % Male samples
Mean = 55.1 years
Sd = 5.5 years
Participants were all men hypercholesterolemia but without a history of myocardial infarction, allocated to the placebo group
PSS000092 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina Median = 4.7 years
[
  • 675 cases
  • , 4,685 controls
]
,
64.8 % Male samples
Mean = 62.8 years European Self reported white ACCORD Type 2 Diabetes patients
PSS000093 Incident Major coronary events (MCE) are defined as: fatal or nonfatal coronary artery disease (CAD) events, nonfatal myocardial infarction, or unstable angina Median = 6.2 years
[
  • 163 cases
  • , 1,768 controls
]
European Self reported white ORIGIN Participants are from the Outcome Reduction With Initial Glargine Intervention (ORIGIN) trial and were enrolled based on having some combination of impaired fasting glucose, impaired glucose tolerance or type 2 diabetes, and high cardiovascular risk
PSS000094 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death
[
  • 86 cases
  • , 1,234 controls
]
Mean = 62.6 years European Analysis restricted to "White participants" MESA
PSS000095 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death
[
  • 144 cases
  • , 1,062 controls
]
Mean = 62.7 years European Analysis restricted to "White participants" MESA
PSS000365 Case-control study of first-onset acute myocardial infarction
[
  • 247 cases
]
,
90.7 % Male samples
Mean = 34.0 years
Iqr = [30.0, 35.0] years
South Asian BRAVE
PSS000365 Case-control study of first-onset acute myocardial infarction 244 individuals,
90.2 % Male samples
Mean = 33.0 years
Iqr = [30.0, 35.0] years
South Asian BRAVE
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease.
[
  • 1,800 cases
]
,
90.2 % Male samples
Mean = 54.0 years
Iqr = [46.0, 60.0] years
South Asian MedGenome
PSS000366 Cases composed of men and women diagnosed with coronary artery disease. Controls were selected from consenting men and women without any form of heart disease. 1,163 individuals,
76.4 % Male samples
Mean = 55.0 years
Iqr = [49.0, 62.0] years
South Asian MedGenome
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9).
[
  • 398 cases
]
,
86.7 % Male samples
Mean = 60.6 years
Iqr = [54.4, 66.1] years
South Asian UKB
PSS000367 Ascertainment of coronary artery disease was based on self-report or hospital admission diagnosis. This included individuals with ICD-9 codes of 410.X, 411.0, 412.X, or 429.79, or ICD-10 codes of I21.X, I22.X, I23.X, I24.1, or I25.2 in hospitalization records. Coronary revascularization was assessed based on an OPCS-4 coded procedure for coronary artery bypass grafting (K40.1–40.4, K41.1–41.4, or K45.1–45.5), or coronary angioplasty with or without stenting (K49.1–49.2, K49.8–49.9, K50.2, K75.1–75.4, or K75.8–75.9). 6,846 individuals,
52.1 % Male samples
Mean = 52.8 years
Iqr = [46.3, 60.2] years
South Asian UKB
PSS000383 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,350 cases
  • , 146,635 controls
]
Range = [40.0, 55.0] years Other
(98.3% White European, 1.7% Black/Other)
UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000385 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,339 cases
  • , 145,771 controls
]
Range = [40.0, 55.0] years Other
(2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry)
UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000387 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,922 cases
  • , 199,753 controls
]
Range = [55.0, 69.0] years Other
(98.3% White European, 1.7% Black/Other)
UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000389 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,900 cases
  • , 198,720 controls
]
Range = [55.0, 69.0] years Other
(2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry)
UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000391 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,493 cases
  • , 142,870 controls
]
,
100.0 % Male samples
Mean = 55.79 years
Sd = 8.35 years
Other
(98.3% White European, 1.7% Black/Other)
UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000393 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 4,471 cases
  • , 142,102 controls
]
,
100.0 % Male samples
Mean = 55.8 years
Sd = 8.3 years
Other
(2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry)
UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000395 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,779 cases
  • , 203,518 controls
]
,
0.0 % Male samples
Mean = 56.0 years
Sd = 8.01 years
Other
(98.3% White European, 1.7% Black/Other)
UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000397 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 1,768 cases
  • , 202,389 controls
]
,
0.0 % Male samples
Mean = 56.0 years
Sd = 8.0 years
Other
(2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry)
UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000399 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,272 cases
  • , 346,388 controls
]
,
41.8 % Male samples
Mean = 55.9 years
Range = [40.0, 69.0] years
Other
(98.3% White European, 1.7% Black/Other)
UKB PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000401 Coronary artery disease was defined as myocardial infarction and its related sequelae (coronary angioplasty, and coronary artery bypass grafts). ICD-10 codes: I21, I22, I23, I24.1, I25.2 ICD-9 codes: 410, 411, 412, 429.79 OPCS-4 codes: K40.1-4, K41.1-4, K45.1-5, K49.1-2, K49.8-9, K50.2, K75.1-4, K54.8-9 UKBiobank field 20002 code: 1075 UKBiobank field 20004 codes: 1070, 1095 UKBiobank field 6150 code: 1 See eTable 1 for risk factor codings Mean = 8.01 years
Sd = 1.04 years
[
  • 6,239 cases
  • , 344,491 controls
]
,
41.0 % Male samples
Range = [40.0, 69.0] years Other
(2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry)
UKB QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000283 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 18.8 years
[
  • 1,230 cases
  • , 6,584 controls
]
,
45.0 % Male samples
Mean = 54.0 years
Sd = 5.7 years
European ARIC
PSS000284 Cross-sectional analysis of baseline scores for coronary artery calcification (Agatston score) 4,260 individuals,
44.0 % Male samples
Mean = 69.1 years
Sd = 6.0 years
European BioImage
PSS000285 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 19.4 years
[
  • 2,902 cases
  • , 19,487 controls
]
,
38.0 % Male samples
Mean = 58.0 years
Sd = 7.7 years
European MDC-CC
PSS000286 Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. Mean = 20.5 years
[
  • 971 cases
  • , 20,251 controls
]
,
0.0 % Male samples
Mean = 54.2 years
Sd = 7.1 years
European WGHS
PSS000287 (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics Mean = 3.0 years 1,319 individuals,
69.3 % Male samples
Mean = 68.8 years
Sd = 9.3 years
European
(Dutch)
AEGS1