| Publication Information (EuropePMC) | |
| Title | Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes. |
| PubMed ID | 42698209(Europe PMC) |
| doi | 10.1016/j.xhgg.2026.100671 |
| Publication Date | Sept. 4, 2026 |
| Journal | HGG Adv |
| Author(s) | Jandu HK, Olowofela A, Shuey M, Quade K, Tuftin B, Raffield LM, Li Y, Cox N, Auer PL, Kerns SL. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS012559 (iPRS-M) |
PGP000800 | Jandu HK et al. HGG Adv (2026) |
INFLA-Score | platelet count, C-reactive protein measurement, neutrophil-to-lymphocyte ratio, leukocyte quantity |
1,188 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012559/ScoringFiles/PGS012559.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM030688 | PGS012559 (iPRS-M) |
PSS012248| Multi-ancestry (including European)| 4,833 individuals |
PGP000800 | Jandu HK et al. HGG Adv (2026) |
Reported Trait: INFLA-Score | β: 0.98 [0.797, 1.162] | — | R²: 0.026 | — | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012248 | The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. | — | 713 individuals | Mean = 55.7 years Sd = 16.31 years |
African unspecified | — | AllofUs | Linear regression models were used to test the association between the iPRS with the INFLA-score (the dependant variable), adjusted for age, sex, and PCs |
| PSS012248 | The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. | — | 174 individuals | Mean = 55.7 years Sd = 16.31 years |
Not reported | — | AllofUs | Linear regression models were used to test the association between the iPRS with the INFLA-score (the dependant variable), adjusted for age, sex, and PCs |
| PSS012248 | The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. | — | 3,026 individuals | Mean = 55.7 years Sd = 16.31 years |
European | — | AllofUs | Linear regression models were used to test the association between the iPRS with the INFLA-score (the dependant variable), adjusted for age, sex, and PCs |
| PSS012248 | The INFLA-Score was calculated using biomarker measurments from samples at the time of enrollment of participants into the UK Biobank. Deciles were created for each biomarker and a score that ranged from -4 to 4 was assigned to each decile in ascending order with the 5th and 6th deciles assigned 0. The decile scores for each biomarker were summed up to calculate the INFLA-Score for each individual. | — | 920 individuals | Mean = 55.7 years Sd = 16.31 years |
Hispanic or Latin American (Admixed American) |
— | AllofUs | Linear regression models were used to test the association between the iPRS with the INFLA-score (the dependant variable), adjusted for age, sex, and PCs |